John C. Selby, MD, PhD, FAAD

Portrait
Medical Director, Physical Modalities
Assistant Professor of Dermatology

Contact Information

Primary Office
40033 PFP
200 Hawkins Drive
Iowa City, IA 52242
319-356-2856

Education

BS, Mechanical Engineering, University of Illinois at Urbana-Champaign
MS, Mechanical Engineering, University of Illinois at Urbana-Champaign
PhD, Mechanical Engineering, University of Illinois at Urbana-Champaign
MD, University of Illinois College of Medicine
Internship, Internal Medicine, University of Illinois College of Medicine
Resident, Dermatology, University of Iowa College of Medicine

Licensure and Certifications

ABD Board Certified - American Board of Dermatology
State of Iowa Medical License - Iowa Board of Medicine

Research Summary

My primary research interests revolve around basic science questions in the field of cell mechanics, and more specifically, inquiries into the mechanobiological behaviors of human epidermal keratinocytes in the context of blistering skin diseases and wound healing. In collaborative work with Dr. Edward Sander from the Department of Biomedical Engineering (University of Iowa), we have demonstrated that keratinocyte motility is affected by mechanosensation of substrate deformations. Building from this work, we have more recently begun to explore how extracellular matrix stiffness can affect the motility of epidermal keratinocytes within a model of wound re-epithelialization in vitro. In parallel work, my lab has been developing rheological assays to explore the mechanobiological function of collagen VII in wound healing through a collaboration with Dr. Mei Chen and Dr. David Woodley from the University of Southern California. In another collaborative project with Dr. Anton Kruger from the Department of Electrical and Computer Engineering (University of Iowa), we have been working to build an experimental platform that integrates an electromagnetic microneedle with traction force microscopy for probing the biophysical mechanisms of blister formation in bullous pemphigoid and pemphigus vulgaris (human blistering skin diseases). Clinically, I have a special interest in complex medical dermatology, including the diagnosis and management of psoriasis and chronic pruritus without rash. In sum, I believe that interdisciplinary research done at both the bench and the bedside will have a profound impact on the ways in which we will treat human skin disease in the years to come.

Publications

Selby, J. C. (2018). Infective Endocarditis. In M. A. Rosenbach , R. M. Micheletti , K. A. Wanat , L. A. Taylor (Eds.) Inpatient Dermatology. (1st) Springer. DOI: 10.1007/978-3-319-18449-4.

Zarkoob, H., Chinnathambi, S., Selby, J. C. & Sander, E. A. (2018). Substrate deformations induce directed keratinocyte migration. J Roy Soc Interface, 15(143). DOI: 10.1098/rsif.2018.0133.

Zarkoob, H., Chinnathambi, S., Halberg, S. A., Selby, J. C., Magin, T. M. & Sander, E. A. (2018). Mouse keratinocytes without keratin intermediate filaments demonstrate substrate stiffness dependent behaviors. Cell Mol Bioeng, 1-12. DOI: 10.1007/s12195-018-0526-y.

Dittmer, M. R., Willis, M. S., Selby, J. C. & Liu, V. (2018). Septolobular panniculitis in disseminated Lyme borreliosis. J Cutan Pathol, 45(4), 274-277. PMID: 29293267.

Hammel, J. A., Selby, J. C. (2018). Pustular Eruption (Iododerma?) in a Patient With Cancer Treated With Complementary and Alternative Medicine-Reply. JAMA Dermatol, 154(4), 496. PMID: 29490375.

Hammel, J. A., Selby, J. C. (2017). Pustular Eruption in a Patient With Cancer Treated With Complementary and Alternative Medicine. JAMA Dermatol, 153(12), 1335-1337. PMID: 29049442.

Boes, E. E., Selby, J. C. & Swick, B. L. (2017). 'Super Bloom' Dermatitis. Clin Exp Dermatol, 42(4), 430-431. PMID: 28397285.

Connor, C. J., Selby, J. C. & Wanat, K. A. (2016). Severe pediculosis capitus: a case of "crusted lice" with autoeczematization. (Vols. 22). (3) Dermatol Online J. PMID: 27136626.

