James Howe, MD

Portrait
Director, Division of Surgical Oncology and Endocrine Surgery
Co-Director, Neuroendocrine Cancer Clinic
Professor of Surgery - Surgical Oncology and Endocrine Surgery

Contact Information

Primary Office
4644 JCP
Iowa City, IA 52242
319-356-1727

Education

MD, University of Vermont College of Medicine
Fellow, Surgical Research Fellow, Washington University
Resident, General Surgery, Barnes Hospital
Fellow, Clinical, Surgical Oncology, Memorial Sloan-Kettering Center

Licensure and Certifications

Iowa Medical License - Iowa Board of Medicine
Board Certified, General Surgery - American Board of Surgery
Qualifying Examination - American Board of Surgery

Research Summary

I am a Surgical Oncologist and Endocrine Surgeon who specializes in taking care of patients with cancers of the pancreas, liver, GI tract, soft tissue sarcoma, melanoma, thyroid, parathyroid, and adrenal glands; I am co-director of the neuroendocrine cancer clinic, Division Director of Surgical Oncology and Endocrine Surgery, and Professor of Surgery at the University of Iowa. My area of research expertise is in Familial Cancer Syndromes, genetic linkage, gene discovery, and gene expression studies. My postdoctoral training at Washington University under Helen Donis-Keller, Ph.D. and Samuel Wells, M.D., was directed at the identification of the gene for Multiple Endocrine Neoplasia Type 2. As a faculty member, my focus has been the genetics of Juvenile Polyposis, which led to the discovery of the 2 predisposing genes. More recently, I have developed a large clinical practice and research interest in the genetics of neuroendocrine tumors (NETs). Our current research focus is the study of gene expression profiles in pancreatic and small bowel NETs to identify new targets for imaging and treatment, and collection of families to search for predisposing genes.

Publications

Scott, A. T., Pelletier, D., Maxwell, J. E., Sherman, S. K., Keck, K. J., Li, G., Dillon, J. S., O'Dorisio, T. M., Bellizzi, A. M. & Howe, J. R. (2019). The Pancreas as a Site of Metastasis or Second Primary in Patients with Small Bowel Neuroendocrine Tumors. Annals of surgical oncology. PMID: 31011904.

Umesalma, S., Kaemmer, C. A., Kohlmeyer, J. L., Letney, B., Schab, A. M., Reilly, J. A., Sheehy, R. M., Hagen, J., Tiwari, N., Zhan, F., Leidinger, M. R., O'Dorisio, T. M., Dillon, J., Merrill, R. A., Meyerholz, D. K., Perl, A. L., Brown, B. J., Braun, T. A., Scott, A. T., Ginader, T., Taghiyev, A. F., Zamba, G. K., Howe, J. R., Strack, S., Bellizzi, A. M., Narla, G., Darbro, B. W., Quelle, F. W. & Quelle, D. E. (2019). RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth. The Journal of clinical investigation, 130, 1641-1653. PMID: 30721156.

Scott, A. T., Breheny, P. J., Keck, K. J., Bellizzi, A. M., Dillon, J. S., O'Dorisio, T. M. & Howe, J. R. (2019). Effective cytoreduction can be achieved in patients with numerous neuroendocrine tumor liver metastases (NETLMs). Surgery, 165(1), 166-175. PMID: 30343949.

Howe, J. R. (2019). Radioguided Surgery With Gallium for Neuroendocrine Tumors. JAMA surgery, 154(1), 45-46. PMID: 30267062.

Beck, A. C., Goffredo, P., Hassan, I., Sugg, S. L., Lal, G., Howe, J. R. & Weigel, R. J. (2018). Risk factors for 30-day readmission after adrenalectomy. Surgery, 164(4), 766-773. PMID: 30097166.

Keck, K. J., Maxwell, J. E., Utria, A. F., Bellizzi, A. M., Dillon, J. S., O'Dorisio, T. M. & Howe, J. R. (2018). The Distal Predilection of Small Bowel Neuroendocrine Tumors. Annals of surgical oncology, 25(11), 3207-3213. PMID: 30054825.

Goffredo, P., Utria, A. F., Beck, A. C., Chun, Y. S., Howe, J. R., Weigel, R. J., Vauthey, J. N. & Hassan, I. (2018). The Prognostic Impact of KRAS Mutation in Patients Having Curative Resection of Synchronous Colorectal Liver Metastases. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. PMID: 30276588.

Scott, A. T., Howe, J. R. (2018). Management of Small Bowel Neuroendocrine Tumors. Journal of oncology practice, 14(8), 471-482. PMID: 30096273.

Keutgen, X. M., Schadde, E., Pommier, R. F., Halfdanarson, T. R., Howe, J. R. & Kebebew, E. (2018). Metastatic neuroendocrine tumors of the gastrointestinal tract and pancreas: A surgeon's plea to centering attention on the liver. Seminars in oncology, 45(4), 232-235. PMID: 30318110.

