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Jack Stapleton, MD

Professor of Internal Medicine-Infectious Diseases

Introduction

Dr. Stapleton’s research interests focus on the molecular biology of virus interference with human immune responses. His laboratory studies several positive strand RNA viruses including HIV, hepatitis C virus, human pegivirus (formerly GB virus C), yellow fever virus, SARS-CoV-2, and dengue viruses. In addition, he contributes to a variety of vaccine and HIV-related clinical trials.

Current Positions

  • Professor of Internal Medicine-Infectious Diseases
  • Professor of Microbiology and Immunology

Education

  • MD, University of Kansas, Kansas City, Kansas
  • Resident, Internal Medicine, North Carolina Memorial Hospital, Chapel HIll, North Carolina
  • Postdoctoral Fellow, Microbiology & Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina
  • Fellow, Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina

Graduate Program Affiliations

Center, Program and Institute Affiliations

Licenses & Certifications

  • Certification, American Board of Internal Medicine
  • Certification, American Board of Internal Medicine, Infectious Diseases

Selected Publications

  • Xiang J, Chang Q, McLinden JH, Bhattarai N, Welch JL, Kaufman TM, Stapleton JT.  Characterization of “off-target” immune modulation induced by live attenuated yellow fever vaccine. J Infect Dis, 2023. doi:10.1093/infdis/jiad086
  • Stapleton JT.  Human Pegivirus Type 1:  A common human virus that is beneficial in immune-mediated disease?  Front Immunol, 13:887760, 2022.  Doi:10.3389/fimmu.2022.887760
  • Poli G, Stapleton JT.  Sex Matters… Cytokines and Disease Progression in Men and Women Receiving cART.  AIDS, 36:1307-1309, 2022.
  • Welch JL, Xiang J, Chang Q, Houtman JCD, Stapleton JT.  T cell expression of Angiotensin Converting Enzyme 2 and binding of Severe Acute Respiratory Syndrome coronavirus 2.  J Infect Dis 225:810-819, 2022  doi.org/10.1093/infdis/jiab595
  • Stapleton EM, Welch JL, Ubeda EA, Xiang J, Zabner J, Thornell IM, Nonnenmann MW, Stapleton JT, Comellas AP.  Urban particulate matter impairs airway-surface-liquid-mediated coronavirus inactivation.  J Infect Dis 225:214-218, 2022  doi: doi.org/10.1093/infdis/jiab545
  • Abate G, Stapleton JT, Rouphael N, Creech B, Stout JE, El Sahly HM, Jackson L, Leyva FJ, Tomashek KM, Tibbals M, Watson N, Miller A, Charbek E, Siegner J, Sokol-Anderson M, Nayak R, Dahlberg G, Winokur P, Alaaeddine G Bydoun N, Sokolow K, Prashad Kown N, Phillips S, Baker AW, Turner N, Walter E, Guy E, Fry S.  Variability in the Management of Adults with Pulmonary Nontuberculous Mycobacterial Disease.  Clin Infect Dis, 72:1127-1137, 2021.
  • McLinden JH, Bhattarai N, Stapleton JT, Chang Q, Kaufman TM, Cassel SL, Sutterwala FS, Haim H, Houtman J, Xiang J.  Yellow fever virus, but not Zika or Dengue virus inhibits T cell receptor-mediated T cell function by an RNA-based mechanism.  J Infect Dis, 216:1164-1175, 2017.
  • Welch JL, Xiang J, Okeoma CM, Schlievert PM, Stapleton JT.  Glycerol monolaurate (GML), an analogue to a factor secreted by Lactobacillus, is virucidal against enveloped viruses including HIV-1.  mBio 11:e00686-20, 2020.
  • DeLeon O, Hodis H, O’Malley Y, Johnson J, Salimi H, Zhai Y, Winter E, Remec C, Eichelberger N, Van Cleave B, Puliadi R, Harrington R, Stapleton JT, Haim H.  Accurate Predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled Diffusion Model.  PLoS Biol, 15:32001549, 2017.
  • Bhattarai N, McLinden JH, Xiang J, Mathahs MM, Schmidt WN, Kaufman TM, Stapleton JT.  Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo.  PLoS Pathogens, 13:e1006232, 2017.