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Manasa K. Nayak, PhD

Research Assistant Professor of Internal Medicine-Hematology, Oncology, and Blood and Marrow Transplantation

Current Positions

  • Research Assistant Professor of Internal Medicine-Hematology, Oncology, and Blood & Marrow Transplantation

Education

  • PhD, Banaras Hindu University, Uttar Pradesh, India
  • Postdoctoral Fellow, University of Texas Health Science Center, Tyler, Texas
  • Postdoctoral Research Scholar, University of Iowa, Iowa City, Iowa

Selected Publications

  • Nayak MK, Ghatge M K, Flora G D, Dhanesha N, Jain M, Kathleen Markan, Potthoff M, Lentz S R, Chauhan A K. Metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis. Blood, 2021 137 (12): 1658–1668. [PMID: 33027814]
  • Dhanesha N *, Nayak MK*, Flora G D, N, Doddapattar, P, Chauhan A K. Targeting myeloid-cell specific Integrin α9β1 inhibits arterial thrombosis in Mice. Blood 2020, 135(11):857-861. [PMID:  31951649] (*Joint-first author).
  • Dhanesha N, Jain M, Tripathi AK, Doddapattar P, Chorawala M, Bathla M, Nayak MK, Ghatge M, Lentz S R, MD, Kon S, Chauhan A K. Targeting myeloid-specific integrin α9β1improves short and long-term stroke outcomes in murine models with preexisting comorbidities by limiting thrombosis and inflammation. Circ. Res, 2020, 126(12):1779-1794. [PMID: 32195632]
  • Jain, M, Dhanesha, N, Doddapattar, P, Mehul R. Chorawala, Nayak MK, Anne Cornelissen, Liang Guo, Aloke V. Finn, Lentz, SR and Chauhan, A K. Smooth Muscle Cell-Derived Fibronectin Containing Extra Domain A is a Novel Mediator of SMC Phenotypic Modulation and Neointimal Hyperplasia. J Clin Invest. 2020, 130(1):295-314.
  • Nayak MK, Dhanesha N, Doddapattar P, Rodriguez O, Sonkar VK, Dayal S, Chauhan AK. Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis. Blood Adv. 2018; 2:2029-2038 [PMID: 30108111]
  • Kumari, S., Chaurasia SN., Nayak, MK*, Mallick RL. and Dash, D. Sirtuin inhibition induces apoptosis-like changes in platelets and thrombocytopenia. J Biol Chem, 2015; 290:12290-9. [PMID: 25829495]
  • Nayak, MK., Dash, A., Singh, N. and Dash, D. Aspirin delimits platelet life span by apoptosis induction. Plos One. 2014; 9:e105049 [PMID: 25126950]
  • Nayak, MK., Kulkarni, P., and Dash, D. Regulatory role of the proteasome in the determination of platelet life span. J Biol Chem. 2013; 288:6826-6834. (Published as a research highlight in Nature doi:10.1038/nindia.2013.49) [PMID: 23329846]
  • Nayak, MK., Singh, S. K., Roy A., Prakash V., Kumar A. and Dash, D. “Anti-thrombotic effects of selective estrogen receptor modulator tamoxifen. Thromb Hemost. 2011; 106:624-635. [PMID: 21866300]
  • Nayak, MK., Kumar K. and Dash D. Regulation of proteasome activity in activated human platelets. Cell Calcium. 2011; 49:226-232. [PMID: 21388679]