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Thaddeus J. Wadas, PhD

Portrait
Associate Professor of Radiology - Division of Nuclear Medicine

Contact Information

Primary Office
Iowa City, IA 52242
319-356-8213

Education

BS, Biology, King's College
MS, Chemistry, University of Rochester
PhD, Chemistry, University of Rochester

Publications

Tafreshi, N. K., Doligalski, M. L., Tichacek, C. J., Pandya, D. N., Budzevich, M. M., El-Haddad, G., Khushalani, N. I., Moros, E. G., McLaughlin, M. L., Wadas, T. J. & Morse, D. L. (2019). Development of Targeted Alpha Particle Therapy for Solid Tumors. Molecules (Basel, Switzerland), 24(23). PMID: 31779154.

Tichacek, C. J., Budzevich, M. M., Wadas, T. J., Morse, D. L. & Moros, E. G. (2019). A Monte Carlo Method for Determining the Response Relationship between Two Commonly Used Detectors to Indirectly Measure Alpha Particle Radiation Activity. Molecules (Basel, Switzerland), 24(18). PMID: 31546752.

Tafreshi, N. K., Tichacek, C. J., Pandya, D. N., Doligalski, M. L., Budzevich, M. M., Kil, H., Bhatt, N. B., Kock, N. D., Messina, J. L., Ruiz, E. E., Delva, N. C., Weaver, A., Gibbons, W. R., Boulware, D. C., Khushalani, N. I., El-Haddad, G., Triozzi, P. L., Moros, E. G., McLaughlin, M. L., Wadas, T. J. & Morse, D. L. (2019). Melanocortin 1 Receptor-Targeted a-Particle Therapy for Metastatic Uveal Melanoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 60(8), 1124-1133. PMID: 30733316.

Pandya, D. N., Bhatt, N. B., Almaguel, F., Rideout-Danner, S., Gage, H. D., Solingapuram Sai, K. K. & Wadas, T. J. (2019). 89Zr-Chloride Can Be Used for Immuno-PET Radiochemistry Without Loss of Antigen Reactivity In Vivo. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 60(5), 696-701. PMID: 30442753.

Bhatt, N. B., Pandya, D. N., Rideout-Danner, S., Gage, H. D., Marini, F. C. & Wadas, T. J. (2018). A comprehensively revised strategy that improves the specific activity and long-term stability of clinically relevant 89Zr-immuno-PET agents. Dalton transactions (Cambridge, England : 2003), 47(37), 13214-13221. PMID: 30178793.

Bhatt, N. B., Pandya, D. N. & Wadas, T. J. (2018). Recent Advances in Zirconium-89 Chelator Development. Molecules (Basel, Switzerland), 23(3). PMID: 29534538.

Bhatt, N. B., Pandya, D. N., Dezarn, W. A., Marini, F. C., Zhao, D., Gmeiner, W. H., Triozzi, P. L. & Wadas, T. J. (2018). Practical Guidelines for Cerenkov Luminescence Imaging with Clinically Relevant Isotopes. Methods in molecular biology (Clifton, N.J.), 1790, 197-208. PMID: 29858793.

Sattiraju, A., Xiong, X., Pandya, D. N., Wadas, T. J., Xuan, A., Sun, Y., Jung, Y., Sai KKS,, Dorsey, J. F., Li, K. C. & Mintz, A. (2017). Alpha Particle Enhanced Blood Brain/Tumor Barrier Permeabilization in Glioblastomas Using Integrin Alpha-v Beta-3-Targeted Liposomes. Molecular cancer therapeutics, 16(10), 2191-2200. PMID: 28619756.

Sun, Y., Xiong, X., Pandya, D., Jung, Y., Mintz, A., Hayasaka, S., Wadas, T. J. & Li KCP, (2017). Enhancing tissue permeability with MRI guided preclinical focused ultrasound system in rabbit muscle: From normal tissue to VX2 tumor. Journal of controlled release : official journal of the Controlled Release Society, 256, 1-8. PMID: 28412225.