Czeczok, T. W., Stashek, K. M., Maxwell, J. E., O'Dorisio, T. M., Howe, J. R., Hornick, J. L. & Bellizzi, A. M. (2018). Clusterin in Neuroendocrine Epithelial Neoplasms: Absence of Expression in a Well-differentiated Tumor Suggests a Jejunoileal Origin. Applied immunohistochemistry & molecular morphology : AIMM, 26(2), 94-100. PMID: 29420353.

Hope, T. A., Bergsland, E. K., Bozkurt, M. F., Graham, M., Heaney, A. P., Herrmann, K., Howe, J. R., Kulke, M. H., Kunz, P. L., Mailman, J., May, L., Metz, D. C., Millo, C., O'Dorisio, S., Reidy-Lagunes, D. L., Soulen, M. C. & Strosberg, J. R. (2018). Appropriate Use Criteria for Somatostatin Receptor PET Imaging in Neuroendocrine Tumors. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 59(1), 66-74. PMID: 29025982.

Keck, K. J., Breheny, P., Braun, T. A., Darbro, B., Li, G., Dillon, J. S., Bellizzi, A. M., O'Dorisio, T. M. & Howe, J. R. (2018). Changes in gene expression in small bowel neuroendocrine tumors associated with progression to metastases. Surgery, 163(1), 232-239. PMID: 29154080.

Lee, J. P., Hung, Y. P., O'Dorisio, T. M., Howe, J. R., Hornick, J. L. & Bellizzi, A. M. (2017). Examination of PHOX2B in adult neuroendocrine neoplasms reveals relatively frequent expression in phaeochromocytomas and paragangliomas. Histopathology, 71(4), 503-510. PMID: 28464318.

Choi, A. B., Maxwell, J. E., Keck, K. J., Bellizzi, A. J., Dillon, J. S., O'Dorisio, T. M. & Howe, J. R. (2017). Is Multifocality an Indicator of Aggressive Behavior in Small Bowel Neuroendocrine Tumors?. Pancreas, 46(9), 1115-1120. PMID: 28902780.

Keck, K. J., Choi, A., Maxwell, J. E., Li, G., O'Dorisio, T. M., Breheny, P., Bellizzi, A. M. & Howe, J. R. (2017). Increased Grade in Neuroendocrine Tumor Metastases Negatively Impacts Survival. Annals of surgical oncology, 24(8), 2206-2212. PMID: 28560597.

Menda, Y., O'Dorisio, T. M., Howe, J. R., Schultz, M., Dillon, J. S., Dick, D., Watkins, G. L., Ginader, T., Bushnell, D. L., Sunderland, J. J., Zamba GKD,, Graham, M. & O'Dorisio, M. S. (2017). Localization of Unknown Primary Site with 68Ga-DOTATOC PET/CT in Patients with Metastatic Neuroendocrine Tumor. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 58(7), 1054-1057. PMID: 28153957.

Strosberg, J. R., Halfdanarson, T. R., Bellizzi, A. M., Chan, J. A., Dillon, J. S., Heaney, A. P., Kunz, P. L., O'Dorisio, T. M., Salem, R., Segelov, E., Howe, J. R., Pommier, R. F., Brendtro, K., Bashir, M. A., Singh, S., Soulen, M. C., Tang, L., Zacks, J. S., Yao, J. C. & Bergsland, E. K. (2017). The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Midgut Neuroendocrine Tumors. Pancreas, 46(6), 707-714. PMID: 28609356.

Howe, J. R., Cardona, K., Fraker, D. L., Kebebew, E., Untch, B. R., Wang, Y. Z., Law, C. H., Liu, E. H., Kim, M. K., Menda, Y., Morse, B. G., Bergsland, E. K., Strosberg, J. R., Nakakura, E. K. & Pommier, R. F. (2017). The Surgical Management of Small Bowel Neuroendocrine Tumors: Consensus Guidelines of the North American Neuroendocrine Tumor Society. Pancreas, 46(6), 715-731. PMID: 28609357.

Sharma, N., Naraev, B. G., Engelman, E. G., Zimmerman, M. B., Bushnell, Jr, D. L., O'Dorisio, T. M., O'Dorisio, M. S., Menda, Y., Müller-Brand, J., Howe, J. R. & Halfdanarson, T. R. (2017). Peptide Receptor Radionuclide Therapy Outcomes in a North American Cohort With Metastatic Well-Differentiated Neuroendocrine Tumors. Pancreas, 46(2), 151-156. PMID: 27759712.

Keck, K. J., Maxwell, J. E., Menda, Y., Bellizzi, A., Dillon, J., O'Dorisio, T. M. & Howe, J. R. (2017). Identification of primary tumors in patients presenting with metastatic gastroenteropancreatic neuroendocrine tumors. Surgery, 161(1), 272-279. PMID: 27863780.

Wu, V. T., Lorenzen, A. W., Beck, A. C., Reid, V. J., Sugg, S. L., Howe, J. R., Pollard, J. H., Lal, G. & Weigel, R. J. (2017). Comparative analysis of radioactive iodine versus thyroidectomy for definitive treatment of Graves disease. Surgery, 161(1), 147-155. PMID: 27863789.

