Joseph Cullen, MD

Portrait
Chief, Surgical Services, VA Medical Center
Professor of Surgery - Gastrointestinal, Minimally invasive and Bariatric Surgery

Contact Information

Primary Office
1528 JCP
Iowa City, IA 52242
319-353-8297

Education

BS, Loras College
MD, University of Iowa College of Medicine
Resident, General Surgery, University of Iowa
Fellow, Digestive Disease, NIH Fellow, Mayo Clinic

Licensure and Certifications

Iowa Medical License (permanent) - Iowa Board of Medicine
Board Certified, General Surgery - American Board of Surgery

Education/Training Program Affiliations

Free Radical and Radiation Biology Graduate Program, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Research Summary

Adenocarcinoma of the pancreas is the fourth leading cause of cancer death in the United States and is increasing in incidence. Intravenous ascorbate (i.e., ascorbic acid, vitamin C), but not oral ascorbate, produces high plasma concentrations, which are in the range that are cytotoxic to tumor cells. Studies from our currently funded 2 year U01 grant CA166800 “Ascorbate-induced radiosensitization in pancreatic cancer“ have demonstrated that ascorbate, in doses achievable in humans, synergizes with ionizing radiation in decreasing viability and proliferation in all pancreatic cancer cell lines examined, via a H2O2–mediated mechanism. Our recently completed phase I study demonstrated that pharmacological ascorbate combined with gemcitabine is safe and well-tolerated and may lead to overall clinical benefit in patients with stage IV pancreatic cancer. This proposal focuses on improvement of the therapeutic ratio of a standard anti-cancer therapy (ionizing radiation) using a complementary approach (high dose ascorbate), in the treatment of pancreatic cancer. If pancreatic cancer cells (relative to normal cells) are more susceptible to ascorbate-induced cytotoxicity due to increased ascorbate auto-oxidation leading to increased H2O2 production, then ascorbate would be expected to be efficacious and well-tolerated adjuvant to chemo-radiation in patients. Furthermore, increasing the rate of auto-oxidation of ascorbate with redox active metal catalysts to generate more H2O2 should selectively increase ascorbate-induced radiosensitization and oxidative stress. Finally, ascorbate-induced radiosensitization would be expected to sensitize tumor cells to clinically relevant pharmacological agents that inhibit the removal of H2O2 The current proposal will test the hypothesis that production of H2O2 via the metal ion catalyzed auto-oxidation of ascorbate mediates ascorbate-induced cytotoxicity and chemo-radiosensitization in human pancreatic cancer. We will test our hypothesis with the following three Specific Aims. 1) Determine in a phase I trial the safety of administering pharmacological ascorbate during concurrent gemcitabine-radiation therapy for the treatment of non-resectable pancreatic cancer; 2) Determine if ascorbate-induced radiosensitization can be selectively enhanced by redox active metal catalysts; 3) Determine if the ascorbate-induced radiosensitization can be enhanced by clinically relevant pharmacological inhibitors of glucose and hydroperoxide metabolism. The phase I trial will quantify adverse events and determine changes in systemic parameters indicative of oxidative stress in patients. The preclinical studies will use biochemistry/molecular biology techniques to determine ascorbate-induced radiosensitization and oxidative stress and employ a non-invasive in vivo index of cell proliferation. If we can rigorously demonstrate that the radiosensitization mediated by pharmacological ascorbate induces preferential oxidative stress and subsequent cytotoxicity in human pancreatic cancer cells, then the results of this proposed research program will provide a foundation for the rational design of a novel combined modality cancer therapy.

Publications

Sibenaller, Z. A., Welsh, J. L., Du, C., Witmer, J. R., Schrock, H. E., Du, J., Buettner, G. R., Goswami, P. C., Cieslak III, J. A. & Cullen, J. J. (2014). Extracellular superoxide dismutase suppresses hypoxia-inducible factor-1a in pancreatic cancer. Free Radical Biology and Medicine, 69, 357-66. PMID: 24509158.

Rawal, M., Schroeder, S. R., Wagner, B. A., Cushing, C. M., Welsh, J. L., Button, A. M., Du, J., Sibenaller, Z. A., Buettner, G. R. & Cullen, J. J. (2013). Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation. Cancer Research, 73(16), 5232-5241. PMID: 23764544.

Du, J., Nelson, E. S., Simons, A. L., Olney, K. E., Moser, J. C., Schrock, H. E., Wagner, B. A., Buettner, G. R., Smith, B. J., Teoh, M. L., Tsao, M. S. & Cullen, J. J. (2013). Regulation of pancreatic cancer growth by superoxide. Molecular Carcinogenesis, 52(7), 555-567. PMID: 22392697.

Welsh, J. L., Wagner, B. A., van 't Erve, T. J., Zehr, P. S., Berg, D. S., Halfdanarson, T. J., Yee, N. S., Bodeker, K. L., Du, J., Roberts, L. J., Drisko, J., Levine, M., Buettner, G. R. & Cullen, J. J. (2013). Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): Results from a phase I clinical trial. Cancer Chemotherapy and Pharmacology, 71(3), 765-775. PMID: 23381814.

Du, J., Cullen, J. J. & Buettner, G. R. (2012). Ascorbic acid: chemistry, biology and the treatment of cancer. BBA Reviews on Cancer, 1826(2), 443-457. PMID: 22728050.

Du, J., Liu, J., Smith, B. J., Tsao, M. S. & Cullen, J. J. (2011). Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer. Cancer Gene Therapy, 18(2), 135-143. PMID: 21037555.

Du, J., Martin, S. M., Levine, M., Wagner, B. A., Buettner, G. R., Wang, S. H., Taghiyev, A. F., Du, C., Knudson, C. M. & Cullen, J. J. (2010). Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer. Clinical Cancer Research, 16(2), 509-520. PMID: 20068072.

Weydert, C. J., Cullen, J. J. (2010). Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nature Protocols, 5(1), 51-66. PMID: 20057381.

Sun, W., Kalen, A. L., Smith, B. J., Cullen, J. J. & Oberley, L. W. (2009). Enhancing the antitumor activity of adriamycin and ionizing radiation. Cancer Research, 69(10), 4294-4300. PMID: 19401447.

Du, J., Daniels, D. H., Asbury, C. A., Venkataraman, S., Liu, J., Spitz, D. R., Oberley, L. W. & Cullen, J. J. (2006). Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells. Journal of Biological Chemistry, 281(49), 37416-37426. PMID: 17040906.

Brandt, K. E., Falls, K. C., Schoenfeld, J. D., Rodman, S. N., Gu, Z., Zhan, F., Cullen, J. J., Wagner, B. A., Buettner, G. R., Allen, B. G., Berg, D. J., Spitz, D. R. & Fath, M. A. (2018). Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells. Redox biology, 14, 82-87. PMID: 28886484.

Wilkes, J. G., Alexander, M. S. & Cullen, J. J. (2017). Superoxide Dismutases in Pancreatic Cancer. Antioxidants (Basel, Switzerland), 6(3). PMID: 28825637.

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H., Kauffman EPS,, Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Schultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G. (2017). O2·- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer cell, 32(2), 268. PMID: 28810149.

Lewis, A. M., Ough, M., Du, J., Tsao, M. S., Oberley, L. W. & Cullen, J. J. (2017). Targeting NAD(P)H:Quinone Oxidoreductase (NQO1) in Pancreatic Cancer. Molecular carcinogenesis, 56(7), 1825-1834. PMID: 28639725.

Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H., Shanahan Kauffman, E. P., Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Schultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R. & Allen, B. G. (2017). O2·- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer cell, 31(4), 487-500.e8. PMID: 28366679.

Doskey, C. M., Buranasudja, V., Wagner, B. A., Wilkes, J. G., Du, J., Cullen, J. J. & Buettner, G. R. (2016). Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy. Redox biology, 10, 274-284. PMID: 27833040.

Ols, M. L., Cullen, J. L., Turqueti-Neves, A., Giles, J. & Shlomchik, M. J. (2016). Dendritic Cells Regulate Extrafollicular Autoreactive B Cells via T Cells Expressing Fas and Fas Ligand. Immunity, 45(5), 1052-1065. PMID: 27793595.

Cullen, J. N., Sargeant, J. M., Makielski, K. M. & O'Connor, A. M. (2016). The case-control design in veterinary sciences: A survey. Preventive veterinary medicine, 134, 179-187. PMID: 27836041.

Hartlage, A. S., Cullen, J. M. & Kapoor, A. (2016). The Strange, Expanding World of Animal Hepaciviruses. Annual review of virology, 3(1), 53-75. PMID: 27741408.

Witmer, J. R., Wetherell, B. J., Wagner, B. A., Du, J., Cullen, J. J. & Buettner, G. R. (2016). Direct spectrophotometric measurement of supra-physiological levels of ascorbate in plasma. Redox biology, 8, 298-304. PMID: 26928133.

