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Carlos H. Chan, MD, PhD

Portrait
Director-Biospecimen Procurement and Molecular Epidemiology Resource Core
Assistant Professor of Surgery - Surgical Oncology and Endocrine Surgery
Assistant Professor of Radiation Oncology

Contact Information

Primary Office
4642 JCP
200 Hawkins Drive
Iowa City, IA 52242
319-356-1727

Education

BSc, Biochemistry & Computer Science, McGill University
PhD, Biochemistry, McGill University
MD, McGill University
Postdoctoral Research Fellow, Cancer Biology, McGill University Health Center
Resident, General Surgery, McGill University Health Centre
Fellow, Complex Surgical Oncology, Dana Farber Cancer Institute, Brigham & Women's Hospital & Harvard Medical School

Licensure and Certifications

Complex General Surgical Oncology Boards - American Board of Surgery
Medical License - Iowa Board of Medicine
General Surgery Boards - American Board of Surgery
General Surgery License - Collège des médecins du Québec
General Surgery Boards (Canada) - Royal College of Physicians and Surgeons of Canada

Research Summary

Dr. Chan's primary research focus is divided into the following three areas:
1) Study of the tumor immune microenvironment in the peritoneal cavity
2) Approaches of regional therapy for peritoneal surface malignancy
3) Cancer biomarker discovery and detection

Publications

Chan, C. (2020). The Chicago Consensus on Peritoneal Surface Malignancies: Management of Appendiceal Neoplasms. Annals of surgical oncology. PMID: 32285275.

Chan, C. (2020). The Chicago Consensus on peritoneal surface malignancies: Management of appendiceal neoplasms. Cancer. PMID: 32282073.

Chan, C. (2020). The Chicago Consensus on Peritoneal Surface Malignancies: Management of Colorectal Metastases. Annals of surgical oncology. PMID: 32285270.

Chan, C. (2020). The Chicago Consensus on peritoneal surface malignancies: Management of colorectal metastases. Cancer. PMID: 32282070.

Chan, C. (2020). The Chicago Consensus on Peritoneal Surface Malignancies: Management of Desmoplastic Small Round Cell Tumor, Breast, and Gastrointestinal Stromal Tumors. Annals of surgical oncology. PMID: 32285268.

Chan, C. (2020). The Chicago Consensus on peritoneal surface malignancies: Management of desmoplastic small round cell tumor, breast, and gastrointestinal stromal tumors. Cancer. PMID: 32282072.

Chan, C. (2020). The Chicago Consensus on Peritoneal Surface Malignancies: Management of Gastric Metastases. Annals of surgical oncology. PMID: 32285269.

Chan, C. (2020). The Chicago Consensus on peritoneal surface malignancies: Management of gastric metastases. Cancer. PMID: 32282074.

Chan, C. (2020). The Chicago Consensus on Peritoneal Surface Malignancies: Management of Neuroendocrine Tumors. Annals of surgical oncology. PMID: 32285274.

Chan, C. (2020). The Chicago Consensus on peritoneal surface malignancies: Management of neuroendocrine tumors. Cancer. PMID: 32282069.

Chan, C. (2020). The Chicago Consensus on Peritoneal Surface Malignancies: Management of Ovarian Neoplasms. Annals of surgical oncology. PMID: 32285271.

Chan, C. (2020). The Chicago Consensus on peritoneal surface malignancies: Management of ovarian neoplasms. Cancer. PMID: 32282068.

Chan, C. (2020). The Chicago Consensus on Peritoneal Surface Malignancies: Management of Peritoneal Mesothelioma. Annals of surgical oncology. PMID: 32285273.

Chan, C. (2020). The Chicago Consensus on peritoneal surface malignancies: Management of peritoneal mesothelioma. Cancer. PMID: 32282077.

Chan, C. (2020). The Chicago Consensus on Peritoneal Surface Malignancies: Palliative Care Considerations. Annals of surgical oncology. PMID: 32285272.

Chan, C. (2020). The Chicago Consensus on peritoneal surface malignancies: Palliative care considerations. Cancer. PMID: 32282059.