Maxwell, J. E., Sherman, S. K. & Howe, J. R. (2016). Translational Diagnostics and Therapeutics in Pancreatic Neuroendocrine Tumors. (Vols. 22). (20), pp. 5022-5029. Clinical cancer research : an official journal of the American Association for Cancer Research. PMID: 27742788.

Maxwell, J. E., O'Dorisio, T. M. & Howe, J. R. (2016). Biochemical Diagnosis and Preoperative Imaging of Gastroenteropancreatic Neuroendocrine Tumors. Surgical oncology clinics of North America, 25(1), 171-94. PMID: 26610781.

Maxwell, J. E., Sherman, S. K., O'Dorisio, T. M., Bellizzi, A. M. & Howe, J. R. (2016). Liver-directed surgery of neuroendocrine metastases: What is the optimal strategy?. Surgery, 159(1), 320-33. PMID: 26454679.

Van Dyke, T. J., Johlin, F. C., Bellizzi, A. M. & Howe, J. R. (2016). Serous Cystadenocarcinoma of the Pancreas: Clinical Features and Management of a Rare Tumor. Digestive surgery, 33(3), 240-8. PMID: 26998825.

Maxwell, J. E., Sherman, S. K., Li, G., Choi, A. B., Bellizzi, A. M., O'Dorisio, T. M. & Howe, J. R. (2015). Somatic alterations of CDKN1B are associated with small bowel neuroendocrine tumors. Cancer genetics. PMID: 26603463.

Howe, J. R. (2015). The Supporting Role of (18)FDG-PET in Patients with Neuroendocrine Tumors. (Vols. 22). (7), pp. 2107-9. Annals of surgical oncology. PMID: 25777088.

Sherman, S. K., Maxwell, J. E., Qian, Q., Bellizzi, A. M., Braun, T. A., Iannettoni, M. D., Darbro, B. W. & Howe, J. R. (2015). Esophageal cancer in a family with hamartomatous tumors and germline PTEN frameshift and SMAD7 missense mutations. Cancer genetics, 208(1-2), 41-6. PMID: 25554686.

Maxwell, J. E., Howe, J. R. (2015). Imaging in neuroendocrine tumors: an update for the clinician. International journal of endocrine oncology, 2(2), 159-168. PMID: 26257863.

Sherman, S. K., Maxwell, J. E., Carr, J. C., Wang, D., Bellizzi, A. M., Sue O'Dorisio, M., O'Dorisio, T. M. & Howe, J. R. (2014). Gene expression accurately distinguishes liver metastases of small bowel and pancreas neuroendocrine tumors. Clinical & experimental metastasis, 31(8), 935-44. PMID: 25241033.

Hagen, J., Muniz, V. P., Falls, K. C., Reed, S. M., Taghiyev, A. F., Quelle, F. W., Gourronc, F. A., Klingelhutz, A. J., Major, H. J., Askeland, R. W., Sherman, S. K., O'Dorisio, T. M., Bellizzi, A. M., Howe, J. R., Darbro, B. W. & Quelle, D. E. (2014). RABL6A promotes G1-S phase progression and pancreatic neuroendocrine tumor cell proliferation in an Rb1-dependent manner. Cancer research, 74(22), 6661-70. PMID: 25273089.

Maxwell, J. E., Sherman, S. K., O'Dorisio, T. M. & Howe, J. R. (2014). Medical management of metastatic medullary thyroid cancer. Cancer, 120(21), 3287-301. PMID: 24942936.

Sherman, S. K., Maxwell, J. E., O'Dorisio, M. S., O'Dorisio, T. M. & Howe, J. R. (2014). Pancreastatin predicts survival in neuroendocrine tumors. Annals of surgical oncology, 21(9), 2971-80. PMID: 24752611.

Sherman, S. K., Maxwell, J. E., Carr, J. C., Wang, D., O'Dorisio, M. S., O'Dorisio, T. M. & Howe, J. R. (2014). GIPR expression in gastric and duodenal neuroendocrine tumors. The Journal of surgical research, 190(2), 587-93. PMID: 24565507.

Maxwell, J. E., Sherman, S. K., Menda, Y., Wang, D., O'Dorisio, T. M. & Howe, J. R. (2014). Limitations of somatostatin scintigraphy in primary small bowel neuroendocrine tumors. The Journal of surgical research, 190(2), 548-53. PMID: 24950794.

Spanheimer, P. M., Cyr, A. R., Liao, J., Johlin, F. C., Hoshi, H., Howe, J. R. & Mezhir, J. J. (2014). Complications and survival associated with operative procedures in patients with unresectable pancreatic head adenocarcinoma. Journal of surgical oncology, 109(7), 697-701. PMID: 24395080.

Bhama, A. R., Smith, R. J., Robinson, R. A., Weigel, R. J., Sugg, S. L., Howe, J. R. & Lal, G. (2014). Preoperative evaluation of thyroglossal duct cysts: children versus adults--is there a difference?. American journal of surgery, 207(6), 902-6. PMID: 24246260.

