1. People

Leonid Zingman, MD

Professor of Internal Medicine-Cardiovascular Medicine

Current Positions

  • Professor of Internal Medicine-Cardiovascular Medicine

Education

  • MD, First Leningrad Medical Institute, Leningrad, Russia
  • Intern, First Leningrad City Hospital, Lemingrad, Russia
  • Resident, Medicine, Ben Gurion University, Beersheba, Israel
  • Fellow, Cardiovascular Diseases, Mayo Graduate School of Medicine, Rochester, Minnesota
  • Fellow, Pharmacology, Mayo Graduate School of Medicine, Rochester, Minnesota

Center, Program and Institute Affiliations

Research Interests

  • My current research is focused on the development of new approaches to the prevention and treatment of overweight and obesity. We approach body weight as a balance between energy intake and consumption. Due to limited food availability in the natural habitat, evolutionary pressures favor systems that conserve energy and prevent body weight loss. While naturally protective, these energy-conserving mechanisms under conditions of hyperalimentation and sedentary lifestyle promote obesity. Therefore, comprehension of the mechanisms governing the balance between energy intake and utilization, and the consequences of careful interference with energy-sparing systems, is vital for advances in obesity treatment and prevention.
  • In particular, we are focused on defining the molecular mechanism of skeletal muscle energy efficiency control. Specifically, at this point we are investigating how gating and expression regulation of cardiac and skeletal muscle KATP channels impact energy use. Detailed understanding of these KATP channel related mechanisms will reveal new avenues to promote health and wellbeing by shifting muscle and bodily energy balance in favor of energy use to treat or prevent obesity, or toward energy conservation in cases of heart failure and cancer related cachexia.

Licenses & Certifications

  • Medical License, Iowa Board of Medicine
  • Certification, American Board of Clinical Pharmacology

Selected Publications

  • Gao, Z., Sierra, A., Zhu, Z., Koganti, S. R., Subbotina, E., Maheshwari, A., Anderson, M. E., Zingman, L. V. & Hodgson-Zingman, D. M. (2016). Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury. PloS one 11 (3) e0151337. DOI: 10.1371/journal.pone.0151337. PMID: 26964104. PMCID: PMC4786327.
  • Sierra, A., Subbotina, E., Zhu, Z., Gao, Z., Koganti, S. R., Coetzee, W. A., Goldhamer, D. J., Hodgson-Zingman, D. M. & Zingman, L. V. (2016). Disruption of ATP-sensitive potassium channel function in skeletal muscles promotes production and secretion of musclin. Biochemical and biophysical research communications 471 (1) 129-34. DOI: 10.1016/j.bbrc.2016.01.166. PMID: 26828268. PMCID: PMC4815902.
  • Subbotina, E., Koganti, S. R., Hodgson-Zingman, D. M. & Zingman, L. V. (2016). Morpholino-driven gene editing: A new horizon for disease treatment and prevention. Clinical pharmacology and therapeutics 99 (1) 21-5. DOI: 10.1002/cpt.276. PMID: 26474085. PMCID: PMC4720544.
  • Subbotina, E., Sierra, A., Zhu, Z., Gao, Z., Koganti, S. R., Reyes, S., Stepniak, E., Walsh, S. A., Acevedo, M. R., Perez-Terzic, C. M., Hodgson-Zingman, D. M. & Zingman, L. V. (2016). Musclin is an activity-stimulated myokine that enhances physical endurance. Proceedings of the National Academy of Sciences of the United States of America 112 (52) 16042-7. DOI: 10.1073/pnas.1514250112. PMID: 26668395. PMCID: PMC4702977.
  • Rasmussen, T. P., Wu, Y., Joiner, M. L., Koval, O. M., Wilson, N. R., Luczak, E. D., Wang, Q., Chen, B., Gao, Z., Zhu, Z., Wagner, B. A., Soto, J., McCormick, M. L., Kutschke, W., Weiss, R. M., Yu, L., Boudreau, R. L., Abel, E. D., Zhan, F., Spitz, D. R., Buettner, G. R., Song, L. S., Zingman, L. V. & Anderson, M. E. (2015). Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proceedings of the National Academy of Sciences of the United States of America 112 (29) 9129-34. DOI: 10.1073/pnas.1504705112. PMID: 26153425. PMCID: PMC4517214.
  • Zhu, Z., Sierra, A., Burnett, C. M., Chen, B., Subbotina, E., Koganti, S. R., Gao, Z., Wu, Y., Anderson, M. E., Song, L. S., Goldhamer, D. J., Coetzee, W. A., Hodgson-Zingman, D. M. & Zingman, L. V. (2014). Sarcolemmal ATP-sensitive potassium channels modulate skeletal muscle function under low-intensity workloads. The Journal of general physiology 143 (1) 119-34. DOI: 10.1085/jgp.201311063. PMID: 24344248. PMCID: PMC3874572.
  • Sierra, A., Zhu, Z., Sapay, N., Sharotri, V., Kline, C. F., Luczak, E. D., Subbotina, E., Sivaprasadarao, A., Snyder, P. M., Mohler, P. J., Anderson, M. E., Vivaudou, M., Zingman, L. V. & Hodgson-Zingman, D. M. (2013). Regulation of cardiac ATP-sensitive potassium channel surface expression by calcium/calmodulin-dependent protein kinase II. The Journal of biological chemistry 288 (3) 1568-81. DOI: 10.1074/jbc.M112.429548. PMID: 23223335. PMCID: PMC3548467.
  • Zhu, Z., Burnett, C. M., Maksymov, G., Stepniak, E., Sierra, A., Subbotina, E., Anderson, M. E., Coetzee, W. A., Hodgson-Zingman, D. M. & Zingman, L. V. (2011). Reduction in number of sarcolemmal KATP channels slows cardiac action potential duration shortening under hypoxia. Biochemical and biophysical research communications 415 (4) 637-41. PMID: 22079630. PMCID: PMC3230708.
  • Zhu, Z., Burnett, C. M., Maksymov, G., Stepniak, E., Sierra, A., Subbotina, E., Anderson, M. E., Coetzee, W. A., Hodgson-Zingman, D. M. & Zingman, L. V. (2011). Reduction in number of sarcolemmal KATP channels slows cardiac action potential duration shortening under hypoxia. Biochemical and biophysical research communications 415 (4) 637-41. PMID: 22079630. PMCID: PMC3230708.
  • Zingman, L. V., Zhu, Z., Sierra, A., Stepniak, E., Burnett, C. M., Maksymov, G., Anderson, M. E., Coetzee, W. A. & Hodgson-Zingman, D. M. (2011). Exercise-induced expression of cardiac ATP-sensitive potassium channels promotes action potential shortening and energy conservation. Journal of molecular and cellular cardiology 51 (1) 72-81. PMID: 21439969. PMCID: PMC3103621.

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