1. People

John D. Colgan, PhD

Associate Professor of Internal Medicine-Immunology

Introduction

John Colgan is an Associate Professor in the Immunology Division. He received his Ph.D. from Columbia University in 1994, and performed his postdoctoral studies at Columbia University College of Physicians and Surgeons. Following his postdoctoral training, worked as an Associate Research Scientist at Columbia University College of Physicians and Surgeons before joining the faculty at the University of Iowa in 2005 as an Assistant Professor and was promoted to Associate Professor in 2012. Dr. Colgan’s broad research interest is to understand the transcriptional mechanisms that control lymphocyte development and function. Additionally, he is interested in how surface receptors expressed by T cells act to tune their function. Currently, Dr. Colgan is investigating the role of the nuclear protein GON4L in controlling B and T cell development and also the importance of GON4L for the growth and survival of leukemias that arise from B and T cell precursors. Dr. Colgan’s lab is also characterizing the role of a surface receptor called Tim-3 in the regulation of T cell responses to acute microbial infections.

Current Positions

  • Associate Professor of Internal Medicine - Immunology
  • Associate Professor of Anatomy and Cell Biology

Education

  • BS, Cook College, Rutgers University, New Brunswick, New Jersey
  • MA, Columbia University, New York, New York
  • M Phil, Columbia University, New York, New Jersey
  • PhD, Columbia University, New York, New York, United States
  • Postdoctoral Fellow, Columbia University College of Physicians and Surgeons, New York, New York, United States

Graduate Program Affiliations

Selected Publications

  • Colgan, D. F., Goodfellow, R. X. & Colgan, J. D. (2021). The transcriptional regulator GON4L is required for viability and hematopoiesis in mice. Experimental hematology. DOI: 10.1016/j.exphem.2021.04.001. PMID: 33864850.
  • Colgan, J. D. (2020). mTOR signaling as a driver of Castleman disease. Blood 135 (19) 1614-1615. DOI: 10.1182/blood.2020005361. PMID: 32379877.
  • Andersen, A. M., Lei, M. K., Beach SRH, Philibert, R. A., Sinha, S. & Colgan, J. D. (2020). Cigarette and Cannabis Smoking Effects on GPR15+ Helper T Cell Levels in Peripheral Blood: Relationships with Epigenetic Biomarkers. Genes 11 (2). DOI: 10.3390/genes11020149. PMID: 32019074. PMCID: PMC7074551.
  • Gorman, J. V. & Colgan, J. D. (2018). Acute stimulation generates Tim-3-expressing T helper type 1 CD4 T cells that persist in vivo and show enhanced effector function. Immunology. DOI: 10.1111/imm.12890. PMID: 29315553.
  • Barr, J. Y., Goodfellow, R. X., Colgan, D. F. & Colgan, J. D. (2017). Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division. Journal of immunology (Baltimore, Md. : 1950) 198 (10) 3978-3988. DOI: 10.4049/jimmunol.1602054. PMID: 28381640. PMCID: PMC5444326.
  • Gorman, J. V. & Colgan, J. D. (2014). Regulation of T cell responses by the receptor molecule Tim-3. Immunologic research 59 (1-3) 56-65. DOI: 10.1007/s12026-014-8524-1. PMID: 24825777. PMCID: PMC4125508.
  • Lu, P., Hostager, B. S., Rothman, P. B. & Colgan, J. D. (2013). Sedimentation and immunoprecipitation assays for analyzing complexes that repress transcription. pp. 365-83. Methods in molecular biology (Clifton, N.J.). PMID: 23436378. PMCID: PMC3653426.
  • Curtiss, M. L., Hostager, B. S., Stepniak, E., Singh, M., Manhica, N., Knisz, J., Traver, G., Rennert, P. D., Colgan, J. D. & Rothman, P. B. (2011). Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1). Molecular immunology 48 (13-Dec) 1424-31. PMID: 21513984. PMCID: PMC3109159.
  • Kashiwada, M., Cassel, S. L., Colgan, J. D. & Rothman, P. B. (2011). NFIL3/E4BP4 controls type 2 T helper cell cytokine expression. The EMBO journal 30 (10) 2071-82. PMID: 21499227. PMCID: PMC3098483.
  • Lu, P., Hankel, I. L., Hostager, B. S., Swartzendruber, J. A., Friedman, A. D., Brenton, J. L., Rothman, P. B. & Colgan, J. D. (2011). The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression. The Journal of biological chemistry 286 (20) 18311-9. PMID: 21454521. PMCID: PMC3093903.