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Long-Sheng Song, MD, MS

Portrait
Professor of Internal Medicine - Cardiovascular Medicine

Contact Information

Lab
2269A CBRB
285 Newton Road
Iowa City, IA 52242
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Education

MD, North China University of Science and Technology (formerly North China Coal Medical College)
MS, Kunming Medical University
Postdoctoral Fellow, National Institute on Aging, NIH

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Molecular Medicine, Interdisciplinary Graduate Program in Neuroscience, Medical Scientist Training Program

Center, Program and Institute Affiliations

Cardiovascular Research Center, Fraternal Order of Eagles Diabetes Research Center

Research Summary

Our laboratory is interested in understanding the role of highly spatio-temporal localized Ca2+ signals, namely Ca2+ sparks, in normal cell function and diseases (e.g., heart failure, arrhythmias and other disease). We use state of the art techniques such as patch-clamp and laser scanning confocal microscopy in combination with genetic mouse models to investigate the cellular mechanisms of Ca2+ regulation and dysregulation. Specifically, we are studying 1) the structure-function relationship between t-tubule system and Ca2+ handling in normal and diseased hearts. In this project, we are testing our hypothesis that t-tubule remodeling plays critical role in Ca2+ release instability and therefore Ca2+-dependent arrhythmogenesis in cardiomyopathies; 2) molecular mechanisms of t-tubule remodeling in heart disease. We are actively searching for the molecules that control and regulate t-tubule organization in cardiomyocytes; 3) Local Ca2+ signaling and sinoatrial node automaticity. In the third project, we are testing our hypothesis that Ca2+ sparks are highly locally controlled in sinoatrial nodal cells and that dys-regulation of local Ca2+ signaling in SAN cells contributes to pacemaker dysfunction. Our research projects are funded by National Heart, Lung and Blood Institute, American Heart Association.