Jeffery L. Meier, MD
Introduction
Dr. Meier’s research spans areas of molecular biology and epidemiology of viruses and conduct of clinical trials to test novel drugs and vaccines to treat or prevent infections. He credits the experience he gained from engaging people with HIV in participating in clinical trials in the early days of the HIV epidemic as full filling his research quest of forwarding basic science discoveries to the ultimate delivery of life-saving medications to marginalized populations. Dr. Meier’s bench science laboratory primarily focuses on elucidating mechanisms controlling cytomegalovirus (CMV) gene expression. Using advanced technologies, his laboratory has uncovered mechanisms of viral transcription control not previously known. Their aim is to identify viral-specific targets susceptible to pharmacologic agents that could effectively stop CMV replication. Their recent development of new methods to study transcription control are broadly relevant to other viruses and human diseases. In recent years, his laboratory has also contributed to a multisite collaborative effort to study the molecular epidemiology of SARS-CoV-2 and mpox.
Current Positions
- Professor of Internal Medicine-Infectious Diseases
- Professor, Department of Epidemiology, College of Public Health
Education
- MD, University of Iowa COllege of Medicine, Iowa City, Iowa
- Resident, Internal Medicine, University of Wisconsin Hospital & Clinics, Madison, Wisconsin
- Fellow, Infectious Diseases, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Investigation, Bethesda, Maryland
Center, Program and Institute Affiliations
Selected Publications
- Azeem A, Baartman B, Conrady CD, Meier JL*, El-Herte R*. Herpes simplex virus dissemination with necrotizing hepatitis following Descemet membrane endothelial keratoplasty. BMC Infect Dis. 2023 Jul 12;23(1):465. doi: 10.1186/s12879-023-08414-6. PMID: 37438705. *Co-communicating
- Forte E, Li M, Ayaloglu Butun F, Hu Q, Borst EM, Schipma MJ, Piunti A, Shilatifard A, Terhune SS, Abecassis M, Meier JL*, and Hummel M*. *Co-senior authors. Critical role for the human cytomegalovirus major immediate early proteins in recruitment of RNA polymerase II and H3K27Ac by an enhancer-like element in OriLyt. Microbiol Spect. 2023 Jan 16;e0314422.doi: 10.1128/spectrum.03144-22. PMID: 36645269
- Elliott RP, Freeman BP, Meier JL*, El-Herte R*. Acute Cytomegalovirus Illness in an Immunocompetent Adult Causing Intravascular Hemolysis and Suspected Hemophagocytic Lymphohistiocytosis. Case Rep Infect Dis. 2022:7949471. doi: 10.1155/2022/7949471. PMID: 35847599. *Co-communicating authors
- Ball CB, Parida M., Li M., Spector BM, Suarez, GA, Meier, JL, Price DH. Human cytomegalovirus infection elicits global changes in host transcription by RNA polymerases I, II, and III. Viruses 2022, 14(4) 779: https://doi.org/10.3390/v14040779. PMID: 35458509
- Ball CB, Li M, Parida M, Hu Q, Ince D, Collins GS, Meier, JL, Price, DH. Human cytomegalovirus IE2 both activates and represses initiation and modulates elongation in a context-dependent manner. mBio 2022. PMID: 35579393
- Spector BM, Parida M, Li M, Ball CB, Meier JL, Luse DS, Price DH. Differences in RNA polymerase II complexes and their interactions with surrounding chromatin on human and cytomegalovirus genomes. Nature Communications 2022. 13:2006 PMID: 35422111. PMCID: xxxxx. DOI: https://doi.org/10.1038/s41467-022-29739-x
- Zhu Z, Tra H, Mathahs MM, Fink BD, Albert JA, Moninger TO, Meier, JL, Li, M., Schmidt, WN. Zinc protoporphyrin binding to telomerase complexes and inhibition of telomerase activity. Pharmacology Research & Perspectives. 2021 Dec;9(6):e00882. PMID: 34747573. PMCID: PMC8573827. DOI: 10.1002/prp2.882
- Nguyen, V.-T., Jatta, A., Mayer, R., A., Meier, JL. Evaluation of undiagnosed HIV estimates computed from the CD4 depletion model in a rural, medium-low HIV prevalence state. AIDS and Behavior. 26(2):613-622. DOI: 10.1007/s10461-021-03419-12021. PMID: 34355286
- Li M, Hu Q, Collins G, Parida, M, Ball CB,, Price DH, and Meier JL. Cytomegalovirus Late Transcription Factor Target Sequence Diversity Orchestrates Viral Early to Late Transcription. PLoS Pathog. Published 02 Aug 2021. PMID: 34339482; PMC8360532 https://doi.org/10.1371/journal.ppat.1009796
- Meier, JL. Acute viral gastroenteritis in special populations. Gastroenterol Clin North Am. 2021 Jun;50(2):305-322. PMID: 34024443. DOI: 10.1016/j.gtc.2021.02.003