Naridze, R. L., Selby, J. C., Link, B. K. & Liu, V. (2016). Isolated unilateral facial nerve palsy: an unusual manifestation of recurrent diffuse large B-cell lymphoma. J Eur Acad Dermatol Venereol. PMID: 25753517.

Zarkoob, H., Bodduluri, S., Ponnaluri, S. V., Selby, J. C. & Sanders, E. A. (2015). Substrate Stiffness Affects Human Keratinocyte Colony Formation. (Vols. 8). (1), pp. 32-50. Cell Mol Bioeng. PMID: 26019727.

Holahan, H. M., Farah, R. S., Selby, J. C. & Fairley, J. A. (2014). Erythema annulare-like acantholytic dermatosis: A subset of pemphigus foliaceus. Brit J Dermatol, 171(6), 1558-9. PMID: 24836841.

Zarkoob, H., Selby, J. C., Messingham, K., Fairley, J. A. & Sander, E. (2014). Differences in keratinocyte colony formation in response to substrate stiffness. (Vols. 134). (8), pp. S1-S9. J invest Derm. DOI: doi:10.1038/jid.2014.207.

Hochwalt, P., Asarch, A., Selby, J. C. & VanBeek, M. J. (2013). Surgical corner: Modified buried suture technique for the scalp. (Vols. 1). (12), pp. 692-3. J Drugs Dermatol. PMID: 23839188.

Selby, J. C., Liu, V. (2012). Cutaneous lymphoid hyperplasia: Cases in Dermatopathology. In M. P. Hoang , L. M. Duncan , M. C. Mihm Jr , G. F. Murphy , S. R. Tahan (Eds.) Pediatric Dermatopathology. pp. 101-107. Knowledge Books and Software.

Selby, J. C. (2011). Mechanobiology of epidermal keratinocytes: Desmosomes, hemidesmosomes, keratin intermediate filaments, and blistering skin diseases. In A. Wagoner-Johnson , B. A. Harley (Eds.) Mechanobiology of Cell-Cell and Cell-Matrix Interactions. pp. 169-210. Springer. DOI: 10.1007/978-1-4419-8083-0_9.

Patel, M. V., Selby, J. C. & Yekkirala, L. (2011). Neurosyphilis in a patient with psychotic symptoms: Clinical presentation in the modern era. Carle Selected Papers/A Journal of Practical Medicine, 54(2), 33-37.

Selby, J. C., Shannon, M. A. (2009). Inflation of a circular elastomeric membrane into a horizontally semi-infinite liquid reservoir of finite vertical depth: Quasi-static deformation model. (Vols. 47). (5-6), pp. 700-717. Int J Eng Sci. DOI: 10.1016/j.ijengsci.2009.01.007.

Selby, J. C., Shannon, M. A. (2009). Inflation of a circular elastomeric membrane into a horizontally semi-infinite liquid reservoir of finite vertical depth: Estimation of material parameters from volume-pressure data. (Vols. 47). (5-6), pp. 718-734. Int J Eng Sci. DOI: 10.1016/j.ijengsci.2009.01.007.

Selby, J. C., Shannon, M. A. (2008). A method to fabricate mesoscopic freestanding polydimethylsiloxane membranes used to probe the rheology of an epithelial sheet. (Vols. 70). (6), pp. 932-44. J Biochem Biophs Methods. PMID: 17764751.

Selby, J. C., Shannon, M. A. (2007). Apparatus for measuring the finite load-deformation behavior of a sheet of epithelial cells cultured on a mesoscopic freestanding elastomer membrane. (Vols. 78). (9), pp. 094301. Rev Sci Instrum. DOI: http://dx.doi.org/10.1063/1.2777180.

Prakash, S., Long, T. M., Selby, J. C., Moore, J. S. & Shannon, M. A. (2007). ‘Click’ modification of silica surfaces and glass microfluidic channels. (Vols. 79). (4), pp. 1661-1667. Anal Chem. PMID: 17297970.

Selby, J. C., Shannon, M. A. (2007). Mechanical response of a living human epidermal keratinocyte sheet as measured in a composite diaphragm inflation experiment. (Vols. 44). (5-6), pp. 319-48. Biorheology. PMID: 18401074.

