Eric B. Taylor, PhD

Portrait
Director, FOEDRC Metabolomics Core Facility
Associate Professor of Biochemistry

Contact Information

Office
3316 PBDB
Iowa City, IA 52242
319-384-4098

Lab
Iowa City, IA 52242
319-335-7500

Education

BS, Exercise Physiology, Brigham Young University
PhD, Physiology, Brigham Young University
Postdoctoral Fellow, Skeletal Muscle Signaling, Joslin Diabetes Center and Harvard Medical School
Postdoctoral Fellow, Molecular Metabolism, University of Utah School of Medicine

Education/Training Program Affiliations

Biomedical Science Program, Department of Biochemistry PhD, Department of Cell and Developmental Graduate Program, Interdisciplinary Graduate Program in Molecular Medicine, Interdisciplinary Graduate Program in Neuroscience, Medical Scientist Training Program

Center, Program and Institute Affiliations

Cardiovascular Research Center, Fraternal Order of Eagles Diabetes Research Center, Holden Comprehensive Cancer Center, UI Obesity Research and Education Initiative, UIHC Center for Hypertension Research

Research Summary

The Taylor Lab investigates the molecular mechanisms regulating mitochondrial function and their relationship to disease. Our approach is multidisciplinary. We employ diverse experimental models as necessary to solve fundamental problems in metabolism. We have specific expertise in molecular genetics and metabolomics. We have ongoing projects on diabetes, cancer, and neuroscience.

Publications

Taylor, E. B. (2017). Functional Properties of the Mitochondrial Carrier System. Trends in cell biology, 27(9), 633-644. PMID: 28522206.

DeZwaan-McCabe, D., Sheldon, R., Horecki, M., Guo, D., Gansemer, E., Kaufman, R., Rahmouni, K., Gillum, M., Taylor, E., Teesch, L. & Rutkowski, D. (2017). ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis. Cell Reports, 19(9), 1794-1806. PMID: 28564599.

Vigueira, P., McCommis, K., Hodges, W., Schweitzer, G., Cole, S., Oonthonpan, L., Taylor, E., McDonald, W., Kletzien, R., Colca, J. & Finck, B. (2017). The Beneficial Metabolic Effects of Insulin Sensitizers are not Attenuated by Mitochondrial Pyruvate Carrier 2 Hypomorphism. Experimental Physiology, 109(8), 985-999. PMID: 28597936.

Gray, L., Rouault, A., Oonthonpan, L., Rauckhorst, A., Sebag, J. & Taylor, E. (2017). Measuring Mitochondrial Pyruvate Oxidation. pp. 321-338. Techniques to Investigate Mitochondrial Function in Neurons.

Rauckhorst, A. J., Taylor, E. B. (2016). Mitochondrial pyruvate carrier function and cancer metabolism. Current opinion in genetics & development, 38, 102-109. PMID: 27269731.

Gray, L. R., Rauckhorst, A. J. & Taylor, E. B. (2016). A Method for Multiplexed Measurement of Mitochondrial Pyruvate Carrier Activity. The Journal of biological chemistry, 291(14), 7409-17. PMID: 26823462.

Rauckhorst, A., Taylor, E. (2016). Mitochondrial Pyruvate Carrier Function and Cancer Metabolism. Curr Opin Genet Dev., 4(38), 102-109. PMID: 27269731.

Greenhill, C. (2015). Diabetes: Important Role for MPC Complex in Hepatic Gluconeogenesis. Nature Reviews Endocrinology, 11(11), 629. PMID: 26391977.

Gray, L. R., Sultana, M. R., Rauckhorst, A. J., Oonthonpan, L., Tompkins, S. C., Sharma, A., Fu, X., Miao, R., Pewa, A. D., Brown, K. S., Lane, E. E., Dohlman, A., Zepeda-Orozco, D., Xie, J., Rutter, J., Norris, A. W., Cox, J. E., Burgess, S. C., Potthoff, M. J. & Taylor, E. B. (2015). Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis. Cell metabolism. PMID: 26344103.

Gray, L. R., Tompkins, S. C. & Taylor, E. B. (2013). Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci. PMID: 24363178.

Halestrap, A. (2012). The Mitochondrial Pyruvate Carrier: Has it Been Unearthed At Last?. Cell Metabolism, 16(2), 141-143. PMID: 22883228.

Bricker*, D. K., Taylor*, E. B., Schell, J. C., Orsak, T., Boutron, A., Chen, Y. C., Cox, J. E., Cardon, C. M., Van Vranken, J. G., Dephoure, N., Redin, C., Boudina, S., Gygi, S. P., Brivet, M., Thummel, C. S. & Rutter, J. (2012). A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science (New York, N.Y.), 337(6090), 96-100. PMID: 22628558.

Divakaruni, A., Murphy, A. (2012). A Mitochrondrial Mystery, Solved. Science, 337(6090), 41-43. PMID: 22767917.

