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Recent Publications (2021)

Fueling the cytoskeleton- links between cell metabolism and actin remodeling

Gillian DeWane, Alicia M. Salvi, Kris A. DeMali
Journal of Cell Science 2021 134:jcs248385 doi:10.1242/jcs.248385 Published 8 February 2021

Drosophila female germline stem cells undergo mitosis without nuclear breakdown

Tingting Duan, Rebecca Cupp, Pamela K. Geyer
Current Biology 2021 doi:10.1016/j.cub.2021.01.033

RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis

Adam Hefel, Masayoshi Honda, Nicholas Cronin, Kailey Harrell, Pooja Patel, Maria Spies, Sarit Smolikove
Nucleic Acids Research 2021 doi:10.1093/nar/gkaa1293

Cryo-Electron Microscopy Structures of Yeast Alcohol Dehydrogenase

Sai Rohit Guntupalli, Zhuang Li, Leifu Chang, Bryce V. Plapp, Ramaswamy Subramanian
Biochemistry 2021 doi:10.1021/acs.biochem.0c00921

An Atomistic Understanding of Allosteric Inhibition of Glutamate Racemase: a Dampening of Native Activation Dynamics

Katie R. Witkin, Nicholas R. Vance, Colleen Caldwell, Quinn Li, Liping Yu, M. Ashley Spies
ChemMedChem 2020 doi:10.1002/cmdc.201900642

Ca2+-Saturated calmodulin binds tightly to the N- terminal domain of A-type fibroblast growth factor homologous factors

Ryan Mahling, Cade R Rahlf, Samuel C Hansen, Matthew R Hayden, Madeline A Shea
Journal of Biological Chemistry 2021 doi:10.1016/j.jbc.2021.100458

Deacylcortivazol- like pyrazole regioisomers reveal a more accomodating expanded binding pocket for the glucocorticoid receptor - ALSO ON FRONT COVER OF RSC

Jessica A. O. Zimmerman, Mimi Fang, Bintou Doumbia, Alexis Neyman, Ji Hyeon Cha, Micahel Thomas, Bonnie Hall, Meng Wu, Anne M. Wilson, and Miles A. Pufall
Royal Society of Chemistry 2021 doi:10.1039/d0md00278j

Glucocorticoids, a type of steroid that includes dexamethasone and prednisone, are among the most widely prescribed drugs for a number of different conditions.  Though incredibly effective, their use is plagued by serious side effects.  Through systematic chemical modification of a glucocorticoid by their partners at Butler University, Zimmerman et al were surprised to find that the glucocorticoid receptor could not only bind molecules not expected to fit within its structure, but that some of the compounds were very potent. This finding opens the door to development of new classes of glucocorticoids.

Wednesday, March 3, 2021