Chan, C. (2020). The Chicago Consensus on Peritoneal Surface Malignancies: Standards. Annals of surgical oncology. PMID: 32285276.

Chan, C. (2020). The Chicago Consensus on peritoneal surface malignancies: Standards. Cancer. PMID: 32282066.

Jiang, H. Y., Najmeh, S., Martel, G., MacFadden-Murphy, E., Farias, R., Savage, P., Leone, A., Roussel, L., Cools-Lartigue, J., Gowing, S., Berube, J., Giannias, B., Bourdeau, F., Chan, C. H., Spicer, J. D., McClure, R., Park, M., Rousseau, S. & Ferri, L. E. (2020). Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis. Protein and Cell, 11(3), 187-201. DOI: 10.1007/s13238-019-00687-5.

Behrens, I. K., Busch, B., Ishikawa-Ankerhold, H., Palamides, P., Shively, J. E., Stanners, C., Chan, C., Leung, N., Gray-Owen, S. & Haas, R. (2020). The Hopq-CEACAM interaction controls CagA translocation, phosphorylation, and phagocytosis of helicobacter pylori in neutrophils. mBio, 11(1). DOI: 10.1128/mBio.03256-19.

Chan,, C. (2020). ASO Author Reflections: Targeting the Immunosuppressive Tumor Microenvironment for Treating Peritoneal Carcinomatosis of Gastrointestinal and Pancreaticobiliary Cancer. ANNALS OF SURGICAL ONCOLOGY. DOI: 10.1245/s10434-020-08640-1.

Chitphet, K., Gear, S. M., Chan, C., Simons, A. L., Weiner, G. J. & Salem, A. K. (2020). Combining Doxorubicin-Loaded PEGylated Poly(Lactide-co-glycolide) Nanoparticles with Checkpoint Inhibition Safely Enhances Therapeutic Efficacy in a Melanoma Model. ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(5), 2659-2667. DOI: 10.1021/acsbiomaterials.9b01108.

Miller, A. M., Lemke-Miltner, C. D., Blackwell, S., Tomanek-Chalkley, A., Gibson-Corely, K. N., Coleman, K. L., Weiner, G. J. & Chan, C. H. (2020). Intraperitoneal CMP-001: A Novel Immunotherapy for Treating Peritoneal Carcinomatosis of Gastrointestinal and Pancreaticobiliary Cancer. ANNALS OF SURGICAL ONCOLOGY. DOI: 10.1245/s10434-020-08591-7.

Kasi, P. M., Toskich, B. M., Chandrasekharan, C., Prabhakar, D., Sharif, S., Berg, D. J., Miller, A., Chan, Carlos Hou Fai, & Laroia, S. (2020). Immunotherapy with Y90-radioembolization for metastatic colorectal cancer (iRE-C). (Vols. 38). (4) JOURNAL OF CLINICAL ONCOLOGY.

Kasi, P. M., Shen, L., Ramachandran, P., Moser, K., Xu, G., Buckley, P., Serie, D., Lebrilla, C., Xu, H. & Chan, Carlos Hou Fai, (2020). Serum glycoproteomic-based liquid biopsy for the detection of pancreatic ductal adenocarcinoma. (Vols. 38). (4) JOURNAL OF CLINICAL ONCOLOGY.

Chau, J. J., Yadav, M., Furqan, M., Mercer, K., Eastman, E., Shahi, S., Dai, Q., Chan, C., Weiner, G., Abu Hejleh, Taher,, Mangalam, A. & Zhang, J. (2020). The microbiome in lung cancer under immunotherapy: Significant compositional differences associated with treatment response and AEs. (Vols. 80). (8), pp. 60-61. CANCER RESEARCH.

Davis, K., Bellizzi, A. M. & Chan, C. H. (2019). An Unusual Progression of Signet-Ring Cell Carcinoma of the Appendix in a Caucasian Woman. Journal of Gastrointestinal Cancer, 50(2), 331-333. DOI: 10.1007/s12029-017-0018-7.