Cieslak, J. A., Sibenaller, Z. A., Walsh, S. A., Ponto, L. L., Du, J., Sunderland, J. J. & Cullen, J. J. (2016). Fluorine-18-Labeled Thymidine Positron Emission Tomography (FLT-PET) as an Index of Cell Proliferation after Pharmacological Ascorbate-Based Therapy. Radiation research, 185(1), 31-8. PMID: 26720803.

Du, J., Cieslak, 3rd, J. A., Welsh, J. L., Sibenaller, Z. A., Allen, B. G., Wagner, B. A., Kalen, A. L., Doskey, C. M., Strother, R. K., Button, A. M., Mott, S. L., Smith, B., Tsai, S., Mezhir, J., Goswami, P. C., Spitz, D. R., Buettner, G. R. & Cullen, J. J. (2015). Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer. Cancer research, 75(16), 3314-26. PMID: 26081808.

Du, J., Wagner, B. A., Buettner, G. R. & Cullen, J. J. (2015). Role of labile iron in the toxicity of pharmacological ascorbate. Free radical biology & medicine, 84, 289-295. PMID: 25857216.

Cieslak, J. A., Cullen, J. J. (2015). Treatment of Pancreatic Cancer with Pharmacological Ascorbate. Current pharmaceutical biotechnology, 16(9), 759-70. PMID: 26201606.

Wilkes, J., Cullen, J. J. (In Press). Internal Hernias: Congenital and Acaquired. In D. McFadden , J. Matthews , J. Fleshman , S. Demeester (Eds.) Shackelford's Suyrgery of the Alimentary tract. (8)

(2014). Pharmacological ascorbate: Oxidative stress and the treatment of pancreatic cancer. In Free Radicals: The role of Antioxidants and Pro-oxidants in Cancer Development. pp. 159-188. New York, NY: Nova Biomedical Publishers.

Olney, K. E., Du, J., van 't Erve, R. J., Witmer, J. R., Sibenaller, Z. A., Wagner, B. A., Buettner, G. R. & Cullen, J. J. (2013). Inhibitors of hydroperoxide metabolism enhance ascorbate-induced cytotoxicity. Free Radical Research, 47(3), 154-163. PMID: 23205739.

Welsh, J. L., Du, J., Sibenaller, Z. A., Martin, S. M., Knudson, C. M. & Cullen, J. J. (2013). Ascorbate-induced autophagy in pancreatic cancer. Pancreatic Cancer Disorders, 3, 1-7.

Frietze, D., Welsh, J., Cullen, J. J. & Mulholland, M. (2013). Concepts in Surgery of the Small Intestine and Appendix. In , C. S. Connor (Eds.) Chassin’s Operative Strategy in General Surgery. (4), pp. 385-394. Springer.

Welsh, J. L., Bodeker, K., Fallon, E., Bhatia, S. K., Buatti, J. M. & Cullen, J. J. (2012). Comparison of response evaluation criteria in solid tumors with volumetric measurements for estimation of tumor burden in pancreatic adenocarcinoma and hepatocellular carcinoma. American Journal of Surgery, 204(5), 580-585. PMID: 22902100.

Wakefield, H., Vaughan-Sarrazin, M. & Cullen, J. J. (2012). Influence of obesity on complications and costs after intestinal surgery. American Journal of Surgery, 204(4), 434-440. PMID: 22575400.

Kamath, A. S., Vaughan-Sarrazin, M., Vander Weg, M. W., Cai, X., Cullen, J. J. & Katz, D. A. (2012). Hospital costs associated with smoking in veterans undergoing general surgery. Journal of the American College of Surgeons, 214(6), 901-908. PMID: 22502993.

Klionsky, D. J., Abdalla, F. C., Cullen, J. J. & al, E. (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), 445-544. PMID: 22966490.

Welsh, J. L., Du, J., Sibenaller, Z. A., Kalen, A. L., Wagner, B. A., Allen, B. G., Spitz, D. R., Goswami, P. C., Buettner, G. R. & Cullen, J. J. (2012). Ascorbate is a radiosensitizer in pancreatic cancer. (Vols. 53). pp. S52. Free Radical Biology and Medicine.

Welsh, J. L., Du, J., Sibenaller, Z. & Cullen, J. J. (2012). Ascorbate-induced autophagy: Mode of cell death or mechanism for survival. (Vols. 215). pp. S130. Journal of the American College of Surgeons.

Welsh, J. L., Sibenaller, Z., Du, C., Schrock, H., Du, J. & Cullen, J. J. (2012). Extracellular superoxide dismutase (EcSOD) suppresses hypoxia-inducible factor-1-alpha (HIF-1a) and inhibits growth in pancreatic cancer. (Vols. 215). pp. S17. Journal of the American College of Surgeons.

Allen, B. G., Sibenaller, Z. A., Cullen, J. J., Buettner, G. R., Welsh, J. L., Wagner, B. A., Van 'T Erve, T. J., Buatti, J. M., Carlisle, T. L., Smith, M. C., Walsh, S. A., Bayouth, J. E., TenNapel, M. & Spitz, D. R. (2012). Pharmacological ascorbate enhances chemo-radio-sensitization in brain and lung cancer. (Vols. 53). pp. S39. Free Radical Biology and Medicine.

Rawal, M., Schroeder, S. R., Wagner, B. A., Du, J., Buettner, G. R. & Cullen, J. J. (2012). Potential of manganoporphyrins to enhance the efficacy of pharmacological ascorbate in the treatment of pancreatic cancer. (Vols. 53). pp. S115. Free Radical Biology and Medicine.

Cushing, C., Wagner, B., Cullen, J. J. & Buettner, G. R. (2012). Predicting plasma levels of ascorbate upon infusion of pharmacological doses. (Vols. 53). pp. S104. Free Radical Biology and Medicine.

Smith, J., Carr, J. & Cullen, J. J. (2012). Small bowel diverticula. In , D. McFadden & C. Yeo (Eds.) Schakelford’s Surgery of the Alimentary Tract, 7th Edition. pp. 691-700. Elsevier.

Du, J., Rawal, M., Moser, J. C., Olney, K. E., Buettner, G. R. & Cullen, J. J. (2012). The role of redox active transition metals in ascorbate-induced cytotoxicity in pancreatic cancer. (Vols. 53). pp. S42. Free Radical Biology and Medicine.

Smith, J. K., Cullen, J. J. (2012). Ulcer-associated conditions, ulcer surgery, and post-gastrectomy complications. In , J. Dibaise (Eds.) Gastroenterology and Hepatology Board Review, 3rd Edition. pp. 149-155. New York, NY: McGraw-Hill.

Vaughan-Sarrazin, M. S., Bayman, L. & Cullen, J. J. (2011). Costs of postoperative sepsis: the business case for quality improvement to reduce postoperative sepsis in veterans affairs hospitals. Archives of Surgery, 146(8), 944-951. PMID: 21502443.

Steelman, V. M., Cullen, J. J. (2011). Designing a safer process to prevent retained surgical sponges: a healthcare failure mode and effect analysis. AORN Journal, 94(2), 132-141. PMID: 21802540.

Cullen, J. J., Spitz, D. R. & Buettner, G. R. (2011). Comment on "Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer," i.e., all we are saying is, give C a chance. Free Radical Biology and Medicine, 50(12), 1726-1727. PMID: 21459141.

Vaughan-Sarrazin, M., Bayman, L., Rosenthal, G., Henderson, W., Hendricks, A. & Cullen, J. J. (2011). The business case for the reduction of surgical complications in VA hospitals. Surgery, 149(4), 474-483. PMID: 21333313.

Welsh, J., Wagner, B., Zehr, P., Berg, D., Halfdanorson, T., Yee, N., Bodeker, K., Bhatia, S., Buettner, G. R., Levine, M. A. & Cullen, J. J. (2011). A phase I clinical trial of ascorbic acid and gemcitabine for the treatment of metastatic pancreatic cancer. (Vols. 51). pp. S130. Free Radical Biology and Medicine.

Rawal, M., Schroeder, S., Du, J., Wagner, B., Buettner, G. R. & Cullen, J. J. (2011). Manganoporphyrin MnTMPyP enhances ascorbate-induced cytotoxicity in pancreatic cancer cells via generation of H2O2. (Vols. 51). pp. S128. Free Radical Biology and Medicine.

Cullen, J. J. (2011). Oxidative stress and pancreatic cancer. In , Spitz , Dornfeld , Guis , Krishnan (Eds.) Oxidative Stress in Applied Basic Research and Clinical Practice: Cancer. pp. 257-277. Totowa, NJ: Humana Press, Inc..

Hrabe, J. E., Cullen, J. J. (2011). Small Bowel Tumors. In , J. Cameron , A. Cameron (Eds.) Current Surgical Therapy 10th Edition. (10), pp. 106-110. Elseveir.

Muniz, V., Barnes, J., Zhan, X., Tang, X., Chen, S., Zamba, K., Cullen, J. J., Meyerholz, D., Meyers, S., Davis, N., Henry, M. & Quelle, D. (2011). The ARF tumor suppressor inhibits tumor cell colonization in a novel mouse model of pancreatic ductal adenocarcinoma metastasis. Molecular Cancer Research, 146, 944-951.

