Stephen A. Graves, PhD

Portrait
Assistant Professor of Radiology - Division of Nuclear Medicine

Contact Information

Primary Office
3895 JPP
200 Hawkins Drive
Iowa City, IA 52242
319-678-7986

Education

BS, Physics, Tennessee Technological University
MS, Medical Physics, University of Wisconsin
PhD, Medical Physics, University of Wisconsin
Resident, Medical Physics, University of Iowa

Publications

Shi, S., Chen, F., Goel, S., Graves, S. A., Luo, H., Theuer, C. P., Engle, J. W. & Cai, W. (2018). In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem. Nano-Micro Letters, 10(4). DOI: 10.1007/s40820-018-0216-2.

Graves, S. A., Kutyreff, C., Barrett, K. E., Hernandez, R., Ellison, P. A., Happel, S., Aluicio-Sarduy, E., Barnhart, T. E., Nickles, R. J. & Engle, J. W. (2018). Evaluation of a chloride-based 89 Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin. Nuclear Medicine and Biology, 64-65, 1-7. DOI: 10.1016/j.nucmedbio.2018.06.003.

Voyles, A. S., Bernstein, L. A., Birnbaum, E. R., Engle, J. W., Graves, S. A., Kawano, T., Lewis, A. M. & Nortier, F. M. (2018). Excitation functions for (p,x) reactions of niobium in the energy range of Ep?=?40–90?MeV. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 429, 53-74. DOI: 10.1016/j.nimb.2018.05.028.

Zhan, Y., Ehlerding, E. B., Shi, S., Graves, S. A., Goel, S., Engle, J. W., Liang, J. & Cai, W. (2018). Intrinsically zirconium-89-labeled manganese oxide nanoparticles for in vivo dual-modality positron emission tomography and magnetic resonance imaging. Journal of Biomedical Nanotechnology, 14(5), 900-909. DOI: 10.1166/jbn.2018.2498.

Valdovinos, H. F., Hernandez, R., Graves, S., Ellison, P. A., Barnhart, T. E., Theuer, C. P., Engle, J. W., Cai, W. & Nickles, R. J. (2017). Cyclotron production and radiochemical separation of 55 Co and 58m Co from 54 Fe, 58 Ni and 57 Fe targets. Applied Radiation and Isotopes, 130, 90-101. DOI: 10.1016/j.apradiso.2017.09.005.

Graves, S. A., Hernandez, R., Valdovinos, H. F., Ellison, P. A., Engle, J. W., Barnhart, T. E., Cai, W. & Nickles, R. J. (2017). Preparation and in vivo characterization of 51 MnCl 2 as PET tracer of Ca 2+ channel-mediated transport. Scientific Reports, 7(1). DOI: 10.1038/s41598-017-03202-0.

Zhan, Y., Shi, S., Ehlerding, E. B., Graves, S. A., Goel, S., Engle, J. W., Liang, J., Tian, J. & Cai, W. (2017). Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging. ACS Applied Materials and Interfaces, 9(44), 38304-38312. DOI: 10.1021/acsami.7b12216.

Hernandez, R., Graves, S. A., Gregg, T., VanDeusen, H. R., Fenske, R. J., Wienkes, H. N., England, C. G., Valdovinos, H. F., Jeffery, J. J., Barnhart, T. E., Severin, G. W., Nickles, R. J., Kimple, M. E., Merrins, M. J. & Cai, W. (2017). Radiomanganese PET detects changes in functional ß-cell mass in mouse models of diabetes. In Diabetes. (Vols. 66). (8), pp. 2163-2174. DOI: 10.2337/db16-1285.

Graves, S. A., Ellison, P. A., Valdovinos, H. F., Barnhart, T. E., Nickles, R. J. & Engle, J. W. (2017). Half-life of Mn 51. Physical Review C, 96(1). DOI: 10.1103/PhysRevC.96.014613.

Ehlerding, E. B., England, C. G., Jiang, D., Graves, S. A., Kang, L., Lacognata, S., Barnhart, T. E. & Cai, W. (2017). CD38 as a PET Imaging Target in Lung Cancer. Molecular Pharmaceutics, 14(7), 2400-2406. DOI: 10.1021/acs.molpharmaceut.7b00298.

Valdovinos, H. F., Graves, S., Ellison, P., Barnhart, T. & Nickles, R. J. (2017). Earth, air, fire and water: A targetry quartet. In AIP Conference Proceedings. (Vols. 1845). DOI: 10.1063/1.4983553.

Ellison, P. A., Graves, S. A., Murali, D., De Jesus, O. T., Barnhart, T. E., Thomadsen, B. R., Speer, T. & Nickles, R. J. (2017). Radiobromine production, isolation and radiosynthesis for the development of a novel prostate cancer radiotherapeutic agent. In AIP Conference Proceedings. (Vols. 1845). DOI: 10.1063/1.4983538.

