Chad Grueter, PhD

Portrait
Assistant Professor of Internal Medicine - Cardiovascular Medicine

Contact Information

Primary Office
4332 Pappajohn Biomedical Discovery Building
Iowa City, IA 52242
319-335-3379

Education

PhD, Molecular Physiology and Biophysics, Vanderbilt University
Postdoctoral Fellow, UT Southwestern Medical Center

Center, Program and Institute Affiliations

Fraternal Order of Eagles Diabetes Research Center

Research Summary

The basis for the research in my laboratory lies in my strong interest in understanding the transcriptional and posttranscriptional processes that are disrupted in heart disease. In our previous studies, we identified a novel transcriptional signaling pathway in the heart that mediates the heart’s ability to regulate whole body metabolism. Through a combination of pharmacological and genetic gain- and loss-of-function studies in mice, we found the heart is capable of regulating whole body metabolism through a mechanism that is governed by MED13 and miR-208a. MED13 is a particularly interesting component of the Mediator complex because it functions as a molecular bridge between the core complex and kinase submodule, providing a mechanism for spatial and temporal control of Mediator-dependent regulation of transcription. Recently, we have identified a key role for other components of the Mediator complex including CDK8 and MED1 in regulation cardiac function and the cardiac transcriptional profile. We primarily utilize mutant mouse models to study the proteomic, molecular, bioinformatic and biochemical methods to study the molecular signaling events controlling cardiac transcriptional response to stress.