Our research portfolio in the Department of Anesthesia includes a number of studies conducted by our outstanding clinical faculty. The effective collaboration of these dedicated individuals accounts for our growing success. Check out the ongoing faculty research studies below! To learn more about our research faculty, please select their individual laboratories.
Intraoperative Severe Hyperglycemia During Hypothermic Circulatory Arrest in Cardiac Surgery Patients: A Retrospective Study
Principal Investigator: Satoshi Hanada, MD, FASE
Target Participants and Study Period:
The study includes patients undergoing cardiac surgery requiring hypothermic circulatory arrest (HCA) at the University of Iowa Hospitals & Clinics from January 1, 2007, to December 31, 2022.
Overview:
Hypothermic circulatory arrest (HCA) is a critical technique in complex cardiac surgery, involving reducing body temperature to between 18°C and 28°C, thereby protecting the brain by lowering its metabolic demand for oxygen. Despite its benefits, postoperative neurological dysfunction remains a significant concern, with high incidences reported. This study investigates the prevalence and impacts of severe hyperglycemia (blood glucose > 300 mg/dL) during HCA, a condition believed to exacerbate cerebral ischemic damage.
Research Objectives & Significance:
This study aims to determine the incidence of severe hyperglycemia during HCA and its association with postoperative complications such as neurological dysfunction, stroke, and extended stays in intensive care units (ICU) and hospitals. Understanding these relationships can guide better management strategies during surgery and improve patient outcomes.
Research Period
From the date of Institutional Review Board approval through March 31, 2028.
Purpose and Method of Information Use
Patient data, including electronic medical records and the Society of Thoracic Surgeons database, will be used to analyze operative details and postoperative outcomes. Data will be anonymized to ensure privacy, with findings potentially published in academic journals and presented at conferences without disclosing identifiable patient information.
Information to be Used
Patient histories, intraoperative blood glucose measurements, insulin dosages, operative records, anesthesia records, postoperative complications, and outcome data, such as mortality and length of hospital stays.
Person Responsible for Data Management
The data management and overall responsibility of the research lie with the principal investigator at the Department of Anesthesia, University of Iowa.
Contact Information for Inquiries
If there are any questions or concerns regarding the study, or if you wish to withdraw enrollment, please contact:
Satoshi Hanada, MD, FASE
Department of Anesthesia, University of Iowa
Tel: 319-356-2633