Joel Shilyansky, MD

Portrait
Surgeon-in-Chief
Robert and Hélène Soper Chair of Pediatric Surgery
Professor of Surgery - Pediatric Surgery
Professor of Pediatrics

Contact Information

Primary Office: 2967 JPP
Iowa City, IA 52242
319-356-1766

Education

Biology, University of Michigan
BS, Biology, University of California at Los Angeles
MD, University of California at Los Angeles

Internship, Surgery, University of Michigan Medical Center
Resident, General Surgery, University of Michigan Medical Center
Fellow, NIH Staff Fellow in Surgical Oncology, Surgery Branch, National Cancer Institute NIH
Resident, General Surgery Residency, University of Michigan Medical Center
Chief Resident, Chief Residency, University of Michigan Chief Residency Medical Center
Fellow, Pediatric Surgery, University of Toronto Hospital for Sick Children

Licensure and Certifications

Iowa Medical License
Board Certified, Pediatric Surgery - American Board of Surgery
Illinois Medical License

Research Summary

Dr. Shilyansky studies the immune response in pediatric cancer patients. Specifically the mechanism allowing cancers to avoid immune destruction are being addressed. By understanding these mechanisms vaccines that can induce anti-cancer immunity and lead to cancer regression may be developed. Dendritic cells, white blood cells that regulate the immune response, are critically important for effective anti-tumor responses. Cancer cells appear adept at inhibiting dendritic cells. Recent studies in the laboratory examined phosphatidylserine as a mechanism for inhibiting dendritic cells and for evading tumor immunity. Phosphatidylserine is a membrane phospholipid that is normally restricted to the inner surface of the cell membrane (envelope) and is exposed on the cell surface during programmed cell death (apoptosis). However, live cancer cells can express phosphatidylserine on the cell surface. Dr. Shilyansky's laboratory has demonstrated that tumor phosphatidylserine inhibits human peripheral blood derived dendritic cells. Phosphatidylserine appear to interfere with NF-kappaB and p38 MAPK activation, signaling events required for dendritic cell maturation and function. Recent work has concentrated on the in vivo mechanisms by which phosphatidylserine affects tumor immunity. Additional studies in Dr. Shilyansky's laboratory relate to cancer vaccine development and effects of ligating CD40, a critical receptor on antigen presenting cells, in tumor immunity.

Publications

Shilyansky, J., Masadeh, M., Petersen, J., Krein, M., Bauer, M., Phearman, L., Liao, J. & Pitcher, G. (2013). Outcome of antegrade continent enema (ACE) procedures in children and young adults. (Vols. 48). (10), pp. 2128-2133. J Ped Surg.

Sun, R., Skeete, D., Wetjen, K., Lilienthal, M., Liao, J., Madsen, M., Shilyansky, J., Lancaster, G. & Choi, K. (2013). A pediatric cervical spine clearance protocol to reduce radiation exposure in children. J Surg Res, 341-346.

Shilyansky, J., Yan, X., Doffek, K., Yin, C., Krein, M., Phillips, M., Sugg, S. & Johnson, B. (2012). Annexin-V promotes anti-tumor immunity and inhibits neuroblastoma growth in vivo.

Shilyansky, J., Masadeh, M. & Yin, C. (2012). Annexin V inhibits CMS5 fibrosarcoma growth by blocking phosphatidylserine.

Shilyansky, J., O'Malley, Y., Weigel, R., Lal, G., Komorowski, R. & Howe (2012). Invasion in Follicular Thyroid Cancer (FTC) Cell Lines is Mediated by EphA2 and pAkt.

Shilyansky, J. (2011). Pediatric Laparoscopic Nissen Fundoplication. In Hoballah , Scott-Conner (Eds.) Operative Dictations in General and Vascular Surgery. (2) Springer.

Shilyansky, J., Ostedgaard, L., Meyerholz, D., Chen, J., Pezzulo, A., Hanfland, R., Reznikov, L., Hornick, E., Rector, M., Ludwig, P., Rogan, M., Dohrn, C., Davis, G., Rokhlina, T., Nassar, P., Samuel, S., Taft, P., McCray, P., Karp, P., Richter, S., Uc, A., Stoltz, D., Welsh, M., Zabner, J., Prather, P. & Ernst, S. (2011). The ?F508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. (Vols. 3). (74), pp. 74ra24. Si Transl Med.

