Isaac Samuel, MD, FRCS, FACS
Professor of Surgery - Gastrointestinal Surgery
Introduction
I have done extensive research into the pathogenesis of gallstone pancreatitis and have contributed novel experimental models to the field. This basic science research was supported by 12 years of federal funding. I have contributed important research findings in the field of bariatric surgery and made novel observations regarding the association between severe obesity and migraine headaches, infertility, and hyperlipidemia. Most recently, I led a collaborative team that showed that gallbladder hyperkinesia is associated with acalculous biliary colic that shows substantial amelioration with cholecystectomy, which is an important new contribution to the field of gallbladder diseases and has helped several patients in chronic pain.
Current Positions
- Professor of Surgery - Gastrointestinal Surgery, University of Iowa
Education
- MBBS, Bangalore Medical College, Bangalore University, Karnataka State, India
- Internship in Surgery and Medicine, Bangalore Medical College Hospitals, Karnataka State, India
- Resident in Surgery and Medicine, St. Martha's and St. Philomena's Hospitals, Karnatake State, India
- Resident in Surgery and Medicine, Tiruvella Medical Mission Hospital, Kerala State, India
- Resident in Emergency Room, Eastbourne District, General Hospital, Eastbourne, United Kingdom
- Resident in General Surgery, Leeds General Infirmary, University of Leeds, Leeds, United Kingdom
- Registrar in General Surgery, St. Thomas' Hospital, University of London, London, United Kingdom
- Fellow in Research, General Surgery, Northwestern University, Chicago, Illinois
- Resident in General Surgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois
Center, Program and Institute Affiliations
Research Interests
- Clinical research on gallbladder dysfunction.
- Investigating surgical aspects, energy balance, pre-operative evaluation, and long-term outcomes in bariatric surgery patients.
- Basic science research project investigating role of: Enteral exclusion and GPCRs in pathogenesis of acute pancreatitis, Stress-activated protein kinases in acute pancreatitis pathogenesis, RGS proteins in acute pancreatitis pathogenesis.
Licenses & Certifications
- Board Certified, General Surgery, American Board of Surgery
- Iowa Medical License, Iowa Board of Medicine, Iowa
- Fellow, American College of Surgeons
- Certified, Basic Life Support, American Heart Association
- FRCS, Royal College of Surgeons, Glasgow, United Kingdom
- Permanent Medical License, California
- Permanent Medical License, Illinois
- Permanent Licensure, General Medical Council, London, United Kingdom
- Permanent Licensure, Karnataka State, India
Selected Publications
- Samuel I. Cholescintigraphy protocols for the Chronic Acalculous Symptomatic hyPERkinetic (CASPER) gallbladder. Editorial invited by Med Res Arch (2024).
- Samuel, I. (2024). Negative impact of prolonged fasting on gallbladder ejection fraction measurement with cholescintigraphy in Chronic Acalculous Symptomatic hyPERkinetic (CASPER) gallbladders. Medical Research Archives, 12(3). [S.l.], v. 12, n. 3, apr. 2024. ISSN 2375-1924. doi:10.18103/mra.v12i3.5129
- Joseph S, Molinarolo K, Rajput M, Kuehn D, Samuel I. Not yet submitted, In Preparation. Etiological analysis of post-gastric bypass small bowel obstruction for preventive strategies.
- McDermott, T., Samuel, I. & Aswani, Y. Not yet submitted, In Preparation. Retro-Cecal Sigmoid Colon Internal Herniation via Posterior Paracecal Recess. Case-report.
- Samuel I (2023) The Chronic Acalculous Symptomatic Hyperkinetic (CASPER) Gallbladder or “The Excitable Gallbladder”. JSM Gastroenterology and Hepatology 10(1): 1113. DOI: 10.47739/2373-9487/1113
- Gunasekar, S. K., Xie, L., Kumar, A., Hong, J., Chheda, P. R., Kang, C., Kern, D. M., My-Ta, C., Maurer, J., Heebink, J., Gerber, E. E., Grzesik, W. J., Elliot-Hudson, M., Zhang, Y., Key, P., Kulkarni, C. A., Beals, J. W., Smith, G. I., Samuel, I., Smith, J. K., Nau, P., Imai, Y., Sheldon, R. D., Taylor, E. B., Lerner, D. J., Norris, A. W., Klein, S., Brohawn, S. G., Kerns, R. & Sah, R. (2022). Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. Nature communications 13 (1) 784. DOI: 10.1038/s41467-022-28435-0. PMID: 35145074. PMCID: PMC8831520.
- Twait, EC & Samuel, I. (2021). Exocrine Pancreatic Cell NF-κB/AP-1 Crosstalk Downstream of ERK MAPK. Journal of Clinical and Laboratory Medicine. 6. DOI: 10.16966/2572-9578.137
- Pillenahalli Maheshwarappa, R., Menda, Y., Graham, M. M., Boukhar, S. A., Zamba GKD & Samuel, I. (2020). Association of gallbladder hyperkinesia with acalculous chronic cholecystitis: A case-control study. Surgery 168 (5) 800-808. DOI: 10.1016/j.surg.2020.06.005. PMID: 32653205.
- Kempuraj, D., Twait, E., Williard, D., Yuan, Z., Meyerholz, D. & Samuel, I. (2013). The Novel Cytokine IL-33 Activates Acinar Cell Proinflammatory Pathways and Induces Acute Pancreatic Inflammation in Mice. (Vols. 8). (2) PLoS. PMID: 23418608.
- Gunay, Y., Jamal, M., Capper, A., Eid, A., Heitshusen, D. & Samuel, I. (2013). Roux-en-Y Gastric Bypass Achieves Substantial Resolution of Migraine Headache in Severely Obese: a 9-yr experience in 81 patients. (Vols. 9). (1), pp. 55-62. Surgery for Obesity and Related Disorders. PMID: 22445649.