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Donald Macfarlane, MD, PhD

Emeritus Professor of Internal Medicine-Hematology, Oncology, and Blood and Marrow Transplantation

Current Positions

  • Emeritus Professor of Internal Medicine-Hematology, Oncology, and Blood and Marrow Transplantation

Education

  • MD, University of London, London, England
  • PhD, Experimental Pathology, University of London, London, England
  • Resident, St. Bartholomew's Hospital, London, England
  • Fellow, Hmatology/Oncology, University of Iowa, Iowa City, Iowa

Selected Publications

  • Kempton, C. L., Abshire, T. C., Deveras, R. A., Hoots, W. K., Gill, J. C., Kessler, C. M., Key, N. S., Konkle, B. A., Kuriakose, P., Macfarlane, D. E. & Bergman, G. (2012). Pharmacokinetics and safety of OBI-1, a recombinant B domain-deleted porcine factor VIII, in subjects with haemophilia A. Haemophilia : the official journal of the World Federation of Hemophilia 18 (5) 798-804. DOI: 10.1111/j.1365-2516.2012.02789.x. PMID: 22512291.
  • Hursting, M. J., Lewis, B. E. & Macfarlane, D. E. (2005). Transitioning from argatroban to warfarin therapy in patients with heparin-induced thrombocytopenia. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 11 (3) 279-87. PMID: 16015413.
  • Strekowski, L., Say, M., Henary, M., Ruiz, P., Manzel, L., Macfarlane, D. E. & Bojarski, A. J. (2003). Synthesis and activity of substituted 2-phenylquinolin-4-amines, antagonists of immunostimulatory CpG-oligodeoxynucleotides. Journal of medicinal chemistry 46 (7) 1242-9. DOI: 10.1021/jm020374y. PMID: 12646034.
  • Strekowski, L., Say, M., Zegrocka, O., Tanious, F. A., Wilson, W. D., Manzel, L. & Macfarlane, D. E. (2003). Bis-4-aminoquinolines: novel triple-helix DNA intercalators and antagonists of immunostimulatory CpG-oligodeoxynucleotides. Bioorganic & medicinal chemistry 11 (6) 1079-85. PMID: 12614895.
  • Rosenfeld, S. B., Watkinson, K. K., Thompson, B. H., Macfarlane, D. E. & Lentz, S. R. (2002). Pulmonary embolism after sequential use of recombinant factor VIIa and activated prothrombin complex concentrate in a factor VIII inhibitor patient. (Vols. 87). (5), pp. 925-6. Thrombosis and haemostasis. PMID: 12038803.
  • Schultz, K. R., Su, W. N., Hsiao, C. C., Doho, G., Jevon, G., Bader, S., MacFarlane, D. E. & Gilman, A. L. (2002). Chloroquine prevention of murine MHC-disparate acute graft-versus-host disease correlates with inhibition of splenic response to CpG oligodeoxynucleotides and alterations in T-cell cytokine production. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 8 (12) 648-55. PMID: 12523576.
  • Manzel, L., Strekowski, L., Ismail, F. M., Smith, J. C. & Macfarlane, D. E. (1999). Antagonism of immunostimulatory CpG-oligodeoxynucleotides by 4-aminoquinolines and other weak bases: mechanistic studies. The Journal of pharmacology and experimental therapeutics 291 (3) 1337-47. PMID: 10565859.
  • Macfarlane, D. E. & Manzel, L. (1999). Immunostimulatory CpG-oligodeoxynucleotides induce a factor that inhibits macrophage adhesion. The Journal of laboratory and clinical medicine 134 (5) 501-9. PMID: 10560944.
  • Manzel, L. & Macfarlane, D. E. (1999). CpG-oligodeoxynucleotide-resistant variant of WEHI 231 cells. Journal of leukocyte biology 66 (5) 817-21. PMID: 10577514.
  • Manzel, L. & Macfarlane, D. E. (1999). Lack of immune stimulation by immobilized CpG-oligodeoxynucleotide. Antisense & nucleic acid drug development 9 (5) 459-64. DOI: 10.1089/oli.1.1999.9.459. PMID: 10555153.