Joel Shilyansky, MD

Portrait
Professor (Tenure)
Robert and Hélène Soper Chair of Pediatric Surgery
Surgeon-in-Chief
Professor of Surgery - Pediatric Surgery
Professor of Pediatrics - Pediatric Surgery

Contact Information

Primary Office
2967 JPP
Iowa City, IA 52242
319-356-1766

Education

Biology, University of Michigan
BS, Biology, University of California at Los Angeles
MD, University of California at Los Angeles
Internship, Surgery, University of Michigan Medical Center
Resident, General Surgery, University of Michigan Medical Center
Fellow, NIH Staff Fellow in Surgical Oncology, Surgery Branch, National Cancer Institute NIH
Resident, General Surgery Residency, University of Michigan Medical Center
Chief Resident, Chief Residency, University of Michigan Chief Residency Medical Center
Fellow, Pediatric Surgery, University of Toronto Hospital for Sick Children

Licensure and Certifications

Iowa Medical License
Board Certified, Pediatric Surgery - American Board of Surgery
General Surgery Boards - American Board of Surgery

Research Summary

Dr. Shilyansky studies the immune response in pediatric cancer patients. Specifically the mechanism allowing cancers to avoid immune destruction are being addressed. By understanding these mechanisms vaccines that can induce anti-cancer immunity and lead to cancer regression may be developed. Dendritic cells, white blood cells that regulate the immune response, are critically important for effective anti-tumor responses. Cancer cells appear adept at inhibiting dendritic cells. Recent studies in the laboratory examined phosphatidylserine as a mechanism for inhibiting dendritic cells and for evading tumor immunity. Phosphatidylserine is a membrane phospholipid that is normally restricted to the inner surface of the cell membrane (envelope) and is exposed on the cell surface during programmed cell death (apoptosis). However, live cancer cells can express phosphatidylserine on the cell surface. Dr. Shilyansky's laboratory has demonstrated that tumor phosphatidylserine inhibits human peripheral blood derived dendritic cells. Phosphatidylserine appear to interfere with NF-kappaB and p38 MAPK activation, signaling events required for dendritic cell maturation and function. Recent work has concentrated on the in vivo mechanisms by which phosphatidylserine affects tumor immunity. Additional studies in Dr. Shilyansky's laboratory relate to cancer vaccine development and effects of ligating CD40, a critical receptor on antigen presenting cells, in tumor immunity.

Publications

Shilyansky, J. (2017). Pediatric Laparoscopic Nissen Fundoplication. In J. Hoballah , C. E. Scott-Conner , H. Chong (Eds.) Operative Dictations in Genearal and Vascular Surgery 3rd Edition. (3), pp. 611-613. Springer 2011: In: Hoballah, Scott-Conner and Chong (Ed).

Pitcher, G., Zaghal, A., Sato, Y. & Shilyansky, J. (2015). The Thoracic Inlet Index in patients with tracheal obstruction caused by chest wall deformity: Validation in patients and age-matched controls. Journal of pediatric surgery, 50(12), 2028-31. PMID: 26388128.

Harshman, L. A., Muff-Luett, M., Neuberger, M. L., Dagle, J. M., Shilyansky, J., Nester, C. M., Brophy, P. D. & Jetton, J. G. (2014). Peritoneal dialysis in an extremely low-birth-weight infant with acute kidney injury. Clinical Kidney Journal, 7(6), 582-5. PMID: 25859376.

Bagrodia, N., Cassel, S., Liao, J., Pitcher, G. & Shilyansky, J. (2014). Segmental resection for the treatment of congenital pulmonary malformations. Journal of pediatric surgery, 49(6), 905-9. PMID: 24888832.

Sun, R., Skeete, D., Wetjen, K., Lilienthal, M., Liao, J., Madsen, M., Shilyansky, J., Lancaster, G. & Choi, K. (2013). A pediatric cervical spine clearance protocol to reduce radiation exposure in children. J Surg Res, 341-346.

Shilyansky, J., Masadeh, M., Petersen, J., Krein, M., Bauer, M., Phearman, L., Liao, J. & Pitcher, G. (2013). Outcome of antegrade continent enema (ACE) procedures in children and young adults. (Vols. 48). (10), pp. 2128-2133. J Ped Surg.

Shilyansky, J., Masadeh, M. & Yin, C. (2012). Annexin V inhibits CMS5 fibrosarcoma growth by blocking phosphatidylserine.

