Grant Awardees May-July 2015
Date: Monday, August 24, 2015
Monday, August 24, 2015
Congratulations to Carver College of Medicine Grant Awardees from May-July 2015!
| Name | Department | Sponsor | Proposal Title |
| Abbi, Kamal | Internal Medicine | Janssen Research and Development, LLC | A Phase 3 Study Comparing Daratumumab, Lenalidomide, and Dexamethasone (DRd) vs Lenalidomide and Dexamethasone (Rd) in Subjects with Previously Untreated Multiple Myeloma who are Ineligible for High Dose Therapy |
| Abel, Evan Dale | Internal Medicine | US Department of Health & Human Services, National Institutes of Health | Cardiac dysfunction in the Metabolic Syndrome: Cross Talk between IR and bAR Signaling |
| Abu Hejleh, Taher | Internal Medicine | Lilly USA, LLC | A Randomized Phase 3 Study of Abemaciclib plus Best Supportive Care versus Erlotinib plus Best Supportive Care in Patients with Stage IV NSCLC with a Detectable KRAS Mutation Who Have Progressed After Platinum-Based Chemotherapy |
| Abushahin, Laith | Internal Medicine | PPD Development, LP | A 3-Arm Phase 2 Double-Blind Randomized StudY of Gemcitabine, Abraxane Plus PlacebO versuS GEMcitabIne, Abraxane plus 1 or 2 TruncatEd Courses of Demcizumab in Subjects with 1st-Line Metastatic Pancreatic Ductal Adenocarcinoma |
| Adams, Christopher Maxin | Internal Medicine | US Department of Veterans Affairs | VA263-15-P-0411 (636D53040) Prevention and Treatment of Skeletal Muscle Atrophy |
| Adams, Christopher Maxin | Internal Medicine | US Department of Veterans Affairs | VA263-15-P-0499 (636D53033) Molecular Mechanisms of Age-related Muscle Loss |
| Ahmad, Ferhaan | Internal Medicine | MyoKardia, Inc. | MyoKardia MYH7 R403Q knock-in pigs |
| Ahmad, Ferhaan | Internal Medicine | American Heart Association | A Genetic Analysis of the Role of SGLT1 in Cardiac Ischemia-Reperfusion |
| Ahrens, Richard C | Pediatrics | Vertex Pharmaceuticals, Inc. | A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Efficacy and Safety of Ivacaftor and VX-661 in Combination With Ivacaftor in Subjects Aged12 Years and Older With Cystic Fibrosis, Heterozygous for F508del mutation |
| Aksan, Nazan Suheyla | Neurology | University of Nebraska Medical Center | Predicting Driving Safety in Advancing Age |
| Alambert, Renata Pereira | Internal Medicine | American Heart Association | Energy-Deficient Muscle as a Source for Circulating Fibroblast Growth Factor 21 |
| Alberico, Stephanie | Neurology | US Department of Health & Human Services, National Institutes of Health | Role of dorsal raphe serotonergic neurons in L-dopa induced dyskinesias |
| Andresen, Nick | Internal Medicine | Howard Hughes Medical Institute | HHMI Medical Fellowship |
| Assouline-Dayan, Yehudith | Internal Medicine | Receptos, Inc. | A Phase 2, Multi-Center, Multi-National, Randomized, Double-Blind, Placebo-Controlled Parallel-Group Clinical Trial to Evaluate the Efficacy and Safety of RPC4046 in Adolescent and Adult Subjects with Eosinophilic Esophagitis |
| Badovinac, Vladimir | Pathology | US Department of Health & Human Services, National Institutes of Health | Molecular mechanisms controlling differentiation of memory CD8 T cells |
| Benson, Christopher J | Internal Medicine | US Department of Veterans Affairs | VA263-15-P-0416 (636D53035) ASICs as metabolic sensors in muscle afferents |
| Black, Donald W | Psychiatry | Nellie Ball Trust | The Treatment of Men and Women Incarcerated Offenders with combined Borderline Personality Disorder and Antisocial Personality Disorder Using the STEPPS Program |
| Boudreau, Ryan Lee | Internal Medicine | Michael J. Fox Foundation for Parkinson's Research | Modulation of microRNA activities in Parkinson's Disease |
| Brophy, Patrick David | Pediatrics | Cincinatti Children's Hospital Medical Center | Spread of Ninja |
| Brown, James Andrew | Urology | Myriad Genetics, Inc. | Prognostic Utility of CCP Score in Patients with T1A/T1B Renal Cell Carcinoma after Nephrectomy |
| Buchanan, Gordon F | Neurology | US Department of Health & Human Services, National Institutes of Health | Serotonin neurons in arousal, epilepsy and SUDEP |
