Joel N. Kline, MD

Professor of Internal Medicine - Pulmonary, Critical Care and Occupational Medicine
Professor of Occupational and Environmental Health

Contact Information

C506-B GH
Iowa City, IA 52242


AB, Brown University, Providence, Rhode Island
MD, Brown University, Providence, Rhode Island
MSc, Occupational and Environmental Health, University of Iowa Hospitals and Clinics, College of Public Health
Resident, Internal Medicine, UCSF - Fresno Medical Education Program, Fresno, CA
Chief Resident, Internal Medicine, UCSF - Fresno Medical Education Program, Fresno, CA
Fellow, Pulmonary and Critical Care Medicine, University of Iowa Carver College of Medicine

Licensure and Certifications

ABIM, Special Certification in Critical Care
ABIM, Subspecialty Board in Pulmonary Diseases
American Board of Internal Medicine

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Human Toxicology, Interdisciplinary Graduate Program in Translational Biomedicine

Research Summary

Study of the modulation of airway inflammatory responses in asthma. 1) Role of CpG oligodeoxynucleotides in the modulation of the airway inflammatory response in a murine model of asthma. We have previously demonstrated that administration of CpG at the time of sensitization to allergen (ovalbumin) in a murine model of asthma can prevent the development of eosinophilic inflammation and bronchial hyperreactivity. We are now in the process of studying (in vitro and in vivo) the mechanisms through which CpG ODN can accomplish these results and also examining how administration of CpG ODN (with and without specific immunotherapy) can lead to treatment of established inflammatory responses. 2) Dendritic cells in antigen-mediated asthma. We are developing murine and human (in vitro) models to evaluate the role of dendritic cells in sensitization and re-challenge with antigen in asthma.