Shilyansky, J., Orion, K., Krein, M., Liao, J., Shaaban, A. & Pitcher, A. (2011). Outcomes of plastic closure of abdominal wall defects in gastroschisis.

Shilyansky, J., Orion, K., Krein, M., Liao, J., Shaaban, A. & Pitcher, G. (2011). Outcomes of plastic closure in gastroschisis.

Shilyansky, J., Doffek, K., Chen, X. & Sugg, S. (2011). Phosphatidylserine inhibits NFkB and p38 MAPK activation in human monocyte derived dendritic cells.

Shilyansky, J., McCray, P., Welsh, M., Abu-El-Haija, M., Uc, A., Meyerholz, D., Ramachandran, S., Giriyappa, R., Pezzulo, A., Taft, P., Hanfland, R., Davis, G., Rogan, M., Zabner, J. & Stoltz, D. (2010). Inflammation may play a role in the destruction of pancreas in cystic fibrosis.

Shilyansky, J., Pitcher, G. (2010). Intestinal Atresias, Webs, and Duplications. In Bishop (Eds.) Pediatric Practice: Gastroenterology, Hepatology and Nutrition. McGraw Hill.

Shilyansky, J., Kirby, P., Tannous, R. & Day, K. (2010). Outcome Following Hepatic Metastasectomy of Stage IV Neuroblastoma.

Shilyansky, J., Stoltz, D., Meyerholz, D., Pezulo, A., Ramachandran, S., Roga, M., Davis, G., Hanfland, R., Wohlford-Lenane, C., Dohrn, C., Bartlett, J., Nelson IV, G., Chang, E., Taft, P., Ludwig, P. & Hornick, E. M. (2010). Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth.

Shilyansky, J., Pitcher, A., Shaaban, A., Liao, J., Krein, M. & Orion, K. (2010). Plastic closure in gastroschisis.

Shilyansky, J., Fan, J. (2009). Phosphatidylserine(PS) regulates the in vivo function of bone marrow-derived dendritic cells(BMDC).

Shilyansky, J. (2009). Berlin, Springer N Engl J Med, 360(10).

Shilyansky, J., Yin, C., Fan, J. & Ray, B. (2009). Exposure to phosphatidylserine (PS) inhibits CD80 expression in mouse A20 B cells in vitro.

Shilyansky, J., Kirby, P., Tannous, R. & Day, K. (2009). Hepatic Metastasectomy in Stage IV Neuroblastoma.

Shilyansky, J., Stoltz, D., Meyerholz, D., Hanfland, R., Pezzulo, A., Rogan, M., Davis, G., Taft, P., Starner, T., Uc, A., Brogden, K., McCray, P., Zabner, J. & Welsh, M. (2009). Surgical correction of meconium ileus obstruction in neonatal CFTR-/- pigs.

Shilyansky, J., Krein, M. & Yin, C. (2009). Blocking Phosphatidylserine Enhances The Efficacy of Neuroblastoma Vaccine.

Shilyansky, J., Rogers, C., Stoltz, D., Meyerholz, D., Ostegaard, L., Rokhlina, T., Taft, P., Rogan, M., Pezzulo, A., Karp, P., Itani, O., Kabel, A., Wohlford-Lenane, C., Davis, G., Hanfland, R., Smith, T., Samuel, M., Wax, D., Murphy, C., Rieke, A., Whitworth, K., Uc, A., Starner, T., Brogden, K., McCray Jr, P., Zabner, J., Prather, R. & Welsh, M. (2008). Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs. (Vols. 321). pp. 1837-1841. Science.

Shilyansky, J., Yin, C. & Krein, M. (2008). Inhibition of phosphatidylserine on the surface of tumor cells promotes anti-tumor immunity and slows tumor growth in vivo.

Shilyansky, J. (2007). Diarrhea From Hormone-Secreting Tumors. In Behrman (Eds.) Nelson Textbook of Pediatrics, 18th Edition. Philadelphia, W.B. Saunders.

