1. People

John J. Sunderland, PhD, MBA

Professor of Radiology-Division of Nuclear Medicine

Current Positions

  • Professor of Radiology - Division of Nuclear Medicine
  • Professor of Physics and Astronomy
  • Professor of Radiation Oncology
  • Director, PET Imaging Center

Education

  • BA in Physics, Williams College, Williamstown, Massachusetts, United States
  • MS in Medical Physics, University of Wisconsin, Madison, Wisconsin, United States
  • PhD in Medical Physics, University of Wisconsin, Madison, Wisconsin, United States
  • MBA in Business, Centenary College, Frost School of Business, Shreveport, Louisiana, United States

Graduate Program Affiliations

Center, Program and Institute Affiliations

Research Interests

  • Quantitative Positron Emission Tomography, cyclotron-based radionuclide production, and small animal imaging.
  • Active Clinical Trials—Industry Sponsored - A Phase 1, First-in-Human, Single-Dose, Open-Label, Positron Emission Tomography (PET) Imaging Study of [68Ga]MLN6907 in Patients with Metastatic Colorectal Carcinoma [IRB pending]
  • Active Clinical Trials—Investigator Initiated - Brain pH and Alzheimer's Disease [IRB 201301784, Ponto PI]
  • Completed Clinical Trials—Investigator Initiated -RB-82 Normal Database [IRB 200910716, Sunderland PI]
  • Completed Clinical Trials—Investigator Initiated - PET/CT in Head and Neck Cancer [IRB 200807750]
  • Completed Clinical Trials—Investigator Initiated - Neural Mechanisms of Decision Making [IRB 200806751, Denburg PI]
  • Completed Clinical Trials—Investigator Initiated - Patient Specific FDG PET Thresholding [IRB 200804711, McGuire PI]
  • Active Clinical Trials—Investigator Initiated - F-18 Fluorothymidine ([18F]FLT) PET Imaging for Early Evaluation of Response to Chemoradiation Therapy in Patients with Gynecologic Cancer [IRB 200906786, Menda PI]
  • Active Clinical Trials—Investigator Initiated - Alzheimer’s Disease Neuroimaging Initiative – 2 [IRB 201101715, Schultz PI]
  • Active Clinical Trials—Investigator Initiated Quantitative Assessment of Minimal Detectable Disease in N0 and N1 Head and Neck Cancers [IRB 201409726, Sunderland, PI]

Selected Publications

  • Herington J, McCradden MD, Creel K, Boellaard R, Jones EC, Jha AK, Rahmim A, Scott PJH, Sunderland JJ, Wahl RL, Zuehlsdorff S, Saboury B. Ethical Considerations for Artificial Intelligence in Medical Imaging: Data Collection, Development, and Evaluation. J Nucl Med. 2023 Oct 12:jnumed.123.266080. doi: 10.2967/jnumed.123.266080. Epub ahead of print. PMID: 37827839.
  • Herington J, McCradden MD, Creel K, Boellaard R, Jones EC, Jha AK, Rahmim A, Scott PJH, Sunderland JJ, Wahl RL, Zuehlsdorff S, Saboury B. Ethical Considerations for Artificial Intelligence in Medical Imaging: Deployment and Governance. J Nucl Med. 2023 Oct;64(10):1509-1515. doi: 10.2967/jnumed.123.266110. Epub 2023 Aug 24. PMID: 37620051.
  • Sunderland JJ, Graves SA, York DM, Mundt CA, Bartel TB. Multicenter Evaluation of Frequency and Impact of Activity Infiltration in PET Imaging, Including Microscale Modeling of Skin-Absorbed Dose. J Nucl Med. 2023 Jul;64(7):1095-1101. doi: 10.2967/jnumed.123.265891. Epub 2023 May 25. Erratum in: J Nucl Med. 2023 Oct;64(10):1668. PMID: 37230534; PMCID: PMC10315693.
  • Brosch-Lenz J, Ke S, Wang H, Frey E, Dewaraja YK, Sunderland J, Uribe C. An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 2: Overall Variabilities in Absorbed Dose. J Nucl Med. 2023 Jul;64(7):1109-1116. doi: 10.2967/jnumed.122.265094. Epub 2023 Apr 6. PMID: 37024302; PMCID: PMC10315703.
  • Rajagopal A, Natsuaki Y, Wangerin K, Hamdi M, An H, Sunderland JJ, Laforest R, Kinahan PE, Larson PEZ, Hope TA. Synthetic PET via Domain Translation of 3-D MRI. IEEE Trans Radiat Plasma Med Sci. 2023 Apr;7(4):333-343. doi: 10.1109/trpms.2022.3223275. Epub 2022 Nov 18. PMID: 37396797; PMCID: PMC10311993.
  • Saboury B, Bradshaw T, Boellaard R, Buvat I, Dutta J, Hatt M, Jha AK, Li Q, Liu C, McMeekin H, Morris MA, Scott PJH, Siegel E, Sunderland JJ, Pandit-Taskar N, Wahl RL, Zuehlsdorff S, Rahmim A. Artificial Intelligence in Nuclear Medicine: Opportunities, Challenges, and Responsibilities Toward a Trustworthy Ecosystem. J Nucl Med. 2023 Feb;64(2):188-196. doi: 10.2967/jnumed.121.263703. Epub 2022 Dec 15. PMID: 36522184; PMCID: PMC9902852.
  • Smith AM, Obuchowski NA, Foster NL, Klein G, Mozley PD, Lammertsma AA, Wahl RL, Sunderland JJ, Vanderheyden JL, Benzinger TLS, Kinahan PE, Wong DF, Perlman ES, Minoshima S, Matthews D. The RSNA QIBA Profile for Amyloid PET as an Imaging Biomarker for Cerebral Amyloid Quantification. J Nucl Med. 2023 Feb;64(2):294-303. doi: 10.2967/jnumed.122.264031. Epub 2022 Sep 22. PMID: 36137760; PMCID: PMC9902844.
  • Jha AK, Bradshaw TJ, Buvat I, Hatt M, Kc P, Liu C, Obuchowski NF, Saboury B, Slomka PJ, Sunderland JJ, Wahl RL, Yu Z, Zuehlsdorff S, Rahmim A, Boellaard R. Nuclear Medicine and Artificial Intelligence: Best Practices for Evaluation (the RELAINCE Guidelines). J Nucl Med. 2022 Sep;63(9):1288-1299. doi: 10.2967/jnumed.121.263239. Epub 2022 May 26. PMID: 35618476; PMCID: PMC9454473.
  • Graves SA, Martin M, Tiwari A, Merrick M, Sunderland J. SIR-Spheres Activity Measurements Reveal Systematic Miscalibration. J Nucl Med. 2022 Aug;63(8):1131-1135. doi: 10.2967/jnumed.121.262650. Epub 2022 Jan 6. PMID: 34992155.
  • Seifert R, Sandach P, Kersting D, Fendler WP, Hadaschik B, Herrmann K, Sunderland JJ, Pollard JH. Repeatability of 68Ga-PSMA-HBED-CC PET/CT-Derived Total Molecular Tumor Volume. J Nucl Med. 2022 May;63(5):746-753. doi: 10.2967/jnumed.121.262528. Epub 2021 Aug 26. PMID: 34446454; PMCID: PMC9051594.

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