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Ian Thornell, PhD

Research Assistant Professor of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine

Introduction

Dr. Thornell's research interests include ion transport and its regulation in health and disease. His research focuses on epithelial transport with an emphasis on chloride and acid-base transport using electrophysiological and live-cell imaging techniques.

Current Positions

  • Research Assistant Professor of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine

Education

  • PhD, Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama

Selected Publications

  • Evonuk, K. S., Doyle, R. E., Moseley, C. E., Thornell, I. M., Adler, K., Bingaman, A. M., Bevensee, M. O., Weaver, C. T., Min, B. & DeSilva, T. M. (2020). Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation. Science Advances 6 (2). DOI: 10.1126/sciadv.aax5936.
  • Thornell, I. M. (2020). SAME MOLECULE, DIFFERENT EFFECTS: PROTONATION STATE PREDICTS NICOTINE TARGETS. (Vols. 128). (4), pp. 1061--1061. JOURNAL OF APPLIED PHYSIOLOGY.
  • Thornell, I. M., Rehman, T., Pezzulo, A. A. & Welsh, M. J. (2020). Paracellular bicarbonate flux across human cystic fibrosis airway epithelia tempers changes in airway surface liquid pH. The Journal of Physiology 598 (19) 4307--4320.
  • Zarei, K., Stroik, M. R., Gansemer, N. D., Thurman, A. L., Ostedgaard, L. S., Ernst, S. E., Thornell, I. M., Powers, L. S., Pezzulo, A. A., Meyerholz, D. K. & others (2020). Early pathogenesis of cystic fibrosis gallbladder disease in a porcine model. Laboratory Investigation 100 (11) 1388--1399.
  • Rehman, T., Thornell, I. M., Pezzulo, A. A., Thurman, A. L., Romano Ibarra, G. S., Karp, P. H., Tan, P., Duffey, M. E. & Welsh, M. J. (2020). TNFa and IL-17 alkalinize airway surface liquid through CFTR and pendrin. American Journal of Physiology-Cell Physiology 319 (2) C331--C344.
  • Stapleton, E. M., Kizhakke Puliyakote, A., Metwali, N., Jeronimo, M., Thornell, I. M., Manges, R. B., Bilas, M., Kamal Batcha, M. A., Kumaravel, M. S., Durairaj, K., Karuppusamy, K., Kathiresan, G., Rahim, S. A., Shanmugam, K., Thorne, P. S., Peters, T. M., Hoffman, E. A. & Comellas, A. P. (2020). Lung function of primary cooks using LPG or biomass and the effect of particulate matter on airway epithelial barrier integrity. Environmental Research 189. DOI: 10.1016/j.envres.2020.109888.
  • Bratcher, P. E., Yadav, S., Shaughnessy, C. A., Thornell, I. M. & Zeitlin, P. L. (2020). Effect of apical chloride concentration on the measurement of responses to CFTR modulation in airway epithelia cultured from nasal brushings. Physiological Reports 8 (19) e14603.
  • Cooney, A. L., Thornell, I. M., Singh, B. K., Shah, V. S., Stoltz, D. A., McCray, P. B., Zabner, J. & Sinn, P. L. (2019). A novel AAV-mediated gene delivery system corrects CFTR function in pigs. Am J Respir Cell Mol Biol 61 (6) 747-754. DOI: 10.1165/rcmb.2019-0006OC.
  • Thornell, I., Rehman, T. & Welsh, M. (2019). PARACELLULAR BICARBONATE FLUX IS MINIMAL IN HUMAN CYSTIC FIBROSIS AIRWAY EPITHELIA. In PEDIATRIC PULMONOLOGY. (Vols. 54). pp. S164--S164.
  • Thornell, I. M., Rehman, T. & Welsh, M. J. (2019). Inflammatory Cytokines IL-13 or IL-17/TNF$\alpha$ Do Not Alter the Low Paracellular Bicarbonate Permeability of Cystic Fibrosis Airway Epithelia. (Vols. 33). (1\_supplement), pp. 544--15. The FASEB Journal.