Doffek, K., Yan, X., Sugg, S., Johnson, B. & Shilyansky, J. (2007). Neuroblastoma express phosphatidylserine: mechanism for immune evasion.

Shilyansky, J. (2007). Tumors of the Digestive Tract. In Behrman (Eds.) Nelson Textbook of Pediatrics, 18th Edition. Philadelphia, W.B. Saunders.

Jacobs, P., Doffek, K., Sugg, S. & Shilyansky, J. (2007). Induction of cytolytic T lymphocytes (CTL) agaisnt pediatric solid tumors in vitro using autologous DCs pulsed with necrotic primary tumor. (Vols. 42). (1), pp. 54-61; discussion 61. Journal of Pediatric Surgery.

Phillips, M., Doffek, K., Sugg, S. & Shilyansky, J. (2007). Phosphatidylserine expression on the surface of tumor cells inhibits anti-tumor immunity and promotes tumor growth in vivo.

Shilyansky, J., Xu, H., Doffek, K., Sugg, S., Oldham, K. T. & Pritchard, K. A. (2007). Targeting heat shock protein in cancer angiogenesis.

Shilyansky, J. (2006). Oncology-Neuroblastoma. In Stringer (Eds.) Pediatric Surgery and Urology: Long-Term Outcomes, 2nd Edition. Cambridge University Press.

Shilyansky, J., Chen, X., Doffek, K. & Sugg, S. (2006). Neuroblastoma inhibit dendritic cell maturation by expressing phosphatidylserine on the cell surface.

Shilyansky, J., Jacobs, P., Doffek, K. & Sugg, S. (2006). Induction of cytolytic T lymphocytes (CTL) against pediatric solid tumors in vitro using autologous DCs pulsed with necrotic primary tumor. In American Pediatric Surgery. Journal of Pediatric Surgery.

Shilyansky, J., Doffek, K., Macallister, D., Chen, X. & Sugg, S. (2006). PS inhibits DC maturation by interferring with P38 MAPK and NF-kappaB Signaling.

Lodge, A., Yu, P., Nicholl, M., Brown, I., Jackson, C., Schreiber, K., Sugg, S., Schreiber, H. & Shilyansky, J. (2006). CD40 ligation restores cytolytic T lymphocyte (CTL) response and eliminates murine fibrosarcoma in mice lacking CD4+ T cells. (Vols. 55). (12), pp. 1542-52. Cancer Immunology Immunotherapy.

Arca, M., Somers, K., Derks, T. E., Goldin, A. B., Aiken, J. J., Sato, T. T., Shilyansky, J., Winthrop, A. & Oldham, K. T. (2005). Use of vacuum-assisted closure system in the management of complex wounds in the neonate. (Vols. 21). pp. 532-535. Pediatric Surgery International.

Cole, D., Weil, D., Shilyansky, J., Custer, M., Kawakami, Y., Rosenberg, S. & Nishimura, M. (2005). Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen. (Vols. 55). pp. 748-752. Cancer Research.

Densmore, J., Doffek, K., Kaul, S., Pritchard, K. A., Guice, K. S., Oldham, K. T. & Shilyansky, J. (2005). Endothelium-derived microparticles induce dendritic cell apoptosis.

Gavin, C., Jacobs, P., Doffek, K. & Shilyansky, J. (2004). Phosphatidylserine mediates the inhibitory effects of apoptotic cells on dendritic cells. pp. 453-459. International Proceedings of Immunology.

Nicholl, M., Lodge, A., Brown, I., Sugg, S. & Shilyansky, J. (2004). Restored immune response to an MHC-II-restricted antigen in tumor-bearing hosts after elimination of regulatory T cells. (Vols. 39). (6), pp. 941-946. Journal of Pediatric Surgery.

Bannister, K., Lodge, A., Sugg, S. & Shilyansky, J. (2004). Role of CTLA4 in tumor immunity.

Alloo, J., Gerstle, T., Shilyansky, J. & Ein, S. H. (2004). Appendicitis in children less than 3 years of age: A 28-year review. (Vols. 19). pp. 777-779. Pediatric Surgery International.