Chen, Y. C., Taylor, E. B., Dephoure, N., Heo, J. M., Tonhato, A., Papandreou, I., Nath, N., Denko, N. C., Gygi, S. P. & Rutter, J. (2012). Identification of a protein mediating respiratory supercomplex stability. Cell metabolism, 15(3), 348-60. PMID: 22405070.

Taylor, E. B., Rutter, J. (2011). Mitochondrial quality control by the ubiquitin-proteasome system. Biochemical Society transactions, 39(5), 1509-13. PMID: 21936843.

Heo, J. M., Livnat-Levanon, N., Taylor, E. B., Jones, K. T., Dephoure, N., Ring, J., Xie, J., Brodsky, J. L., Madeo, F., Gygi, S. P., Ashrafi, K., Glickman, M. H. & Rutter, J. (2010). A stress-responsive system for mitochondrial protein degradation. Molecular cell, 40(3), 465-80. PMID: 21070972.

An, D., Toyoda, T., Taylor, E. B., Yu, H., Fujii, N., Hirshman, M. F. & Goodyear, L. J. (2010). TBC1D1 regulates insulin- and contraction-induced glucose transport in mouse skeletal muscle. Diabetes, 59(6), 1358-65. PMID: 20299473.

Treebak, J. T., Taylor, E. B., Witczak, C. A., An, D., Toyoda, T., Koh, H. J., Xie, J., Feener, E. P., Wojtaszewski, J. F., Hirshman, M. F. & Goodyear, L. J. (2010). Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle. American journal of physiology. Cell physiology, 298(2), C377-85. PMID: 19923418.

Taylor, E. B., An, D., Kramer, H. F., Yu, H., Fujii, N. L., Roeckl, K. S., Bowles, N., Hirshman, M. F., Xie, J., Feener, E. P. & Goodyear, L. J. (2008). Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle. The Journal of biological chemistry, 283(15), 9787-96. PMID: 18276596.

Kramer, H. F., Taylor, E. B., Witczak, C. A., Fujii, N., Hirshman, M. F. & Goodyear, L. J. (2007). Calmodulin-binding domain of AS160 regulates contraction- but not insulin-stimulated glucose uptake in skeletal muscle. Diabetes, 56(12), 2854-62. PMID: 17717281.

Taylor, E. B., Goodyear, L. J. (2007). Targeting skeletal muscle AMP-activated protein kinase to treat type 2 diabetes. Current diabetes reports, 7(6), 399-401. PMID: 18254999.

Winder, W. W., Taylor, E. B. & Thomson, D. M. (2006). Role of AMP-activated protein kinase in the molecular adaptation to endurance exercise. Medicine and science in sports and exercise, 38(11), 1945-9. PMID: 17095928.

Kramer, H. F., Witczak, C. A., Taylor, E. B., Fujii, N., Hirshman, M. F. & Goodyear, L. J. (2006). AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle. The Journal of biological chemistry, 281(42), 31478-85. PMID: 16935857.

Kramer, H. F., Witczak, C. A., Fujii, N., Jessen, N., Taylor, E. B., Arnolds, D. E., Sakamoto, K., Hirshman, M. F. & Goodyear, L. J. (2006). Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle. Diabetes, 55(7), 2067-76. PMID: 16804077.

Taylor, E. B., Ellingson, W. J., Lamb, J. D., Chesser, D. G., Compton, C. L. & Winder, W. W. (2006). Evidence against regulation of AMP-activated protein kinase and LKB1/STRAD/MO25 activity by creatine phosphate. American journal of physiology. Endocrinology and metabolism, 290(4), E661-9. PMID: 16278246.

Taylor, E. B., Lamb, J. D., Hurst, R. W., Chesser, D. G., Ellingson, W. J., Greenwood, L. J., Porter, B. B., Herway, S. T. & Winder, W. W. (2005). Endurance training increases skeletal muscle LKB1 and PGC-1alpha protein abundance: effects of time and intensity. American journal of physiology. Endocrinology and metabolism, 289(6), E960-8. PMID: 16014350.

Hurst, D., Taylor, E. B., Cline, T. D., Greenwood, L. J., Compton, C. L., Lamb, J. D. & Winder, W. W. (2005). AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance-trained rats. American journal of physiology. Endocrinology and metabolism, 289(4), E710-5. PMID: 15928023.

Taylor, E. B., Ellingson, W. J., Lamb, J. D., Chesser, D. G. & Winder, W. W. (2005). Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25. American journal of physiology. Endocrinology and metabolism, 288(6), E1055-61. PMID: 15644453.

Taylor, E. B., Hurst, D., Greenwood, L. J., Lamb, J. D., Cline, T. D., Sudweeks, S. N. & Winder, W. W. (2004). Endurance training increases LKB1 and MO25 protein but not AMP-activated protein kinase kinase activity in skeletal muscle. American journal of physiology. Endocrinology and metabolism, 287(6), E1082-9. PMID: 15292028.

Winder, W. W., Hardie, D. G., Mustard, K. J., Greenwood, L. J., Paxton, B. E., Park, S. H., Rubink, D. S. & Taylor, E. B. (2003). Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle. Biochemical Society transactions, 31(Pt 1), 182-5. PMID: 12546681.