Maxwell, J. E., O'Dorisio, T. M., Bellizzi, A. M. & Howe, J. R. (2014). Elevated pancreatic polypeptide levels in pancreatic neuroendocrine tumors and diabetes mellitus: causation or association?. Pancreas, 43(4), 651-6. PMID: 24713673.

Maxwell, J. E., Sherman, S. K., Stashek, K. M., O'Dorisio, T. M., Bellizzi, A. M. & Howe, J. R. (2014). A Practical Method to Determine the Site of Unknown Primary in Metastatic Neuroendocrine Tumors. Surgery.

Sherman, S. K., Maxwell, J. E., O'Dorisio, M. S., O'Dorisio, T. M. & Howe, J. R. (2014). Preoperative Pancreastatin Predicts Survival in Neuroendocrine Tumors. Annals of Surgical Oncology, 21, 2971-2980. PMID: 24752611.

Sherman, S. K., Carr, J. C., Wang, D., O'Dorisio, M. S., O'Dorisio, T. M. & Howe, J. R. (2013). Gastric inhibitory polypeptide receptor (GIPR) is a promising target for imaging and therapy in neuroendocrine tumors. Surgery, 154(6), 1206-13; discussion 1214. PMID: 24238043.

Carr, J. C., Sherman, S. K., Wang, D., Dahdaleh, F. S., Bellizzi, A. M., O'Dorisio, M. S., O'Dorisio, T. M. & Howe, J. R. (2013). Overexpression of membrane proteins in primary and metastatic gastrointestinal neuroendocrine tumors. Annals of surgical oncology, 20 Suppl 3, S739-46. PMID: 24114056.

Sherman, S. K., Howe, J. R. (2013). Translational research in endocrine surgery. Surgical oncology clinics of North America, 22(4), 857-84. PMID: 24012403.

Howe, J. R., Dahdaleh, F. S., Carr, J. C., Wang, D., Sherman, S. K. & Howe, J. R. (2013). BMPR1A mutations in juvenile polyposis affect cellular localization. The Journal of surgical research, 184(2), 739-45. PMID: 23433720.

Spanheimer, P. M., Stoltze, A. J., Howe, J. R., Sugg, S. L., Lal, G. & Weigel, R. J. (2013). Do giant parathyroid adenomas represent a distinct clinical entity?. Surgery, 154(4), 714-8; discussion 718-9. PMID: 23978594.

Lorenzen, A. W., O'Dorisio, T. M. & Howe, J. R. (2013). Neuroendocrine tumors arising in Meckel's diverticula: frequency of advanced disease warrants aggressive management. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 17(6), 1084-91. PMID: 23558715.

Dahdaleh, F. S., Lorenzen, A., Rajput, M., Carr, J. C., Liao, J., Menda, Y., O'Dorisio, T. M. & Howe, J. R. (2013). The value of preoperative imaging in small bowel neuroendocrine tumors. Annals of surgical oncology, 20(6), 1912-7. PMID: 23283442.

Bodei, L., Mueller-Brand, J., Baum, R. P., Pavel, M. E., Hörsch, D., O'Dorisio, M. S., O'Dorisio, T. M., Howe, J. R., Cremonesi, M., Kwekkeboom, D. J. & Zaknun, J. J. (2013). The joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours. European journal of nuclear medicine and molecular imaging, 40(5), 800-16. PMID: 23389427.

Sun, R. C., Button, A. M., Smith, B. J., Leblond, R. F., Howe, J. R. & Mezhir, J. J. (2013). A comprehensive assessment of transfusion in elective pancreatectomy: risk factors and complications. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 17(4), 627-35. PMID: 23423430.

Carr, J. C., Spanheimer, P. M., Rajput, M., Dahdaleh, F. S., Lal, G., Weigel, R. J., Sugg, S. L., Liao, J. & Howe, J. R. (2013). Discriminating Pheochromocytomas from Other Adrenal Lesions: The Dilemma of Elevated Catecholamines. Annals of Surgical Oncology, 20, 3855-3861.

Sherman, S. K., Carr, J. C., Wang, D., O'Dorisio, M. S., O'Dorisio, T. M. & Howe, J. R. (2013). Gastric inhibitory polypeptide receptor is a promising target for therapy in neuroendocrine tumors. Surgery, 154, 1206-1214. PMID: 23884753.

Carr, J. C., Boese, E. A., Spanheimer, P. M., Dahdaleh, F. S., Martin, M., Calva, D., Schafer, B., Thole, D. M., Braun, T., O'Dorisio, T. M., O'Dorisio, M. S. & Howe, J. R. (2012). Differentiation of small bowel and pancreatic neuroendocrine tumors by gene-expression profiling. Surgery, 152(6), 998-1007. PMID: 23158174.