Sun, W. G., Weydert, C. J., Zhang, Y., Yu, L., Liu, J., Spitz, D. R., Cullen, J. J. & Oberley, L. W. (2010). Superoxide Enhances the Antitumor Combination of AdMnSOD Plus BCNU in Breast Cancer. Cancers, 2(1), 68-87. PMID: 20532186.

Du, J., Kalen, A., Sibenaller, Z., Goswami, P. & Cullen, J. J. (2010). Ascorbate augments radiation-induced DNA damage and cytotoxicity in pancreatic cancer cells. (Vols. 49). pp. S58-S59. Free Radical Biology and Medicine.

Cullen, J. J. (2010). Ascorbate induces autophagy in pancreatic cancer. Autophagy, 6, 1-2.

Zibenaller, Z., Schrock, H., Walsh, S., Du, J., Sunderland, J. & Cullen, J. J. (2010). Fluoro-labeled thymidine positron emission tomography (FLT-PET) imaging predicts ascorbate-induced cytotoxicity. (Vols. 49). pp. S70-S71. Free Radical Biology and Medicine.

Du, J., Olney, K., Witmer, J., Van 't Erve, T., Sibenaller, Z., Buettner, G. & Cullen, J. J. (2010). Inhibitors of hydroperoxide metabolism enhance ascorbate-induced cytotoxicity. (Vols. 49). pp. S58. Free Radical Biology and Medicine.

Du, J., Olney, K., Schrock, H., Moser, J., Wagner, B., Sibenaller, Z., Buettner, G. & Cullen, J. J. (2010). Tempol inhibits pancreatic cancer cell growth. (Vols. 49). pp. S58. Free Radical Biology and Medicine.

Du, C., Gao, Z., Venkatesha, V. A., Kalen, A. L., Chaudhuri, L., Spitz, D. R., Cullen, J. J., Oberley, L. W. & Goswami, P. C. (2009). Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts. Cancer Biology and Therapy, 8(20), 1962-1971. PMID: 19738419.

Cloos, C. R., Daniels, D. H., Kalen, A., Matthews, K., Du, J., Goswami, P. C. & Cullen, J. J. (2009). Mitochondrial DNA depletion induces radioresistance by suppressing G2 checkpoint activation in human pancreatic cancer cells. Radiation Research, 171(5), 581-587. PMID: 19580493.

Du, C., Du, J. & Cullen, J. J. (2009). Extracellular superoxide dismutase (EcSOD) inhibits cell growth and the accumulation of hypoxia-inducible factor-1? (HIF-1?) in pancreatic cancer. (Vols. 47). pp. S168. Free Radical Biology and Medicine.

Du, J., Olney, K., Venkatesha, V., Du, C., Wagner, B., Goswami, P., Buettner, G. & Cullen, J. J. (2009). Pharmacologic doses of ascorbate enhance the antineoplastic effects of irradiation and chemotherapeutic drugs. (Vols. 47). pp. S168. Free Radical Biology and Medicine.

Thoreson, R., Cullen, J. J. (2008). Indications and results of reversal of vertical banded gastroplasty (VBG). Journal of Gastrointestinal Surgery, 12(11), 2032-2036. PMID: 18766418.

Chaiswing, L., Zhong, W., Cullen, J. J., Oberley, L. W. & Oberley, T. D. (2008). Extracellular redox state regulates features associated with prostate cancer cell invasion. Cancer Research, 68(14), 5820-5826. PMID: 18632636.

Coleman, M. C., Asbury, C. R., Daniels, D., Du, J., Aykin-Burns, N., Smith, B. J., Li, L., Spitz, D. R. & Cullen, J. J. (2008). 2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer. Free Radical Biology and Medicine, 44(3), 322-331. PMID: 18215740.

Du, J., Levine, M., Wagner, B., Buettner, G. R. & Cullen, J. J. (2008). Ascorbate-induced cytotoxicity in pancreatic cancer. (Vols. 134). pp. A694-A695. Gastroenterology.

Thoreson, R., Cullen, J. J. (2008). Indications and results of reversal of vertical banded gastroplasty (VBG). (Vols. 134). pp. A872-A873. Gastroenterology.

Du, J., Krebill, E., Wagner, B., Buettner, G. & Cullen, J. J. (2008). Pancreatic caner cells undergo cell death via ascorbate-mediated hydrogen peroxide production in vitro. (Vols. 45). pp. S52. Free Radical Biology and Medicine.

Du, J., Cullen, J. J. (2008). Role of Rac1 superoxide generation in the growth of pancreatic cancer. (Vols. 45). pp. S52. Free Radical Biology and Medicine.

Chaiswing, L., Zhong, W., Cullen, J. J., Oberley, L. W. & Oberley, T. D. (2007). Extracellular redox state of human prostate cancer cells regulates biological and biochemical properties related to metastatic behavior. (Vols. 43). pp. S51. Free Radical Biology and Medicine.

Du, J., Tsao, M. S., Oberley, L. W. & Cullen, J. J. (2007). K-ras oncogene increases reactive oxygen species (ROS): Mechanisms involved in regulating pancreatic cancer cell growth. (Vols. 43). pp. S53. Free Radical Biology and Medicine.

Teoh, M. L., Sun, W., Smith, B. J., Oberley, L. W. & Cullen, J. J. (2007). Modulation of reactive oxygen species (ROS) in pancreatic cancer: Insight into tumor growth suppression by the superoxide dismutases. Clinical Cancer Research, 13, 7441-7450.

Thoreson, R., Cullen, J. J. (2007). Pathophysiology of Inflammatory Bowel Disease: An Overview. In , J. J. Cullen (Eds.) Surgical Clinics of North America. pp. 575-585. Philadelphia, PA: W.B. Saunders Company.

Cullen, J. J. (2007). Pathophysiology of Inflammatory Bowel Disease: Preface. In , J. J. Cullen (Eds.) Surgical Clinics of North America,. pp. xii-xiv. Philadelphia, PA: W.B. Saunders Company.

Du, J., Buettner, G. R., Oberley, L. W. & Cullen, J. J. (2007). Potential mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer cells. (Vols. 43). pp. S53. Free Radical Biology and Medicine.

Jabbari, N., Cullen, J. J. (2007). The role of antioxidant enzymes in the growth of pancreatic carcinoma. Current Cancer Therapy Reviews, 3, 61-65.

Herwaldt, L. A., Cullen, J. J., Scholz, D., French, P., Zimmerman, M. B., Pfaller, M. A., Wenzel, R. P. & Perl, T. M. (2006). A prospective study of outcomes, healthcare resource utilization, and costs associated with postoperative nosocomial infections. Infection Control and Hospital Epidemiology, 27(12), 1291-1298. PMID: 17152025.

Cullen, J. J. (2006). Laparoscopic cholecystectomy--Avoiding complications. In C. Scott-Connor (Eds.) The SAGES Manual: Fundamentals of Laparoscopy and GI Endoscopy, 2nd edition.. pp. 140-144. New York, NY: Springer-Verlag.

Daniels, D. H., Du, J., Asbury, C. A., Oberley, L. W. & Cullen, J. J. (2006). Mitochondrial reactive oxygen species mediate dicumarol-induced cytotoxicity in pancreatic cancer cells. (Vols. 203). pp. S13. Journal of the American College of Surgeons.

Liu, J., Oberley, L. W. & Cullen, J. J. (2006). Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer. (Vols. 130). pp. A426. Gastroenterology.

Teoh, M. L., Oberley, L. W. & Cullen, J. J. (2006). Suppression of the malignant phenotype in human pancreatic cancer cells by overexpression of superoxide dismutases. (Vols. 41). pp. S113. Free Radical Biology and Medicine.

Liu, J., Du, J., Zhang, Y., Sun, W., Smith, B. J., Oberley, L. W. & Cullen, J. J. (2006). Suppression of the malignant phenotype in pancreatic cancer by the overexpression of phospholipid hydroperoxide glutathione peroxidase (PhGPx). Human Gene Therapy, 17, 105-116.

Du, J., Venkataraman, S., Oberley, L. W. & Cullen, J. J. (2006). Tempol as a superoxide scavenger in pancreatic cancer. (Vols. 41). pp. S107. Free Radical Biology and Medicine.

Lewis, A. M., Ough, M., Hinkhouse, M. M., Tsao, M. S., Oberley, L. W. & Cullen, J. J. (2005). Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer. Molecular Carcinogenesis, 43(4), 215-224. PMID: 16003741.

Daniels, D. H., Lewis, A. M., Oberley, L. W. & Cullen, J. J. (2005). Dicumarol induces oxidative stress, cytotoxicity, and mitochondrial superoxide generation in pancreatic cancer cells. (Vols. 46). pp. 725. Proceedings of the American Association of Cancer Research.

