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Frank M. Faraci, PhD

Professor of Internal Medicine-Cardiovascular Medicine

Current Positions

  • Professor of Internal Medicine-Cardiovascular Medicine
  • Professor of Neuroscience and Pharmacology

Education

  • PhD, Kansas State University
  • Postdoctoral Fellow, Cardiology, University of Iowa, Iowa City, Iowa
  • MA, University of Kansas
  • Postdoctoral Fellow, University of Iowa

Graduate Program Affiliations

Center, Program and Institute Affiliations

Research Interests

  • Dr. Faraci's research deals with vascular biology with an emphasis on studies of the carotid artery and cerebral circulation. A major focus of this work is the study of endothelium, cells that form the inner lining of blood vessels, and the role of these cells in determining vascular structure and function. His work has two major goals. The first is to better understand how blood vessels function normally. The second goal is to define mechanisms that produce vascular dysfunction in the presence of risk factors for cardiovascular disease including hypertension, diabetes, inflammation, and aging. Physiological, pharmacological and molecular approaches are used to provide greater insight into mechanisms believed to contribute to vascular disease and stroke. There is a major emphasis on the role of oxidative stress in mechanisms that contribute to stroke and vascular cognitive impairment. The research relies heavily on the use of genetically altered mice and viral mediated gene transfer. He is director of an NIH Program Project Grant on Cerebral Vascular Biology.

Selected Publications

  • Dayal, S., Baumbach, G. L., Arning, E., Bottiglieri, T., Faraci, F. M. & Lentz, S. R. (In Press). Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia. PLoS One.
  • De Silva, T. M. & Faraci, F. M. (2017). Hypertension. In Zhang, J., Yenari, M., Lo, E., Thomas, A., Leary, M., Biller, J. & Caplan, L. R. (Eds.) Primer on Cerebrovascular Diseases. 2nd Edition. pp. 153-157. Elsevier.
  • Baron-Menguy, C., Domenga-Denier, V., Ghezali, L., Faraci, F. M. & Joutel, A. (2017). Increased Notch3 activity mediates pathological changes in structure of cerebral arteries. Hypertension (featured in Clinical Implications, Hypertension 69:2, 2017) 69 60-70. DOI: org/10.1161/HYPERTENSIONAHA.116.08015.
  • Hu, X., De Silva, T. M., Chen, J. & Faraci, F. M. (2017). Cerebral vascular disease and neurovascular injury in ischemic stroke (Compendium on Stroke) (featured on cover). Circulation Res 120 449-471. DOI: 10.1161/CIRCRESAHA.116.308427.
  • De Silva, T. M. & Faraci, F. M. (2017). Reactive oxygen species and the regulation of cerebrovascular tone. In Miller, J. D. & Rodriguez-Porcel, M. (Eds.) Oxidative Stress in Vascular Disease: Basic Research and Clinical Practice. pp. 89-112. Springer.
  • De Silva, T. M. & Faraci, F. M. (2017). Cerebral Vascular Muscle. In Zhang, J., Yenari, M., LO, E., Thomas, A., Leary, M., Biller, J. & Caplan, L. R. (Eds.) Primer on Cerebrovascular Diseases, 2nd Edition. pp. 42-47. Elsevier.
  • De Silva, T. M., Pena Silva, R. A. & Faraci, F. M. (2016). Endothelium, the blood-brain barrier, and hypertension. In Girouard, H. (Eds.) Arterial Hypertension and Brain as an End-Organ Target. pp. 155-180. Springer.
  • De Silva, T. M. & Faraci, F. M. (2016). Microvascular dysfunction and cognitive impairment. Cell Molecular Neurobiol 36 241-258. DOI: 10.1007/s10571-015-0308-1.
  • Hu, C., Lu, K. T., Mukohda, M., Davis, D. R., Faraci, F. M. & Sigmund, C. D. (2016). Interference with PPARγ in endothelium accelerates angiotensin II induced endothelial dysfunction. Physiol Genomics 48 124-134. DOI: 10.1152/physiolgenomics.00087.2015.
  • Iadecola, C., Yaffe, K., Al-Hassouri, A. Z., Biller, J., Bratzke, L. C., Faraci, F. M., Gorelick, P. B., Gulati, M., Kamel, H., Knopman, D. S., Launer, L. J., Saczynski, J. S. & Seshadri, S. (2016). Impact of hypertension on cognitive function: A scientific statement from the American Heart Association. PMID: 27977393.