Anti-Müllerian Hormone (AMH) Testing

Who would request this test?
   Reproductive and Endocrinology Physicians

How to order the test?
   Contact Client Services - 866-844-2522 or
   Refer to the Anti-Müllerian Hormone test entry in the UIDL Test Directory

Anti-Müllerian Hormone (AMH) is a protein produced by ovarian granulosa cells in females and Sertoli cells in the testis in males.  The major clinical uses of AMH are assessment of ovarian function and menopausal status.  Lesser common clinical uses are for diagnosis of polycystic ovarian syndrome (PCOS) and the evaluation of intersex conditions in children.  AMH is used in the evaluation of infertility and assisted reproductive protocols (e.g., in vitro fertilization).  Women with a higher concentration of AMH have a better response to ovarian stimulation than those with lower concentrations.  Very elevated concentrations of AMH are associated with higher risk of hyperstimulation syndrome after gonadotropin stimulation.  Very low AMH concentrations are seen in menopausal women and those with premature ovarian failure of any cause, often below the lower detection limit of the assay (0.03 ng/mL).  In women with PCOS, AMH concentrations may be two- to five-fold higher than age-appropriate reference intervals. Reference ranges for females less than 20 years old have not been established for this assay. AMH concentrations in women typically reach peak values between 18-25 years old.

Reference ranges for males have not been established for this assay. However, AMH concentration in boys up through 12 years old are generally much higher than those found in adult females. In boys with cryptorchidism, a measurable AMH concentration is predictive of undescended tests, while an undetectable value is suggestive of anorchia or functional failure of the abnormally sited gonad.