Coleman, M. C., Walsh, S. A., Li, L., Hinkhouse, M. M., Spitz, D. R. & Cullen, J. J. (2005). Inhibition of glucose metabolism in pancreatic cancer induces cytotoxicity via metabolic oxidative stress. (Vols. 128). pp. A484. Gastroenterology.

Lewis, A., Du, J., Liu, J., Ritchie, J. M., Oberley, L. W. & Cullen, J. J. (2005). Metastatic progression of pancreatic cancer: changes in antioxidant enzymes and cell growth. Clinical and Experimental Metastasis, 22(7), 523-532. PMID: 16475022.

Asbury, C. R., Daniels, D. H., Kalen, A., Du, J., Matthews, K., Liu, J., Cullen, J. J. & Goswami, P. C. (2005). Mitochondrial DNA depletion induces radioresistance by suppressing G2-checkpoint activation in human pancreatic cancer cells. (Vols. 39). pp. S163. Free Radical Biology and Medicine.

Daniels, D. H., Asbury, C. R., Du, J., Liu, J., Oberley, L. W. & Cullen, J. J. (2005). Mitochondrial production of reactive oxygen species mediates dicumarol-induced cytotoxicity in pancreatic cancer cells. (Vols. 39). pp. S164. Free Radical Biology and Medicine.

Cullen, J. J., Liu, J., Weydert, C. J. & Oberley, L. W. (2005). Pancreatic cancer: New Research. In , M. A. Loft (Eds.) Focus on Pancreatic Cancer. pp. 1-28. Hauppage, NY: Nova Science Publishers, Inc..

Fang, S., Skeete, D. & Cullen, J. J. (2005). Preoperative risk factors for postoperative Staphylococcus aureus nosocomial infections. In , Z. Szabo & J. E. Lewis , G. A. Fantini , R. S. Savalgi (Eds.) Surgical Technology International XIII. pp. 35-38. San Francisco, CA: Universal Medical Press, Inc..

Ough, M., Lewis, A., Bey, E. A., Gao, J., Ritchie, J. M., Bornmann, W., Boothman, D. A., Oberley, L. W. & Cullen, J. J. (2005). Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1. Cancer Biology and Therapy, 4(1), 95-102. PMID: 15662131.

Ough, M., Lewis, A., Zhang, Y., Hinkhouse, M. M., Ritchie, J. M., Oberley, L. W. & Cullen, J. J. (2004). Inhibition of cell growth by overexpression of manganese superoxide dismutase (MnSOD) in human pancreatic carcinoma. Free Radical Research, 38(11), 1223-1233. PMID: 15621700.

Ingham, J. M., Cullen, J., Ogdie, A. R., Mangan, P. A. & Taylor, K. L. (2004). A cohort study of desired services and barriers to service access among informal caregivers of patients with advanced cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 22(14_suppl), 8013. PMID: 28015839.

Lewis, A., Ough, M., Li, L., Hinkhouse, M. M., Ritchie, J. M., Spitz, D. R. & Cullen, J. J. (2004). Treatment of pancreatic cancer cells with dicumarol induces cytotoxicity and oxidative stress. Clinical Cancer Research, 10(13), 4550-4558. PMID: 15240547.

Herwaldt, L. A., Cullen, J. J., French, P., Hu, J., Pfaller, M. A., Wenzel, R. P. & Perl, T. M. (2004). Preoperative risk factors for nasal carriage of Staphylococcus aureus. Infection Control and Hospital Epidemiology, 25(6), 481-484. PMID: 15242196.

Liu, J., Hinkhouse, M. M., Sun, W., Weydert, C. J., Ritchie, J. M., Oberley, L. W. & Cullen, J. J. (2004). Redox regulation of pancreatic cancer cell growth: role of glutathione peroxidase in the suppression of the malignant phenotype. Human Gene Therapy, 15(3), 239-250. PMID: 15018733.

Coleman, M. C., Walsh, S. A., Li, L., Hinkhouse, M. M., Spitz, D. R. & Cullen, J. J. (2004). Inhibition of glucose metabolism in pancreatic cancer induces cytotoxicity via metabolic oxidative stress. (Vols. 199). pp. S24. Journal of the American College of Surgeons.

Liu, J., Lewis, A., Hinkhouse, M. M., Oberley, L. W. & Cullen, J. J. (2004). Metastatic progression of pancreatic cancer: changes in antioxidant enzymes and cell growth. (Vols. 37). pp. S174. Free Radical Biology and Medicine.

Cullen, J. J. (2004). Postoperative Ileus. In , J. L. Cameron (Eds.) Current Surgical Therapy, 8th edition. pp. 111-112. Elsevier.

Cullen, J. J. (2004). Preventing postoperative infections due to Staphylococcus. (Vols. 74). pp. A17. Australian New Zealand Journal of Surgery.

Cullen, J. J. (2004). Report of the 2004 Australia and New Zealand Traveling Fellow. Bulletin of the American College of Surgeons, 89, 44-45.

Liu, J., Oberley, L. W. & Cullen, J. J. (2004). Suppression of human pancreatic cancer cell growth by the overexpression of PhGPx. (Vols. 37). pp. S173-S174. Free Radical Biology and Medicine.

Fitzgerald, M., Oshiro, M., Holtan, N., Krager, K., Cullen, J. J., Futscher, B. W. & Domann, F. E. (2003). Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control. Neoplasia, 5(5), 427-436. PMID: 14670180.

Cullen, J. J., Weydert, C., Hinkhouse, M. M., Ritchie, J., Domann, F. E., Spitz, D. & Oberley, L. W. (2003). The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma. Cancer Research, 63(6), 1297-1303. PMID: 12649190.

Mason, E. E., Cullen, J. J. (2003). Management of complications in vertical banded gastroplasty. Current Surgery, 60(1), 33-37. PMID: 14972308.

Ough, M., Lewis, A. M., Hinkhouse, M. M., Li, L., Spitz, D. R., Oberley, L. W. & Cullen, J. J. (2003). A role for oxidative stress in the potent inhibition of pancreatic tumor growth by 2-deoxy-D-glucose plus dicumarol. (Vols. 35). pp. S167. Free Radical Biology and Medicine.

Cullen, J. J., Hinkhouse, M. M., Grady, M., Gaut, A. W., Liu, J., Zhang, Y., Weydert, C. J., Domann, F. E. & Oberley, L. W. (2003). Dicumarol inhibition of NAD(P)H:quinone oxidoreductase (NQO1) induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism. Cancer Research, 63, 5513-5520.

Cullen, J. J., Mitros, F. A. & Oberley, L. W. (2003). Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer. Pancreas, 26, 23-27.

Darby-Weydert, C. J., Hinkhouse, M., Oberley, L. W. & Cullen, J. J. (2003). Inhibition of NAD(P)H:quinone oxidoreductase (NQO1) induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism. (Vols. 197). pp. S17. Journal of the American College of Surgeons.

Lewis, A. M., Ough, M., Hinkhouse, M. M., Oberley, L. W. & Cullen, J. J. (2003). Inhibition of NAD(P)H:quinone oxidoreductase(NQO1) with dicumarol induces cell death in pancreatic cancer. (Vols. 35). pp. S167. Free Radical Biology and Medicine.

Dubay, D. A., Ephgrave, K. S., Cullen, J. J. & Broadhurst, K. A. (2003). Intracerebralventricular calcitonin prevents stress-induced gastric dysfunction. Journal of Surgical Research, 110, 188-192.

Ough, M., Lewis, A. M., Zhang, Y., Hinkhouse, M. M., Oberley, L. W. & Cullen, J. J. (2003). Overexpression of manganese superoxide dismutase suppresses human pancreatic cancer cell growth. (Vols. 35). pp. S167. Free Radical Biology and Medicine.

Grady, M. A., Cullen, J. J. (2003). Preventing postoperative Staphylococcus infections: an update. In , Z. Szabo , J. E. Lewis , G. A. Fantini , R. S. Savalgi (Eds.) Surgical Technology International XI. pp. 57-62. San Francisco, CA: Universal Medical Press, Inc..

Weydert, C., Roling, B., Liu, J., Hinkhouse, M. M., Ritchie, J. M., Oberley, L. W. & Cullen, J. J. (2003). Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase. Molecular Cancer Therapeutics, 2, 361-369.

Liu, J., Weydert, C., Ritchie, J., Oberley, L. W. & Cullen, J. J. (2003). Suppression of the malignant phenotype in pancreatic cancer by the overexpression of glutathione peroxidase (GPx). (Vols. 124). pp. A289. Gastroenterology.

Cullen, J. J., Hinkhouse, M. M., Gaut, A. W., Liu, J., Weydert, C., Domann, F. E. & Oberley, L. W. (2003). The role of NAD(P)H:quinone oxidoreductase (NQO1) in redox regulation of pancreatic cancer cell growth. (Vols. 124). pp. A291. Gastroenterology.

Lindaman, B. A., Hinkhouse, M. M., Conklin, J. L. & Cullen, J. J. (2002). The effect of phosphodiesterase inhibition on gallbladder motility in vitro. Journal of Surgical Research, 105(2), 102-108. PMID: 12121694.

