Julia Klesney-Tait, MD, PhD
Professor of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine
Office
Introduction
Dr. Klesney-Tait's research focuses on the role of the innate immune system in the regulation of inflammation as it impacts on the evolution of sepsis and the development of bronchiolitis obliterans following lung transplantation. Her area of clinical interest is lung transplantation.
Current Positions
- Professor of Internal Medicine-Pulmonary, Critical Care and Occupational Medicine
- Administrative Director of Thoracic Transplant, Heart and Vascular Center
- Medical Director, Lung Transplantation, University of Iowa Health Care
Education
- MD/PhD, Medical Scientist Training Program, UT Southwestern Medical Center at Dallas, Dallas, Texas
- Resident, Internal Medicine, Washington University School of Medicine, St. Louis, Missouri
- Fellow, Pulmonary & Critical Care Medicine, Washington University School of Med, Barnes Jewish Hospital, St. Louis, Missouri
Center, Program and Institute Affiliations
Selected Publications
- Baruah, S., Murthy, S., Keck, K., Galvan, I., Prichard, A., Allen, L. H., Farrelly, M. & Klesney-Tait, J. (2019). TREM-1 regulates neutrophil chemotaxis by promoting NOX-dependent superoxide production. Journal of leukocyte biology. DOI: 10.1002/JLB.3VMA0918-375R. PMID: 30667543.
- Urak, K. T., Blanco, G. N., Shubham, S., Lin, L. H., Dassie, J. P., Thiel, W. H., Chen, Y., Sonkar, V. K., Lei, B., Murthy, S., Gutierrez, W. R., Wilson, M. E., Stiber, J. A., Klesney-Tait, J., Dayal, S., Miller, Jr, F. J. & Giangrande, P. H. (2019). RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome. Nature communications 10 (1) 116. DOI: 10.1038/s41467-018-08030-y. PMID: 30631065. PMCID: PMC6328615.
- Swatek, A. M., Lynch, T. J., Crooke, A. K., Anderson, P. J., Tyler, S. R., Brooks, L., Ivanovic, M., Klesney-Tait, J. A., Eberlein, M., Pena, T., Meyerholz, D. K., Engelhardt, J. F. & Parekh, K. R. (2018). Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis. American journal of respiratory and critical care medicine 197 (8) 1045-1057. DOI: 10.1164/rccm.201707-1368OC. PMID: 29236513. PMCID: PMC5909161.
- Pena, T. & Klesney-Tait, J. (2017). Mycobacterial Infections in Solid Organ and Hematopoietic Stem Cell Transplantation. Clinics in chest medicine 38 (4) 761-770. DOI: 10.1016/j.ccm.2017.07.011. PMID: 29128024.
- Cook, D. P., Adam, R. J., Abou Alaiwa, M. H., Eberlein, M., Klesney-Tait, J. A., Parekh, K. R., Meyerholz, D. K. & Stoltz, D. A. (2016). Mounier-Kuhn syndrome: a case of tracheal smooth muscle remodeling. Clinical case reports 5 (2) 93-96. DOI: 10.1002/ccr3.794. PMID: 28174630. PMCID: PMC5290513.
- Thiel, W. H., Esposito, C. L., Dickey, D. D., Dassie, J. P., Long, M. E., Adam, J., Streeter, J., Schickling, B., Takapoo, M., Flenker, K. S., Klesney-Tait, J., Franciscis Vd, Miller, Jr, F. J. & Giangrande, P. H. (2016). Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation. Molecular therapy : the journal of the American Society of Gene Therapy 24 (4) 779-87. DOI: 10.1038/mt.2015.235. PMID: 26732878.
- Baruah, S., Keck, K., Vrenios, M., Pope, M. R., Pearl, M., Doerschug, K. & Klesney-Tait, J. (2015). Identification of a Novel Splice Variant Isoform of TREM-1 in Human Neutrophil Granules. Journal of immunology (Baltimore, Md. : 1950) 195 (12) 5725-31. DOI: 10.4049/jimmunol.1402713. PMID: 26561551.
- Barnes, L., Reed, R. M., Parekh, K. R., Bhama, J. K., Pena, T., Rajagopal, S., Schmidt, G. A., Klesney-Tait, J. A. & Eberlein, M. (2015). MECHANICAL VENTILATION FOR THE LUNG TRANSPLANT RECIPIENT. Current pulmonology reports 4 (2) 88-96. DOI: 10.1007/s13665-015-0114-8. PMID: 26495241.
- Stuart, B. D., Choi, J., Zaidi, S., Xing, C., Holohan, B., Chen, R., Choi, M., Dharwadkar, P., Torres, F., Girod, C. E., Weissler, J., Fitzgerald, J., Kershaw, C., Klesney-Tait, J., Mageto, Y., Shay, J. W., Ji, W., Bilguvar, K., Mane, S., Lifton, R. P. & Garcia, C. K. (2015). Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening. Nature genetics 47 (5) 512-7. DOI: 10.1038/ng.3278. PMID: 25848748.
- Klesney-Tait, J., Eberlein, M., Geist, L., Keech, J., Zabner, J., Gruber, P. J., Iannettoni, M. D. & Parekh, K. (2015). Starting a lung transplant program: a roadmap for long-term excellence. Chest 147 (5) 1435-43. DOI: 10.1378/chest.14-2241. PMID: 25940255.