Isabella Grumbach, MD, PhD
Professor of Internal Medicine-Cardiovascular Medicine
Current Positions
- Kate Daum Endowed Professor
- Professor of Internal Medicine-Cardiovascular Medicine
- Professor of Radiation Oncology
Education
- MD, Ruhr-University Medical School, Bochum, Germany
- PhD, Neuroanatomy, Ruhr-University, Bochum, Germany
- Resident, Internal Medicine, Georg-August-University Medical Center, Göttingen, Germany
- Postdoctoral Fellow, University of Illinois at Chicago, Chicago, Illinois
- Resident, Internal Medicine, Cook County Hospital, Chicago, Illinois
- Fellow, Cardiovascular Diseases, Emory University, Atlanta, Georgia
Graduate Program Affiliations
Center, Program and Institute Affiliations
Licenses & Certifications
- Medical License, Iowa Board of Medicine
- Board Certification in Internal Medicine, ACP-ASIM
- Board Certification in Cardiovascular Diseases, ACP-ASIM
Selected Publications
- Koval OM, Nguyen EK, Mittauer DJ, Ait-Aissa K, Chinchankar W, Qian L, Madesh M, Dai DF, Grumbach IM. The mitochondrial regulation of smooth muscle cell proliferation in type 2 diabetes. bioRxiv. 2023 Feb 16:2023.02.15.528765. doi: 10.1101/2023.02.15.528765. Preprint. PMID: 36824758.
- Guo DF, Merrill RA, Qian L, Hsu Y, Zhang Q, Lin Z, Thedens DR, Usachev YM, Grumbach I, Sheffield VC, Strack S, Rahmouni K. The BBSome regulates mitochondria dynamics and function. Mol Metab. 2023 Jan;67:101654. doi: 10.1016/j.molmet.2022.101654. Epub 2022 Dec 10. PMID: 36513220.
- Herbach E, O'Rorke MA, Carnahan RM, McDowell BD, Allen B, Grumbach I, London B, Smith BJ, Spitz DR, Seaman A, Chrischilles EA. Cardiac Adverse Events Associated With Chemo-Radiation Versus Chemotherapy for Resectable Stage III Non-Small-Cell Lung Cancer: A Surveillance, Epidemiology and End Results-Medicare Study. J Am Heart Assoc. 2022 Dec 6;11(23):e027288. doi: 10.1161/JAHA.122.027288. Epub 2022 Dec 1. PMID: 36453633.
- Ait-Aissa K, Koval OM, Lindsey NR, Grumbach IM. Mitochondrial Ca2+ Uptake Drives Endothelial Injury By Radiation Therapy. Arterioscler Thromb Vasc Biol. 2022 Sep;42(9):1121-1136. doi: 10.1161/ATVBAHA.122.317869. Epub 2022 Jul 28. PMID: 35899616.
- Damacena de Angelis C, Endoni BT, Nuno D, Lamping K, Ledolter J, Koval OM, Grumbach IM. Sex-Specific Differences in Endothelial Function Are Driven by Divergent Mitochondrial Ca2+ Handling. J Am Heart Assoc. 2022 Jul 5;11(13):e023912. doi: 10.1161/JAHA.121.023912. Epub 2022 Jun 29. PMID: 35766269.
- Tamplin MR, Wang JK, Vitale AH, Hashimoto R, Garvin MK, Binkley EM, Hyer DE, Buatti JM, Boldt HC, Kardon RH, Grumbach IM. Reduced blood flow by laser speckle flowgraphy after 125I-plaque brachytherapy for uveal melanoma. BMC Ophthalmol. 2022 Jun 28;22(1):285. doi: 10.1186/s12886-022-02505-9. PMID: 35765019.
- McLendon JM, Zhang X, Matasic DS, Kumar M, Koval OM, Grumbach IM, Sadayappan S, London B, Boudreau RL. Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice. J Am Heart Assoc. 2022 Jul 5;11(13):e025687. doi: 10.1161/JAHA.122.025687. Epub 2022 Jun 22.PMID: 35730644.
- Binkley EM, Tamplin MR, Vitale AH, Boldt HC, Kardon RH, Grumbach IM. Longitudinal optical coherence tomography angiography (OCT-A) in a patient with radiation retinopathy following plaque brachytherapy for uveal melanoma. Am J Ophthalmol Case Rep. 2022 Mar 25;26:101508. doi: 10.1016/j.ajoc.2022.101508. eCollection 2022 Jun. PMID: 35392251.
- Tamplin MR, Broadhurst KA, Vitale AH, Hashimoto R, Kardon RH, Grumbach IM. Measuring hyperemic response to light flicker stimulus using continuous laser speckle flowgraphy in mice. Exp Eye Res. 2022 Mar;216:108952. doi: 10.1016/j.exer.2022.108952. Epub 2022 Jan 17.PMID: 35051429.
- Zhang H, Chen ZB, Fredman G, Gomez D, Grumbach IM, Huang NF, Nguyen PKP, Ouimet M, Sutton NR, Aikawa E. What Makes a Great Mentor: Interviews With Recipients of the ATVB Mentor of Women Award. Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2641-2647. doi: 10.1161/ATVBAHA.121.316558. Epub 2021 Sep 22.PMID: 34547925. Review.