Perl, T. M., Cullen, J. J., Wenzel, R. P., Zimmerman, M. B., Pfaller, M. A., Sheppard, D., Twombley, J., French, P. P., Herwaldt, L. A. (2002). Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections. New England Journal of Medicine, 346(24), 1871-7. PMID: 12063371.

Park, H., Clark, E., Cullen, J. J., Koland, J. G., Kim, M. S. & Conklin, J. L. (2002). Expression of inducible nitric oxide synthase in the lower esophageal sphincter of the endotoxemic opossum. Journal of Gastroenterology, 37(12), 1000-1004. PMID: 12522530.

Grady, M., Gaut, A. W., Liu, J., Zhang, Y. P., Zhang, H. J., Weydert, C., Domann, F. E., Oberley, L. W. & Cullen, J. J. (2002). K-ras mutations in pancreatic cancer. (Vols. 33). pp. S440. Free Radical Biology and Medicine.

Merg, A. R., Kalinowski, S., Hinkhouse, M. M., Mitros, F. A., Ephgrave, K. S. & Cullen, J. J. (2002). Mechanisms of impaired gallbladder contractile response in chronic acalculous cholecystitis. Journal of Gastrointestinal Surgery, 6, 432-437.

Liu, J., Weydert, C., Ritchie, J., Oberley, L. W. & Cullen, J. J. (2002). Suppression of pancreatic cancer by overexpressing glutathione peroxidase. (Vols. 33). pp. S441. Free Radical Biology and Medicine.

Cullen, J. J., Park, H., Ephgrave, K. S. & Conklin, J. L. (2001). Lipopolysaccharide temporarily impairs sphincter of Oddi motility. Nitric Oxide: Biology and Chemistry, 5(6), 547-554. PMID: 11730361.

Sarr, M. G., Cullen, J. J. & Otterson, M. A. (2001). Gastrointestinal Motility. In , W. W. Souba & D. Wilmore (Eds.) Surgical Research. pp. 507-532. San Diego, CA: Academic Press.

Merg, A. R., Kalinowski, S., Hinkhouse, M. M., Ephgrave, K. S. & Cullen, J. J. (2001). Mechanisms of impaired gallbladder contractile response in chronic acalculous cholecystitis. (Vols. 120). pp. A341. Gastroenterology.

Cullen, J. J. (2001). Percutaneous Endoscopic Gastrostomy. In , J. A. van Heerden , D. R. Farley (Eds.) Operative Techniques in General Surgery. pp. 263-268. Philadelphia, PA: W. B. Saunders Company.

Bailey, S., Cullen, J. J. (2001). Preventing Staphylococcus Infections in High-Risk Patients. In , Z. Szabo , J. E. Lewis , G. A. Fantini , R. S. Savalgi. (Eds.) Surgical Technology International IX. pp. 55-59. San Francisco, CA: Universal Medical Press, Inc..

Cullen, J. J., Oberley, L. W. (2001). Role of antioxidant enzymes in pancreatic cancer. (Vols. 31). pp. S138. Free Radical Biology and Medicine.

Cullen, J. J., Maes, E. B., Aggrawal, S., Conklin, J. L., Ephgrave, K. S. & Mitros, F. A. (2000). Effect of endotoxin on opossum gallbladder motility: a model of acalculous cholecystitis. Annals of Surgery, 232(2), 202-207. PMID: 10903598.

Park, H., Calrk, E., Cullen, J. J. & Conklin, J. L. (2000). Effect of endotoxin on opossum oesophageal motor function. Neurogastroenterology and Motility, 12(3), 215-221. PMID: 10867618.

Mon, R. A., Cullen, J. J. (2000). Standard Roux-en-Y gastrojejunostomy vs. "uncut" Roux-en-Y gastrojejunostomy: a matched cohort study. Journal of Gastrointestinal Surgery, 4(3), 298-303. PMID: 10769093.

Ephgrave, K. S., Scott, D. L., Ong, A., Cullen, J. J. & Broadhurst, K. A. (2000). Are gastric, jejunal, or both forms of enteral feeding gastroprotective during stress?. Journal of Surgical Research, 88(1), 1-7. PMID: 10644458.

Cullen, J. J., Hinkhouse, M. M. & Conklin, J. L. (2000). Characterization of the off response to electrical field stimulation in gallbladder smooth muscle. Journal of Surgical Research, 88(1), 8-12. PMID: 10644459.

Park, H., Cullen, J. J., Clark, E. & Conklin, J. L. (2000). Effect of inhibiting nitric oxide synthase on endotoxin-induced changes of esophageal motor function. (Vols. 118). pp. A386. Gastroenterology.

Lindamann, B. A., Conklin, J. L. & Cullen, J. J. (2000). Effect of phosphodiesterase inhibition on sphincter of Oddi motility: Another mechanism to decrease gallstone formation?. (Vols. 118). pp. A200. Gastroenterology.

Cullen, J. J. (2000). Peptic Ulcer Disease. In , J. D. Corson , R. C. Williamson (Eds.) SURGERY. pp. 7.1-7.22. London, England: Mosby International.

Cullen, J. J., Lindamann, B. A., Maes, E. B., Conklin, J. L., Ephgrave, K. S. & Bates, J. N. (2000). Peroxynitrite: Physiology, function, and detection in gallbladder disease. (Vols. 118). pp. A198. Gastroenterology.

Maes, E. B., Lindamann, B. A., Conklin, J. L., Ephgrave, K. S., Bates, J. N. & Cullen, J. J. (2000). Peroxynitrite: role and detection in gallbladder disease. (Vols. 191). pp. S25. Journal of the American College of Surgeons.

Maes, E. B., Lindaman, B. A., Conklin, J. L., Ephgrave, K. S., Bates, J. N. & Cullen, J. J. (2000). Peroxynitrite: role and detection in gallbladder disease. Surgical Forum, 51, 9-11.

Cullen, J. J. (2000). Postoperative Ileus. In American College of Surgeons Postgraduate Course in Gastrointestinal Disease.. pp. 39-40. American College of Surgeons Clinical Congress.

Cullen, J. J., Fedotin, M. S. (2000). Stomach, Ulcer-associated Conditions, Ulcer Surgery and Post-gastric Surgery Syndromes. In J. K. DiBaise (Eds.) Gastroenterology and Hepatology: Pearls of Wisdom. pp. 160-168. Boston, MA: Boston Medical Publishing, Corp..

Cullen, J. J., Titler, S., Ephgrave, K. S. & Hinkhouse, M. M. (1999). Gastric emptying of liquids and postprandial pancreatobiliary secretion are temporarily impaired during endotoxemia. Digestive Diseases and Sciences, 44(11), 2172-7. PMID: 10573359.

Ephgrave, K. S., Buchmiller, C., Jones, M. P. & Cullen, J. J. (1999). The cup is half full: An analysis of clinical outcomes following feeding enterostomies. American Journal of Surgery, 178(5), 406-410. PMID: 10612538.

Cullen, J. J., Conklin, J. L., Ephgrave, K. S. & Oberley, L. W. (1999). The role of antioxidant enzymes in the control of opossum gallbladder motility. Journal of Surgical Research, 86(1), 155-161. PMID: 10452883.

Cullen, J. J., Mercer, D., Hinkhouse, M., Ephgrave, K. S. & Conklin, J. L. (1999). Effects of endotoxin on regulation of intestinal smooth muscle nitric oxide synthase and intestinal transit. Surgery, 125(3), 339-344. PMID: 10076620.

Cullen, J. J., Doty, R. C., Ephgrave, K. S., Hinkhouse, M. M. & Broadhurst, K. (1999). Changes in intestinal transit and absorption during endotoxemia are dose dependent. Journal of Surgical Research, 81(1), 81-86. PMID: 9889063.

Herrmann, B. W., Cullen, J. J., Ledlow, A., Murray, J. A. & Conklin, J. L. (1999). The effect of peroxynitrite on sphincter of Oddi motility. Journal of Surgical Research, 81(1), 55-58. PMID: 9889058.

Cullen, J. J., Conkln, J. L. (1999). Characterization of the off response to electrical field stimulation in gallbladder smooth muscle. (Vols. 116). pp. A981. Gastroenterology.

Cullen, J. J., Hinkhouse, M. M., Park, H., Ephgrave, K. S. & Conklin, J. L. (1999). Does impaired sphincter of Oddi motility contribute to the jaundice of sepsis?. (Vols. 116). pp. A7. Gastroenterology.

Park, H., Clark, E., Cullen, J. J. & Conklin, J. L. (1999). Effect of endotoxin on esophageal motor function. (Vols. 116). pp. A1058. Gastroenterology.

Park, H., Cullen, J. J., Clark, E. & Conklin, J. L. (1999). Effect of inhibiting iNOS on endotoxin-induced changes in esophageal motor function. (Vols. 11). pp. 278. Neurogastroenterology and Motility.