Shilyansky, J., Chen, X., Doffek, K. & Sugg, S. (2004). Phosphatidylserine modulated the maturation and function of human dendritic cells: A possible mechanism for immune evasion by Neuroblastoma.

Shilyansky, J. (2004). Oncogenesis. In Oldham (Eds.) Surgery of Infants and Children: Scientific Principles and Practices. Philadelphia, Lippincott-Raven.

Metzger, S., Nusair, S., Planer, D., Barash, V., Pappo, P., Shilyansky, J. & Chajek-Shaul, T. (2004). Inhibition of hepatic gluconeogenesis and enhanced glucose uptake contribute to the development in mice bearing IL-1 {beat}-secreting tumor. (Vols. 145). (11), pp. 5150-5156. Endocrinology.

Nicholl, M., Pitt, H., Wolf, P., Cooney, N. P., Kalayoglu, M., Shilyansky, J. & Rikkers, L. F. (2004). Choledochal cysts in western adults: complexities compared to children. (Vols. 8). (3), pp. 245-252. Journal of Gastrointestinal Surgery.

Gavin, C., Doffek, K., Chen, X., Sugg, S. & Shilyansky, J. (2004). Downregulation of dendritic cell surface antigen expression and stimulatory function by apoptotic neutrophils is partly reversed by Annexin V blockade.

Xiang, B., Du, L., Kappes, A., Shilyansky, J., Hessner, M., Jiang, N., Demeure, M. J., Wilson, S. & Sugg, S. (2004). Altered gene expression in metastatic vs primary follicular thyroid carcinoma cell lines by cDNA microarray. In Society of Surgical Oncology. Annals of Surgical Oncology.

Chen, X., Doffek, K., Gavin, C., Sugg, S. & Shilyansky, J. (2004). Immune evasion by neuroblastoma (NB): Role of Phosphatidylserine (PS).

Doffek, K., Chen, X., Gavin, C., Sugg, S. & Shilyansky, J. (2004). Phosphatidylserine inhibits ERK1/2, NFkB and p38 MAPK but not AKT activation in response to LPS, modulating DC maturation and function.

Lodge, A., Shilyansky, J. (2004). Mechanisms for restored CTL response and elimination of murine fibrosarcoma (MF) by CD40 ligation in mice lacking CD4+ T cells.

Aziz, R., Lodge, A., Chen, X., Sugg, S. & Shilyansky, J. (2004). Phosphatidylserine modulates the phenotype of mouse dendritic cells.

Doffek, K., Chen, X., Gavin, C., Sugg, S. & Shilyansky, J. (2004). Phosphatidylserine modulates DC maturation and function by inhibiting ERK1/2, NFkB and p38 MAPK activation response to LPS.

Lodge, A., Shilyansky, J. (2004). Restored cytolytic T lymphocyte (CTL) response and elimination of murine fibrosarcoma (MF) by CD40 ligation in mice lacking CD4+T cells. In American Association of Immunology/Experimental Biology. FASEB Journal.

Shilyansky, J., Chen, X., Doffek, K. & Sugg, S. (2004). Phosphatidylserine modulated the maturation and function of human dendritic cells (DC): A mechanism for immune evasion by neuroblastoma (NB). In American Association of Immunology/Experimental Biology. FASEB Journal.

Shilyansky, J. (2004). Phosphatidylserine (PS) modulated the maturation and function of human dendritic cells (DC): A possible mechanism for immune evasion by Neuroblastoma (NB). In American Association of Immunology/Experimental Biology. FASEB Journal.

Chen, X., Doffek, K., Sugg, S. & Shilyansky, J. (2004). Phosphatidylserine modulates the human dendritic cell maturation and function. (Vols. 173). pp. 2985-2994. Journal of Immunology.

Doffek, K., Chen, X., Gavin, C., Sugg, S. & Shilyansky, J. (2004). PS modulates DC maturation and function by inhibiting ERK1/2, NFkB and p38 MAPK activation in response to LPS. pp. 395-400. International Proceedings of Immunology.

Nicholl, M., Lodge, A., Brown, I., Sugg, S. & Shilyansky, J. (2004). Restored immune response to a MHC-II restricted antigen in tumor bearing Hosts after elimination of regulatory T-cells. (Vols. 39). pp. 941-946. Journals of Pediatric Surgery.