Shilyansky, J., Yan, X., Doffek, K., Yin, C., Krein, M., Phillips, M., Sugg, S. & Johnson, B. (2012). Annexin-V promotes anti-tumor immunity and inhibits neuroblastoma growth in vivo.

Shilyansky, J., O'Malley, Y., Weigel, R., Lal, G., Komorowski, R. & Howe (2012). Invasion in Follicular Thyroid Cancer (FTC) Cell Lines is Mediated by EphA2 and pAkt.

Shilyansky, J., Orion, K., Krein, M., Liao, J., Shaaban, A. & Pitcher, G. (2011). Outcomes of plastic closure in gastroschisis.

Shilyansky, J., Doffek, K., Chen, X. & Sugg, S. (2011). Phosphatidylserine inhibits NFkB and p38 MAPK activation in human monocyte derived dendritic cells.

Shilyansky, J., Ostedgaard, L., Meyerholz, D., Chen, J., Pezzulo, A., Hanfland, R., Reznikov, L., Hornick, E., Rector, M., Ludwig, P., Rogan, M., Dohrn, C., Davis, G., Rokhlina, T., Nassar, P., Samuel, S., Taft, P., McCray, P., Karp, P., Richter, S., Uc, A., Stoltz, D., Welsh, M., Zabner, J., Prather, P. & Ernst, S. (2011). The ?F508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. (Vols. 3). (74), pp. 74ra24. Si Transl Med.

Shilyansky, J., Orion, K., Krein, M., Liao, J., Shaaban, A. & Pitcher, A. (2011). Outcomes of plastic closure of abdominal wall defects in gastroschisis.

Shilyansky, J. (2011). Pediatric Laparoscopic Nissen Fundoplication. In Hoballah , Scott-Conner (Eds.) Operative Dictations in General and Vascular Surgery. (2) Springer.

Shilyansky, J., Pitcher, A., Shaaban, A., Liao, J., Krein, M. & Orion, K. (2010). Plastic closure in gastroschisis.

Shilyansky, J., Kirby, P., Tannous, R. & Day, K. (2010). Outcome Following Hepatic Metastasectomy of Stage IV Neuroblastoma.

Shilyansky, J., Stoltz, D., Meyerholz, D., Pezulo, A., Ramachandran, S., Roga, M., Davis, G., Hanfland, R., Wohlford-Lenane, C., Dohrn, C., Bartlett, J., Nelson IV, G., Chang, E., Taft, P., Ludwig, P. & Hornick, E. M. (2010). Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth.

Shilyansky, J., McCray, P., Welsh, M., Abu-El-Haija, M., Uc, A., Meyerholz, D., Ramachandran, S., Giriyappa, R., Pezzulo, A., Taft, P., Hanfland, R., Davis, G., Rogan, M., Zabner, J. & Stoltz, D. (2010). Inflammation may play a role in the destruction of pancreas in cystic fibrosis.

Shilyansky, J., Pitcher, G. (2010). Intestinal Atresias, Webs, and Duplications. In Bishop (Eds.) Pediatric Practice: Gastroenterology, Hepatology and Nutrition. McGraw Hill.

Shilyansky, J., Kirby, P., Tannous, R. & Day, K. (2009). Hepatic Metastasectomy in Stage IV Neuroblastoma.

Shilyansky, J., Stoltz, D., Meyerholz, D., Hanfland, R., Pezzulo, A., Rogan, M., Davis, G., Taft, P., Starner, T., Uc, A., Brogden, K., McCray, P., Zabner, J. & Welsh, M. (2009). Surgical correction of meconium ileus obstruction in neonatal CFTR-/- pigs.

Shilyansky, J., Krein, M. & Yin, C. (2009). Blocking Phosphatidylserine Enhances The Efficacy of Neuroblastoma Vaccine.

Shilyansky, J., Yin, C., Fan, J. & Ray, B. (2009). Exposure to phosphatidylserine (PS) inhibits CD80 expression in mouse A20 B cells in vitro.

Shilyansky, J., Fan, J. (2009). Phosphatidylserine(PS) regulates the in vivo function of bone marrow-derived dendritic cells(BMDC).

Shilyansky, J. (2009). Berlin, Springer N Engl J Med, 360(10).

