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Brandon S. Davies, PhD

Associate Professor of Biochemistry and Molecular Biology

Introduction

The primary focus of my laboratory is on the regulation of triglyceride-rich lipoprotein metabolism and fatty acid partitioning.

Lipoprotein lipase (LPL) is the primary enzyme responsible for hydrolyzing lipoprotein triglycerides for the delivery of fatty acids to tissues. To become functional LPL must be trafficked across endothelial cells. As a postdoctoral fellow I identified the endothelial cell protein GPIHBP1 as the transporter responsible for trafficking LPL across capillary endothelial cells. My current research program is investigating how this trafficking, and subsequent LPL-mediated triglyceride clearance, is regulated and how it may become misregulated in metabolic disease.

Visit Google Scholar for all of Dr. Brandon Davies's publications.

Current Positions

  • Associate Professor of Biochemistry and Molecular Biology

Education

  • BA in Biology and English, University of Utah, Salt Lake City, Utah, United States
  • PhD in Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States
  • Postdoctoral Fellow in Cardiology, University of California, Los Angeles, Los Angeles, California, United States

Graduate Program Affiliations

Center, Program and Institute Affiliations

Research Interests

  • Regulation of Endothelial Lipase and HDL Metabolism by ANGPTL3 (R01HL162698)
  • Regulation of GPIHBP1-dependent and independent triglyceride clearance
  • Regulation of fat absorption by ANGPTL4 (Iowa MADE pilot grant)
  • ANGPTL8 function, mechanism, and therapeutic potential

Selected Publications

  • Spitler KM, Shetty SK, Davies BSJ (2024). Effects of Age and Diet on Triglyceride Metabolism in Mice. bioRxiv [Preprint]. 2024 Jul 22:2024.07.19.602944. doi: 10.1101/2024.07.19.602944. Submitted to Journal of Lipid Research
  • Jin Z, De U, Tithi TI, Kleberg J, Nataraj A, Jolley E, Carelock ME, Davies BSJ, Zhang W, Kolb R (2024). ANGPTL4 suppresses clear cell renal cell carcinoma via inhibition of lysosomal acid lipase. Cancer Res Commun. 2024 Aug 6. doi: 10.1158/2767-9764.CRC-24-0016. Epub ahead of print. PMID: 39105498.
  • Sylvers-Davie KL, Bierstedt KC, Schnieders MJ, Davies BSJ (2024). Endothelial Lipase Variant T111I Does Not Alter Inhibition by Angiopoietin-like Proteins. Sci. Rep. 2024 Feb 20; 14(1):4246
  • Sylvers-Davie KL and Davies BSJ. Lipoprotein Lipase. In: Encyclopedia of Biological Chemistry 3rd Edition, Joseph Jez editor, Elsevier; 2021
  • Kim H, Song Z, Zhang R, Davies BSJ, Zhang K. (2023) A Novel CREBH-derived Hepatokine Regulates Triglyceride Metabolism by Interacting with ANGPTL-LPL Complex. Sci. Signal. 2023 Jan 17;16(768)
  • Spitler KM, Shetty SK, Cushing EM, Sylvers-Davie KL, Davies BSJ (2021). Chronic high-fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice. Am J Physiol Endocrinol Metab. 321(4):E464-E478. PubMed PMID: 34396783. DOI: 10.1152/ajpendo.00144.2021.
  • Sylvers-Davie KL, Davies BSJ (2021). Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8. Am J Physiol Endocrinol Metab. 321(4):E493-E508. PubMed PMID: 34338039. doi: 10.1152/ajpendo.00195.2021.
  • Sylvers-Davie KL, Segura-Roman A, Salvi AM, Schache KJ, Davies BSJ (2021). Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8. J Lipid Res. 62:100112. PubMed PMID: 34461133; PubMed Central PMCID: PMC8456055. DOI: 10.1016/j.jlr.2021.100112.
  • Spitler KM, Shetty SK, Cushing EM, Sylvers-Davie KL, Davies BSJ (2021). Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice. Sci Rep. 11(1):7873. PubMed PMID: 33846453; PubMed Central PMCID: PMC8041937. DOI: 10.1038/s41598-021-87020-5.
  • Spitler KM, Davies BSJ (2020). Aging and plasma triglyceride metabolism. J Lipid Res. 61 (8) 1161-1167. DOI: 10.1194/jlr.R120000922. PMID: 32586846. PMCID: PMC7397742.