| Buchanan, Gordon F | Neurology | Epilepsy Foundation | Norepinephrine & serotonin in seizure-induced respiratory arrest and death |
| Cadaret, Linda Marie | Internal Medicine | Arena Pharmaceuticals, Inc. | APD811-003 |
| Cadaret, Linda Marie | Internal Medicine | Duke University | ASC01 |
| Cadaret, Linda Marie | Internal Medicine | Arena Pharmaceuticals, Inc. | APD811-007 |
| Cadaret, Linda Marie | Internal Medicine | Bayer HealthCare Pharmaceuticals Inc. | MOTION |
| Campbell, Kevin P | Molecular Physiology & Biophysics | US Department of Health & Human Services, National Institutes of Health | Muscular Dystrophy Cooperative Research Center |
| Cassel, Suzanne | Internal Medicine | American Lung Association | Role of discrete Th17 subsets in steroid refractory asthma |
| Choi, Kent Choung | Surgery | IrriMax Corporation | A Phase IV, multicenter, prospective, randomized, controlled clinical study to compare the IrriSept system versus Standard of Care (SoC) on the prevalence of Surgical Site Infection (SSI) in patients with abdominal trauma or acute surgical abdomen |
| Ciliberto, Heather | Dermatology | INC Research, LLC | A PHASE II, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE SAFETY AND EFFICACY OF LEBRIKIZUMAB IN PATIENTS WITH PERSISTENT MODERATE TO SEVERE ATOPIC DERMATITIS THAT IS INADEQUATELY CONTROLLED BY TOPICAL CORTICOSTEROIDS PROTOCOL NUMBER: |
| Comellas, Alejandro | Internal Medicine | AstraZeneca Pharmaceuticals LP | AZSTRATOS 1 |
| Coryell, William H | Psychiatry | Janssen Research & Development, Inc. | A Prospective, Longitudinal, Observational Study to Evaluate Potential Predictors of |
| Coryell, William H | Psychiatry | American Foundation for Suicide Prevention | Elucidating Inflammatory Markers of Suicidal Behavior in Depression and Bipolar Disorder |
| Denburg, Natalie Lisa | Neurology | US Department of Health & Human Services, National Institutes of Health | Stress and Decision-Making in Older Persons: Toward a Neurobehavioral Phenotype |
| Diekema, Daniel James | Pathology | bioMerieux, Inc. | VITEK 2 and VITEK 2 Compact GP18 Antimicrobial Susceptibility Tests |
| Duchman, Kyle Robert | Orthopaedics and Rehabilitation | Orthopaedic Research & Education Foundation | The Effects of Recombinant Human Parathyroid Hormone (rhPTH) Treatment Duration on Tendon-to-Bone healing in a Rat Rotator Cuff Repair Model |
| Engelhardt, John F | Anatomy & Cell Biology | University of Massachusetts Medical School | Ferret Knockout Model for Alpha-1 Antitrypsin Deficiency |
| Engelhardt, John F | Anatomy & Cell Biology | US Department of Health & Human Services, National Institutes of Health | Early Pathogenesis of Cystic Fibrosis Related Diabetes |
| Farooq, Umar | Internal Medicine | Kite Pharma, Inc. | A Phase 1-2 Multi-Center Study Evaluating the Safety and Efficacy of KTE-C19 in Subjects with Refractory Aggressive Non-Hodgkin Lymphoma (NHL) |
| Fuentes, Ernesto J | Biochemistry | American Heart Association, Midwest Affiliate | Biological function and inhibition of Tiam1/Syndecan-1 interactions |
| Gantz, Bruce Jay | Otolaryngology - Head & Neck Surgery | EarLens Corporation | The EarLens Contact Hearing Device (CHD) Spectrum Study |
| Gerke, Alicia | Internal Medicine | F. Hoffmann-La Roche Ltd | A PHASE II, RANDOMIZED, DOUBLE-BLIND, |
| Goel, Apollina | Radiation Research Laboratory | US Department of Health & Human Services, National Institutes of Health | Targeting Cancer Stem Cells in Multiple Myeloma Therapy |
| Grumbach, Isabella Maria | Internal Medicine | US Department of Veterans Affairs | VA263-15-P-0405 (636D53036) Calmodulin kinase II inhibition as novel molecular treatment hypertension |
| Grumbach, Isabella Maria | Internal Medicine | US Department of Veterans Affairs | VA263-15-P-0504 (636D53041) CaMKII as a Regulator of Diabetic Retinopathy |
| Hansen, Marlan Rex | Otolaryngology - Head & Neck Surgery | Cochlear Americas | Electro-Acoustic Stimulation Research |
