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Michelle Ouyang, MD

Clinical Assistant Professor of Radiology-Division of Body Imaging

Current Positions

  • Clinical Assistant Professor - Radiology

Education

  • Fellowship in Abdominal Imaging, University of Iowa Carver College of Medicine, Iowa City, Iowa
  • Resident in Diagnostic Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa
  • MD, Wayne State University School of Medicine, Detroit, Michigan
  • BS in Neuroscience, University of Michigan, Ann Arbor, Michigan

Research Interests

  • University of Iowa Hospital and Clinics Nov ’17 – Jun ‘18 Iowa City, IA − Investigated inter-reader variability in characterizing biopsied PIRADS 3 lesions on prostate MRI and correlations between specific lesion characteristics (ADC/DWI value, size, percent circumscribed, T2 signal) and malignancy. Presented at Senior Resident Research Day. − Conducted a comprehensive review on the topic of tumefactive demyelination that included many cases with pertinent imaging findings and pathologic correlation. Presented at RSNA 2018.
  • Wayne State University Research assistant May ’12 – May ‘13 Laboratory of Sokol V. Todi, Ph.D. Detroit, MI − Pursued a research project through the WSU Medical Alumni Summer Research Grant. The project focused on crossing and managing Drosophila lines, dissecting fly eyes, and performing light microscopy to explore how the deubiquitinating enzyme ataxin-3 protects from neurodegeneration in polyglutamine diseases.
  • University of Michigan Research assistant Sept ’07 – July ‘11 Laboratory of Henry L. Paulson, M.D., Ph.D. Ann Arbor, MI − Assisted with data collection on protein misfolding and aggregation in Spinocerebellar Ataxia Type 3 (SCA3). This included a high volume of immunohistochemistry and microscopy work on mouse brain tissue. − Also characterized the behavioral phenotype of the SCA3 mouse model (YAC84.2) by genotyping, behavioral testing with footprinting and rotarod, and organ harvesting at specific timepoints. Research projects also included extensive work with the protein ataxin-3 in vitro through Western Blotting.

Licenses & Certifications

  • American Board of Radiology
  • Iowa Medical License
  • Washington State Medical License

Selected Publications

  • Alwaqfi RR, Samuelson MI, Guseva NN, Ouyang M, Bossler AD, Ma D. PTCH1-GLI1 fusion–positive ovarian tumor: Report of a unique case with response to tyrosine kinase inhibitor pazopanib. JNCCN J Nat Compr Cancer Netw 2021;19(9):998-1004.
  • Nakayama M, Naganawa S, Ouyang M, Jones KA, Kim J, Capizzano AA, Moritani T. A Review of Clinical and Imaging Findings in Tumefactive Demyelination. AJR Am J Roentgenol. 2021 May 19:1-12. doi: 10.2214/AJR.20.23226. Epub ahead of print. PMID: 34010036.
  • Ouyang M, Pollard J, Laroia AT. Case of the Month: Plasmacytoma. Society of Thoracic Imaging. 2018. Available from: http://thoracicrad.org/assets/index/2018/Case_of_the_Month/cardio/04-2018/index.htm
  • Costa MDC, Ashraf NS, Fischer S, Yang Y, Schapka E, Joshi G, McQuade TJ, Dharia RM, Dulchavsky M, Ouyang M, Cook D, Sun D, Larsen MJ, Gestwicki JE, Todi SV, Ivanova MI, Paulson HL. Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3. Brain. 2016 Nov 1;139(11):2891-2908. doi: 10.1093/brain/aww228. PMID: 27645800; PMCID: PMC5840879.
  • Tsou WL, Ouyang M, Hosking RR, Sutton JR, Blount JR, Burr AA, Todi SV. The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster. Neurobiol Dis. 2015 Oct;82:12-21. doi: 10.1016/j.nbd.2015.05.010. Epub 2015 May 22. PMID: 26007638; PMCID: PMC4710962.
  • Tsou WL, Hosking RR, Burr AA, Sutton JR, Ouyang M, Du X, Gomez CM, Todi SV. DnaJ-1 and karyopherin α3 suppress degeneration in a new Drosophila model of Spinocerebellar Ataxia Type 6. Hum Mol Genet. 2015 Aug 1;24(15):4385-96. doi: 10.1093/hmg/ddv174. Epub 2015 May 7. PMID: 25954029; PMCID: PMC4492400.
  • Blount JR, Tsou WL, Ristic G, Burr AA, Ouyang M, Galante H, Scaglione KM, Todi SV. Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. Nat Commun. 2014 Aug 21;5:4638. doi: 10.1038/ncomms5638. PMID: 25144244; PMCID: PMC4237202.
  • Tsou WL, Burr AA, Ouyang M, Blount JR, Scaglione KM, Todi SV. Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo. J Biol Chem. 2013 Nov 29;288(48):34460-9. doi: 10.1074/jbc.M113.513903. Epub 2013 Oct 8. PMID: 24106274; PMCID: PMC3843061.
  • Costa Mdo C, Luna-Cancalon K, Fischer S, Ashraf NS, Ouyang M, Dharia RM, Martin-Fishman L, Yang Y, Shakkottai VG, Davidson BL, Rodríguez-Lebrón E, Paulson HL. Toward RNAi therapy for the polyglutamine disease Machado-Joseph disease. Mol Ther. 2013 Oct;21(10):1898-908. doi: 10.1038/mt.2013.144. Epub 2013 Jun 14. PMID: 23765441; PMCID: PMC3808129.