Chen, X., Shilyansky, J. (2003). Phosphatidylserine (PS) exposure is a sufficient signal to alter the maturation and function of human dendritic cells.

Chen, X., Doffek, K., Sugg, S. & Shilyansky, J. (2003). Neuroblastoma cells inhibit the immunostimulatory function of dendritic cells. (Vols. 38). (6), pp. 901-05. Journal of Pediatric Surgery.

Lodge, A., Yu, P., Brown, I., Sugg, S. & Shilyansky, J. (2003). Helper T cells are required for persistent CTL response and tumor elimination.

Shilyansky, J. (2003). immunostimulatory function of dendritic cells. Journal of Pediatric Surgery, 38(6), 901-05.

Nicholl, M., Shilyansky, J. (2003). Restored Immune response to an MHC-II restricted antigen in tumor-bearing hosts after elimination of regulatory T cells.

Nicholl, M., Shilyansky, J. (2003). T regulatory cells infiltrate murine fibrosarcoma and enhance tumor establishment.

Chen, X., Doffek, K., Chan, E., Gavin, C., Sugg, S. & Shilyansky, J. (2003). Phosphatidylserine-dependent suppression of dendritic cell function by neuroblastoma: A novel mechanism of tumor evasion.

Nicholl, M., Shilyansky, J. (2003). Treg depletion in tumor-bearing mice enhances response to tumor antigen immunization.

Lodge, A., Yu, P., Brown, I., Sugg, S. & Shilyansky, J. (2003). Tumor elimination requires helper T cells for persistent CTL response.

Shilyansky, J. (2002). Diarrhea From Hormone-Secreting Tumors. In Behrman (Eds.) Nelson: Textbook of Pediatrics. Philadelphia, W.B. Saunders.

Shilyansky, J. (2002). Tumors of the Gastrointestinal Tract. In Behrman (Eds.) Nelson: Textbook of Pediatrics. Philadelphia, W.B. Saunders.

Chen, X., Shilyansky, J. (2002). Neuroblastoma induce regulatory dendritic cells and inhibit T cell activation.

Nicholl, M., Shilyansky, J. & Ota, D. (2002). Current management of malignant large-bowel obstruction. (Vols. 58). (8), pp. 396-400. Contemporary Surgery.

Chen, X., Doffek, K. & Shilyansky, J. (2002). Neuroblastoma cells inhibit the immunostimulatory function of dendritic cells.

Nicholl, M., Shilyansky, J. (2002). Local immune privilege promotes establishment of fibrosarcoma.

Brown, I., Yu, P., Seeley, E. & Shilyansky, J. (2001). Tumor progression in immunocompetent mice despite the presence of activated tumor-specific T cells.

Brown, I. A., Yu, P., Schreiber, H. & Shilyansky, J. (2001). Established tumors escape elimination, despite activation of specific T cells.

Sugg, S., Niu, Q., Zimmerman, T. & Shilyansky, J. (2001). Detection of bone marrow micrometastases in advanced breast cancer using multiple genetic markers. Proceedings of the American Association for Cancer Research.

Jackson, C. C., Yu, P., Brown, I., Seely, E., Schreiber, H. & Shilyansky, J. (2001). CD4+ T cells or IL-2 are required to eliminate peritoneal tumor spread.

Shilyansky, J. (2000). Pancreas. In Glick (Eds.) Pediatric Surgery Secrets. Philadelphia, Hanley and Belfus.

Shilyansky, J., Jackson, C. C., Yu, P., Brown, I., Seely, E. & Schreiber, H. (2000). CD4+ T cells are required to prevent intraperitoneal spread of an immunogenic tumor after repeat challenges.

Shilyansky, J., Navarro, O., Superina, R. A., Babyn, P. S., Filler, R. M. & Pearl, R. H. (1999). Delayed hemorrhage after non-operative management for blunt hepatic trauma in children: A rare but significant event. (Vols. 34). (1), pp. 60-64. Journal of Pediatric Surgery.

