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Haider Mehdi, PhD

Research Associate Professor of Internal Medicine-Cardiovascular Medicine

Current Positions

  • Research Associate Professor of Internal Medicine-Cardiovascular Medicine

Education

  • PhD, Biochemistry, AM University/CDRI, Aligarh, UP India
  • Postdoctoral Fellow, Rush-Presbyterian-St. Lukes Medical Center, Chicago, Illinois

Center, Program and Institute Affiliations

Research Interests

  • Dr. Haider Mehdi's research interests include genetics of common diseases of public health with special emphasis on cardiovascular disease. Over the past several years, Dr. Mehdi has been instrumental in identifying and characterizing a candidate gene, glycerol-3-phosphate dehydrogenase 1-like (GPD1-L), for Brugada syndrome (BrS), an inherited arrhythmia disorder. Dr. Mehdi has then developed a mouse model for BrS by knocking down GPD1-L which mimicked the Brugada phenotype. In addition to this, his other focus of research is to elucidate the mechanism by which the post-translational modification (may be some novel one?) affects the membrane-trafficking and function of cardiac sodium channel (Nav1.5, SCN5A).

Selected Publications

  • McTiernan, C. F., Mathier, M. A., Zhu, X., Xiao, X., Klein, E., Swan, C. H., Mehdi, H., Gibson, G., Trichel, A. M., Glorioso, J. C., Feldman, A. M., McCurry, K. R. & London, B. (2007). MYOCARDITIS FOLLOWING ADENO-ASSOCIATED VIRAL GENE EXPRESSION OF HUMAN SOLUBLE TNF RECEPTOR (TNFRII-FC) IN BABOON HEARTS. GENE THERAPY 14 (23) 1613-22. DOI: 10.1038/sj.gt.3303020. PMID: 17851548.
  • London, B., Michalec, M., Mehdi, H., Zhu, X., Kerchner, L., Sanyal, S., Viswanathan, P. C., Pfahnl, A. E., Shang, L. L., Madhusudanan, M., Baty, C. J., Lagana, S., Aleong, R., Gutmann, R., Ackerman, M. J., McNamara, D. M., Weiss, R. & Dudley, Jr, S. C. (2007). MUTATION IN GLYCEROL-3-PHOSPHATE DEHYDROGENASE 1 LIKE GENE (GPD1-L) DECREASES CARDIAC NA+ CURRENT AND CAUSES INHERITED ARRHYTHMIAS. CIRCULATION 116 (20) 2260-8. DOI: 10.1161/CIRCULATIONAHA.107.703330. PMID: 17967977. PMCID: PMC3150966.
  • Petkova-Kirova, P. S., Gursoy, E., Mehdi, H., McTiernan, C. F., London, B. & Salama, G. (2006). ELECTRICAL REMODELING OF CARDIAC MYOCYTES FROM MICE WITH HEART FAILURE DUE TO THE OVEREXPRESSION OF TUMOR NECROSIS FACTOR-ALPHA. AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY 290 (5) H2098-107. DOI: 10.1152/ajpheart.00097.2005. PMID: 16339842.
  • Kamboh, M. I., Sanghera, D. K., Mehdi, H., Nestlerode, C. S., Chen, Q., Khalifa, O., Naqvi, A., Manzi, S. & Bunker, C. H. (2004). SINGLE NUCLEOTIDE POLYMORPHISMS IN THE CODING REGION OF THE APOLIPOPROTEIN H (Β2-GLYCOPROTEIN I) GENE AND THEIR CORRELATION WITH THE PROTEIN POLYMORPHISM, ANTI-Β2 GLYCOPROTEIN I ANTIBODIES AND CARDIOLIPIN BINDING: DESCRIPTION OF NOVEL HAPLOTYPES AND THEIR EVOLUTION. ANNALS OF HUMAN GENETICS 68 (4) 285-299. DOI: 10.1046/j.1529-8817.2004.00097.x.
  • Mehdi, H., Manzi, S., Desai, P., Chen, Q., Nestlerode, C., Bontempo, F., Strom, S. C., Zarnegar, R. & Kamboh, M. I. (2003). A FUNCTIONAL POLYMORPHISM AT THE TRANSCRIPTIONAL INITIATION SITE IN BETA2-GLYCOPROTEIN I (APOLIPOPROTEIN H) ASSOCIATED WITH REDUCED GENE EXPRESSION AND LOWER PLASMA LEVELS OF BETA2-GLYCOPROTEIN I. EUROPEAN JOURNAL OF BIOCHEMISTRY 270 (2) 230-8. DOI: 10.1046/j.1432-1033.2003.03379.x. PMID: 12605674.
  • Luedecking, E. K., DeKosky, S. T., Mehdi, H., Ganguli, M. & Kamboh, M. I. (2000). ANALYSIS OF GENETIC POLYMORPHISMS IN THE TRANSFORMING GROWTH FACTOR-BETA1 GENE AND THE RISK OF ALZHEIMER'S DISEASE. HUMAN GENETICS 106 (5) 565-9. DOI: 10.1007/s004390000313. PMID: 10914688.
  • Mehdi, H., Naqvi, A. & Kamboh, M. I. (2000). A HYDROPHOBIC SEQUENCE AT POSITION 313-316 (LEU-ALA-PHE-TRP) IN THE FIFTH DOMAIN OF APOLIPOPROTEIN H (BETA2-GLYCOPROTEIN I) IS CRUCIAL FOR CARDIOLIPIN BINDING. EUROPEAN JOURNAL OF BIOCHEMISTRY 267 (6) 1770-6. DOI: 10.1046/j.1432-1327.2000.01174.x. PMID: 10712609.
  • Mehdi, H., Aston, C. E., Sanghera, D. K., Hamman, R. F. & Kamboh, M. I. (1999). GENETIC VARIATION IN THE APOLIPOPROTEIN H (BETA2-GLYCOPROTEIN I) GENE AFFECTS PLASMA APOLIPOPROTEIN H CONCENTRATIONS. HUMAN GENETICS 105 (1-2) 63-71. DOI: 10.1007/s004399900089. PMID: 10480357.
  • Kamboh, M. I., Manzi, S., Mehdi, H., Fitzgerald, S., Sanghera, D. K., Kuller, L. H. & Atson, C. E. (1999). GENETIC VARIATION IN APOLIPOPROTEIN H (BETA2-GLYCOPROTEIN I) AFFECTS THE OCCURRENCE OF ANTIPHOSPHOLIPID ANTIBODIES AND APOLIPOPROTEIN H CONCENTRATIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS. LUPUS 8 (9) 742-50. DOI: 10.1191/096120399678840909. PMID: 10602447.
  • Kamboh, M. I. & Mehdi, H. (1998). GENETICS OF APOLIPOPROTEIN H (BETA2-GLYCOPROTEIN I) AND ANIONIC PHOSPHOLIPID BINDING. LUPUS 7 Suppl 2 S10-3. DOI: 10.1177/096120339800700203. PMID: 9814664.