Research Summary

Research interests are directed toward the neural regulation of the circulation. Specific studies examine the cellular and molecular mechanisms of 1. Mechanical activation of baroreceptor neurons and the role of mechanosensitive ion channels in the generation of baroreceptor nerve activity 2. Chemical activation of chemoreceptor neurons and the role of ASICs (Acid Sensitive Ion Channels) in responses to hypoxia and acidosis. The work is done in isolated neurons, glomus cells, and in transgenic mice. Integrated control of sympathetic activity during sleep apnea and hypertension has been the focus of studies in humans.