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Duane Hall, PhD

Research Associate Professor of Internal Medicine-Cardiovascular Medicine

Current Positions

  • Research Associate Professor of Internal Medicine-Cardiovascular Medicine

Education

  • PhD, Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin
  • Postdoctoral Fellow, The University of Iowa, Iowa City, Iowa

Center, Program and Institute Affiliations

Research Interests

  • The heart has long been known to be sensitive to a variety of stresses and adapts structurally and functionally to meet cardiac workload demands. Changes in gene expression play a vital role in cardiac remodeling processes but become maladaptive over time as occurs in heart failure. Using molecular, biochemical, genetic and bioinformatics techniques, we are defining the transcriptional mechanisms by which different cardiac stresses and hereditary cardiac diseases lead to heart failure. Much of my research is collaborative in nature by providing bioinformatics-related insight into projects with an interest in altered gene expression. In a long-standing collaboration with Dr. Chad Grueter using RNA-seq and ChIP-seq techniques, we have explored how localization of the Mediator co-activator complex is regulated at gene promoters and enhancers during heart failure. In more recent efforts with Dr. Long-Sheng Song we are defining a novel cardioprotective transcriptional mechanism that involves the post-translation processing of Junctophilin-2 (JP2), an essential protein necessary for efficient calcium-induced calcium release at cardiac dyad junctional sites. In failing hearts, JP2 is proteolytically cleaved leading to disassembly of the cardiac dyad and inefficient calcium handling with its N-terminal fragment of JP2 (JP2NT) translocating into the nucleus to repress maladaptive gene expression. We are currently defining the mechanisms that mediate JP2NT generation, trafficking, and transcriptional regulation.

Selected Publications

  • Hall, D. D., Dai, S., Tseng, P. Y., Malik, Z., Nguyen, M., Matt, L., Schnizler, K., Shephard, A., Mohapatra, D. P., Tsuruta, F., Dolmetsch, R. E., Christel, C. J., Lee, A., Burette, A., Weinberg, R. J. & Hell, J. W. (2013). Competition between alpha-actinin and Ca2+-calmodulin controls surface retention of the L-type Ca2+ channel Ca(V)1.2. Neuron 78 (3) 483-97. PMID: 23664615.
  • Hall, D. D., Joiner, M. L., Wu, X. Q., Swaminathan, P. D., Purohit, A., Zimmerman, K., Weiss, R. M., Philipson, K. D., Song, L. S., Hund, T. J., Anderson, M. E., Wu, Y., Gao, Z., Rasmussen, T. P., Li, Y., Kutschke, W., Koval, O. M. & Wu, Y. (2013). Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate. Circulation research 112 (2) 309-17. PMID: 23192947.
  • Joiner, M. L., Koval, O. M., Li, J., He, B. J., Allamargot, C., Gao, Z., Luczak, E. D., Hall, D. D., Fink, B. D., Chen, B., Yang, J., Moore, S. A., Scholz, T. D., Strack, S., Mohler, P. J., Sivitz, W. I., Song, L. S. & Anderson, M. E. (2012). CaMKII determines mitochondrial stress responses in heart. Nature 491 (7423) 269-73. PMID: 23051746. PMCID: PMC3471377.
  • Lu, Y., Zha, X. M., Kim, E. Y., Schachtele, S., Dailey, M. E., Hall, D. D., Strack, S., Green, S. H., Hoffman, D. A. & Hell, J. W. (2011). A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density. The Journal of biological chemistry 286 (30) 26496-506. PMID: 21652711. PMCID: PMC3143614.
  • Gao, Z., Singh, M. V., Hall, D. D., Koval, O. M., Luczak, E. D., Joiner, M. L., Chen, B., Wu, Y., Chaudhary, A. K., Martins, J. B., Hund, T. J., Mohler, P. J., Song, L. S. & Anderson, M. E. (2011). Catecholamine-independent heart rate increases require Ca2+/calmodulin-dependent protein kinase II. Circulation. Arrhythmia and electrophysiology 4 (3) 379-87. PMID: 21406683. PMCID: PMC3116039.
  • Xu, H., Ginsburg, K. S., Hall, D. D., Zimmermann, M., Stein, I. S., Zhang, M., Tandan, S., Hill, J. A., Horne, M. C., Bers, D. & Hell, J. W. (2010). Targeting of protein phosphatases PP2A and PP2B to the C-terminus of the L-type calcium channel Ca v1.2. Biochemistry 49 (48) 10298-307. PMID: 21053940. PMCID: PMC3075818.
  • Joiner, M. L., Lise, M. F., Yuen, E. Y., Kam, A. Y., Zhang, M., Hall, D. D., Malik, Z. A., Qian, H., Chen, Y., Ulrich, J. D., Burette, A. C., Weinberg, R. J., Law, P. Y., El-Husseini, A., Yan, Z. & Hell, J. W. (2010). Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling. The EMBO journal 29 (2) 482-95. PMID: 19942860. PMCID: PMC2824466.
  • Tandan, S., Wang, Y., Wang, T. T., Jiang, N., Hall, D. D., Hell, J. W., Luo, X., Rothermel, B. A. & Hill, J. A. (2009). Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel. Circulation research 105 (1) 51-60. PMID: 19478199. PMCID: PMC3038593.
  • Dai, S., Hall, D. D. & Hell, J. W. (2009). Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiological reviews 89 (2) 411-52. PMID: 19342611. PMCID: PMC2733249.
  • Dai, S., Hall, D. D. & Hell, J. W. (2009). Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev 89 411-452.