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Thaddeus J. Wadas, PhD

Associate Professor of Radiology-Division of Nuclear Medicine

Current Positions

  • Associate Professor of Radiology - Division of Nuclear Medicine
  • Co-Director, Theranostics Lab and Production Facility
  • Director, Small Animal Imaging Facility
  • Director, Wadas Laboratory
  • Associate Professor of Radiation Oncology

Education

  • BS in Biology, King's College, Wilkes-Barre, Pennsylvania, United States
  • MS in Chemistry, University of Rochester, Rochester, New York, United States
  • PhD in Chemistry, University of Rochester, Rochester, New York, United States

Graduate Program Affiliations

Selected Publications

  • Yuan F, Gasser GN, Lemire E, Montoro DT, Jagadeesh K, Zhang Y, Duan Y, Ievlev V, Wells KL, Rotti PG, Shahin W, Winter M, Rosen BH, Evans I, Cai Q, Yu M, Walsh SA, Acevedo MR, Pandya DN, Akurathi V, Dick DW, Wadas TJ, Joo NS, Wine JJ, Birket S, Fernandez CM, Leung HM, Tearney GJ, Verkman AS, Haggie PM, Scott K, Bartels D, Meyerholz DK, Rowe SM, Liu X, Yan Z, Haber AL, Sun X, Engelhardt JF. Transgenic ferret models define pulmonary ionocyte diversity and function. Nature. 2023 Sep;621(7980):857-867. doi: 10.1038/s41586-023-06549-9. Epub 2023 Sep 20. PMID: 37730992; PMCID: PMC10533402.
  • Choi PS, Lee JY, Chae JH, Wadas T, Cheng Z, Hur MG, Park JH. Theranostics through Utilizing Cherenkov Radiation of Radioisotope Zr-89 with a Nanocomposite Combination of TiO2 and MnO2. ACS Appl Mater Interfaces. 2023 Jan 25;15(3):3689-3698. doi: 10.1021/acsami.2c09195. Epub 2022 Dec 27. PMID: 36573583.
  • Zaher A, Stephens LM, Miller AM, Hartwig SM, Stolwijk JM, Petronek MS, Zacharias ZR, Wadas TJ, Monga V, Cullen JJ, Furqan M, Houtman JCD, Varga SM, Spitz DR, Allen BG. Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy. Front Immunol. 2022 Aug 22;13:989000. doi: 10.3389/fimmu.2022.989000. PMID: 36072595; PMCID: PMC9444023.
  • Abou DS, Zerkel P, Robben J, McLaughlin M, Hazlehurst T, Morse D, Wadas TJ, Pandya DN, Oyama R, Gaehle G, Nickels ML, Thorek DLJ. Radiopharmaceutical Quality Control Considerations for Accelerator-Produced Actinium Therapies. Cancer Biother Radiopharm. 2022 Jun;37(5):355-363. doi: 10.1089/cbr.2022.0010. PMID: 35695807; PMCID: PMC9242709.
  • Tran CG, Borbon LC, Mudd JL, Abusada E, AghaAmiri S, Ghosh SC, Vargas SH, Li G, Beyer GV, McDonough M, Li R, Chan CHF, Walsh SA, Wadas TJ, O'Dorisio T, O'Dorisio MS, Govindan R, Cliften PF, Azhdarinia A, Bellizzi AM, Fields RC, Howe JR, Ear PH. Establishment of Novel Neuroendocrine Carcinoma Patient-Derived Xenograft Models for Receptor Peptide-Targeted Therapy. Cancers (Basel). 2022 Apr 10;14(8):1910. doi: 10.3390/cancers14081910. PMID: 35454817; PMCID: PMC9033026.
  • Patel, C. M., Wadas, T. J. & Shiozawa, Y. (2021). Progress in Targeted Alpha-Particle-Emitting Radiopharmaceuticals as Treatments for Prostate Cancer Patients with Bone Metastases. Molecules (Basel, Switzerland) 26 (8). DOI: 10.3390/molecules26082162. PMID: 33918705. PMCID: PMC8070008.
  • Tafreshi, N. K., Pandya, D. N., Tichacek, C. J., Budzevich, M. M., Wang, Z., Reff, J. N., Engelman, R. W., Boulware, D. C., Chiappori, A. A., Strosberg, J. R., Ji, H., Wadas, T. J., El-Haddad, G. & Morse, D. L. (2021). Preclinical evaluation of [225Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms. European journal of nuclear medicine and molecular imaging. DOI: 10.1007/s00259-021-05315-1. PMID: 33772332.
  • Tafreshi, N. K., Kil, H., Pandya, D. N., Tichacek, C. J., Doligalski, M. L., Budzevich, M. M., Delva, N. C., Langsen, M. L., Vallas, J. A., Boulware, D. C., Engelman, R. W., Gage, K. L., Moros, E. G., Wadas, T. J., McLaughlin, M. L. & Morse, D. L. (2021). Lipophilicity Determines Routes of Uptake and Clearance, and Toxicity of an Alpha-Particle-Emitting Peptide Receptor Radiotherapy. ACS pharmacology & translational science 4 (2) 953-965. DOI: 10.1021/acsptsci.1c00035. PMID: 33860213. PMCID: PMC8033749.
  • Merrick, M. J., Rotsch, D. A., Tiwari, A., Nolen, J., Brossard, T., Song, J., Wadas, T. J., Sunderland, J. J. & Graves, S. A. (2021). Imaging and dosimetric characteristics of 67 Cu. Physics in medicine and biology 66 (3) 035002. DOI: 10.1088/1361-6560/abca52. PMID: 33496267.
  • Pandya, D. N., Henry, K. E., Day, C. S., Graves, S. A., Nagle, V. L., Dilling, T. R., Sinha, A., Ehrmann, B. M., Bhatt, N. B., Menda, Y., Lewis, J. S. & Wadas, T. J. (2020). Polyazamacrocycle Ligands Facilitate 89Zr Radiochemistry and Yield 89Zr Complexes with Remarkable Stability. Inorganic chemistry 59 (23) 17473-17487. DOI: 10.1021/acs.inorgchem.0c02722. PMID: 33169605.