Yeom, J., Wu, Y., Selby, J. C. & Shannon, M. A. (2005). Maximum achievable aspect ratio in deep reactive ion etching of silicon due to aspect ratio dependent transport and the microloading effect. (Vols. 23). (6), pp. 2319-2329. Virtual Journal of Nanoscale Science & Technology (VJNST).

Selby, J. C., Boppart, S. A. & Shannon, M. A. (2005). Cytoskeletal networks in an epithelial sheet: Mechanical characterization using composite diaphragm inflation. pp. 201-4. Microtechnology in Medicine & Biology/IEEE-EMBS Special Topic Conference. DOI: http://dx.doi.org/10.1109/MMB.2005.1548425.

Xu, K., Selby, J. C., Shannon, M. A. & Economy, J. (2004). Adhesion mechanisms in the solid-state bonding technique using submicrometer aromatic thermosetting colpolyester adhesive. J Appl Polym Sci, 92(6), 384-3856.

Selby, J. C., Boppart, S. A. & Shannon, M. A. (2003). Measurement of the mechanical properties of actin filament and keratin intermediate filament networks in a monolayer of cultured human epidermal keratinocytes. (Vols. 121). (1), pp. Abstract No. 0280. J Invest Dermatol.

Selby, J. C., Boppart, S. A. & Shannon, M. A. (2003). Cytoskeletal networks in an epithelial sheet: Mechanical characterization using elastic microfabricated membranes. pp. 885-6. 2003 ASME Summer Bioengineering Conference. DOI: http://dx.doi.org/10.1109/MMB.2005.1548425.

Engel, J., Chen, J., Liu, C., Flachsbart, B. R., Selby, J. C. & Shannon, M. A. (2002). Development of polyimide based flexible tactile sensing skin. (Vols. 736). pp. 165-70. Materials Research Society Symposium Proceedings.

Alaca, B. E., Selby, J. C., Saif, M. T. & Sehitoglu, H. (2002). Biaxial testing of nano-scale films on compliant substrates: fatigue and fracture. Rev Sci Instrum, 73(8), 2963-2970. DOI: http://dx.doi.org/10.1063/1.1488685.

Selby, J. C., Shannon, M. A. & Boppart, S. A. (2002). Design of a microfabricated cell straining device for investigating cellular response to finite mechanical strains. pp. 174-9. Microtechnologies in Medicine & Biology/IEEE-EMBS Special Topic Conference. DOI: http://dx.doi.org/10.1109/MMB.2002.1002308.

Xi, C., Balberg, M., Selby, J. C., Boppart, S. & Raskin, L. (2002). Use of molecular beacons to study mixing and hybridization in microfluidic devices. pp. 541-4. Microtechnologies in Medicine & Biology/IEEE-EMBS Special Topic Conference. DOI: http://dx.doi.org/10.1109/MMB.2002.1002404.

Selby, J. C., Shannon, M. A., Xu, K. & Economy, J. (2001). Sub-micrometer solid-state adhesive bonding with aromatic thermosetting copolyesters for the assembly of polyimide membranes in silicon-based devices. (Vols. 11). (6), pp. 672-685. J Micromech Microeng.

Selby, J. C., Philpott, M. L. & Shannon, M. A. (2001). Fabrication of mesoscopic flexible, high pressure, microchannel heat exchangers (MHEx). In Transactions of NAMRI/SME. (Vols. 29). pp. 469-476. 29th North American Manufacturing Research Conference (NAMRC).

Philpott, M. L., Beebe, D. J., Fischer, A., Flachsbart, B., Marshall, M., Miller, N. R., Selby, J. C., Shannon, M. A. & Wu, Y. (2000). Switchable electrostatic micro-valves with high hold-off pressure. pp. 226-9. Technical Digest of the 2000 Solid-State Sensor and Actuator Workshop.

Selby, J. C., Shannon, M. A. (1998). Anodic sacrificial layer etch (ASLE) for large area and blind cavity release of metallic structures. In , L. Bousse (Eds.) Technical Digest of the 1998 Solid-State Sensor and Actuator Workshop. pp. 252-5. Transducer Research Foundation Inc.