| Harty, John | Microbiology | US Department of Health & Human Services, National Institutes of Health | Regulation of primary and secondary CD4 and CD8 T cell memory |
| Hodgson-Zingman, Denice Marie | Internal Medicine | Medtronic, Inc. | EP Fellowship Grant |
| Hodgson-Zingman, Denice Marie | Internal Medicine | Boston Scientific Corporation | EP Fellowship Grant |
| Hodgson-Zingman, Denice Marie | Internal Medicine | BIOTRONIK SE & Co.KG | EP Fellowship Grant |
| Iannone, Alexandra Bastian | Pediatrics | Cystic Fibrosis Foundation | Fellowship |
| Joy, Parijat | Internal Medicine | American Heart Association, Midwest Affiliate | Epithelial Sodium Channel Stimulation by Elevated Glucose |
| Klesney-Tait, Julia | Internal Medicine | US Department of Health & Human Services, National Institutes of Health | The Role of TREM-1 in Neutrophil Transepithelial Migration |
| Klesney-Tait, Julia | Internal Medicine | Washington University | Extracorporeal Photopheresis for the Management of Progressive Bronchiolitis Obliterans Syndrome in Medicare-Eligible Recipients of Lung Allografts (CAG-00324R2) |
| Kowalski, Joseph T | Obstetrics & Gynecology | PFD Research Foundation | PFD Research Foundation |
| Lamping, Kathryn G | Internal Medicine | US Department of Veterans Affairs | VA263-15-P-0498 (636D53032) Effect of dietary fat on diet-induced insulin resistance and vascular dysfunction |
| Laux, Douglas Earl | Internal Medicine | Merck Sharp & Dohme Company | A Phase 3 Clinical Trial of Pembrolizumab (MK-3475) in First Line Treatment of |
| Legge, Kevin L | Pathology | American Association of Immunologists | Regulation of the CD8 T cell Response to Lethal Influenza A Virus Infections |
| Mathews, Katherine Dianne | Pediatrics | University of Rochester | Horizon/Steadfast Clinical Trial |
| Maury, Wendy | Microbiology | Iowa State University | Isolating Rare Aptamers to Viral Surface Epitopes |
| Milhem, Mohammed Mahmoud | Internal Medicine | Amgen, Inc. | Phase I, Investigator Initiatied Trial-TVEC+Radiation Therapy in Sarcoma |
| Milhem, Mohammed Mahmoud | Internal Medicine | NewLink Genetics Corporation | A Phase 1/2 Study of the Combination of Indoximod and Temozolomide |
| Milhem, Mohammed Mahmoud | Internal Medicine | Merck Sharp & Dohme Company | Randomized, Phase II Study of MK-3475 versus Chemotherapy in Patients with Advanced Melanoma |
| Morita, Craig T | Internal Medicine | US Department of Veterans Affairs | VA263-15-P-0500 (636D53034) Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells |
| Morrison, Emma A | Biochemistry | Arnold & Mabel Beckman Foundation | Multivalent readout of histone PTMs in epigenetic regulation by BPTF: a structural and dynamic perspective |
| Moye-Rowley, William | Molecular Physiology & Biophysics | US Department of Health & Human Services, National Institutes of Health | A new pathway for azole resistance in Aspergillus fumigatus |
| Munch, Erika Maria Sehne | Obstetrics & Gynecology | Foundation for the Assessment and Enhancement of Embryonic Competence | Embryonic Gene Expression for Blastocyst Competence |
| Nau, Peter Nealey | Surgery | Covidien | Roux-en-y gastric bypass versus sleeve gastrectomy - analysis of the disparate effects on body composition and associated comorbidity resolution |
| Nicholson, Nathan Allan | Orthopaedics and Rehabilitation | American Orthopaedic Foot & Ankle Society | Direct Delivery of Bone Morphogenetic Protein-2 and Fibroblast Growth Factor-2 Plasmid Genes for Diabetic Fracture Healing in a Rabbit Model |
| Pak, Thomas Kun | Pediatrics | Howard Hughes Medical Institute | The Role of BBS Genes in Hypothalamic Neurogensis Mediated Metabolism |
| Parker, Krystal Lynn | Neurology | US Department of Health & Human Services, National Institutes of Health | The Therapeutic Potential of the Cerebellum in Schizophrenia |
| Perepu, Usha S | Internal Medicine | ARIAD Pharmaceuticals, Inc. | A Randomized, Open-label, Phase 2 Trial of Ponatinib in Patients with Resistant Chronic Phase Chronic Myeloid Leukemia to Characterize the Efficacy and Safety of a Range of Doses |
