Andrew Norris, MD, PhD

Portrait
Professor of Biochemistry
Professor of Pediatrics - Endocrinology and Diabetes

Contact Information

Primary Office
1270B CBRB
Iowa City, IA 52242
319-335-7383

Education

BS, Chemistry, Massachusetts Institute of Technology
MD, Washington University School of Medicine
PhD, Molecular Biophysics, Washington University School of Medicine
Resident, Pediatrics, University of Iowa Hospitals & Clinics
Fellow, Pediatric Endocrinology, Children's Hospital Boston & Joslin Diabetes Center
Postdoctoral Fellow, Diabetes Research, Joslin Diabetes Center

Licensure and Certifications

Pediatric Endocrinology

Education/Training Program Affiliations

Department of Biochemistry PhD, Interdisciplinary Graduate Program in Informatics

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases, Fraternal Order of Eagles Diabetes Research Center, UI Obesity Research and Education Initiative

Research Summary

Our work is currently focused on three questions. (1) How does fetal over- or under-exposure to macronutrients incite poor metabolism? To study this, we have developed an in vivo fetal model accomplished via unilateral infusion of macronutrients into the uterine artery. (2) How does cystic fibrosis cause diabetes? We are working collaboratively with other University of Iowa investigators to better understand the pathophysiology of cystic fibrosis related diabetes. (3) How does direct action on skeletal muscle of the thiazolidinediones and their target, the transcription factor PPARgamma, help treat diabetes? We have recently demonstrated that PPARgamma directly augments the PDK1:AKT nexus of insulin signaling despite increasing muscle lipid uptake.