Shilyansky, J., Yin, C. & Krein, M. (2008). Inhibition of phosphatidylserine on the surface of tumor cells promotes anti-tumor immunity and slows tumor growth in vivo.

Shilyansky, J., Rogers, C., Stoltz, D., Meyerholz, D., Ostegaard, L., Rokhlina, T., Taft, P., Rogan, M., Pezzulo, A., Karp, P., Itani, O., Kabel, A., Wohlford-Lenane, C., Davis, G., Hanfland, R., Smith, T., Samuel, M., Wax, D., Murphy, C., Rieke, A., Whitworth, K., Uc, A., Starner, T., Brogden, K., McCray Jr, P., Zabner, J., Prather, R. & Welsh, M. (2008). Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs. (Vols. 321). pp. 1837-1841. Science.

Phillips, M., Doffek, K., Sugg, S. & Shilyansky, J. (2007). Phosphatidylserine expression on the surface of tumor cells inhibits anti-tumor immunity and promotes tumor growth in vivo.

Shilyansky, J., Xu, H., Doffek, K., Sugg, S., Oldham, K. T. & Pritchard, K. A. (2007). Targeting heat shock protein in cancer angiogenesis.

Shilyansky, J. (2007). Diarrhea From Hormone-Secreting Tumors. In Behrman (Eds.) Nelson Textbook of Pediatrics, 18th Edition. Philadelphia, W.B. Saunders.

Jacobs, P., Doffek, K., Sugg, S. & Shilyansky, J. (2007). Induction of cytolytic T lymphocytes (CTL) agaisnt pediatric solid tumors in vitro using autologous DCs pulsed with necrotic primary tumor. (Vols. 42). (1), pp. 54-61; discussion 61. Journal of Pediatric Surgery.

Doffek, K., Yan, X., Sugg, S., Johnson, B. & Shilyansky, J. (2007). Neuroblastoma express phosphatidylserine: mechanism for immune evasion.

Shilyansky, J. (2007). Tumors of the Digestive Tract. In Behrman (Eds.) Nelson Textbook of Pediatrics, 18th Edition. Philadelphia, W.B. Saunders.

Lodge, A., Yu, P., Nicholl, M., Brown, I., Jackson, C., Schreiber, K., Sugg, S., Schreiber, H. & Shilyansky, J. (2006). CD40 ligation restores cytolytic T lymphocyte (CTL) response and eliminates murine fibrosarcoma in mice lacking CD4+ T cells. (Vols. 55). (12), pp. 1542-52. Cancer Immunology Immunotherapy.

Shilyansky, J., Doffek, K., Macallister, D., Chen, X. & Sugg, S. (2006). PS inhibits DC maturation by interferring with P38 MAPK and NF-kappaB Signaling.

Shilyansky, J., Jacobs, P., Doffek, K. & Sugg, S. (2006). Induction of cytolytic T lymphocytes (CTL) against pediatric solid tumors in vitro using autologous DCs pulsed with necrotic primary tumor. In American Pediatric Surgery. Journal of Pediatric Surgery.

Shilyansky, J., Chen, X., Doffek, K. & Sugg, S. (2006). Neuroblastoma inhibit dendritic cell maturation by expressing phosphatidylserine on the cell surface.

Shilyansky, J. (2006). Oncology-Neuroblastoma. In Stringer (Eds.) Pediatric Surgery and Urology: Long-Term Outcomes, 2nd Edition. Cambridge University Press.

Densmore, J., Doffek, K., Kaul, S., Pritchard, K. A., Guice, K. S., Oldham, K. T. & Shilyansky, J. (2005). Endothelium-derived microparticles induce dendritic cell apoptosis.

Cole, D., Weil, D., Shilyansky, J., Custer, M., Kawakami, Y., Rosenberg, S. & Nishimura, M. (2005). Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen. (Vols. 55). pp. 748-752. Cancer Research.

Arca, M., Somers, K., Derks, T. E., Goldin, A. B., Aiken, J. J., Sato, T. T., Shilyansky, J., Winthrop, A. & Oldham, K. T. (2005). Use of vacuum-assisted closure system in the management of complex wounds in the neonate. (Vols. 21). pp. 532-535. Pediatric Surgery International.

Chen, X., Doffek, K., Gavin, C., Sugg, S. & Shilyansky, J. (2004). Immune evasion by neuroblastoma (NB): Role of Phosphatidylserine (PS).

