Co-Director, Neuroendocrine Cancer Clinic
Contact Information
Primary Office
4644 JCP
Iowa City, IA 52242
319-356-1727
Education
MD, University of Vermont College of MedicineResident, General Surgery, Barnes Hospital
Fellow, Clinical, Surgical Oncology, Memorial Sloan-Kettering Center
Licensure and Certifications
Iowa Medical License - Iowa Board of MedicineBoard Certified, General Surgery - American Board of Surgery
Qualifying Examination - American Board of Surgery
Research Summary
I am a Surgical Oncologist and Endocrine Surgeon who specializes in taking care of patients with cancers of the pancreas, liver, GI tract, soft tissue sarcoma, melanoma, thyroid, parathyroid, and adrenal glands; I am co-director of the neuroendocrine cancer clinic, Division Director of Surgical Oncology and Endocrine Surgery, and Professor of Surgery at the University of Iowa. My area of research expertise is in Familial Cancer Syndromes, genetic linkage, gene discovery, and gene expression studies. My postdoctoral training at Washington University under Helen Donis-Keller, Ph.D. and Samuel Wells, M.D., was directed at the identification of the gene for Multiple Endocrine Neoplasia Type 2. As a faculty member, my focus has been the genetics of Juvenile Polyposis, which led to the discovery of the 2 predisposing genes. More recently, I have developed a large clinical practice and research interest in the genetics of neuroendocrine tumors (NETs). Our current research focus is the study of gene expression profiles in pancreatic and small bowel NETs to identify new targets for imaging and treatment, and collection of families to search for predisposing genes.Publications
Sharma, N., Naraev, B. G., Engelman, E. G., Zimmerman, M. B., Bushnell, Jr, D. L., O'Dorisio, T. M., O'Dorisio, M. S., Menda, Y., Müller-Brand, J., Howe, J. R. & Halfdanarson, T. R. (2017). Peptide Receptor Radionuclide Therapy Outcomes in a North American Cohort With Metastatic Well-Differentiated Neuroendocrine Tumors. Pancreas, 46(2), 151-156. PMID: 27759712.
Keck, K. J., Maxwell, J. E., Menda, Y., Bellizzi, A., Dillon, J., O'Dorisio, T. M. & Howe, J. R. (2017). Identification of primary tumors in patients presenting with metastatic gastroenteropancreatic neuroendocrine tumors. Surgery, 161(1), 272-279. PMID: 27863780.
Wu, V. T., Lorenzen, A. W., Beck, A. C., Reid, V. J., Sugg, S. L., Howe, J. R., Pollard, J. H., Lal, G. & Weigel, R. J. (2017). Comparative analysis of radioactive iodine versus thyroidectomy for definitive treatment of Graves disease. Surgery, 161(1), 147-155. PMID: 27863789.
Maxwell, J. E., Sherman, S. K. & Howe, J. R. (2016). Translational Diagnostics and Therapeutics in Pancreatic Neuroendocrine Tumors. (Vols. 22). (20), pp. 5022-5029. Clinical cancer research : an official journal of the American Association for Cancer Research. PMID: 27742788.
Maxwell, J. E., O'Dorisio, T. M. & Howe, J. R. (2016). Biochemical Diagnosis and Preoperative Imaging of Gastroenteropancreatic Neuroendocrine Tumors. Surgical oncology clinics of North America, 25(1), 171-94. PMID: 26610781.
Maxwell, J. E., Sherman, S. K., O'Dorisio, T. M., Bellizzi, A. M. & Howe, J. R. (2016). Liver-directed surgery of neuroendocrine metastases: What is the optimal strategy?. Surgery, 159(1), 320-33. PMID: 26454679.
Van Dyke, T. J., Johlin, F. C., Bellizzi, A. M. & Howe, J. R. (2016). Serous Cystadenocarcinoma of the Pancreas: Clinical Features and Management of a Rare Tumor. Digestive surgery, 33(3), 240-8. PMID: 26998825.