Davis, K., Dunseth, C., Mott, S., Cramer-Morales, K., Miller, A., Ear, P., Mezhir, J., Bellizzi, A. & Chan, C. (2019). Nicotinamide phosphoribosyltransferase expression and clinical outcome of resected stage I/II pancreatic ductal adenocarcinoma. PLoS ONE, 14(3), e0213576.

Kazarian, A. G., Mott, S. L. & Chan, Carlos Hou Fai, (2019). Clinical outcome of pancreatic cancer patients with indeterminate pulmonary nodules. (Vols. 37). (4) JOURNAL OF CLINICAL ONCOLOGY.

Miller, A. M., Lemke-Miltner, C., Blackwell, S., Tomanek-Chalkley, A., Coleman, K., Weiner, G. & Chan, C. (2019). CMP-001, a virus-like particle containing immunostimulatory CpG-A, for treatment of peritoneal carcinomatosis of gastrointestinal and pancreatic cancers. (Vols. 79). (13) CANCER RESEARCH. DOI: 10.1158/1538-7445.AM2019-3273.

Hoshi, H., Zaheer, A., El Abiad, R. G., Maxwell, J. E., Chu, L. C., Gerke, H. & Chan, C. H. (2018). Management of pancreatic intraductal papillary mucinous neoplasm. Current Problems in Surgery, 55(4), 126-152. DOI: 10.1067/j.cpsurg.2018.03.001.

Welsh, J. L., Jaber, O., Ivanovic, M., Johlin, F. C., El Abiad, R. G., Clamon, G. H., Smith, M. C. & Chan, C. H. (2018). Rapidly Progressing Primary Extrahepatic Bile Duct Signet-Ring Cell Carcinoma in a Caucasian Woman. Journal of Gastrointestinal Cancer, 49(1), 63-66. DOI: 10.1007/s12029-016-9843-3.

Tran, C. G., Hill, E. E., Jensen, B. S., Stark, A. C., Flannery, M. E., Berg, D. J. & Chan, C. H. (2018). Survival benefit of obesity in stage IV colorectal cancer: Better tolerability of chemotherapy?. In The 2018 ASCO Annual Meeting. (Vols. 36). (Suppl), pp. e15629. Journal of Clinical Oncology.

Gibson, A., O'Leary, B., Du, J., Chan, C. & Cullen, J. (2018). Dual oxidase expression is epigenetically silenced in pancreatic ductal adenocarcinoma. (Vols. 128). pp. S71-S72. FREE RADICAL BIOLOGY AND MEDICINE. DOI: 10.1016/j.freeradbiomed.2018.10.153.

Kruspe, S., Dickey, D. D., Urak, K. T., Blanco, G. N., Miller, M. J., Clark, K. C., Burghardt, E., Gutierrez, W. R., Phadke, S. D., Kamboj, S., Ginader, T., Smith, B. J., Grimm, S. K., Schappet, J., Ozer, H., Thomas, A., McNamara, J. O., Chan, C. H. & Giangrande, P. H. (2017). Rapid and Sensitive Detection of Breast Cancer Cells in Patient Blood with Nuclease-Activated Probe Technology. Molecular Therapy - Nucleic Acids, 8, 542-557. DOI: 10.1016/j.omtn.2017.08.004.

Chan, C. H., Liesenfeld, L. F., Ferreiro-Neira, I. & Cusack, J. C. (2017). Preclinical Evaluation of Cathepsin-Based Fluorescent Imaging System for Cytoreductive Surgery. Annals of Surgical Oncology, 24(4), 931-938. DOI: 10.1245/s10434-016-5690-5.

Chan, C. H. (2017). Total pancreaticoduodenectomy. In J. J. Hoballah , C. E. Scott-Conner (Eds.) Operative dictations in general and vascular surgery. (3rd edition) New York: Springer Science+Business Media, 2016.

Chan, C. H. (2017). Distal Pancreatectomy. In J. J. Hoballah , C. E. Scott-Conner (Eds.) Operative dictations in general and vascular surgery. (3rd edition) New York: Springer Science+Business Media.

Chan, C. H. (2017). Pancreatic cystogastrostomy. In J. J. Hoballah , C. E. Scott-Conner (Eds.) Operative dictations in general and vascular surgery. (3rd edition) New York: Springer Science+Business Media.