Lodge, A., Shilyansky, J. (2004). Mechanisms for restored CTL response and elimination of murine fibrosarcoma (MF) by CD40 ligation in mice lacking CD4+ T cells.

Doffek, K., Chen, X., Gavin, C., Sugg, S. & Shilyansky, J. (2004). Phosphatidylserine inhibits ERK1/2, NFkB and p38 MAPK but not AKT activation in response to LPS, modulating DC maturation and function.

Aziz, R., Lodge, A., Chen, X., Sugg, S. & Shilyansky, J. (2004). Phosphatidylserine modulates the phenotype of mouse dendritic cells.

Gavin, C., Doffek, K., Chen, X., Sugg, S. & Shilyansky, J. (2004). Downregulation of dendritic cell surface antigen expression and stimulatory function by apoptotic neutrophils is partly reversed by Annexin V blockade.

Doffek, K., Chen, X., Gavin, C., Sugg, S. & Shilyansky, J. (2004). Phosphatidylserine modulates DC maturation and function by inhibiting ERK1/2, NFkB and p38 MAPK activation response to LPS.

Shilyansky, J. (2004). Phosphatidylserine (PS) modulated the maturation and function of human dendritic cells (DC): A possible mechanism for immune evasion by Neuroblastoma (NB). In American Association of Immunology/Experimental Biology. FASEB Journal.

Shilyansky, J., Chen, X., Doffek, K. & Sugg, S. (2004). Phosphatidylserine modulated the maturation and function of human dendritic cells (DC): A mechanism for immune evasion by neuroblastoma (NB). In American Association of Immunology/Experimental Biology. FASEB Journal.

Lodge, A., Shilyansky, J. (2004). Restored cytolytic T lymphocyte (CTL) response and elimination of murine fibrosarcoma (MF) by CD40 ligation in mice lacking CD4+T cells. In American Association of Immunology/Experimental Biology. FASEB Journal.

Xiang, B., Du, L., Kappes, A., Shilyansky, J., Hessner, M., Jiang, N., Demeure, M. J., Wilson, S. & Sugg, S. (2004). Altered gene expression in metastatic vs primary follicular thyroid carcinoma cell lines by cDNA microarray. In Society of Surgical Oncology. Annals of Surgical Oncology.

Shilyansky, J., Chen, X., Doffek, K. & Sugg, S. (2004). Phosphatidylserine modulated the maturation and function of human dendritic cells: A possible mechanism for immune evasion by Neuroblastoma.

Bannister, K., Lodge, A., Sugg, S. & Shilyansky, J. (2004). Role of CTLA4 in tumor immunity.

Alloo, J., Gerstle, T., Shilyansky, J. & Ein, S. H. (2004). Appendicitis in children less than 3 years of age: A 28-year review. (Vols. 19). pp. 777-779. Pediatric Surgery International.

Nicholl, M., Pitt, H., Wolf, P., Cooney, N. P., Kalayoglu, M., Shilyansky, J. & Rikkers, L. F. (2004). Choledochal cysts in western adults: complexities compared to children. (Vols. 8). (3), pp. 245-252. Journal of Gastrointestinal Surgery.

Metzger, S., Nusair, S., Planer, D., Barash, V., Pappo, P., Shilyansky, J. & Chajek-Shaul, T. (2004). Inhibition of hepatic gluconeogenesis and enhanced glucose uptake contribute to the development in mice bearing IL-1 {beat}-secreting tumor. (Vols. 145). (11), pp. 5150-5156. Endocrinology.

Shilyansky, J. (2004). Oncogenesis. In Oldham (Eds.) Surgery of Infants and Children: Scientific Principles and Practices. Philadelphia, Lippincott-Raven.

Gavin, C., Jacobs, P., Doffek, K. & Shilyansky, J. (2004). Phosphatidylserine mediates the inhibitory effects of apoptotic cells on dendritic cells. pp. 453-459. International Proceedings of Immunology.

Chen, X., Doffek, K., Sugg, S. & Shilyansky, J. (2004). Phosphatidylserine modulates the human dendritic cell maturation and function. (Vols. 173). pp. 2985-2994. Journal of Immunology.

Doffek, K., Chen, X., Gavin, C., Sugg, S. & Shilyansky, J. (2004). PS modulates DC maturation and function by inhibiting ERK1/2, NFkB and p38 MAPK activation in response to LPS. pp. 395-400. International Proceedings of Immunology.

