Isaac Samuel, MD

Gastrointestinal, and Minimally-Invasive Surgeon
Professor of Surgery - Gastrointestinal, Minimally invasive and Bariatric Surgery

Contact Information

Primary Office
4625 JCP
Iowa City, IA 52242


MBBS, Bangalore Medical College, Bangalore University
Internship, Surgery and Medicine, Bangalore Medical College Hospitals
Resident, Surgery and Medicine, St. Martha's and St. Philomena's Hospitals
Resident, Surgery and Medicine, Tiruvella Medical Mission Hospital
Resident, Emergency Room, Eastbourne District, General Hospital
Resident, General Surgery, Leeds General Infirmary, University of Leeds
Resident, General Surgery, St. Thomas' Hospital, University of London
Fellow, Research, General Surgery, Northwestern University
Resident, General Surgery, Rush-Presbyterian-St. Luke's Medical Center

Licensure and Certifications

Fellow (FACS) - American College of Surgeons
Board Certified, General Surgery - American Board of Surgery
Iowa Medical License - Iowa Board of Medicine
FRCS - Royal College of Surgeons, Glasgow, UK

Research Summary

Acute pancreatitis pathogenesis: The laboratory investigates the role of acinar cell signaling pathways such as the stress kinase (p38, JNK, ERK) pathway and the Akt/NFkB pathway as applied to a novel hypothesis for gallstone pancreatitis pathogenesis. The role of pancreatic hyperstimulation via G-protein coupled receptors (CCK receptor and cholinergic receptor) and their regulation by a novel group of proteins called RGS (regulation of G-protein signaling) proteins are also being investigated. Our long- term goal is to elucidate the pathogenesis of acute pancreatitis with a view to implement new treatment modalities. Current funding from NIH is a NIDDK K08 Career Development Award. Samuel Clinical Research: Measurement of physical activity and energy expenditure in bariatric surgery patients to improve pre-operative evaluation and long-term post-operative outcomes.