Maxwell, J. E., Sherman, S. K., Li, G., Choi, A. B., Bellizzi, A. M., O'Dorisio, T. M. & Howe, J. R. (2015). Somatic alterations of CDKN1B are associated with small bowel neuroendocrine tumors. Cancer genetics. PMID: 26603463.
Howe, J. R. (2015). The Supporting Role of (18)FDG-PET in Patients with Neuroendocrine Tumors. (Vols. 22). (7), pp. 2107-9. Annals of surgical oncology. PMID: 25777088.
Sherman, S. K., Maxwell, J. E., Qian, Q., Bellizzi, A. M., Braun, T. A., Iannettoni, M. D., Darbro, B. W. & Howe, J. R. (2015). Esophageal cancer in a family with hamartomatous tumors and germline PTEN frameshift and SMAD7 missense mutations. Cancer genetics, 208(1-2), 41-6. PMID: 25554686.
Maxwell, J. E., Howe, J. R. (2015). Imaging in neuroendocrine tumors: an update for the clinician. International journal of endocrine oncology, 2(2), 159-168. PMID: 26257863.
Sherman, S. K., Maxwell, J. E., Carr, J. C., Wang, D., Bellizzi, A. M., Sue O'Dorisio, M., O'Dorisio, T. M. & Howe, J. R. (2014). Gene expression accurately distinguishes liver metastases of small bowel and pancreas neuroendocrine tumors. Clinical & experimental metastasis, 31(8), 935-44. PMID: 25241033.
Hagen, J., Muniz, V. P., Falls, K. C., Reed, S. M., Taghiyev, A. F., Quelle, F. W., Gourronc, F. A., Klingelhutz, A. J., Major, H. J., Askeland, R. W., Sherman, S. K., O'Dorisio, T. M., Bellizzi, A. M., Howe, J. R., Darbro, B. W. & Quelle, D. E. (2014). RABL6A promotes G1-S phase progression and pancreatic neuroendocrine tumor cell proliferation in an Rb1-dependent manner. Cancer research, 74(22), 6661-70. PMID: 25273089.
Maxwell, J. E., Sherman, S. K., O'Dorisio, T. M. & Howe, J. R. (2014). Medical management of metastatic medullary thyroid cancer. Cancer, 120(21), 3287-301. PMID: 24942936.
Sherman, S. K., Maxwell, J. E., O'Dorisio, M. S., O'Dorisio, T. M. & Howe, J. R. (2014). Pancreastatin predicts survival in neuroendocrine tumors. Annals of surgical oncology, 21(9), 2971-80. PMID: 24752611.
Sherman, S. K., Maxwell, J. E., Carr, J. C., Wang, D., O'Dorisio, M. S., O'Dorisio, T. M. & Howe, J. R. (2014). GIPR expression in gastric and duodenal neuroendocrine tumors. The Journal of surgical research, 190(2), 587-93. PMID: 24565507.
Maxwell, J. E., Sherman, S. K., Menda, Y., Wang, D., O'Dorisio, T. M. & Howe, J. R. (2014). Limitations of somatostatin scintigraphy in primary small bowel neuroendocrine tumors. The Journal of surgical research, 190(2), 548-53. PMID: 24950794.
Spanheimer, P. M., Cyr, A. R., Liao, J., Johlin, F. C., Hoshi, H., Howe, J. R. & Mezhir, J. J. (2014). Complications and survival associated with operative procedures in patients with unresectable pancreatic head adenocarcinoma. Journal of surgical oncology, 109(7), 697-701. PMID: 24395080.
Bhama, A. R., Smith, R. J., Robinson, R. A., Weigel, R. J., Sugg, S. L., Howe, J. R. & Lal, G. (2014). Preoperative evaluation of thyroglossal duct cysts: children versus adults--is there a difference?. American journal of surgery, 207(6), 902-6. PMID: 24246260.
Maxwell, J. E., Sherman, S. K., Stashek, K. M., O'Dorisio, T. M., Bellizzi, A. M. & Howe, J. R. (2014). A Practical Method to Determine the Site of Unknown Primary in Metastatic Neuroendocrine Tumors. Surgery.