Nicholl, M., Lodge, A., Brown, I., Sugg, S. & Shilyansky, J. (2004). Restored immune response to a MHC-II restricted antigen in tumor bearing Hosts after elimination of regulatory T-cells. (Vols. 39). pp. 941-946. Journals of Pediatric Surgery.

Nicholl, M., Lodge, A., Brown, I., Sugg, S. & Shilyansky, J. (2004). Restored immune response to an MHC-II-restricted antigen in tumor-bearing hosts after elimination of regulatory T cells. (Vols. 39). (6), pp. 941-946. Journal of Pediatric Surgery.

Chen, X., Doffek, K., Chan, E., Gavin, C., Sugg, S. & Shilyansky, J. (2003). Phosphatidylserine-dependent suppression of dendritic cell function by neuroblastoma: A novel mechanism of tumor evasion.

Nicholl, M., Shilyansky, J. (2003). Restored Immune response to an MHC-II restricted antigen in tumor-bearing hosts after elimination of regulatory T cells.

Nicholl, M., Shilyansky, J. (2003). T regulatory cells infiltrate murine fibrosarcoma and enhance tumor establishment.

Nicholl, M., Shilyansky, J. (2003). Treg depletion in tumor-bearing mice enhances response to tumor antigen immunization.

Lodge, A., Yu, P., Brown, I., Sugg, S. & Shilyansky, J. (2003). Tumor elimination requires helper T cells for persistent CTL response.

Lodge, A., Yu, P., Brown, I., Sugg, S. & Shilyansky, J. (2003). Helper T cells are required for persistent CTL response and tumor elimination.

Chen, X., Shilyansky, J. (2003). Phosphatidylserine (PS) exposure is a sufficient signal to alter the maturation and function of human dendritic cells.

Shilyansky, J. (2003). immunostimulatory function of dendritic cells. Journal of Pediatric Surgery, 38(6), 901-05.

Chen, X., Doffek, K., Sugg, S. & Shilyansky, J. (2003). Neuroblastoma cells inhibit the immunostimulatory function of dendritic cells. (Vols. 38). (6), pp. 901-05. Journal of Pediatric Surgery.

Chen, X., Doffek, K. & Shilyansky, J. (2002). Neuroblastoma cells inhibit the immunostimulatory function of dendritic cells.

Nicholl, M., Shilyansky, J. (2002). Local immune privilege promotes establishment of fibrosarcoma.

Chen, X., Shilyansky, J. (2002). Neuroblastoma induce regulatory dendritic cells and inhibit T cell activation.

Nicholl, M., Shilyansky, J. & Ota, D. (2002). Current management of malignant large-bowel obstruction. (Vols. 58). (8), pp. 396-400. Contemporary Surgery.

Shilyansky, J. (2002). Diarrhea From Hormone-Secreting Tumors. In Behrman (Eds.) Nelson: Textbook of Pediatrics. Philadelphia, W.B. Saunders.

Shilyansky, J. (2002). Tumors of the Gastrointestinal Tract. In Behrman (Eds.) Nelson: Textbook of Pediatrics. Philadelphia, W.B. Saunders.

Brown, I. A., Yu, P., Schreiber, H. & Shilyansky, J. (2001). Established tumors escape elimination, despite activation of specific T cells.

Jackson, C. C., Yu, P., Brown, I., Seely, E., Schreiber, H. & Shilyansky, J. (2001). CD4+ T cells or IL-2 are required to eliminate peritoneal tumor spread.

Sugg, S., Niu, Q., Zimmerman, T. & Shilyansky, J. (2001). Detection of bone marrow micrometastases in advanced breast cancer using multiple genetic markers. Proceedings of the American Association for Cancer Research.

Brown, I., Yu, P., Seeley, E. & Shilyansky, J. (2001). Tumor progression in immunocompetent mice despite the presence of activated tumor-specific T cells.

Shilyansky, J., Jackson, C. C., Yu, P., Brown, I., Seely, E. & Schreiber, H. (2000). CD4+ T cells are required to prevent intraperitoneal spread of an immunogenic tumor after repeat challenges.

Shilyansky, J. (2000). Pancreas. In Glick (Eds.) Pediatric Surgery Secrets. Philadelphia, Hanley and Belfus.