Valdovinos, H. F., Graves, S., Barnhart, T. & Nickles, R. J. (2017). Simplified and reproducible radiochemical separations for the production of high specific activity 61 Cu, 64 Cu, 86 Y and 55 Co. In AIP Conference Proceedings. (Vols. 1845). DOI: 10.1063/1.4983552.

Luo, H., England, C. G., Goel, S., Graves, S. A., Ai, F., Liu, B., Theuer, C. P., Wong, H. C., Nickles, R. J. & Cai, W. (2017). ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment. Molecular Pharmaceutics, 14(5), 1646-1655. DOI: 10.1021/acs.molpharmaceut.6b01123.

Fonslet, J., Tietze, S., Jensen, A. I., Graves, S. A. & Severin, G. W. (2017). Optimized procedures for manganese-52: Production, separation and radiolabeling. Applied Radiation and Isotopes, 121, 38-43. DOI: 10.1016/j.apradiso.2016.11.021.

England, C. G., Ehlerding, E. B., Hernandez, R., Rekoske, B. T., Graves, S. A., Sun, H., Liu, G., McNeel, D. G., Barnhart, T. E. & Cai, W. (2017). Preclinical pharmacokinetics and biodistribution studies of 89 Zr-Labeled Pembrolizumab. Journal of Nuclear Medicine, 58(1), 162-168. DOI: 10.2967/jnumed.116.177857.

Ellison, P. A., Valdovinos, H. F., Graves, S. A., Barnhart, T. E. & Nickles, R. J. (2016). Spot-welding solid targets for high current cyclotron irradiation. Applied Radiation and Isotopes, 118, 350-353. DOI: 10.1016/j.apradiso.2016.10.010.

Goel, S., Chen, F., Luan, S., Valdovinos, H. F., Shi, S., Graves, S. A., Ai, F., Barnhart, T. E., Theuer, C. P. & Cai, W. (2016). Engineering Intrinsically Zirconium-89 Radiolabeled Self-Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies. Advanced Science, 3(11). DOI: 10.1002/advs.201600122.

Sun, H., England, C. G., Hernandez, R., Graves, S. A., Majewski, R. L., Kamkaew, A., Jiang, D., Barnhart, T. E., Yang, Y. & Cai, W. (2016). ImmunoPET for assessing the differential uptake of a CD146-specific monoclonal antibody in lung cancer. European Journal of Nuclear Medicine and Molecular Imaging, 43(12), 2169-2179. DOI: 10.1007/s00259-016-3442-1.

Graves, S. A., Ellison, P. A., Barnhart, T. E., Valdovinos, H. F., Birnbaum, E. R., Nortier, F. M., Nickles, R. J. & Engle, J. W. (2016). Nuclear excitation functions of proton-induced reactions (Ep = 35–90 MeV) from Fe, Cu, and Al. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 386, 44-53. DOI: 10.1016/j.nimb.2016.09.018.

England, C. G., Im, H. J., Feng, L., Chen, F., Graves, S. A., Hernandez, R., Orbay, H., Xu, C., Cho, S. Y., Nickles, R. J., Liu, Z., Lee, D. S. & Cai, W. (2016). Re-assessing the enhanced permeability and retention effect in peripheral arterial disease using radiolabeled long circulating nanoparticles. Biomaterials, 100, 101-109. DOI: 10.1016/j.biomaterials.2016.05.018.

Brunnquell, C. L., Hernandez, R., Graves, S. A., Smit-Oistad, I., Nickles, R. J., Cai, W., Meyerand, M. E. & Suzuki, M. (2016). Uptake and retention of manganese contrast agents for PET and MRI in the rodent brain. Contrast Media and Molecular Imaging, 11(5), 371-380. DOI: 10.1002/cmmi.1701.

Luo, H., England, C. G., Shi, S., Graves, S. A., Hernandez, R., Liu, B., Theuer, C. P., Wong, H. C., Nickles, R. J. & Cai, W. (2016). Dual targeting of tissue factor and CD105 for preclinical PET imaging of pancreatic cancer. Clinical Cancer Research, 22(15), 3821-3830. DOI: 10.1158/1078-0432.CCR-15-2054.

Im, H. J., England, C. G., Feng, L., Graves, S. A., Hernandez, R., Nickles, R. J., Liu, Z., Lee, D. S., Cho, S. Y. & Cai, W. (2016). Accelerated Blood Clearance Phenomenon Reduces the Passive Targeting of PEGylated Nanoparticles in Peripheral Arterial Disease. ACS Applied Materials and Interfaces, 8(28), 17955-17963. DOI: 10.1021/acsami.6b05840.