Dubay, D., Ephgrave, K. S. & Cullen, J. J. (1999). Late abdominal pain following laparoscopic cholecystectomy: the relative incidence. (Vols. 116). pp. A1308. Gastroenterology.

Cullen, J. J., Park, H., Conklin, J. L. & Ephgrave, K. S. (1999). Sphincter of Oddi motility may contribute to the jaundice of sepsis. Surgical Forum, 50, 12-13.

Mon, R., Cullen, J. J. (1999). Standard Roux-en-Y gastrojejunostomy vs “uncut” Roux-en-Y gastrojejunostomy. (Vols. 116). pp. A1306. Gastroenterology.

Bailey, S., Cullen, J. J., Scholz, D., Zimmerman, B., Herwaldt, L. & Perl, T. M. (1999). The economic impact of postoperative nosocomial infections: A prospective study of outcomes, health care utilization and costs. (Vols. 86). pp. 289. Journal of Surgical Research.

Herwaldt, L., Scholz, D., Zimmerman, B., Pfaller, M. A., Perl, T. M. & Cullen, J. J. (1999). The economic impact of surgical site infections: A prospective study of outcomes, health care utilization and hospital costs. Surgical Forum, 50, 680-681.

Cullen, J. J., Maes, E. B., Aggrawal, S., Hinkhouse, M. M., Conklin, J. L. & Ephgrave, K. S. (1999). The effect of endotoxin on gallbladder motility: a model of acalculous cholecystitis. (Vols. 116). pp. A981. Gastroenterology.

Mason, E. E., Doherty, C., Cullen, J. J., Scott, D., Rodriguez, E. M. & Maher, J. W. (1998). Vertical gastroplasty: evolution of vertical banded gastroplasty. Wourld Journal of Surgery, 22(9), 919-924. PMID: 9717417.

Spates, S. T., Cullen, J. J., Ephgrave, K. S. & Hinkhouse, M. M. (1998). Effect of endotoxin on canine colonic motility and transit. Journal of Gastrointestinal Surgery, 2(4), 391-398. PMID: 9841998.

Ephgrave, K. S., Brasel, K. J., Cullen, J. J. & Broadhurst, K. A. (1998). Gastric mucosal protection from enteral nutrients: role of motility. Journal of the American College of Surgeons, 186(4), 434-440. PMID: 9544958.

Cullen, J. J., Spates, S. T., Ephgrave, K. S. & Hinkhouse, M. M. (1998). Endotoxin temporarily impairs canine colonic absorption of water and sodium. Journal of Surgical Research, 74(1), 34-38. PMID: 9536970.

Perl, T., Herwaldt, L., Pfaller, M. & Cullen, J. J. (1998). A new look at surgical site infections (SSI): The role of S. aureus nasal carriage. Surgical Forum, 49, 552-553.

Cullen, J. J., Dotie, R., Ephgrave, K. S., Hinkhouse, M. M. & Broadhurst, K. (1998). Changes in intestinal transit and absorption during endotoxemia are dose-dependent. (Vols. 114). pp. A362. Gastroenterology.

Cullen, J. J. (1998). Clinical Research/Outcomes Research. In Fundamentals of Surgical Research: A Course for Surgical Residents. Association of Academic Surgery.

Cullen, J. J., Titler, S., Ephgrave, K. S. & Hinkhouse, M. M. (1998). Gastric emptying of liquids and postprandial pancreatobiliary secretion are temporarily impaired during endotoxemia. (Vols. 114). pp. A740. Gastroenterology.

Cullen, J. J., Conklin, J. L., Ephgrave, K. S. & Hinkhouse, M. M. (1998). Generation of oxygen-free radicals alters gallbladder motility in vitro. (Vols. 43). pp. 1589. Digestive Diseases and Sciences.

Ephgrave, K. S., Ong, A., Broadhurst, K. & Cullen, J. J. (1998). Glucose infusions into stomach or jejunum decrease gastric injury from restraint stress. (Vols. 114). pp. A114. Gastroenterology.

Cullen, J. J. (1998). Laparoscopic cholecystectomy--Avoiding complications. In , C. Scott-Connor (Eds.) The SAGES Manual: Fundamentals of Laparoscopy and GI Endoscopy. pp. 137-142. New York, NY: Springer-Verlag.

Cullen, J. J., Ephgrave, K. S., Hemann, L. L., Hinkhouse, M. & Conklin, J. L. (1998). Metabolism of superoxide dismutase during the adynamic ileus of endotoxemia. European Surgical Research, 30(5), 326-333. PMID: 9731101.

Ephgrave, K. S., Cullen, J. J., Broadhurst, K., Kleiman-Wexler, R., Shirazi, S. S. & Schulze-Delrieu, K. (1997). Gastric contractions, secretions and injury in cold restraint. Neurogastroenterology and Motility, 9(3), 187-192. PMID: 9347475.

Mason, E. E., Tang, S., Renquist, K. E., Barnes, D. T., Cullen, J. J., Doherty, C. & Maher, J. W. (1997). A decade of change in obesity surgery. National Bariatric Surgery Registry (NBSR) Contributors. Obesity Surgery, 7(3), 189-197. PMID: 9730547.

Cullen, J. J., Hemann, L. L., Ephgrave, K. S. & Hinkhouse, M. M. (1997). Endotoxin temporarily impairs canine jejunal absorption of water, electrolytes, and glucose. Journal of Gastrointestinal Surgery, 1(3), 286-291. PMID: 9834360.

Cullen, J. J., Herrmann, B. M., Thomas, R. M., Fang, S., Murray, J. A., Ledlow, A., Christensen, J. & Conklin, J. L. (1997). The role of antioxidant enzymes in the control of opossum sphincter of Oddi motility. The American Journal of Physiology, 272(5), G1050-6. PMID: 9176213.

Cullen, J. J., Caropreso, D. K., Hemann, L. L., Hinkhouse, M., Conklin, J. L. & Ephgrave, K. S. (1997). Pathophysiology of adynamic ileus. Digestive Diseases and Sciences, 42(4), 731-737. PMID: 9125641.

Ephgrave, K., Kremer, T., Broadhurst, K. & Cullen, J. J. (1997). The role of platelet-activating factor (PAF) in conscious, normotensive endotoxemia. Journal of Surgical Research, 68(2), 170-174. PMID: 9184676.

Cullen, J. J., Caropreso, D. K., Ephgrave, K. S., Hemann, L. L. & Hinkhouse, M. M. (1997). The effect of endotoxin on canine jejunal motility and transit. Journal of Surgical Research, 67(1), 54-57. PMID: 9070181.

Cullen, J. J., Ledlow, A., Murray, J. A. & Conklin, J. L. (1997). The effect of ethanol on sphincter of Oddi motility in vitro. Journal of Surgical Research, 67(1), 58-61. PMID: 9070182.

Cullen, J. J., Ledlow, A., Murray, J. A. & Conklin, J. L. (1997). Effect of hydroxyl radical (OH.) on sphincter of Oddi motility. Digestion, 58(5), 452-457. PMID: 9383636.

Herrmann, B. W., Cullen, J. J., Ledlow, A., Murray, J. A. & Conklin, J. L. (1997). Effect of peroxynitrite on sphincter of Oddi motility. (Vols. 112). pp. A508. Gastroenterology.

Dubay, D., Mason, E. E., Broadhurst, K. & Cullen, J. J. (1997). Intracerebroventricular calcitonin reduces the force of stress induced gastric contractions. (Vols. 112). pp. A724. Gastroenterology.

Ephgrave, K. S., Dubay, D., Broadhurst, K. & Cullen, J. J. (1997). Intracranial hypertension produces variable gastric hypercontractility. (Vols. 7). pp. 55. Shock.

Cullen, J. J., Ephgrave, K. S., Hemann, L. L., Hinkhouse, M. M. & Conklin, J. L. (1997). Metabolism of superoxide dismutase (SOD) during the adynamic ileus of endotoxemia. (Vols. 112). pp. A718. Gastroenterology.

Cullen, J. J., Ramirez, A., Mason, E. E., Scott, D. H., Doherty, C. & Maher, J. W. (1997). Revising the failed vertical banded gastroplasty: A "simple" approach to a complex problem. (Vols. 7). pp. 102. Obesity Surgery.

Spates, S. T., Cullen, J. J., Ephgrave, K. S. & Hinkhouse, M. M. (1997). The effect of endotoxin on canine colonic motility and transit. (Vols. 112). pp. A1475. Gastroenterology.

Cullen, J. J., Mercer, D., Qalbani, A., Hinkhouse, M. & Ephgrave, K. S. (1997). The effects of endotoxin on regulation of intestinal smooth muscle nitric oxide synthase and intestinal transit. Surgical Forum, 48, 162-164.

Doherty, C., Mason, E. E., Cullen, J. J., Scott, D. H. & Maher, J. W. (1997). Vertical silastic ring gastroplasty revisions. (Vols. 7). pp. 113. Obesity Surgery.

