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Ling Yang, Ph.D.

Associate Professor of Anatomy and Cell Biology

Contact Information

3332 Pappajohn Biomedical Discovery Building (PBDB)
169 Newton Rd.
Iowa City, IA 52242


BS, Biology, Northwest Normal University, Department of Biology
MS, Cellular Biology, School of Life Science, Lanzhou University
PhD, Cellular and Molecular Biology, School of Biomedical Sciences, Kent State University
Postdoctoral Fellow, (Department of) Genetics and Complex Diseases, Harvard School of Public Health

Center, Program and Institute Affiliations

Fraternal Order of Eagles Diabetes Research Center

Research Summary

Organisms have developed a wide range of sophisticated stress response mechanisms, which act at the cellular or organelle-specific level to restore homeostasis when they experience noxious stimuli. Compromised stress responses contribute to the onset of many human diseases including obesity. Our research aims to identify the molecular components of integration between organelle stress responses that are in play in obesity and diabetes at the cellular and organismic levels. Autophagy is a ubiquitous process in eukaryotic cells that results in the breakdown of damaged or superfluous proteins and organelles within the lysosome to allow cells to adapt to environmental stress. We recently identified that autophagy is an important regulator of hepatic glucose metabolism and insulin signaling, and that loss of autophagy is a critical contributor to the defective ER function characteristic of obesity. We are specifically interested in identifying the physiological causes of defective hepatic autophagy in obesity, and defining the molecular mechanisms underlying how autophagy, as a catabolic pathway, controls energy homeostasis in obesity-associated metabolic disorders.