Davis, K., Dunseth, C., Mott, S. L., Bellizzi, A. & Chan, Carlos Hou Fai, (2017). NAMPT expression in stage I/II pancreatic ductal adenocarcinoma. (Vols. 35). Journal of Clinical Oncology. DOI: 10.1200/JCO.2017.35.15_suppl.e15735.

Chan, C. H., Wong, P. (2016). Molecular Predictors of Radiotherapy Response in Sarcoma. Current Treatment Options in Oncology, 17(1), 1-11. DOI: 10.1007/s11864-015-0381-1.

Wagh, M., Draganov, P. (2016). Pancreatic masses: Advances in diagnosis and therapy. Springer International Publishing.

Yan, L. (2016). Operative techniques in liver resection. Dordrechit: Springer Science+Business Media.

Ferreiro-Neira, I., Torres, N., Liesenfeld, L., Chan, C. H., Penson, T., Landesman, Y., Senapedis, W., Shacham, S., Hong, T. S. & Cusack, J. C. (2015). XPO1 inhibition enhances radiation response in preclinical models of rectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. PMID: 26603256.

Chan, C. H., Coopey, S. B., Freer, P. E. & Hughes, K. S. (2015). False-negative rate of combined mammography and ultrasound for women with palpable breast masses. Breast cancer research and treatment, 153(3), 699-702. PMID: 26341750.

Chow, S. C., Gowing, S. D., Cools-Lartigue, J. J., Chen, C. B., Berube, J., Yoon, H. W., Chan, C. H., Rousseau, M. C., Bourdeau, F., Giannias, B., Roussel, L., Qureshi, S. T., Rousseau, S. & Ferri, L. E. (2015). Gram negative bacteria increase non-small cell lung cancer metastasis via Toll-like receptor 4 activation and mitogen-activated protein kinase phosphorylation. International journal of cancer. Journal international du cancer, 136(6), 1341-50. PMID: 25082668.

Chan, C., Cusack, J. & Ryan, D. (2015). A critical look at local-regional management of peritoneal metastasis. Hematology/oncology clinics of North America, 29(1), 153-8. PMID: 25475577.

Sintsova, A., Sarantis, H., Islam, E. A., Sun, C. X., Amin, M., Chan, C. H., Stanners, C. P., Glogauer, M. & Gray-Owen, S. D. (2014). Global analysis of neutrophil responses to Neisseria gonorrhoeae reveals a self-propagating inflammatory program. PLoS pathogens, 10(9), e1004341. PMID: 25188454.

Rousseau, M. C., Hsu, R. Y., Spicer, J. D., McDonald, B., Chan, C. H., Perera, R. M., Giannias, B., Chow, S. C., Rousseau, S., Law, S. & Ferri, L. E. (2013). Lipopolysaccharide-induced toll-like receptor 4 signaling enhances the migratory ability of human esophageal cancer cells in a selectin-dependent manner. Surgery, 154(1), 69-77. PMID: 23809486.

Arabzadeh, A., Chan, C., Nouvion, A. L., Breton, V., Benlolo, S., DeMarte, L., Turbide, C., Brodt, P., Ferri, L. & Beauchemin, N. (2013). Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer. Oncogene, 32(7), 849-60. PMID: 22469976.

Chan, C. H., Cools-Lartigue, J., Marcus, V. A., Feldman, L. S. & Ferri, L. E. (2012). The impact of incidental gastrointestinal stromal tumours on patients undergoing resection of upper gastrointestinal neoplasms. Canadian journal of surgery. Journal canadien de chirurgie, 55(6), 366-70. PMID: 22992402.

Denizot, J., Sivignon, A., Barreau, F., Darcha, C., Chan, H. F., Stanners, C. P., Hofman, P., Darfeuille-Michaud, A. & Barnich, N. (2012). Adherent-invasive Escherichia coli induce claudin-2 expression and barrier defect in CEABAC10 mice and Crohn's disease patients. Inflammatory bowel diseases, 18(2), 294-304. PMID: 21688348.