Shilyansky, J., Navarro, O., Superina, R. A., Babyn, P. S., Filler, R. M. & Pearl, R. H. (1999). Delayed hemorrhage after non-operative management for blunt hepatic trauma in children: A rare but significant event. (Vols. 34). (1), pp. 60-64. Journal of Pediatric Surgery.

Shilyansky, J., Roberts, E. A. & Superina, R. A. (1999). Distal splenorenal shunts for the treatment of severe thrombocytopenia from portal hypertension in children. (Vols. 3). (2), pp. 167-172. Journal of Gastrointestinal Surgery.

Shilyansky, J., Navarro, O., Superina, R., Babyn, P., Filler, R. & Pearl, R. (1998). Late hemorrhage after non-operative management for blunt hepatic trauma in children: A rare but significant event.

Ky, A., Shilyansky, J., Gerstle, J. T., Filler, R. M., Taylor, G. & Superina, R. A. (1998). Experience with papillary and solid epithelial neoplasms of the pancreas in children. (Vols. 33). (1), pp. 42-44. Journal of Pediatric Surgery.

Shilyansky, J., Sena, L., Kreller, M., Chait, P., Babyn, P., Filler, R. & Pearl, R. (1998). Non-operative management of pancreatic injuries in children. (Vols. 33). (2), pp. 343-349. Journal of Pediatric Surgery.

Shilyansky, J., Roberts, E. & Superina, R. (1997). Distal splenorenal shunts for severe thrombocytopenia from portal hypertension.

Ky, A., Shilyansky, J., Gerstle, J., Filler, R., Taylor, G. & Superina, R. (1997). Experience with papillary and solid epithelial neoplasms of the pancreas in children.

Shilyansky, J., Sena, L., Chait, P., Gerstle, J., Babyn, P., Pearl, R. & Filler, R. (1997). Diagnosis and management of pancreatic injuries in children.

Shilyansky, J., Kreller, M., Sena, L. M., Babyn, P. S. & Pearl, R. H. (1997). Diagnosis and management of duodenal injuries in children. (Vols. 32). (6), pp. 880-891. Journal of Pediatric Surgery.

Shilyansky, J., Lelli Jr., J. L., Drongowski, R. A. & Coran, A. G. (1997). Efficacy of the straight endorectal pull-through in the management of familial adenomatous polyposis coli-a 16-year experience. (Vols. 32). (8), pp. 1139-1143. Journal of Pediatric Surgery.

Shilyansky, J., Cutz, E. & Filler, R. M. (1997). Endogenous hyperinsulinism: Diagnosis, management and long-term follow-up. (Vols. 6). (3), pp. 115-120. Seminars in Pediatric Surgery.

Shilyansky, J., Yang, J. C., Custer, M. C., Spiess, P., Mixon, A., Cole, D. J., Mule, J. J., Rosenburg, S. A. & Nishimura, M. I. (1997). Identificatioin of a T-cell receptor from a therapeutic murine T-cell clone. (Vols. 20). (4), pp. 247-55. Journal of Immunotherapy.

Metzger, S., Goldschmidt, N., Barash, V., Peretz, T., Drize, O., Shilyansky, J., Shiloni, E. & Chajek-Shaul, T. (1997). Interleukin-6 secretion in mice is associated with reduced glucose-6-phosphate and liver glycogen levels. (Vols. 273). (36), pp. E262-267. The American Journal of Physiology.

Shilyansky, J., Fisher, S., Cutz, E., Perlman, K. & Filler, R. M. (1997). Is 95% pancreatectomy the procedure of choice for the treatment of persistent hyperinsulinemic hypolglycemia of the neonate?. (Vols. 32). (2), pp. 342-346. Journal of Pediatric Surgery.

Shilyansky, J., Kreller, M., Sena, L., Babyn, P. & Pearl, R. (1996). Diagnosis and management of duodenal injuries in children.

Shilyansky, J., Fisher, S., Cutz, E., Perlman, K. & Filler, R. (1996). Is 95% Pancreatectomy the procedure of choice for treatment of persistent hyperinsulinemic hypoglycemia of the neonate?.

Shilyansky, J., Lelli Jr., J., Drongowski, R. & Coran, A. (1996). The ileal endorectal pull-through procedure in the management of familial adenomatous polyposis coli -- A 16-year experience.