O'Malley, Y., Lal, G., Howe, J. R., Weigel, R. J., Komorowski, R. A., Shilyansky, J. & Sugg, S. L. (2012). Invasion in follicular thyroid cancer cell lines is mediated by EphA2 and pAkt. Surgery, 152(6), 1218-24. PMID: 23158188.

Lal, G., Groff, M., Howe, J. R., Weigel, R. J., Sugg, S. L. & Lynch, C. F. (2012). Risk of subsequent primary thyroid cancer after another malignancy: latency trends in a population-based study. Annals of surgical oncology, 19(6), 1887-96. PMID: 22227921.

Carr, J. C., Dahdaleh, F. S., Wang, D. & Howe, J. R. (2012). Germline mutations in SMAD4 disrupt bone morphogenetic protein signaling. The Journal of surgical research, 174(2), 211-4. PMID: 22316667.

Dahdaleh, F. S., Carr, J. C., Calva, D. & Howe, J. R. (2012). Juvenile polyposis and other intestinal polyposis syndromes with microdeletions of chromosome 10q22-23. Clinical genetics, 81(2), 110-6. PMID: 21834858.

Dahdaleh, F. S., Calva, D., O'Dorisio, T. M., Carr, J. C., Liao, J., Mezhir, J. J. & Howe, J. R. (2012). Comparison of Clinicopathologic Factors in 122 Patients with Resected Pancreatic and Ileal Neuroendocrine Tumors from a Single Institution. Annals of Surgical Oncology, 19, 966-972.

Dahdaleh, F. S., Carr, J. C., Calva, D., Howe, J. R. & Howe, J. R. (2011). SP1 regulates the transcription of BMPR1A. The Journal of surgical research, 171(1), e15-20. PMID: 21872883.

Calva, D., Dahdaleh, F. S., Woodfield, G., Weigel, R. J., Carr, J. C., Chinnathambi, S. & Howe, J. R. (2011). Discovery of SMAD4 promoters, transcription factor binding sites and deletions in juvenile polyposis patients. Nucleic acids research, 39(13), 5369-78. PMID: 21421563.

Straub, C., Zhang, W. & Howe, J. R. (2011). Neto2 modulation of kainate receptors with different subunit compositions. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(22), 8078-82. PMID: 21632929.

Spanheimer, P. M., Sugg, S. L., Lal, G., Howe, J. R. & Weigel, R. J. (2011). Surveillance and intervention after thyroid lobectomy. Annals of surgical oncology, 18(6), 1729-33. PMID: 21246403.

Calva-Cerqueira, D., Dahdaleh, F. S., Woodfield, G., Chinnathambi, S., Nagy, P. L., Larsen-Haidle, J., Weigel, R. J. & Howe, J. R. (2010). Discovery of the BMPR1A promoter and germline mutations that cause juvenile polyposis. Human molecular genetics, 19(23), 4654-62. PMID: 20843829.

Lal, G., Fairchild, T., Howe, J. R., Weigel, R. J., Sugg, S. L. & Menda, Y. (2010). PET-CT scans in recurrent or persistent differentiated thyroid cancer: is there added utility beyond conventional imaging?. Surgery, 148(6), 1082-9; discussion 1089-90. PMID: 21134537.

O'Dorisio, T. M., Krutzik, S. R., Woltering, E. A., Lindholm, E., Joseph, S., Gandolfi, A. E., Wang, Y. Z., Boudreaux, J. P., Vinik, A. I., Go, V. L., Howe, J. R., Halfdanarson, T., O'Dorisio, M. S. & Mamikunian, G. (2010). Development of a highly sensitive and specific carboxy-terminal human pancreastatin assay to monitor neuroendocrine tumor behavior. Pancreas, 39(5), 611-6. PMID: 20124939.

Calva, D., Dahdeleh, F. S., Chinnathambi, S., Nagy, P. L., Larsen Haidle, J., Weigel, R. J., Howe, J. R. & Woodfield, G. (2010). Discovery of the BMPR1A Promoter and Germline Mutations that cause Juvenile Polyposis. Human Molecular Genetics, 19, 4654-4662. PMID: 20843829.

Fang, S. H., Guidroz, J. A., O'Malley, Y., Lal, G., Sugg, S. L., Howe, J. R., Jensen, C. S. & Weigel, R. J. (2010). Expansion of a cell population expressing stem cell markers in parathyroid glands from patients with hyperparathyroidism. Annals of surgery, 251(1), 107-13. PMID: 20009751.

Lal, G., Nowell, A. G., Liao, J., Sugg, S. L., Weigel, R. J. & Howe, J. R. (2009). Determinants of survival in patients with calciphylaxis: a multivariate analysis. Surgery, 146(6), 1028-34. PMID: 19958929.

Calva, D., O'Dorisio, T. M., Sue O'Dorisio, M., Lal, G., Sugg, S., Weigel, R. J. & Howe, J. R. (2009). When is prophylactic thyroidectomy indicated for patients with the RET codon 609 mutation?. Annals of surgical oncology, 16(8), 2237-44. PMID: 19472011.

