Gourav Bhardwaj, MSc, PhD
Research Assistant Professor of Internal Medicine-Endocrinology and Metabolism
Current Positions
- Research Assistant Professor of Internal Medicine-Endocrinology and Metabolism
Education
- MSc, Guru Nanak Dev University, Amritsar, India
- PhD, Heart Failure Lab, Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Germany
- Postdoctoral Research Scholar, Diabetes Lab, University of Iowa Carver College of Medicine, Iowa City, Iowa
Center, Program and Institute Affiliations
Selected Publications
- Bhardwaj G, Penniman CM, Klaus K, Weatherford ET, Pan H, Dreyfuss JM, Nair KS, Kahn CR, O'Neill BT. Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors. Front Physiol. 2022 Feb 4;12:779121. doi: 10.3389/fphys.2021.779121. eCollection 2021.
- Bhardwaj G, Penniman CM, Jena J, Suarez Beltran PA, Foster C, Poro K, JunckTL, Hinton Jr AO, Souvenir R, Fuqua JD, Morales PE, Bravo-Sagua R, Sivitz WI, Lira VA, Abel ED, O'Neill BT. Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle. J Clin Invest. 2021 Sep 15;131(18):e146415. doi: 10.1172/JCI146415.
- O'Neill BT, Bhardwaj G, Penniman CM, Krumpoch MT, Suarez Beltran PA, Klaus K, Poro K, Li M, Pan H, Dreyfuss JM, Nair KS, Kahn CR. FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy. Diabetes. 2019 Mar;68(3):556-570. doi: 10.2337/db18-0416. Epub 2018 Dec 6.
- Bhardwaj G, Dörr M, Sappa PK, Ameling S, Dhople V, Steil L, Klingel K, Empen K, Beug D, Völker U, Felix SB, Hammer E. Endomyocardial proteomic signature corresponding to the response of patients with dilated cardiomyopathy to immunoadsorption therapy. J Proteomics. 2017 Jan 6;150:121-129. doi: 10.1016/j.jprot.2016.09.001. Epub 2016 Sep 9.
- Ameling S, Bhardwaj G*, Hammer E, Beug D, Steil L, Reinke Y, Weitmann K, Grube M, Trimpert C, Klingel K, Kandolf R, Hoffmann W, Nauck M, Dörr M, Empen K, Felix SB, Völker U. Changes of myocardial gene expression and protein composition in patients with dilated cardiomyopathy after immunoadsorption with subsequent immunoglobulin substitution. Basic Res Cardiol. 2016 Sep;111(5):53. doi: 10.1007/s00395-016-0569-y. Epub 2016 Jul 13. *Equal First Author
- Daneshgar N, Liang P-I, Lan RS, Horstmann M, Pack L, Bhardwaj G, Penniman CM, O’Neill BT, Dai D-F. Elamipretide treatment during pregnancy ameliorates the progression of polycystic kidney disease in maternal and neonatal mice with PKD1 mutations. Kidney Int. 2022 May;101(5):906-911. doi: 10.1016/j.kint.2021.12.006
- Penniman CM, Bhardwaj G, Junck TL, Boyer C, Jena J, Fuqua JD, Lira VA, O’Neill BT. Loss of FoxOs in Muscle Increases Strength and Mitochondrial Function during Ageing. J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):243-259. doi: 10.1002/jcsm.13124
- Tadinada SM, Weatherford ET, Collins GV, Bhardwaj G, Cochran J, Kutschke W, Zimmerman K, Bosko A, O'Neill BT, Weiss RM, Abel ED. Functional Resilience of C57BL/6J Mouse Heart to Dietary Fat Overload. Am J Physiol Heart Circ Physiol. 2021 Sep 3. doi: 10.1152/ajpheart.00419.2021. PMID: 34477461.
- Mishra A, Liu S, Promes J, Harata M, Sivitz WI, Fink BD, Bhardwaj G, O'Neill BT, Kang C, Sah R, Strack S, Stephens SB, King TH, Jackson L, Greenberg AS, Anokye-Danso F, Ahima RS, Ankrum JA, Imai Y. Perilipin2 down-regulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria. JCI Insight, 2021 Mar 30;144341. doi: 10.1172/jci.insight.144341.
- Skurski J, Penniman CM, Geesala R, Dixit G, Pulipati P, Bhardwaj G, Meyerholz DK, Issuree PD, O'Neill BT, Maretzky T. Loss of iRhom2 accelerates fat gain and insulin resistance in diet-induced obesity despite reduced adipose tissue inflammation. Metabolism, 2020 May;106:154194. doi: 10.1016/j.metabol.2020.154194.