| Philibert, Robert Alan | Psychiatry | University of Georgia | Romantic Partner Effects on Biomarkers of Health Risk among African Americans |
| Pieper, Connie Lynn Chen | Neurology | University of Virginia | SHINE - clinical trial |
| Potthoff, Matthew Joseph | Pharmacology | US Department of Health & Human Services, National Institutes of Health | Regulation of Carbohydrate Metabolism by FGF21 Action on Brown Adipose Tissue |
| Price, David H | Biochemistry | University of Utah School of Medicine | A family of Compounds that Reactivate Latent HIV without T Cell Activation |
| Reisinger, Heather Schacht | Internal Medicine | US Department of Veterans Affairs | VA263-15-P-0613 (636D53047) Qualitative Research and Consultation for two Research Projects CRE 12-291 and CRE 12-289. |
| Rysted, Jacob | Pharmacology | American Heart Association, Midwest Affiliate | The Role of Mitochondrial Ca2+ Uniporters MCU and MCUb in Neuronal Ca2+ Signaling and Stroke Associated Neurotoxicity |
| Sah, Rajan | Internal Medicine | Roy J. Carver Charitable Trust | Tuning fat cell size and obesity through SWELL1 |
| Salgado-Pabon, Wilmara | Microbiology | American Heart Association | Toxin-mediated Cellular Mechanism for Development of Staphylococcus aureus Infective Endocarditis |
| Samuel, Isaac | Surgery | Foundation for Surgical Fellowships | Fellowship in Bariatric Surgery |
| Sanchez, Antonio Jaime | Internal Medicine | Merck Research Laboratories | Follow-Up Study MK-5172-017-0256 study |
| Schultz, Michael K | Radiology | inviCRO, LLC | Ga-68 labeling of inviCRO peptide - Process optimization, automation, and documentation |
| Schultz, Michael K | Radiology | Radiomedix, Inc. | Radiomedix Contract Work Projects |
| Schultz, Susan Kay | Psychiatry | US Department of Health & Human Services, Health Resources & Services Administration | Interprofessional Strategic Healthcare Alliance for Rural Education: iSHARE |
| Schultz, Susan Kay | Psychiatry | University of California, San Diego | Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - The LEARN Study |
| Schultz, Susan Kay | Psychiatry | University of California, San Diego | Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - The LEARN Study |
| Schultz, Susan Kay | Psychiatry | Brain Image Analysis, LLC | Brain Image Analys |
| Sebag, Julien Albert | Molecular Physiology & Biophysics | Roy J. Carver Charitable Trust | Role and mechanism of MRAP2 mediated regulation of prokineticin receptors |
| Serrano Russi, Alvaro | Pediatrics | Protalix Biotherapeutics | A Multi Center Extension Study of PRX-102 Administered by Intravenous Infusions Every 2 Weeks for 24 Months to Adult Fabry Patients |
| Sharafuddin, Melhem J | Surgery | Endologix, Inc. | Multicenter, Post-Market, Real World Study to Assess Outcomes of Patients Treated with the AFX System compared to other EVAR devices for Endovascular Abdominal Aortic Aneurysm Repair: LEOPARD (Looking at EVAR Outcomes by Primary Analysis of Randomized Dat |
| Sharafuddin, Melhem J | Surgery | W. L. Gore & Associates, Inc. | GREAT (Global Registry for Endovascular Aortic Treatment) |
| Sharafuddin, Melhem J | Surgery | Diagnostica Stago S.A.S. | STA - Liatest D-Di - Exclusion of Venous Thromboembolism (VTE) |
| Shields, Richard Kemp | Physical Therapy | US Department of Health & Human Services, National Institutes of Health | Musculoskeletal Plasticity after Spinal Cord Injury |
| Shields, Richard Kemp | Physical Therapy | US Department of Health & Human Services, National Institutes of Health | Long Duration Activity and Metabolic Control after Spinal Cord Injury |
| Shinozaki, Gen | Psychiatry | US Department of Health & Human Services, National Institutes of Health | Epigenetic Investigation of Trauma on PTSD and Depression |
| Shivapour, Ezzatollah Torage | Neurology | Biogen Idec Inc. | Biogen-105MS401- Plegridy |
| Sieren, Jessica Corinne | Radiology | US Department of Health & Human Services, National Institutes of Health | Nondestruction Multi-Scale Micro-CT Imaging System |
| Sigmund, Curt D | Pharmacology | US Department of Health & Human Services, National Institutes of Health | Hypertension: Role of Smooth Muscle Cullin-3 and the CRL3 Complex |