Sattiraju, A., Solingapuram Sai, K. K., Xuan, A., Pandya, D. N., Almaguel, F. G., Wadas, T. J., Herpai, D. M., Debinski, W. & Mintz, A. (2017). IL13RA2 targeted alpha particle therapy against glioblastomas. Oncotarget, 8(26), 42997-43007. PMID: 28562337.

Bhatt, N. B., Pandya, D. N., Xu, J., Tatum, D., Magda, D. & Wadas, T. J. (2017). Evaluation of macrocyclic hydroxyisophthalamide ligands as chelators for zirconium-89. PloS one, 12(6), e0178767. PMID: 28575044.

Pandya, D. N., Bhatt, N., Yuan, H., Day, C. S., Ehrmann, B. M., Wright, M., Bierbach, U. & Wadas, T. J. (2017). Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development. Chemical science, 8(3), 2309-2314. PMID: 28451334.

Pandya, D. N., Hantgan, R., Budzevich, M. M., Kock, N. D., Morse, D. L., Batista, I., Mintz, A., Li, K. C. & Wadas, T. J. (2016). Preliminary Therapy Evaluation of (225)Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from (225)Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization. Theranostics, 6(5), 698-709. PMID: 27022417.

Tinianow, J., Pandya, D. N., Pailloux, S. L., Ogasawara, A., Vanderbilt, A. N., Gill, H. S., Williams, S. P., Wadas, T. J., Magda, D. & Marik, J. (2016). Evaluation of a 3-hydroxypyridin-2-one (2,3-HOPO) Based Macrocyclic Chelator for (89)Zr(4+) and Its Use for ImmunoPET Imaging of HER2 Positive Model of Ovarian Carcinoma in Mice. Theranostics, 6(4), 511-21. PMID: 26941844.

Lears, K. A., Parry, J. J., Andrews, R., Nguyen, K., Wadas, T. J. & Rogers, B. E. (2015). Adenoviral-mediated imaging of gene transfer using a somatostatin receptor-cytosine deaminase fusion protein. Cancer gene therapy, 22(4), 215-21. PMID: 25837665.

Pandya, D. N., Pailloux, S., Tatum, D., Magda, D. & Wadas, T. J. (2015). Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89. Chemical communications (Cambridge, England), 51(12), 2301-3. PMID: 25556851.

Wadas, T. J., Pandya, D. N., Solingapuram Sai, K. K. & Mintz, A. (2014). Molecular targeted a-particle therapy for oncologic applications. AJR. American journal of roentgenology, 203(2), 253-60. PMID: 25055256.

Zheleznyak, A., Wadas, T. J., Sherman, C. D., Wilson, J. M., Kostenuik, P. J., Weilbaecher, K. N. & Anderson, C. J. (2012). Integrin a(v)ß3 as a PET imaging biomarker for osteoclast number in mouse models of negative and positive osteoclast regulation. Molecular imaging and biology, 14(4), 500-8. PMID: 21853370.

Shokeen, M., Wadas, T. J. (2011). The development of copper radiopharmaceuticals for imaging and therapy. Medicinal chemistry (Shariqah (United Arab Emirates)), 7(5), 413-29. PMID: 21711219.

Odendaal, A. Y., Fiamengo, A. L., Ferdani, R., Wadas, T. J., Hill, D. C., Peng, Y., Heroux, K. J., Golen, J. A., Rheingold, A. L., Anderson, C. J., Weisman, G. R. & Wong, E. H. (2011). Isomeric trimethylene and ethylene pendant-armed cross-bridged tetraazamacrocycles and in vitro/in vivo comparisions of their copper(II) complexes. Inorganic chemistry, 50(7), 3078-86. PMID: 21381676.

Wadas, T. J., Sherman, C. D., Miner, J. H., Duncan, J. R. & Anderson, C. J. (2010). The biodistribution of [153Gd]Gd-labeled magnetic resonance contrast agents in a transgenic mouse model of renal failure differs greatly from control mice. Magnetic resonance in medicine, 64(5), 1274-80. PMID: 20648683.

Wadas, T. J., Wong, E. H., Weisman, G. R. & Anderson, C. J. (2010). Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease. Chemical reviews, 110(5), 2858-902. PMID: 20415480.