Shilyansky, J., Roberts, E. A. & Superina, R. A. (1999). Distal splenorenal shunts for the treatment of severe thrombocytopenia from portal hypertension in children. (Vols. 3). (2), pp. 167-172. Journal of Gastrointestinal Surgery.

Shilyansky, J., Sena, L., Kreller, M., Chait, P., Babyn, P., Filler, R. & Pearl, R. (1998). Non-operative management of pancreatic injuries in children. (Vols. 33). (2), pp. 343-349. Journal of Pediatric Surgery.

Ky, A., Shilyansky, J., Gerstle, J. T., Filler, R. M., Taylor, G. & Superina, R. A. (1998). Experience with papillary and solid epithelial neoplasms of the pancreas in children. (Vols. 33). (1), pp. 42-44. Journal of Pediatric Surgery.

Shilyansky, J., Navarro, O., Superina, R., Babyn, P., Filler, R. & Pearl, R. (1998). Late hemorrhage after non-operative management for blunt hepatic trauma in children: A rare but significant event.

Shilyansky, J., Yang, J. C., Custer, M. C., Spiess, P., Mixon, A., Cole, D. J., Mule, J. J., Rosenburg, S. A. & Nishimura, M. I. (1997). Identificatioin of a T-cell receptor from a therapeutic murine T-cell clone. (Vols. 20). (4), pp. 247-55. Journal of Immunotherapy.

Metzger, S., Goldschmidt, N., Barash, V., Peretz, T., Drize, O., Shilyansky, J., Shiloni, E. & Chajek-Shaul, T. (1997). Interleukin-6 secretion in mice is associated with reduced glucose-6-phosphate and liver glycogen levels. (Vols. 273). (36), pp. E262-267. The American Journal of Physiology.

Shilyansky, J., Fisher, S., Cutz, E., Perlman, K. & Filler, R. M. (1997). Is 95% pancreatectomy the procedure of choice for the treatment of persistent hyperinsulinemic hypolglycemia of the neonate?. (Vols. 32). (2), pp. 342-346. Journal of Pediatric Surgery.

Shilyansky, J., Cutz, E. & Filler, R. M. (1997). Endogenous hyperinsulinism: Diagnosis, management and long-term follow-up. (Vols. 6). (3), pp. 115-120. Seminars in Pediatric Surgery.

Shilyansky, J., Roberts, E. & Superina, R. (1997). Distal splenorenal shunts for severe thrombocytopenia from portal hypertension.

Shilyansky, J., Lelli Jr., J. L., Drongowski, R. A. & Coran, A. G. (1997). Efficacy of the straight endorectal pull-through in the management of familial adenomatous polyposis coli-a 16-year experience. (Vols. 32). (8), pp. 1139-1143. Journal of Pediatric Surgery.

Ky, A., Shilyansky, J., Gerstle, J., Filler, R., Taylor, G. & Superina, R. (1997). Experience with papillary and solid epithelial neoplasms of the pancreas in children.

Shilyansky, J., Sena, L., Chait, P., Gerstle, J., Babyn, P., Pearl, R. & Filler, R. (1997). Diagnosis and management of pancreatic injuries in children.

Shilyansky, J., Kreller, M., Sena, L. M., Babyn, P. S. & Pearl, R. H. (1997). Diagnosis and management of duodenal injuries in children. (Vols. 32). (6), pp. 880-891. Journal of Pediatric Surgery.

Shilyansky, J., Lelli Jr., J., Drongowski, R. & Coran, A. (1996). The ileal endorectal pull-through procedure in the management of familial adenomatous polyposis coli -- A 16-year experience.

Shilyansky, J., Fisher, S., Cutz, E., Perlman, K. & Filler, R. (1996). Is 95% Pancreatectomy the procedure of choice for treatment of persistent hyperinsulinemic hypoglycemia of the neonate?.

Shilyansky, J., Kreller, M., Sena, L., Babyn, P. & Pearl, R. (1996). Diagnosis and management of duodenal injuries in children.

Cole, D. J., Weil, D. P., Shilyansky, J., Custer, M., Kawakami, Y., Rosenberg, S. A. & Nishimura, M. I. (1995). Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen. (Vols. 55). (4), pp. 748-52. Cancer Research.

