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Alejandro Pezzulo Colmenares, MD

Associate Professor of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine
Photo of Alejandro Pezzulo Colmenares, MD
Alejandro Pezzulo Colmenares, MD - University of Iowa
Office
6316 Pappajohn Biomedical Discovery Building
Iowa City, IA 52242

Current Positions

  • Associate Professor of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine

Education

  • MD, Universidad Central de Venezuela, Caracas, Venezuela
  • Resident, Internal Medicine, University of Iowa Hospitals & Clinics, Iowa City, Iowa
  • Fellow, Pulmonary Disease and Critical Care Medicine, University of Iowa Hospitals & Clinics, Iowa City, Iowa

Center, Program and Institute Affiliations

Selected Publications

  • Kobayashi, T., Ortiz, M. E., Imborek, K. L., Alsuhaibani, M., Holley, S. A., Trannel, A., Marra, A. R., Etieene, W., Jenn, K. E., Abosi, O. J., Meacham, H., Sheeler, L. L., Dains, A., Kukla, M. E., McCray, P. B., Perlman, S., Ford, B., Diekema, D. J., Wellington, M., Salinas, J. L. & Pezzulo, A. A. (In Press). Suspected COVID-19 Reinfections at a Tertiary Care Center, Iowa 2020. DOI: https://doi.org/10.1093/ofid/ofab188.
  • Thurman, A. L., Ratcliff, J. A., Chimenti, M. S. & Pezzulo, A. A. (In Press). Differential gene expression analysis for multi-subject single cell RNA sequencing studies with aggregateBioVar. Bioinformatics.
  • Ortiz, M. E., Thurman, A., Pezzulo, A. A., Leidinger, M. R., Klesney-Tait, J. A., Karp, P. H., Tan, P., Wohlford-Lenane, C., McCray, Jr, P. B. & Meyerholz, D. K. (2020). Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract. EBioMedicine 60 102976. DOI: 10.1016/j.ebiom.2020.102976. PMID: 32971472. PMCID: PMC7505653.
  • Rehman, T., Thornell, I. M., Pezzulo, A. A., Thurman, A. L., Romano Ibarra, G. S., Karp, P. H., Tan, P., Duffey, M. E. & Welsh, M. J. (2020). TNFα and IL-17 alkalinize airway surface liquid through CFTR and pendrin. American journal of physiology. Cell physiology 319 (2) C331-C344. DOI: 10.1152/ajpcell.00112.2020. PMID: 32432926. PMCID: PMC7500220.
  • Zarei, K., Stroik, M. R., Gansemer, N. D., Thurman, A. L., Ostedgaard, L. S., Ernst, S. E., Thornell, I. M., Powers, L. S., Pezzulo, A. A., Meyerholz, D. K. & Stoltz, D. A. (2020). Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model. Laboratory investigation; a journal of technical methods and pathology. DOI: 10.1038/s41374-020-0474-8. PMID: 32719544.
  • Thornell, I. M., Rehman, T., Pezzulo, A. A. & Welsh, M. J. (2020). Paracellular bicarbonate flux across human cystic fibrosis airway epithelia tempers changes in airway surface liquid pH. The Journal of physiology. DOI: 10.1113/JP280120. PMID: 32627187.
  • Hamilton, B. A., Li, X., Pezzulo, A. A., Abou Alaiwa, M. H. & Zabner, J. (2019). Polarized AAVR expression determines infectivity by AAV gene therapy vectors. Gene therapy 26 (6) 240-249. DOI: 10.1038/s41434-019-0078-3. PMID: 30962536. PMCID: PMC6588428.
  • Pezzulo, A. A., Tudas, R. A., Stewart, C. G., Vargas Buonfiglio, L. G., Lindsay, B. D., Taft, P. J., Gansemer, N. D. & Zabner, J. (2019). HSP90 inhibitor geldanamycin reverts IL-13–and IL-17–induced airway goblet cell metaplasia. Journal of Clinical Investigation 129 (2) 744-758. DOI: 10.1172/JCI123524.
  • Vargas Buonfiglio, L. G., Cano, M., Pezzulo, A. A., Vanegas Calderon, O. G., Zabner, J., Gerke, A. K. & Comellas, A. P. (2017). Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial. BMJ open respiratory research 4 (1) e000211. DOI: 10.1136/bmjresp-2017-000211. PMID: 28883932. PMCID: PMC5531307.
  • Krutsinger, D., Pezzulo, A., Blevins, A. E., Reed, R. M., Voigt, M. D. & Eberlein, M. (2017). Idiopathic hyperammonemia after solid organ transplantation: Primarily a lung problem? A single-center experience and systematic review. Clinical transplantation 31 (5). DOI: 10.1111/ctr.12957. PMID: 28295601.