Barros, R., Mendes, N., Howe, J. R., Reis, C. A., de Bolos, C., Carneiro, F., David, L. & Almeida, R. (2009). Juvenile polyps have gastric differentiation with MUC5AC expression and downregulation of CDX2 and SMAD4. Histochemistry and cell biology, 131(6), 765-72. PMID: 19266212.

Zhang, W., St-Gelais, F., Grabner, C. P., Trinidad, J. C., Sumioka, A., Morimoto-Tomita, M., Kim, K. S., Straub, C., Burlingame, A. L., Howe, J. R. & Tomita, S. (2009). A transmembrane accessory subunit that modulates kainate-type glutamate receptors. Neuron, 61(3), 385-96. PMID: 19217376.

Morimoto-Tomita, M., Zhang, W., Straub, C., Cho, C. H., Kim, K. S., Howe, J. R. & Tomita, S. (2009). Autoinactivation of neuronal AMPA receptors via glutamate-regulated TARP interaction. Neuron, 61(1), 101-12. PMID: 19146816.

Calva-Cerqueira, D., Chinnathambi, S., Pechman, B., Bair, J., Larsen-Haidle, J. & Howe, J. R. (2009). The rate of germline mutations and large deletions of SMAD4 and BMPR1A in juvenile polyposis. Clinical genetics, 75(1), 79-85. PMID: 18823382.

Zhang, W., Howe, J. R. & Popescu, G. K. (2008). Distinct gating modes determine the biphasic relaxation of NMDA receptor currents. Nature neuroscience, 11(12), 1373-5. PMID: 18953348.

Lal, G., Padmanabha, L., Nicholson, R., Smith, B. J., Zhang, L., Howe, J. R., Robinson, R. A. & O'Dorisio, M. S. (2008). ECM1 expression in thyroid tumors--a comparison of real-time RT-PCR and IHC. The Journal of surgical research, 149(1), 62-8. PMID: 18374945.

Calva, D., Howe, J. R. (2008). Hamartomatous polyposis syndromes. The Surgical clinics of North America, 88(4), 779-817, vii. PMID: 18672141.

Adam, L. A., Smith, B. J., Calva-Cerqueira, D., Howe, J. R. & Lal, G. (2008). Role for limited neck exploration in young adults with apparently sporadic primary hyperparathyroidism. World journal of surgery, 32(7), 1518-24. PMID: 18335277.

Howe, J. R., Chinnathambi, S., Calva, D., Bair, J., Pechman, B., Salamon, A., Tam, B. & Simon, L. (2008). A family with two consecutive nonsense mutations in BMPR1A causing juvenile polyposis. Cancer genetics and cytogenetics, 181(1), 52-4. PMID: 18262054.

Zhang, W., Cho, Y., Lolis, E. & Howe, J. R. (2008). Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(4), 932-43. PMID: 18216201.

Calva-Cerqueira, D., Smith, B. J., Hostetler, M. L., Lal, G., Menda, Y., O'Dorisio, T. M. & Howe, J. R. (2007). Minimally invasive parathyroidectomy and preoperative MIBI scans: correlation of gland weight and preoperative PTH. Journal of the American College of Surgeons, 205(4 Suppl), S38-44. PMID: 17916517.

Cho, C. H., St-Gelais, F., Zhang, W., Tomita, S. & Howe, J. R. (2007). Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents. Neuron, 55(6), 890-904. PMID: 17880893.

Howe, J. R., Haidle, J. L., Lal, G., Bair, J., Song, C., Pechman, B., Chinnathambi, S. & Lynch, H. T. (2007). ENG mutations in MADH4/BMPR1A mutation negative patients with juvenile polyposis. (Vols. 71). (1), pp. 91-2. Clinical genetics. PMID: 17204053.

Lal, G., Padmanabha, L., Smith, B. J., Nicholson, R. M., Howe, J. R., O'Dorisio, M. S. & Domann, Jr, F. E. (2006). RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma. Cancer, 107(12), 2752-9. PMID: 17103461.

Howe, J. R. (2006). Desensitization at the interface. ACS chemical biology, 1(10), 623-6. PMID: 17168566.

Sheridan, D. L., Robert, A., Cho, C. H., Howe, J. R. & Hughes, T. E. (2006). Regions of alpha-amino-5-methyl-3-hydroxy-4-isoxazole propionic acid receptor subunits that are permissive for the insertion of green fluorescent protein. Neuroscience, 141(2), 837-49. PMID: 16765522.

Zhang, W., Robert, A., Vogensen, S. B. & Howe, J. R. (2006). The relationship between agonist potency and AMPA receptor kinetics. Biophysical journal, 91(4), 1336-46. PMID: 16731549.

Tomita, S., Adesnik, H., Sekiguchi, M., Zhang, W., Wada, K., Howe, J. R., Nicoll, R. A. & Bredt, D. S. (2005). Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature, 435(7045), 1052-8. PMID: 15858532.

Merg, A., Lynch, H. T., Lynch, J. F. & Howe, J. R. (2005). Hereditary colorectal cancer-part II. Current problems in surgery, 42(5), 267-333. PMID: 15900295.

