Research in Dr. Chauhan's laboratory is focused on the interface between thrombosis, inflammation, and vascular biology in the setting of stroke and atherosclerosis. The current work is centered on understanding how metabolic plasticity regulates platelet and leukocyte function and whether targeting aerobic glycolysis can inhibit thrombo-inflammation. If successful, this could be developed as a therapeutic strategy for better managing patients at high risk for acute coronary events and stroke. We utilize state-of-the-art techniques like intravital microscopy, laser-speckle imaging, and magnetic resonance imaging to study the mechanistic role of thrombo-inflammation in the modulation of acute ischemic stroke and thrombosis. In addition, research projects use molecular and cellular techniques combined with genetically modified mice to investigate the role of novel molecules in the pathophysiology of atherosclerosis. In addition, Dr. Chauhan's laboratory is part of NINDS, Stroke Preclinical Assessment Network (https://spannetwork.org/lowaun) which supports translational studies for acute neuroprotection. The main objective of the SPAN network is to address this need by prioritizing the testing of different neuroprotective agents in humans based on their measured comparative efficacy in experimental stroke models.