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Jian Xie, PhD

Research Assistant Professor of Internal Medicine-Nephrology

Current Positions

  • Research Assistant Professor of Internal Medicine-Nephrology

Education

  • PhD, Genetics & Development, University of Texas Southwestern, Dallas, Texas
  • Postdoctoral Fellow, Molecular Genetics, University of Texas Medical Center, Dallas, Texas

Selected Publications

  • Yang, Y. S., Xie, J., Lin, S. H., Huang, C. L. & Yang, S. S. (2018). Differential roles of WNK4 in regulation of NCC in vivo. American journal of physiology. Renal physiology 314 (5) F999-F1007. PMID: 29384416. DOI: 10.1152/ajprenal.00177.2017.
  • Boyd-Shiwarski, C. R., Shiwarski, D. J., Roy, A., Namboodiri, H. N., Nkashama, L. J., Xie, J., McClain, K. L., Marciszyn, A., Kleyman, T. R., Tan, R. J., Stolz, D. B., Puthenveedu, M. A., Huang, C. L. & Subramanya, A. R. (2018). Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent. Molecular biology of the cell 29 (4) 499-509. DOI: 10.1091/mbc.E17-08-0529. PMID: 29237822. PMCID: PMC6014176.
  • Dalton, G. D., Xie, J., An, S. W. & Huang, C. L. (2017). New Insights into the Mechanism of Action of Soluble Klotho. Frontiers in endocrinology 8 323. DOI: 10.3389/fendo.2017.00323. PMID: 29250031. PMCID: PMC5715364.
  • Wright, J. D., An, S. W., Xie, J., Yoon, J., Nischan, N., Kohler, J. J., Oliver, N., Lim, C. & Huang, C. L. (2017). Modeled structural basis for the recognition of α2-3-sialyllactose by soluble Klotho. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31 (8) 3574-3586. DOI: 10.1096/fj.201700043R. PMID: 28442546. PMCID: PMC5503716.
  • Wu, Y. L., Xie, J., An, S. W., Oliver, N., Barrezueta, N. X., Lin, M. H., Birnbaumer, L. & Huang, C. L. (2017). Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho. Kidney international 91 (4) 830-841. DOI: 10.1016/j.kint.2016.09.039. PMID: 27979597. PMCID: PMC5357448.
  • Dalton, G., An, S. W., Al-Juboori, S. I., Nischan, N., Yoon, J., Dobrinskikh, E., Hilgemann, D. W., Xie, J., Luby-Phelps, K., Kohler, J. J., Birnbaumer, L. & Huang, C. L. (2017). Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling. Proceedings of the National Academy of Sciences of the United States of America 114 (4) 752-757. DOI: 10.1073/pnas.1620301114. PMID: 28069944. PMCID: PMC5278494.
  • Kim, J. H., Xie, J., Hwang, K. H., Wu, Y. L., Oliver, N., Eom, M., Park, K. S., Barrezueta, N., Kong, I. D., Fracasso, R. P., Huang, C. L. & Cha, S. K. (2017). Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes. Journal of the American Society of Nephrology : JASN 28 (1) 140-151. DOI: 10.1681/ASN.2015080888. PMID: 27151926. PMCID: PMC5198269.
  • Köchl, R., Thelen, F., Vanes, L., Brazão, T. F., Fountain, K., Xie, J., Huang, C. L., Lyck, R., Stein, J. V. & Tybulewicz, V. L. (2016). WNK1 kinase balances T cell adhesion versus migration in vivo. Nature immunology 17 (9) 1075-83. DOI: 10.1038/ni.3495. PMID: 27400149. PMCID: PMC4994873.
  • Xie, J., Wu, Y. L. & Huang, C. L. (2016). Deficiency of Soluble α-Klotho as an Independent Cause of Uremic Cardiomyopathy. Vitamins and hormones 101 311-30. DOI: 10.1016/bs.vh.2016.02.010. PMID: 27125747.
  • Xie, J., Yoon, J., An, S. W., Kuro-o, M. & Huang, C. L. (2015). Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate. Journal of the American Society of Nephrology : JASN 26 (5) 1150-60. DOI: 10.1681/ASN.2014040325. PMID: 25475745. PMCID: PMC4413766.