Hsu, R. Y., Chan, C. H., Spicer, J. D., Rousseau, M. C., Giannias, B., Rousseau, S. & Ferri, L. E. (2011). LPS-induced TLR4 signaling in human colorectal cancer cells increases beta1 integrin-mediated cell adhesion and liver metastasis. Cancer research, 71(5), 1989-98. PMID: 21363926.

Chan, C., Al-Busafi, S. & Waschke, K. (2011). Massive upper gastrointestinal bleeding secondary to duodenal metastasis of transitional cell carcinoma of urinary bladder. Case Reports in Gastroenterology, 5, 246-8.

Chan, C. H., Nouvion, A. S., DeMarte, L., Breton, V., Turbide, C., Beauchemin, N. & Ferri, L. E. (2011). A Novel Method to Generate Colon Cancer Orthotopic Tumors in Mice: Implantation Using the Cecal Pouch Technique. (Vols. 140). (5), pp. s-1058. Gastroenterology.

Roussel, L., Houle, F., Chan, C., Yao, Y., Bérubé, J., Olivenstein, R., Martin, J. G., Huot, J., Hamid, Q., Ferri, L. & Rousseau, S. (2010). IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation. Journal of immunology (Baltimore, Md. : 1950), 184(8), 4531-7. PMID: 20228195.

Chan, C., El-Hakim, A. & Andonian, S. (2010). Renal pelvic matrix stone managed by ureteroscopic holmium laser lithotripsy. Canadian Journal of Urology, 17(2), 5127-30.

Chan, C. H., Arabzadeh, A., DeMarte, L., Spicer, J., Turbide, C., Brodt, P., Beauchemin, N. & Ferri, L. E. (2010). Impact of CEACAM1 expression in liver metastasis. (Vols. 53). (S93) Canadian Journal of Surgery.

Carvalho, F. A., Barnich, N., Sivignon, A., Darcha, C., Chan, C. H., Stanners, C. P. & Darfeuille-Michaud, A. (2009). Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM. The Journal of experimental medicine, 206(10), 2179-89. PMID: 19737864.

Chan, C. H., Camacho-Leal, P. & Stanners, C. P. (2007). Colorectal hyperplasia and dysplasia due to human carcinoembryonic antigen (CEA) family member expression in transgenic mice. PloS one, 2(12), e1353. PMID: 18159236.

Chan, C., Stanners, C. (2007). Recent advances in the tumour biology of the GPI-anchored carcinoembryonic antigen family members CEACAM5 and CEACAM6. Current oncology (Toronto, Ont.), 14(2), 70-3. PMID: 17576469.

Chan, C. H., Cook, D. & Stanners, C. P. (2006). Increased colon tumor susceptibility in azoxymethane treated CEABAC transgenic mice. Carcinogenesis, 27(9), 1909-16. PMID: 16632476.

Chan, C. H., Stanners, C. P. (2004). Novel mouse model for carcinoembryonic antigen-based therapy. Molecular therapy : the journal of the American Society of Gene Therapy, 9(6), 775-85. PMID: 15194045.

Chan, C. H., Stanners, C. P. (2004). Human GPI-anchored carcinoembryonic antigen family members initiates colon tumorgenesis in vivo. (Vols. 27). (4), pp. 211. Clinical and Investigative Medicine.

Chan, C. H., Stanners, C. P. (2003). Colon tumorigenesis in transgenic mice expressing multiple human GPI-anchored CEA family genes. (Vols. 26). (4), pp. 191. Clinical and Investigative Medicine.

Chan, C. H., Stanners, C. P. (2002). Murine model for preclinical trials of carcinoembryonic antigen targeted therapies. (Vols. 25). (4), pp. 160. Clinical and Investigative Medicine.

Chan, C. H., Stanners, C. P. (2001). Expression of GPI-anchored human carcinoembryonic antigen family members CEA, CEACAM6 and CEACAM7 in mouse rectal carcinoma cell line CMT-93 using a 200kb bacterial artificial chromosome. (Vols. 24). (4), pp. 217. Clinical and Investigative Medicine.

Chan, C. (2001). Human Genome Sequence: What can we get from it?. (Vols. 6). (1), pp. 8-9. McGill Journal of Medicine.