Boone, K. A., Cullen, J. J., Mason, E. E., Scott, D. H., Doherty, C. & Maher, J. W. (1996). Impact of Vertical Banded Gastroplasty (VBG) on Respiratory Insufficiency of Severe Obesity. Obesity Surgery, 6(6), 454-458. PMID: 10729891.

Cullen, J. J., Ephgrave, K. S. & Caropreso, D. K. (1996). Gastrointestinal myoelectric activity during endotoxemia. The American Journal of Surgery, 171(6), 596-599. PMID: 8678207.

Renquist, K. E., Mason, E. E., Tang, S., Cullen, J. J., Doherty, C. & Maher, J. W. (1996). Pay Status as a Predictor of Outcome in Surgical Treatment of Obesity. Obesity Surgery, 6(3), 224-232. PMID: 10729863.

Cullen, J. J., Kelly, K. A. (1996). Functional characteristics of canine pylorus in health, with pyloroplasty, and after pyloric reconstruction. Digestive Diseases and Sciences, 41(4), 711719. PMID: 8674392.

Wirthlin, D. J., Cullen, J. J., Spates, S. T., Conklin, J. L., Murray, J., Caropreso, D. K. & Ephgrave, K. S. (1996). Gastrointestinal transit during endotoxemia: the role of nitric oxide. Journal of Surgical Research, 60(2), 307-311. PMID: 8598659.

Mason, E. E., Tang, S., Renquist, K., Cullen, J. J., Doherty, C. & Maher, J. (1996). A decade of change in obesity surgery. (Vols. 6). pp. 114. Obesity Surgery.

Cullen, J. J., Conklin, J. L., Murray, J., Ledlow, A. & Rosenthal, G. (1996). Effects of recombinant human hemoglobin on opossum sphincter of Oddi motor function in vivo and in vitro. Digestive Diseases and Sciences, 41, 289-294.

Cullen, J. J., Hemann, L. L., Ephgrave, K. S. & Hinkhouse, M. M. (1996). Endotoxin temporarily impairs canine jejunal absorption of water, electrolytes, and glucose. (Vols. 110). pp. A1380. Gastroenterology.

Cullen, J. J., Caropreso, D. K., Hemann, L. L., Hinkhouse, M. M., Conklin, J. L. & Ephgrave, K. S. (1996). Pathophysiology of adynamic ileus. (Vols. 5). pp. 31-32. Shock.

Kremer, T., Ephgrave, K., Broadhurst, K. & Cullen, J. J. (1996). Platelet activating factor (PAF) and the gastric effects of endotoxemia. (Vols. 110). pp. A698. Gastroenterology.

Cullen, J. J., Scott-Connor, C. E. (1996). Surgical anatomy of laparoscopic common duct exploration. In , G. Berci , A. Cuschieri (Eds.) Common Bile Duct Stone Management in the Laparascopic Era. pp. 20-25. Philadelphia, PA: W.B. Saunders Company.

Cullen, J. J., Ledlow, A., Murray, J. A. & Conklin, J. L. (1996). The effect of hydroxyl radical (OH.) on sphincter of Oddi motility. (Vols. 110). pp. A452. Gastroenterology.

Feliciano, P. D., Cullen, J. J. & Corson, J. D. (1996). The management of extrahepatic portal vein aneurysms: observe or treat?. Hepatic, Pancreatic and Biliary Surgery, 10(2), 113-116. PMID: 9184867.

Boone, K. A., Cullen, J. J., Mason, E. E., Scott, D. H., Doherty, C. & Maher, J. W. (1996). Treatment of respiratory insufficiency of obesity with vertical banded gastroplasty (VBG). (Vols. 6). pp. 110. Obesity Surgery.

Economou, T. P., Cullen, J. J., Mason, E. E., Scott, D. H., Doherty, C. & Maher, J. W. (1995). Reversal of small intestinal bypass operations and concomitant vertical banded gastroplasty: long-term outcome. Journal of the American College of Surgeons, 181(2), 160-4. PMID: 7627389.

Renquist, K. E., Cullen, J. J., Barnes, D., Tang, S., Doherty, C. & Mason, E. E. (1995). The Effect of Follow-up on Reporting Success for Obesity Surgery. Obesity Surgery, 5(3), 285-292. PMID: 10733813.

Cullen, J. J., Eagon, J. C., Hould, F. S., Hanson, R. B. & Kelly, K. A. (1995). Ectopic jejunal pacemakers after jejunal transection and their relationship to transit. American Journal of Physiology, 268(1), G959-67. PMID: 7611417.

Mason, E. E., Scott, D. H., Doherty, C., Cullen, J. J., Rodriguez, E. M., Maher, J. W. & Soper, R. T. (1995). Vertical Banded Gastroplasty in the Severely Obese under Age Twenty-One. Obesity Surgery, 5(1), 23-33. PMID: 10733790.

Cullen, J. J., Caropreso, D. K. & Ephgrave, K. S. (1995). Effect of endotoxin on canine gastrointestinal motility and transit. Journal of Surgical Research, 58(1), 90-5. PMID: 7830412.

Basilisco, G., Phillips, S. F., Cullen, J. J. & Chiravuri, M. (1995). Tonic responses of canine proximal colon: effects of eating, nutrients, and simulated diarrhea. American Journal of Physiology, 268(1), G95-101. PMID: 7840212.

Cullen, J. J., Kelly, K. A. (1995). Current management of Meckel's diverticulum. In , J. L. Cameron (Eds.) Advances in Surgery. pp. 207-214. Philadelphia, PA: W.B. Saunders Company.

Ephgrave, K., Schoener, D., Broadhurst, K. & Cullen, J. J. (1995). Effects of angiotensin converting enzyme (ACE) inhibitors on hemodynamics and gastric motility during stress. (Vols. 5). pp. 14. Shock.

Morimoto, H., Cullen, J. J., Kelly, K. A. & Messick, J. M. (1995). Epidural analgesia shortens postoperative ileus after ileal pouch-anal canal anastomosis. American Journal of Surgery, 169, 79-83.

Cullen, J. J., Caropreso, D. K. & Ephgrave, K. S. (1995). Gastrointestinal myoelectric activity during endotoxemia: characterization of the ileus that occurs during sepsis. (Vols. 108). pp. A588. Gastroenterology.

Wirthlin, D. J., Spates, S. T., Cullen, J. J., Conklin, J. L., Murray, J., Caropreso, D. K. & Ephgrave, K. S. (1995). Nitric oxide mediates the rapid gastrointestinal transit of endotoxemia. (Vols. 108). pp. A710. Gastroenterology.

Renquist, K., Mason, E. E., Tang, S., Cullen, J. J., Doherty, C. & Maher, J. W. (1995). Pay status as a predictor of outcome in surgical treatment of obesity. Achieving Acountability in Health Care: Measuring Outcomes and Provider and Payer Partnerships, 1, 18-29.

Renquist, K., Mason, E. E., Tang, S., Cullen, J. J., Doherty, C. & Maher, J. W. (1995). Pay status as a predictor of outcome in surgical treatment of obesity. (Vols. 5). pp. 119. Obesity Surgery.

Economou, T. P., Cullen, J. J., Mason, E. E., Doherty, C. & Maher, J. W. (1995). Reversal of small intestinal bypass operations and concomitant vertical banded gastroplasty: long-term outcome. (Vols. 5). pp. 134-135. Obesity Surgery.

Renquist, K. E., Cullen, J. J., Barnes, D., Doherty, C. H., Mason, E. E. (1995). The effect of follow-up on reporting success for obesity surgery. (Vols. 5). pp. 209. Obesity Surgery.

Cullen, J. J., Thomas, R. M., Murray, J. A., Ledlow, A., Christensen, J. & Conklin, J. L. (1995). The role of antioxidant enzymes in the control of sphincter of Oddi motility. (Vols. 108). pp. A413. Gastroenterology.

Mason, E. E., Doherty, C. H. & Cullen, J. J. (1995). Vertical banded gastroplasty (VBG) for severely obese adolescents. In , V. I. Rickert (Eds.) Adolescent Nutrition: Assessment and Management. pp. 561-577. New York, NY: Chapman and Hall.

Mason, E. E., Doherty, C. H., Cullen, J. J., Scott, D. H., Maher, J. W. & Scott, D. H. (1995). Vertical banded gastroplasty in severely obese adolescent patients. (Vols. 5). pp. 201. Obesity Surgery.

Cullen, J. J., Starr, M. G. & Ilstrup, D. M. (1994). Pancreatic anastomotic leak after pancreaticoduodenectomy: incidence, significance, and management. American Journal of Surgery, 168(4), 295-8. PMID: 7524375.

Cullen, J. J., Kelly, K. A., Moir, C. R., Hodge, D. O., Zinsmeister, A. R. & Melton 3rd, L. J. (1994). Surgical management of Meckel's diverticulum. An epidemiologic, population-based study. Annals of Surgery, 220(4), 564-8. PMID: 7944666.

