Blocking ceramides with fungi extract reverses diabetes, obesity, in mice

A publication earlier this month in Scientific Reports demonstrates that a key lipid metabolite may be a useful target in preventing or even reversing diabetes and many of its comorbidities. Ceramides are a characteristic of obesity, and increased accumulation of these metabolites contributes to glucose and metabolism impairments. In rodents, ceramide degradation prevented and reversed disease like diabetes, hypertension, and cardiomyopathy. Expanding on previous studies, Bhagirath Chaurasia, PhD, assistant professor in Endocrinology and Metabolism, has identified a nutraceutical that inhibits ceramide biosynthesis and improves energy homeostasis.

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