Xu, C., Shi, S., Feng, L., Chen, F., Graves, S. A., Ehlerding, E. B., Goel, S., Sun, H., England, C. G., Nickles, R. J., Liu, Z., Wang, T. & Cai, W. (2016). Long circulating reduced graphene oxide-iron oxide nanoparticles for efficient tumor targeting and multimodality imaging. Nanoscale, 8(25), 12683-12692. DOI: 10.1039/c5nr09193d.

Cox, B. L., Graves, S. A., Farhoud, M., Barnhart, T. E., Jeffery, J. J., Eliceiri, K. W. & Nickles, R. J. (2016). Development of a novel linearly-filled Derenzo microPET phantom. American journal of nuclear medicine and molecular imaging, 6(3), 199-204. PMID: 27508106.

Valdovinos, H. F., Hernandez, R., Goel, S., Graves, S., Barnhart, T., Cai, W. & Nickles, R. J. (2016). Auger electron-based targeted radioimmunotherapy with 58m Co, a feasibility study. In AIP Conference Proceedings. (Vols. 1747). DOI: 10.1063/1.4954126.

Chen, F., Goel, S., Hernandez, R., Graves, S. A., Shi, S., Nickles, R. J. & Cai, W. (2016). Dynamic Positron Emission Tomography Imaging of Renal Clearable Gold Nanoparticles. Small, 12(20), 2775-2782. DOI: 10.1002/smll.201600194.

Luo, H., England, C. G., Graves, S. A., Sun, H., Liu, G., Nickles, R. J. & Cai, W. (2016). PET imaging of VEGFR-2 expression in lung cancer with 64 Cu-labeled ramucirumab. Journal of Nuclear Medicine, 57(2), 285-290. DOI: 10.2967/jnumed.115.166462.

Huang, H., Hernandez, R., Geng, J., Sun, H., Song, W., Chen, F., Graves, S. A., Nickles, R. J., Cheng, C., Cai, W. & Lovell, J. F. (2016). A porphyrin-PEG polymer with rapid renal clearance. Biomaterials, 76, 25-32. DOI: 10.1016/j.biomaterials.2015.10.049.

Yang, Y., Hernandez, R., Rao, J., Yin, L., Qu, Y., Wu, J., England, C. G., Graves, S. A., Lewis, C. M., Wang, P., Meyerand, M. E., Nickles, R. J., Bian, X. W. & Cai, W. (2015). Targeting CD146 with a 64 Cu-labeled antibody enables in vivo immunoPET imaging of high-grade gliomas. Proceedings of the National Academy of Sciences of the United States of America, 112(47), E6525-E6534. DOI: 10.1073/pnas.1502648112.

Hernandez, R., Czerwinski, A., Chakravarty, R., Graves, S. A., Yang, Y., England, C. G., Nickles, R. J., Valenzuela, F. & Cai, W. (2015). Evaluation of two novel 64 Cu-labeled RGD peptide radiotracers for enhanced PET imaging of tumor integrin a v ß 3. European Journal of Nuclear Medicine and Molecular Imaging, 42(12), 1859-1868. DOI: 10.1007/s00259-015-3085-7.

Graves, S. A., Hernandez, R., Fonslet, J., England, C. G., Valdovinos, H. F., Ellison, P. A., Barnhart, T. E., Elema, D. R., Theuer, C. P., Cai, W., Nickles, R. J. & Severin, G. W. (2015). Novel Preparation Methods of 52Mn for ImmunoPET Imaging. Bioconjugate Chemistry, 26(10), 2118-2124. DOI: 10.1021/acs.bioconjchem.5b00414.

Luo, H., Hernandez, R., Hong, H., Graves, S. A., Yang, Y., England, C. G., Theuer, C. P., Nickles, R. J. & Cai, W. (2015). Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry. Proceedings of the National Academy of Sciences of the United States of America, 112(41), 12806-12811. DOI: 10.1073/pnas.1509667112.

Shi, S., Hong, H., Orbay, H., Graves, S. A., Yang, Y., Ohman, J. D., Liu, B., Nickles, R. J., Wong, H. C. & Cai, W. (2015). ImmunoPET of tissue factor expression in triple-negative breast cancer with a radiolabeled antibody Fab fragment. European Journal of Nuclear Medicine and Molecular Imaging, 42(8), 1295-1303. DOI: 10.1007/s00259-015-3038-1.

Chen, F., Hong, H., Goel, S., Graves, S. A., Orbay, H., Ehlerding, E. B., Shi, S., Theuer, C. P., Nickles, R. J. & Cai, W. (2015). In vivo tumor vasculature targeting of CuS@MSN based theranostic nanomedicine. ACS Nano, 9(4), 3926-3934. DOI: 10.1021/nn507241v.