Cole, D., Weil, D., Shilyansky, J., Custer, M., Kawakami, Y. & Rosenberg, S. (1995). Characterization of the functional specificity of a cloned T cell receptor heterodimer recognizing the MART-1 melanoma antigen. (Vols. 36). pp. A2839. Proceedings of the American Association for Cancer Research.

Nishimura, M. I., Kawakami, Y., Charmley, P., O'Neil, B., Shilyansky, J. & Yannelli, J. R. (1994). T-cell receptor repertoire in tumor infiltrating lymphocytes: Analysis of melanoma specific long term lines. (Vols. 16). (2), pp. 85-94. Journal of Immunotherapy.

Shilyansky, J., Wilson, W., Temeck, B. K. & Pass, H. I. (1994). Pulmonary artery-bronchial fistula during lymphoma treatment. (Vols. 108). (4), pp. 790-91. Journal of Cardiovascular Surgery.

Shilyansky, J., Nishimura, M. I., Yannelli, J. R., Kawakami, Y., Jacknin, L. S. & Charmley, P. (1994). T-cell receptor usage by melanoma specific clonal and highly oligoclonal tumor infiltrating lymphocyte lines. (Vols. 91). (7), pp. 2829-2833. Proceedings of the National Academy of Sciences.

Shilyansky, J., Nishimura, M., Kawakami, Y., Yannelli, J. & Rosenberg, S. (1994). T cell receptor usage by melanoma specific clonal and highly ologoclonal tumor infiltrating lymphocyte lines.

Shiloni, E., Karp, S. E., Custer, M. C., Shilyansky, J., Restifo, N. P. & Rosenberg, S. A. (1993). Retroviral transformation of interferon-? cDNA into a non-immunogenic MHC Class-I deficient murine fibrosarcoma: Generation of T-cells capable of treating established parental metastatic tumor. (Vols. 37). pp. 286-92. Cancer Immunology and Immunotherapy.

Kawakami, Y., Nishimura, M. I., Restifo, N. P., Topalian, S. L., O'Neil, B. & Shilyansky, J. (1993). T-cell recognition of human melanoma antigens. (Vols. 14). pp. 88-93. Journals of Immunotherapy.

Shilyansky, J., Nishimura, M. I., Yang, J. C., Custer, M. C., Spiess, P., Mule, J. J. & Rosenberg, S. A. (1993). Murine sarcoma-specific tumor infiltrating lymphocyte (TIL) clone utilizing a unique T-cell receptor rearrangement successfully treats established lung metastases. (Vols. 44). pp. 521-523. Surgical Forum.

Kawakami, Y., O'Neil, B., Nishimura, M., Restifo, N., Topalian, S., Hom, S., Yannelli, J. & Shilyansky, J. (1993). T-Cell recognition of human melanoma antigens. In Keystone Symposia. Molecular and Cellular Immunology.

Shilyansky, J., Nishimura, M., Yannelli, J., Kawakami, Y., O'Neil, B., Mule, J. & Rosenberg, S. (1993). T-cell receptor variable gene usage in melanoma specific TIL clones and lines.

Shilyansky, J., Nishimura, M., Yang, J., Custer, M., Spiess, P., Mule, J. & Rosenberg, S. A. (1993). Derivation of a therapeutic monoclonal tumor infiltrating lymphocyte line and the identification and cloning of the T cell receptor genes responsible for tumor recognition.

Shilyansky, J., Nishimura, M., Kawakami, Y., Tannelli, J. & Rosenberg, S. (1993). Analysis of TCR expression by melanoma specific tumor infiltrating lymphocytes. In Immunotherapy of Cancer Workshop, 22nd Annual Keystone Symposia. Cellular Immunity and Immunotherapy of Cancer.

Nishimura, M., Kawakami, Y., Charmley, O'Neil, B., Shilyansky, J. & Yannelli, J. (1993). T-Cell receptor V gene usage in melanoma specific tumor infiltrating lymphocytes.

Foglia, R. P., Shilyansky, J. & Fonkalsrud, E. W. (1989). Emergency lung biopsy in immunocompromised pediatric patients. (Vols. 21). (1), pp. 90-92. Annals of Surgery.