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Joseph Zabner, MD

Professor of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine

Introduction

Dr. Zabner's research interests are in gene transfer to human airway epithelia in particular to develop gene therapy for cystic fibrosis. Dr. Zabner also has an interest in the fluid composition of the airway surface liquid, and how it affects innate immunity. His clinical interests are in cystic fibrosis and non-cystic fibrosis bronchiectasis.

Current Positions

  • Professor of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine

Education

  • MD, Universidad Central de Venezuela
  • Intern, Presbyterian Hospital, Dallas, Texas
  • Resident, Internal Medicine, Parkland Hospital, Dallas, Texas
  • Research Fellow, Pulmonary Disease, University of Iowa Hospitals & Clinics, Iowa City, Iowa

Graduate Program Affiliations

Center, Program and Institute Affiliations

Selected Publications

  • Gehlbach, B. K., Patel, S. B., Van Cauter, E., Pohlman, A. S., Hall, J. B. & Zabner, J. (2018). The Effects of Timed Light Exposure in Critically Ill Patients: A Randomized Controlled Pilot Clinical Trial. American journal of respiratory and critical care medicine 198 (2) 275-278. DOI: 10.1164/rccm.201801-0170LE. PMID: 29529381.
  • O'Malley, Y., Rotti, P. G., Thornell, I. M., Vanegas Calderón, O. G., Febres-Aldana, C., Durham, K., Yao, J., Li, X., Zhu, Z., Norris, A. W., Zabner, J., Engelhardt, J. F. & Uc, A. (2018). Development of a polarized pancreatic ductular cell epithelium for physiological studies. Journal of applied physiology (Bethesda, Md. : 1985) 125 (1) 97-106. DOI: 10.1152/japplphysiol.00043.2018. PMID: 29517421.
  • Taher, H., Bauer, C., Abston, E., Kaczka, D. W., Bhatt, S. P., Zabner, J., Brower, R. G., Beichel, R. R. & Eberlein, M. (2018). Chest wall strapping increases expiratory airflow and detectable airway segments in computer tomographic scans of normal and obstructed lungs. Journal of applied physiology (Bethesda, Md. : 1985) 124 (5) 1186-1193. DOI: 10.1152/japplphysiol.00184.2017. PMID: 29357485. PMCID: PMC6008079.
  • Vargas Buonfiglio, L. G., Borcherding, J. A., Frommelt, M., Parker, G. J., Duchman, B., Vanegas Calderón, O. G., Fernandez-Ruiz, R., Noriega, J. E., Stone, E. A., Gerke, A. K., Zabner, J. & Comellas, A. P. (2018). Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance. Respiratory research 19 (1) 42. DOI: 10.1186/s12931-018-0743-x. PMID: 29524964. PMCID: PMC5845328.
  • Thornell, I. M., Li, X., Tang, X. X., Brommel, C. M., Karp, P. H., Welsh, M. J. & Zabner, J. (2018). Nominal carbonic anhydrase activity minimizes airway-surface liquid pH changes during breathing. Physiological reports 6 (2). DOI: 10.14814/phy2.13569. PMID: 29380953. PMCID: PMC5789725.
  • Li, X., Vargas Buonfiglio, L. G., Adam, R. J., Stoltz, D. A., Zabner, J. & Comellas, A. P. (2017). Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs. Critical care medicine 45 (12) e1240-e1246. DOI: 10.1097/CCM.0000000000002720. PMID: 28953499. PMCID: PMC5693779.
  • Abston, E., Comellas, A., Reed, R. M., Kim, V., Wise, R. A., Brower, R., Fortis, S., Beichel, R., Bhatt, S., Zabner, J., Newell, J., Hoffman, E. A. & Eberlein, M. (2017). Higher BMI is associated with higher expiratory airflow normalised for lung volume (FEF25-75/FVC) in COPD. BMJ open respiratory research 4 (1) e000231. DOI: 10.1136/bmjresp-2017-000231. PMID: 29071083. PMCID: PMC5652498.
  • Adam, R. J., Abou Alaiwa, M. H., Bouzek, D. C., Cook, D. P., Gansemer, N. D., Taft, P. J., Powers, L. S., Stroik, M. R., Hoegger, M. J., McMenimen, J. D., Hoffman, E. A., Zabner, J., Welsh, M. J., Meyerholz, D. K. & Stoltz, D. A. (2017). Postnatal airway growth in cystic fibrosis piglets. Journal of applied physiology (Bethesda, Md. : 1985) 123 (3) 526-533. DOI: 10.1152/japplphysiol.00263.2017. PMID: 28620056. PMCID: PMC5625074.
  • Vargas Buonfiglio, L. G., Mudunkotuwa, I. A., Abou Alaiwa, M. H., Vanegas Calderón, O. G., Borcherding, J. A., Gerke, A. K., Zabner, J., Grassian, V. H. & Comellas, A. P. (2017). Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid. Environmental health perspectives 125 (7) 077003. DOI: 10.1289/EHP876. PMID: 28696208.
  • Vargas Buonfiglio, L. G., Cano, M., Pezzulo, A. A., Vanegas Calderon, O. G., Zabner, J., Gerke, A. K. & Comellas, A. P. (2017). Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial. BMJ open respiratory research 4 (1) e000211. DOI: 10.1136/bmjresp-2017-000211. PMID: 28883932. PMCID: PMC5531307.