Wadas, T. J., Deng, H., Sprague, J. E., Zheleznyak, A., Weilbaecher, K. N. & Anderson, C. J. (2009). Targeting the alphavbeta3 integrin for small-animal PET/CT of osteolytic bone metastases. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 50(11), 1873-80. PMID: 19875645.

Barnard, P. J., Holland, J. P., Bayly, S. R., Wadas, T. J., Anderson, C. J. & Dilworth, J. R. (2009). Macrocyclic diamide ligand systems: potential chelators for 64Cu- and 68Ga-based positron emission tomography imaging agents. Inorganic chemistry, 48(15), 7117-26. PMID: 19588930.

Wei, L., Ye, Y., Wadas, T. J., Lewis, J. S., Welch, M. J., Achilefu, S. & Anderson, C. J. (2009). (64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity. Nuclear medicine and biology, 36(3), 277-85. PMID: 19324273.

Wadas, T. J., Eiblmaier, M., Zheleznyak, A., Sherman, C. D., Ferdani, R., Liang, K., Achilefu, S. & Anderson, C. J. (2008). Preparation and biological evaluation of 64Cu-CB-TE2A-sst2-ANT, a somatostatin antagonist for PET imaging of somatostatin receptor-positive tumors. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(11), 1819-27. PMID: 18927338.

Anderson, C. J., Wadas, T. J., Wong, E. H. & Weisman, G. R. (2008). Cross-bridged macrocyclic chelators for stable complexation of copper radionuclides for PET imaging. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the, 52(2), 185-92. PMID: 18043536.

Heroux, K. J., Woodin, K. S., Tranchemontagne, D. J., Widger, P. C., Southwick, E., Wong, E. H., Weisman, G. R., Tomellini, S. A., Wadas, T. J., Anderson, C. J., Kassel, S., Golen, J. A. & Rheingold, A. L. (2007). The long and short of it: the influence of N-carboxyethyl versusN-carboxymethyl pendant arms on in vitro and in vivo behavior of copper complexes of cross-bridged tetraamine macrocycles. Dalton transactions (Cambridge, England : 2003),(21), 2150-62. PMID: 17514336.

Wadas, T. J., Wong, E. H., Weisman, G. R. & Anderson, C. J. (2007). Copper chelation chemistry and its role in copper radiopharmaceuticals. Current pharmaceutical design, 13(1), 3-16. PMID: 17266585.

Wadas, T. J., Anderson, C. J. (2006). Radiolabeling of TETA- and CB-TE2A-conjugated peptides with copper-64. Nature protocols, 1(6), 3062-8. PMID: 17406569.

Chakraborty, S., Wadas, T. J., Hester, H., Schmehl, R. & Eisenberg, R. (2005). Platinum chromophore-based systems for photoinduced charge separation: a molecular design approach for artificial photosynthesis. Inorganic chemistry, 44(20), 6865-78. PMID: 16180842.

Chakraborty, S., Wadas, T. J., Hester, H., Flaschenreim, C., Schmehl, R. & Eisenberg, R. (2005). Synthesis, structure, characterization, and photophysical studies of a new platinum terpyridyl-based triad with covalently linked donor and acceptor groups. Inorganic chemistry, 44(18), 6284-93. PMID: 16124807.

Wadas, T. J., Chakraborty, S., Lachicotte, R. J., Wang, Q. M. & Eisenberg, R. (2005). Facile synthesis, structure, and luminescence properties of Pt(diimine)bis(arylacetylide) chromophore-donor dyads. Inorganic chemistry, 44(8), 2628-38. PMID: 15819547.

Wadas, T. J., Wang, Q. M., Kim, Y. J., Flaschenreim, C., Blanton, T. N. & Eisenberg, R. (2004). Vapochromism and its structural basis in a luminescent Pt(II) terpyridine-nicotinamide complex. Journal of the American Chemical Society, 126(51), 16841-9. PMID: 15612723.

Wadas, T. J., Lachicotte, R. J. & Eisenberg, R. (2003). Synthesis and characterization of platinum diimine bis(acetylide) complexes containing easily derivatizable aryl acetylide ligands. Inorganic chemistry, 42(12), 3772-8. PMID: 12793813.