| Sivitz, William I | Internal Medicine | George Washington University | Glycemia Reduction Approaches in Diabetes (GRADE):comparative effectiveness study |
| Sivitz, William I | Internal Medicine | Case Western Reserve University | Residual Beta Cell Function in Patients with Long-Term Type 1 Diabetes |
| Sluka, Kathleen A | Physical Therapy | US Department of Health & Human Services, National Institutes of Health | Central Mechanisms Involved in the Interactions Between Muscle Pain & Exercise |
| Smith, Richard J | Otolaryngology - Head & Neck Surgery | Greater Cedar Rapids Community Foundation | C3 Glomerulopathy Educational Grant |
| Snyder, Peter M | Internal Medicine | US Department of Veterans Affairs | VA263-15-P-0621 Epithelial Sodium Channel Trafficking |
| Spitz, Douglas Robert | Radiation Research Laboratory | US Department of Health & Human Services, National Institutes of Health | Training in Free Radical and Radiation Biology |
| Stamnes, Mark A | Molecular Physiology & Biophysics | US National Science Foundation | DEEPN analysis of the Ras Superfamily GTPase Interactome |
| Stapleton, Jack T | Internal Medicine | US Department of Health & Human Services, Health Resources & Services Administration | OP Early Intervention Services with Respect to HIV Diseases |
| Stapleton, Jack T | Internal Medicine | US Department of Health & Human Services, National Institutes of Health | Research Training in Infectious Diseases |
| Starner, Timothy Duane | Pediatrics | Seattle Children's Hospital | Saline Hypertonic in Preschoolers (SHIP) |
| Sutterwala, Fayyaz Shiraz | Internal Medicine | US Department of Health & Human Services, National Institutes of Health | Targeting the NLRP3 inflammasome to limit pathologic sterile inflammation |
| Turvey, Carolyn Louise | Psychiatry | US Department of Veterans Affairs, Iowa City Veterans Affairs Medical Center | Veteran Initiated Electronic Care Coordination (VIECC) |
| Uc, Aliye | Pediatrics | National Pancreas Foundation | Genetic Determinants of Pediatric Chronic Pancreatitis |
| Uc, Ergun Y | Neurology | Massachusetts General Hospital | SYNAPSE Study |
| Usachev, Yuriy M | Pharmacology | US Department of Health & Human Services, National Institutes of Health | The Role of Ca-dependent Transcription Factor NFAT in Pain Control |
| Wanat, Karolyn A | Dermatology | Dermatology Foundation | Pathogenesis of cutaneous leishmaniasis: role of mast cells and eosinophils |
| Weiner, George J | Cancer Center | Burke Family Foundation | The Burke Family Foundation Research Fund - UIF Special Award |
| Welsh, Michael James | Internal Medicine | Cystic Fibrosis Foundation Therapeutics, Inc. | Development of CFTR-G551D Pigs |
| Welsh, Michael James | Internal Medicine | Cystic Fibrosis Foundation | Cystic Fibrosis Foundation Research & Development Program |
| Williford, Noah Nicholas | Internal Medicine | Howard Hughes Medical Institute | Epithelial Sodium Channel Regulation by NaCl |
| Wilson, Mary E | Internal Medicine | US Department of Veterans Affairs | VA263-15-P-0408 (636D53037) Macrophage-Activating MicroRNAs in the Pathogenesis of Leishmaniasis |
| Winokur, Patricia Lee | Internal Medicine | US Department of Health & Human Services, National Institutes of Health | VTEU 12-0109.B1C1.0007 Option 1 |
| Winokur, Patricia Lee | Internal Medicine | US Department of Health & Human Services, National Institutes of Health | 14-0107 Yellow Fever Vaccine - Task B - Base Period |
| Xue, Hai-Hui | Microbiology | US Department of Health & Human Services, National Institutes of Health | Epigenomic landscape in naive, effector, and memory CD8 T cells |
| Yan, Ziying | Anatomy & Cell Biology | University of Kansas Medical Center Research Institute, Inc. | Study of Human Bocavirus Gene Expression for Development of a Parvoviral Vector |
| Zakharia, Yousef | Internal Medicine | NewLink Genetics Corporation | NLG0106 A Phase 1 Study of HyperAcute Renal (HAR) Immunotherapy In Patients with Metastatic Renal Cell Cancer |