Hould, F. S., Cullen, J. J. & Kelly, K. A. (1994). Influence of proximal gastric vagotomy on canine gastric motility and emptying. Surgery, 116(1), 83-9. PMID: 8023274.

Cullen, J. J., Eagon, J. C. & Kelly, K. A. (1994). Gastrointestinal peptide hormones during postoperative ileus. Effect of octreotide. Digestive Diseases and Sciences, 39(6), 1179-84. PMID: 7515341.

Cullen, J. J., Kelly, K. A. (1994). Prospectively evaluating anal sphincter function after ileal pouch-anal canal anastomosis. American Journal of Surgery, 167(6), 558-61. PMID: 8209927.

Cullen, J. J., Ephgrave, K. S., Broadhurst, K. A. & Booth, B. (1994). Captopril decreases stress ulceration without affecting gastric perfusion during canine hemorrhagic shock. Journal of Trauma, 37, 43-49.

Schoener, D., Ephgrave, K. S., Broadhurst, K. & Cullen, J. J. (1994). Cold restraint stress, hemodynamics, and gastric motility. (Vols. 106). pp. A1050. Gastroenterology.

Mason, E. E., Cullen, J. J., Doherty, C. & Soper, R. T. (1994). Correspondence on "Laparascopic Nissen fundoplication in children" by Lobe et al (Editorial). (Vols. 29). pp. 1637. Journal of Pediatric Surgery.

Cullen, J. J., Conklin, J. L., Murray, J., Ledlow, A. & Rosenthal, G. (1994). Effects of recombinant human hemoglobin on opossum sphincter of Oddi motor function in vivo and in vitro. (Vols. 107). pp. 1231. Gastroenterology.

Cullen, J. J., Caropreso, D. K. & Ephgrave, K. S. (1994). Endotoxin impairs canine gastric and small intestinal motility in vivo. (Vols. 106). pp. A482. Gastroenterology.

Cullen, J. J., Kelly, K. A. (1994). Future of intestinal pacing. In Gastroenterology Clinics of North America. pp. 391-402. Philadelphia, PA: W.B. Saunders Company.

Cullen, J. J., Ephgrave, K. S. & Booth, B. (1994). Rectosigmoid cancer and radiation: Use and consequences in clinical practice. (Vols. 106). pp. A379. Gastroenterology.

Mason, E. E., Maher, J. W., Doherty, C. & Cullen, J. J. (1994). Surgical approaches to obesity: Part I. Weight Control Digest, 4, 369-370.

Mason, E. E., Maher, J. W., Doherty, C. & Cullen, J. J. (1994). Surgical approaches to obesity: Part II. Weight Control Digest, 4, 371-372.

Mason, E. E., Cullen, J. J., Maher, J. W., Scott, D. H., Rodriguez, E. M. & Doherty, C. H. (1994). Vertical banded gastroplasty in severely obese adolescent patients. (Vols. 4). pp. 110-111. Obesity Surgery.

Cullen, J. J., Mason, E., Economou, T., Scott, D. & Maher, J. (1993). Iowans with intestinal bypass--a status report. Iowa Medicine, 83(11), 413-5. PMID: 8282517.

Cullen, J. J., Eagon, J. C., Dozois, E. J. & Kelly, K. A. (1993). Treatment of acute postoperative ileus with octreotide. American Journal of Surgery, 165(1), 113-119. PMID: 8418686.

Eagon, J. C., Cullen, J. J. & Kelly, K. A. (1993). Ectopic jejunal pacemakers after jejunal transection and their relationship to transit. (Vols. 104). pp. A501. Gastroenterology.

Cullen, J. J., Kelly, K. A. (1993). Functional characteristics of the intact, incised and reconstructed pylorus. Surgical Forum, 44, 163-165.

Cullen, J. J., Kelly, K. A. (1993). Gastric motor physiology and pathophysiology. In , J. M. Becker (Eds.) Surgical Clinics of North America. pp. 1145-1160. Philadelphia, PA: W.B. Saunders Company.

Cullen, J. J., Kelly, K. A. (1993). Prospective evaluation of anal sphincter function after ileal pouch-anal anastomosis. (Vols. 164). pp. 744. American Journal of Surgery.

Heitshusen, D., Cullen, J. J. (1993). Sagittal diameter measurement using bariatric surgery calipers. (Vols. 8). pp. 29. National Bariatric Surgery Registry Newsletter.

Basilisco, G., Phillips, S. F., Cullen, J. J. & Chiravuri, M. (1993). Tonic responses of the canine proximal colon to local stimuli. (Vols. 104). pp. A474. Gastroenterology.

Eagon, J. C., Cullen, J. J., Hould, F. S. & Kelly, K. A. (1992). Dumping syndrome in a 54-year-old woman. Postgraduate General Surgery, 4(210-213).

Cullen, J. J., Eagon, J. C. & Kelly, K. A. (1992). Motilin levels during postoperative ileus. (Vols. 103). pp. 1382. Gastroenterology.

Cullen, J. J., Eagon, J. C., Dozois, E. J. & Kelly, K. A. (1992). Treatment of acute postoperative ileus with octreotide. (Vols. 163). pp. 628. American Journal of Surgery.

Cullen, J. J., Ephgrave, K. S., Kleiman-Wexler, R. L. & Broadhurst, K. (1990). Angiotensin-converting enzyme inhibition, kinins, and stress ulceration. Current Surgery, 47(6), 452-4. PMID: 1703941.

Cullen, J. J., Murray, D. J. & Kealey, G. P. (1989). Changes in coagulation factors in patients with burns during acute blood loss. Journal of Burn Care and Rehabilitation, 10(6), 517-22. PMID: 2513328.

Cullen, J. J., Ephgrave, K. S., Kleiman-Wexler, R. & Broadhurst, K. (1989). The effects of angiotensin-converting enzyme inhibition on gastric mucosal injury. Current Surgery, 46(4), 295-8. PMID: 2670456.

Cullen, J. J., Ephgrave, K. S. & Kleiman-Wexler, R. L. (1989). Angiotensin-converting enzyme (ACE) inhibition and hemorrhagic shock: effects on hemodynamics, organ perfusion and gastric mucosal injury. Surgical Forum, 40, 43-45.

Cullen, J. J., Welsh, M. J. (1987). Regulation of sodium absorption by canine tracheal epithelium. Journal of Clinical Investigation, 79(1), 73-9. PMID: 3098785.

Allison, J. G., Cullen, J. J. & Olney, J. R. (1986). The effects of high-nutrient urea on in vitro bullfrog fundic mucosa. Journal of Surgical Research, 41(4), 445-55. PMID: 3095589.

Allison, J. G., Cullen, J. J. (1986). Paracellular back-diffusion of H+ across bullfrog fundic mucosa resulting from Ca2+ depletion and its effects on taurocholate-induced mucosal injury. The American Surgeon, 4(226-32). PMID: 3082267.

Allison, J. G., Cullen, J. J. (1983). CO2 utilization and distribution during H+ secretion by bullfrog fundic mucosa. American Journal of Physiology, 245, 6404-6410. PMID: 6412566.

Allison, J. G., Cullen, J. J. (1983). Effect of furosemide, prostaglandin and Ca++ chelation on CO2 distribution across bullfrog fundic mucosa. (Vols. 84). pp. 1090. Gastroenterology.

Allison, J. G., Cullen, J. J. (1983). Increasing paracellular back diffusion of H+ secretion by amphibian fundic mucosa. (Vols. 45). pp. 592. Federation Proceedings.

Olney, J. R., Cullen, J. J. & Allison, J. G. (1983). The effects of high nutrient urea on bullfrog gastric fundic mucosa. (Vols. 42). pp. 593. Federation Proceedings.

Allison, J. G., Cullen, J. J. (1982). Increasing paracellular back-diffusion of H+ protects bullfrog gastric mucosa against bile salt (BS) injury. (Vols. 84). pp. 1091. Gastroenterology.

Allison, J. G., Cullen, J. J. (1982). Urea inhibits gastric H+ secretion and does not break the "barrier.". Surgical Forum, 33, 167-170.

Schweizer, M. L., Perencivich, E., Cullen, J. J. & Vaughan-Sarrazin, M. Costs associated with surgical site infections in VA hospitals. JAMA Surgery.

Sun, R., Cullen, J. J. Flexible endoscopy: principles of documentation. In C. Scott-Connor , N. Soper (Eds.) The SAGES Manual: Fundamentals of Laparoscopy and GI Endoscopy, 3nd edition. New York, NY: Springer-Verlag.

Welsh, J., Cullen, J. J. Laparoscopic cholecystectomy: avoiding complications. In C. Scott-Connor , N. Soper (Eds.) The SAGES Manual: Fundamentals of Laparoscopy and GI Endoscopy, 3nd edition. New York, NY: Springer-Verlag.

Hrabe, J., Cullen, J. J. Monitoring, sedation and recovery. In C. Scott-Connor , N. Soper (Eds.) The SAGES Manual: Fundamentals of Laparoscopy and GI Endoscopy, 3nd edition. New York, NY: Springer-Verlag.