Robert, A., Armstrong, N., Gouaux, J. E. & Howe, J. R. (2005). AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(15), 3752-62. PMID: 15829627.

Merg, A., Lynch, H. T., Lynch, J. F. & Howe, J. R. (2005). Hereditary colon cancer--part I. Current problems in surgery, 42(4), 195-256. PMID: 15821699.

Harvey, J. S., Howe, J. R., Lynch, A. M. & Rees, R. W. (2005). The results of five coded compounds: genistein, metaproterenol, rotenone, p-anisidine and resorcinol tested in the pH 6.7 Syrian hamster embryo cell morphological transformation assay. Mutagenesis, 20(1), 51-6. PMID: 15671057.

Merg, A., Howe, J. R. (2004). Genetic conditions associated with intestinal juvenile polyps. American journal of medical genetics. Part C, Seminars in medical genetics, 129C(1), 44-55. PMID: 15264272.

Popescu, G., Robert, A., Howe, J. R. & Auerbach, A. (2004). Reaction mechanism determines NMDA receptor response to repetitive stimulation. Nature, 430(7001), 790-3. PMID: 15306812.

Howe, J. R., Sayed, M. G., Ahmed, A. F., Ringold, J., Larsen-Haidle, J., Merg, A., Mitros, F. A., Vaccaro, C. A., Petersen, G. M., Giardiello, F. M., Tinley, S. T., Aaltonen, L. A. & Lynch, H. T. (2004). The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. Journal of medical genetics, 41(7), 484-91. PMID: 15235019.

Klein, R. M., Howe, J. R. (2004). Effects of the lurcher mutation on GluR1 desensitization and activation kinetics. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(21), 4941-51. PMID: 15163686.

Lynch, H. T., Tinley, S. T., Shaw, T. G., Lynch, J. F., Howe, J. R. & Attard, T. M. (2004). Challenging colonic polyposis pedigrees: differential diagnosis, surveillance, and management concerns. Cancer genetics and cytogenetics, 148(2), 104-17. PMID: 14734220.

McCarthy, D. M., Hruban, R. H., Argani, P., Howe, J. R., Conlon, K. C., Brennan, M. F., Zahurak, M., Wilentz, R. E., Cameron, J. L., Yeo, C. J., Kern, S. E. & Klimstra, D. S. (2003). Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 16(3), 272-8. PMID: 12640108.

Robert, A., Howe, J. R. (2003). How AMPA receptor desensitization depends on receptor occupancy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(3), 847-58. PMID: 12574413.

Sayed, M. G., Ahmed, A. F., Ringold, J. R., Anderson, M. E., Bair, J. L., Mitros, F. A., Lynch, H. T., Tinley, S. T., Petersen, G. M., Giardiello, F. M., Vogelstein, B. & Howe, J. R. (2002). Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis. Annals of surgical oncology, 9(9), 901-6. PMID: 12417513.

Costa, J. A., Kreder, K. J. & Howe, J. R. (2002). Combined urinary and fecal diversion using a no bowel anastomosis technique. The Journal of urology, 167(5), 2063-5. PMID: 11956439.

Howe, J. R., Shellnut, J., Wagner, B., Ringold, J. C., Sayed, M. G., Ahmed, A. F., Lynch, P. M., Amos, C. I., Sistonen, P. & Aaltonen, L. A. (2002). Common deletion of SMAD4 in juvenile polyposis is a mutational hotspot. American journal of human genetics, 70(5), 1357-62. PMID: 11920286.

Robert, A., Hyde, R., Hughes, T. E. & Howe, J. R. (2002). The expression of dominant-negative subunits selectively suppresses neuronal AMPA and kainate receptors. Neuroscience, 115(4), 1199-210. PMID: 12453491.

Robert, A., Irizarry, S. N., Hughes, T. E. & Howe, J. R. (2001). Subunit interactions and AMPA receptor desensitization. The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(15), 5574-86. PMID: 11466429.

Howe, J. R., Karnell, L. H. & Scott-Conner, C. (2001). Small bowel sarcoma: analysis of survival from the National Cancer Data Base. Annals of surgical oncology, 8(6), 496-508. PMID: 11456049.

Howe, J. R., Bair, J. L., Sayed, M. G., Anderson, M. E., Mitros, F. A., Petersen, G. M., Velculescu, V. E., Traverso, G. & Vogelstein, B. (2001). Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nature genetics, 28(2), 184-7. PMID: 11381269.

Howe, J. R., Bair, J. A., Sayed, M. G., Anderson, M. E., Mitros, F. A., Petersen, G. M., Velculescu, V. E., Traverso, G. & Vogelstein, B. (2001). Germline mutations of the gene for bone morphogenetic protein receptor 1A in juvenile polyposis. Nature Genetics, 28, 184-187. PMID: 11381269.

Smith, T. C., Howe, J. R. (2000). Concentration-dependent substate behavior of native AMPA receptors. Nature neuroscience, 3(10), 992-7. PMID: 11017171.

