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M. Nedim Ince, MD

Clinical Professor of Internal Medicine-Gastroenterology and Hepatology

Introduction

Dr. Ince's clinical interests include general gastroenterology with particular interest in inflammatory bowel disease. His research focuses on helminthic regulation of intestinal inflammation. His laboratory investigates the role of T helper 2 and TGF-beta signaling pathways in helminthic mucosal immune modulation. His group uses graft vs. host disease and inflammatory bowel disease preclinical models.

Current Positions

  • Clinical Professor of Internal Medicine-Gastroenterology and Hepatology

Education

  • MD, Istanbul University, Cerrahpasa Medical School, Istanbul, Türkey
  • Resident, Internal Medicine, Istanbul Medical School. Istanbul, Turkey
  • Postdoctoral Fellow, Cancer Biology, Brown University of Medicine, Providence, Rhode Island
  • Postdoctoral Fellow, Cellular Immunology, Harvard Medical School, Boston, Massachusetts
  • Fellow, Gastroenterology and Hepatology, University of Iowa Hospitals & Clinics, Iowa City, Iowa

Center, Program and Institute Affiliations

Selected Publications

  • Metwali A, Winckler S, Ince MN, Elliott DE. Helminth exposure protects intestinal epithelium from acute injury in a model of IEC diphteria toxin receptor transgenic mice.
  • Fury H, Guan X, Atagozli T, Elliott DE, Blazar BR, Ince MN. Modulating donor T cell graft-versus-host and graft-versus-tumor reactivity by STAT6.
  • Atagozli T, Elliott DE, Ince MN. Helminth lessons in inflammatory bowel diseases. Biomedicines 2023, 11:1200. PMID: 37189818.
  • Braseth A, Ellliott DE, Ince MN. Parasitic infections of the gastrointestinal tract and liver. Gastroenterol Clin North Am 2021, 50:361. PMID: 34024446.
  • Truscott J, Guan X, Fury H, Atagozli T, Liu W, Li Y, Metwali A, Li R, Elliott DE, Blazar BR, Ince MN. After bone marrow transplantation, the cell-intrinsic T helper-2 (Th2) pathway promotes recipient T lymphocyte survival and regulates graft-versus-host disease. Immunohorizons 2023, 7:442-455. PMID: 37294277.
  • Metwali, A., Winckler, S., Urban, Jr, J. F., Kaplan, M. H., Ince, M. N. & Elliott, D. E. (2021). Helminth-induced regulation of T-cell transfer colitis requires intact and regulated T cell Stat6 signaling in mice. European journal of immunology 51 (2) 433-444. DOI: 10.1002/eji.201848072. PMID: 33067820.