Christie P. Thomas, MBBS

Portrait
Professor of Internal Medicine - Nephrology

Contact Information

Primary Office: SE419 GH
Iowa City, IA 52242
319-356-4216

Education

MBBS, Christian Medical College, Vellore, India

Resident, Internal Medicine, District General Hospital Sunderland UK
Resident, Nephrology and Transplantation, Royal Hallamshire and Northern General Hospitals (University of Sheffield), Sheffield, U.K.
Fellow, Nephrology, Department of Medicine, Case Western Reserve University and University Hospitals, Cleveland Ohio

Licensure and Certifications

American Board of Internal Medicine, Subspecialty Boards in Nephrology
American Board of Internal Medicine
Medical License
Medical License
National Board of Medical Sciences
Royal College of Physicians UK MRCP
General Medical Council
Indian Medical Council

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Research Summary

Our lab has two principal interests: the first, focuses on regulation of sodium transport in the collecting duct of the kidney which plays a major role in the regulation of volume homeostasis and hypertension. I study the transcriptional and post transcriptional regulation of the epithelial sodium channel, ENaC, and two proteins that interact with ENaC, a ubiquitin ligase Nedd4-2 and the kinase Sgk1. The second focuses on regulation of soluble Flt1, an anti- angiogenesis protein and the effect of soluble Flt1 on the glomerulus, where it appears to disrupt the glomerular capillary barrier and cause proteinuria. we have made several original observations about the genomic organization of Flt1, identified new alternate sFlt1 transcripts and described some aspects of the post transcriptional regulation of sFLT1 and of FLT1 ectodomain cleavage. Recently we described further regulation of FLT1 cleavage and reported that aspirin inhibits sFlt1 expression in trophoblasts.