Howe, J. R. (2000). Minimally invasive parathyroid surgery. The Surgical clinics of North America, 80(5), 1399-426. PMID: 11059711.

Smith, T. C., Wang, L. Y. & Howe, J. R. (2000). Heterogeneous conductance levels of native AMPA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(6), 2073-85. PMID: 10704481.

Howe, J. R., Karnell, L. H., Menck, H. R. & Scott-Conner, C. (1999). The American College of Surgeons Commission on Cancer and the American Cancer Society. Adenocarcinoma of the small bowel: review of the National Cancer Data Base, 1985-1995. Cancer, 86(12), 2693-706. PMID: 10594865.

Howe, J. R., Ringold, J. C., Hughes, J. H. & Summers, R. W. (1999). Direct genetic testing for Smad4 mutations in patients at risk for juvenile polyposis. Surgery, 126(2), 162-70. PMID: 10455879.

Howe, J. R., Karnell, L. H., Menck, H. R. & Scott-Conner, C. (1999). Adenocarcinoma of the small bowel: Prognostic factors from the National Cancer Data Base. Cancer, 86, 2693-2706. PMID: 10594865.

Howe, J. R., Mitros, F. A. & Summers, R. W. (1998). The risk of gastrointestinal carcinoma in familial juvenile polyposis. Annals of surgical oncology, 5(8), 751-6. PMID: 9869523.

Howe, J. R., Klimstra, D. S., Moccia, R. D., Conlon, K. C. & Brennan, M. F. (1998). Factors predictive of survival in ampullary carcinoma. Annals of surgery, 228(1), 87-94. PMID: 9671071.

Howe, J. R., Roth, S., Ringold, J. C., Summers, R. W., Järvinen, H. J., Sistonen, P., Tomlinson, I. P., Houlston, R. S., Bevan, S., Mitros, F. A., Stone, E. M. & Aaltonen, L. A. (1998). Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science (New York, N.Y.), 280(5366), 1086-8. PMID: 9582123.

Howe, J. R., Ringold, J. C., Summers, R. W., Mitros, F. A., Nishimura, D. Y. & Stone, E. M. (1998). A gene for familial juvenile polyposis maps to chromosome 18q21.1. American journal of human genetics, 62(5), 1129-36. PMID: 9545410.

Howe, J. R., Ringold, J. C., Summers, R. W., Mitros, F. A., Nishimura, D. Y. & Stone, E. M. (1998). A gene for familial juvenile polyposis maps to chromosome 18q21.1. American Journal of Human Genetics, 62, 1129-1136. PMID: 9545410.

Howe, J. R., Roth, S., Ringold, J. C., Summers, R. W., Jarvinen, H. J., Sistonen, P., Mitros, F. A., Tomlinson, I., Houlston, R., Bevan, S., Stone, E. M. & Aaltonen, L. A. (1998). Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science, 280, 1086-1088. PMID: 9582123.

Howe, J. R., Guillem, J. G. (1997). The genetics of colorectal cancer. The Surgical clinics of North America, 77(1), 175-95. PMID: 9092109.

Howe, J. R., Klimstra, D. S., Cordon-Cardo, C., Paty, P. B., Park, P. Y. & Brennan, M. F. (1997). K-ras mutation in adenomas and carcinomas of the ampulla of vater. Clinical cancer research : an official journal of the American Association for Cancer Research, 3(1), 129-33. PMID: 9815548.

Howe, J. R., Conlon, K. C. (1997). The molecular genetics of pancreatic cancer. Surgical oncology, 6(1), 1-18. PMID: 9364657.

Howe, J. R., Monsees, B., Destouet, J., Seib, J., Dehner, L. P. & Kraybill, W. G. (1995). Needle localization breast biopsy: a model for multidisciplinary quality assurance. Journal of surgical oncology, 58(4), 233-9. PMID: 7723366.

Howe, J. R., Norton, J. A. & Wells, Jr, S. A. (1993). Prevalence of pheochromocytoma and hyperparathyroidism in multiple endocrine neoplasia type 2A: results of long-term follow-up. Surgery, 114(6), 1070-7. PMID: 7903003.

Donis-Keller, H., Dou, S., Chi, D., Carlson, K. M., Toshima, K., Lairmore, T. C., Howe, J. R., Moley, J. F., Goodfellow, P. & Wells, Jr, S. A. (1993). Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Human molecular genetics, 2(7), 851-6. PMID: 8103403.

Backdahl, M., Howe, J. R., Lairmore, T. C. & Wells, Jr, S. A. (1991). The molecular biology of parathyroid disease. World journal of surgery, 15(6), 756-62. PMID: 1685045.

Lairmore, T. C., Howe, J. R., Korte, J. A., Dilley, W. G., Aine, L., Aine, E., Wells, Jr, S. A. & Donis-Keller, H. (1991). Familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2B map to the same region of chromosome 10 as multiple endocrine neoplasia type 2A. Genomics, 9(1), 181-92. PMID: 1672289.