Sherman, S. K., Maxwell, J. E., O'Dorisio, M. S., O'Dorisio, T. M. & Howe, J. R. (2014). Preoperative Pancreastatin Predicts Survival in Neuroendocrine Tumors. Annals of Surgical Oncology, 21, 2971-2980. PMID: 24752611.
Sherman, S. K., Carr, J. C., Wang, D., O'Dorisio, M. S., O'Dorisio, T. M. & Howe, J. R. (2013). Gastric inhibitory polypeptide receptor (GIPR) is a promising target for imaging and therapy in neuroendocrine tumors. Surgery, 154(6), 1206-13; discussion 1214. PMID: 24238043.
Carr, J. C., Sherman, S. K., Wang, D., Dahdaleh, F. S., Bellizzi, A. M., O'Dorisio, M. S., O'Dorisio, T. M. & Howe, J. R. (2013). Overexpression of membrane proteins in primary and metastatic gastrointestinal neuroendocrine tumors. Annals of surgical oncology, 20 Suppl 3, S739-46. PMID: 24114056.
Sherman, S. K., Howe, J. R. (2013). Translational research in endocrine surgery. Surgical oncology clinics of North America, 22(4), 857-84. PMID: 24012403.
Carr, J. C., Spanheimer, P. M., Rajput, M., Dahdaleh, F. S., Lal, G., Weigel, R. J., Sugg, S. L., Liao, J. & Howe, J. R. (2013). Discriminating Pheochromocytomas from Other Adrenal Lesions: The Dilemma of Elevated Catecholamines. Annals of Surgical Oncology, 20, 3855-3861.
Sherman, S. K., Carr, J. C., Wang, D., O'Dorisio, M. S., O'Dorisio, T. M. & Howe, J. R. (2013). Gastric inhibitory polypeptide receptor is a promising target for therapy in neuroendocrine tumors. Surgery, 154, 1206-1214. PMID: 23884753.
Dahdaleh, F. S., Calva, D., O'Dorisio, T. M., Carr, J. C., Liao, J., Mezhir, J. J. & Howe, J. R. (2012). Comparison of Clinicopathologic Factors in 122 Patients with Resected Pancreatic and Ileal Neuroendocrine Tumors from a Single Institution. Annals of Surgical Oncology, 19, 966-972.
Calva, D., Dahdeleh, F. S., Chinnathambi, S., Nagy, P. L., Larsen Haidle, J., Weigel, R. J., Howe, J. R. & Woodfield, G. (2010). Discovery of the BMPR1A Promoter and Germline Mutations that cause Juvenile Polyposis. Human Molecular Genetics, 19, 4654-4662. PMID: 20843829.
Howe, J. R., Bair, J. A., Sayed, M. G., Anderson, M. E., Mitros, F. A., Petersen, G. M., Velculescu, V. E., Traverso, G. & Vogelstein, B. (2001). Germline mutations of the gene for bone morphogenetic protein receptor 1A in juvenile polyposis. Nature Genetics, 28, 184-187. PMID: 11381269.
Howe, J. R., Karnell, L. H., Menck, H. R. & Scott-Conner, C. (1999). Adenocarcinoma of the small bowel: Prognostic factors from the National Cancer Data Base. Cancer, 86, 2693-2706. PMID: 10594865.
Howe, J. R., Ringold, J. C., Summers, R. W., Mitros, F. A., Nishimura, D. Y. & Stone, E. M. (1998). A gene for familial juvenile polyposis maps to chromosome 18q21.1. American Journal of Human Genetics, 62, 1129-1136. PMID: 9545410.
Howe, J. R., Roth, S., Ringold, J. C., Summers, R. W., Jarvinen, H. J., Sistonen, P., Mitros, F. A., Tomlinson, I., Houlston, R., Bevan, S., Stone, E. M. & Aaltonen, L. A. (1998). Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science, 280, 1086-1088. PMID: 9582123.