Cole, D., Weil, D., Shilyansky, J., Custer, M., Kawakami, Y. & Rosenberg, S. (1995). Characterization of the functional specificity of a cloned T cell receptor heterodimer recognizing the MART-1 melanoma antigen. (Vols. 36). pp. A2839. Proceedings of the American Association for Cancer Research.

Cole, D. J., Weil, D. P., Shilyansky, J., Custer, M., Kawakami, Y., Rosenberg, S. A. & Nishimura, M. I. (1995). Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen. (Vols. 55). (4), pp. 748-52. Cancer Research.

Shilyansky, J., Nishimura, M., Kawakami, Y., Yannelli, J. & Rosenberg, S. (1994). T cell receptor usage by melanoma specific clonal and highly ologoclonal tumor infiltrating lymphocyte lines.

Shilyansky, J., Wilson, W., Temeck, B. K. & Pass, H. I. (1994). Pulmonary artery-bronchial fistula during lymphoma treatment. (Vols. 108). (4), pp. 790-91. Journal of Cardiovascular Surgery.

Nishimura, M. I., Kawakami, Y., Charmley, P., O'Neil, B., Shilyansky, J. & Yannelli, J. R. (1994). T-cell receptor repertoire in tumor infiltrating lymphocytes: Analysis of melanoma specific long term lines. (Vols. 16). (2), pp. 85-94. Journal of Immunotherapy.

Shilyansky, J., Nishimura, M. I., Yannelli, J. R., Kawakami, Y., Jacknin, L. S. & Charmley, P. (1994). T-cell receptor usage by melanoma specific clonal and highly oligoclonal tumor infiltrating lymphocyte lines. (Vols. 91). (7), pp. 2829-2833. Proceedings of the National Academy of Sciences.

Shilyansky, J., Nishimura, M., Yang, J., Custer, M., Spiess, P., Mule, J. & Rosenberg, S. A. (1993). Derivation of a therapeutic monoclonal tumor infiltrating lymphocyte line and the identification and cloning of the T cell receptor genes responsible for tumor recognition.

Shilyansky, J., Nishimura, M., Kawakami, Y., Tannelli, J. & Rosenberg, S. (1993). Analysis of TCR expression by melanoma specific tumor infiltrating lymphocytes. In Immunotherapy of Cancer Workshop, 22nd Annual Keystone Symposia. Cellular Immunity and Immunotherapy of Cancer.

Nishimura, M., Kawakami, Y., Charmley, O'Neil, B., Shilyansky, J. & Yannelli, J. (1993). T-Cell receptor V gene usage in melanoma specific tumor infiltrating lymphocytes.

Shilyansky, J., Nishimura, M., Yannelli, J., Kawakami, Y., O'Neil, B., Mule, J. & Rosenberg, S. (1993). T-cell receptor variable gene usage in melanoma specific TIL clones and lines.

Kawakami, Y., O'Neil, B., Nishimura, M., Restifo, N., Topalian, S., Hom, S., Yannelli, J. & Shilyansky, J. (1993). T-Cell recognition of human melanoma antigens. In Keystone Symposia. Molecular and Cellular Immunology.

Shilyansky, J., Nishimura, M. I., Yang, J. C., Custer, M. C., Spiess, P., Mule, J. J. & Rosenberg, S. A. (1993). Murine sarcoma-specific tumor infiltrating lymphocyte (TIL) clone utilizing a unique T-cell receptor rearrangement successfully treats established lung metastases. (Vols. 44). pp. 521-523. Surgical Forum.

Shiloni, E., Karp, S. E., Custer, M. C., Shilyansky, J., Restifo, N. P. & Rosenberg, S. A. (1993). Retroviral transformation of interferon-? cDNA into a non-immunogenic MHC Class-I deficient murine fibrosarcoma: Generation of T-cells capable of treating established parental metastatic tumor. (Vols. 37). pp. 286-92. Cancer Immunology and Immunotherapy.

Kawakami, Y., Nishimura, M. I., Restifo, N. P., Topalian, S. L., O'Neil, B. & Shilyansky, J. (1993). T-cell recognition of human melanoma antigens. (Vols. 14). pp. 88-93. Journals of Immunotherapy.

Foglia, R. P., Shilyansky, J. & Fonkalsrud, E. W. (1989). Emergency lung biopsy in immunocompromised pediatric patients. (Vols. 21). (1), pp. 90-92. Annals of Surgery.