Hong, H., Yan, Y., Shi, S., Graves, S. A., Krasteva, L. K., Nickles, R. J., Yang, M. & Cai, W. (2015). PET of follicle-stimulating hormone receptor: Broad applicability to cancer imaging. Molecular Pharmaceutics, 12(2), 403-410. DOI: 10.1021/mp500766x.

Lewis, C. M., Graves, S. A., Hernandez, R., Valdovinos, H. F., Barnhart, T. E., Cai, W., Meyerand, M. E., Nickles, R. J. & Suzuki, M. (2015). 52Mn production for PET/MRI tracking of human stem cells expressing divalent metal transporter 1 (DMT1). Theranostics, 5(3), 227-239. DOI: 10.7150/thno.10185.

Rieffel, J., Chen, F., Kim, J., Chen, G., Shao, W., Shao, S., Chitgupi, U., Hernandez, R., Graves, S. A., Nickles, R. J., Prasad, P. N., Kim, C., Cai, W. & Lovell, J. F. (2015). Development and characterization of a hexamodal imaging nanoparticle. In 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. DOI: 10.1109/NEBEC.2015.7117194.

Rieffel, J., Chen, F., Kim, J., Chen, G., Shao, W., Shao, S., Chitgupi, U., Hernandez, R., Graves, S. A., Nickles, R. J., Prasad, P. N., Kim, C., Cai, W. & Lovell, J. F. (2015). Hexamodal imaging with porphyrin-phospholipid-coated upconversion nanoparticles. Advanced Materials, 27(10), 1785-1790. DOI: 10.1002/adma.201404739.

Shi, S., Orbay, H., Yang, Y., Graves, S. A., Nayak, T. R., Hong, H., Hernandez, R., Luo, H., Goel, S., Theuer, C. P., Nickles, R. J. & Cai, W. (2015). PET imaging of abdominal aortic aneurysm with <sup>64</sup>Cu-labeled anti-CD105 antibody fab fragment. Journal of Nuclear Medicine, 56(6), 927-932. DOI: 10.2967/jnumed.114.153098.

Luo, H., Hong, H., Slater, M. R., Graves, S. A., Shi, S., Yang, Y., Nickles, R. J., Fan, F. & Cai, W. (2015). PET of c-Met in cancer with <sup>64</sup>Cu-labeled hepatocyte growth factor. Journal of Nuclear Medicine, 56(5), 758-763. DOI: 10.2967/jnumed.115.154690.

Hong, H., Wang, F., Zhang, Y., Graves, S. A., Eddine, S. B., Yang, Y., Theuer, C. P., Nickles, R. J., Wang, X. & Cai, W. (2015). Red fluorescent zinc oxide nanoparticle: A novel platform for cancer targeting. ACS Applied Materials and Interfaces, 7(5), 3373-3381. DOI: 10.1021/am508440j.

Valdovinos, H. F., Hernandez, R., Barnhart, T. E., Graves, S., Cai, W. & Nickles, R. J. (2015). Separation of cyclotron-produced 44 Sc from a natural calcium target using a dipentyl pentylphosphonate functionalized extraction resin. Applied Radiation and Isotopes, 95, 23-29. DOI: 10.1016/j.apradiso.2014.09.020.

Hong, H., Nayak, T. R., Shi, S., Graves, S. A., Fliss, B. C., Barnhart, T. E. & Cai, W. (2014). Generation and screening of monoclonal antibodies for immunoPET imaging of IGF1R in prostate cancer. Molecular Pharmaceutics, 11(10), 3624-3630. DOI: 10.1021/mp5003637.

Valdovinos, H. F., Graves, S., Barnhart, T. & Nickles, R. J. (2014). 55Co separation from proton irradiated metallic nickel. In AIP Conference Proceedings. (Vols. 1626). pp. 217-220. DOI: 10.1063/1.4901397.

Graves, S., Cox, B., Weisse, N., Hoffman, S. & Nickles, R. J. (2013). SU-E-J-187: Single-Cell Dosimetric Simulation and Evaluation of Sb-119 for Use as Auger Emitting Nuclide in Targeted Radiotherapy. In Medical Physics. (Vols. 40). (6), pp. 194. DOI: 10.1118/1.4814399.

O'Malley, P. D., Bardayan, D. W., Adekola, A. S., Ahn, S., Chae, K. Y., Cizewski, J. A., Graves, S., Howard, M. E., Jones, K. L., Kozub, R. L., Lindhardt, L., Matos, M., Moazen, B. M., Nesaraja, C. D., Pain, S. D., Peters, W. A., Pittman, S. T., Schmitt, K. T., Shriner, J. F., Smith, M. S., Spassova, I., Strauss, S. Y. & Wheeler, J. L. (2011). Search for a resonant enhancement of the 7Be + d reaction and primordial 7Li abundances. Physical Review C - Nuclear Physics, 84(4). DOI: 10.1103/PhysRevC.84.042801.