Andrew Norris, MD, PhD
Introduction
Andrew Norris, MD PhD, is a physician-scientist whose research is focused on the integrative physiology of diabetes across the lifespan. He is currently an Associate Professor of Pediatrics and Biochemistry at the University of Iowa. He received his PhD in molecular biophysics and MD from Washington University School of Medicine in St Louis. Dr. Norris was trained in diabetes research and pediatric endocrinology at the Joslin Diabetes Center and Boston Children's Hospital, both of Harvard Medical School. He has broad experience and training in molecular diabetes research, fetal metabolic physiology, and the lipid biochemistry of metabolic disease. As an NIH funded investigator, Dr. Norris's laboratory currently studies i) the pathogenesis cystic fibrosis related diabetes and ii) the impact of fetal diabetes exposure on subsequent metabolism. His clinical expertise regards diabetes and endocrine disorders in youth.
Current Positions
- Professor of Pediatrics - Endocrinology and Diabetes
- Professor of Biochemistry and Molecular Biology
- Richard O. Jacobson Foundation Chair in Pediatric Endocrinology and Diabetes
- Division Director, Pediatric Endocrinology and Diabetes
Education
- BS in Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts
- PhD in Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri
- MD, Washington University School of Medicine, St Louis, Missouri
- Resident in Pediatrics, University of Iowa Hospitals & Clinics, Iowa City, Iowa
- Fellow in Pediatric Endocrinology, Children's Hospital Boston & Joslin Diabetes Center, Boston, Massachusetts
- Postdoctoral Fellow in Diabetes Research, Joslin Diabetes Center
Graduate Program Affiliations
Center, Program and Institute Affiliations
Research Interests
- Early life programming of type 2 diabetes risk
- Fatty acid metabolism and insulin action
- Fetal exposure to hyperglycemia
- Metabolic actions of PPARγ in skeletal muscle
- Cystic fibrosis-related diabetes
- Bioinformatic study of common metabolic disease
Licenses & Certifications
- Pediatric Endocrinology, American Board of Pediatrics
Selected Publications
- Li Q, Zhang Q, Kim YR, Gaddam RR, Jacobs JS, Bachschmid MM, Younis T, Zhu Z, Zingman L, London B, Rauckhorst AJ, Taylor EB, Norris AW, Vikram A, Irani K. 2023. Deficiency of endothelial sirtuin1 in mice stimulates skeletal muscle insulin sensitivity by modifying the secretome. Nature Communications. 14:5595. PMC10495425.
- Sariol A, Vickers MA, Christensen SM, Weiskopf D, Sette A, Norris AW, Tansey MJ, Pinnaro CT, and Perlman S. 2024. Monovalent SARS-CoV-2 mRNA vaccine does not boost Omicron-specific immune response in diabetic and control pediatric patients. Journal of Infectious Diseases. 229:1059-1067. PMC11011175.
- Putman MS, Norris AW, Hull RL, Rickels MR, Sussel L, Blackman SM, Chan CL, Ode KL, Daley T, Stecenko AA, Moran A, Helmick MJ, Cray S, Alvarez JA, Stallings VA, Tuggle KL, Clancy JP, Eggerman TL, Engelhardt JF, Kelly A. (2023) Cystic Fibrosis-Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes. Diabetes Care May 1:dc230380. doi: 10.2337/dc23-0380. Epub ahead of print. PMID: 37125948.
- Putman MS, Norris AW, Hull RL, Rickels MR, Sussel L, Blackman SM, Chan CL, Ode KL, Daley T, Stecenko AA, Moran A, Helmick MJ, Cray S, Alvarez JA, Stallings VA, Tuggle KL, Clancy JP, Eggerman TL, Engelhardt JF, Kelly A. (2023) Cystic Fibrosis-Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes. Diabetes May 1:db220949. doi: 10.2337/db22-0949. Epub ahead of print. PMID: 37125945.
- Mitsch C, Alexandrou E, Norris AW, Pinnaro CT. (2023) Hyperglycemia in Turner syndrome: Impact, mechanisms, and areas for future research. Front Endocrinol (Lausanne). 14:1116889. PMCID: PMC9974831,
- Uc A, Strandvik B, Yao J, Liu X, Yi Y, Sun X, Welti R, Engelhardt JF, Norris AW (2022) The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models. Clin Sci 136:1773-1791. PMC9747517. doi: 10.1042/CS20220450
- Chan CL, Granados A, Moheet A, singh S, Bigers T, Arbelaez AM, Yi Y, Hu S, Norris AW, Larson Ode K. 2022. Glycemia and β-cell function before and after elexacaftor/tezacaftor/ivacaftor in youthand adults with cystic fibrosis. J Clinl & Translational Endocrinol 30:100311.
- O'Malley Y, Coleman MC, Sun C, Lei J, Yao J, Pulliam CF, Kluz P, McCormick ML, Yi Y, Imai Y, Engelhardt JF, Norris AW, Spitz DR, Uc A (2022) Oxidative stress and impaired insulin secretion in cystic fibrosis pig pancreas. Advances in Redox Research 5:100040. doi: 10.1016/j.arres.2022.100040.
- Gunasekar SK, Xie L, Kumar A, Hong J, Chheda PR, Kang C, Kern DM, My-Ta C, Maurer J, Heebink J, Gerber EE, Grzesik WJ, Elliot-Hudson M, Zhang Y, Key P, Kulkarni CA, Beals JW, Smith GI, Samuel I, Smith JK, Nau P, Imai Y, Sheldon RD, Taylor EB, Lerner DJ, Norris AW, Klein S, Brohawn SG, Kerns R, Sah R (2022) Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. Nat Commun 13:784. doi: 10.1038/s41467-022-28435-0. PMID: 35145074.
- Rotti PG, Evans IA, Zhang Y, Liang B, Cunicelli N, O'Malley Y, Norris AW, Uc A, Engelhardt JF (2022) Lack of CFTR alters the ferret pancreatic ductal epithelial secretome and cellular proteome: Implications for exocrine/endocrine signaling. J Cyst Fibros 21:172-180. PMC8595456.