Mark Yorek, PhD
Professor of Internal Medicine-Endocrinology and Metabolism
Current Positions
- Professor of Internal Medicine-Endocrinology and Metabolism
- Associate Chief of Staff for Research, Iowa City VA Health System
Education
- PhD, University of North Dakota, Grand Forks, North Dakota
- Postdoctoral Fellow, Biochemistry, University of Iowa College of Medicine, Iowa City, Iowa
Center, Program and Institute Affiliations
Research Interests
- Dr. Yorek's research focuses primarily on vascular and neural disease related to obesity and diabetes. They are interested in determining the etiology of peripheral neuropathy associated with these conditions. An overall goal of their studies is to determine the role of vascular dysfunction in obesity- and diabetic-induced peripheral neuropathy and the mechanism responsible for vascular dysfunction. Briefly, they have developed the methodology to examine the effect of diabetes on vasodilation of blood vessels that provide circulation to the sciatic nerve and the retina. Combined with the examination of motor and sensory nerve conduction velocity, neuronal blood flow in the sciatic nerve, and sensory nerve perception they are investigating the etiology of diabetic neuropathy with emphasis on vascular disease. In addition, they have also been conducting studies examining impairment of innervation of the cornea as a marker for obesity- and diabetic-neuropathy. Using animal models of obesity and diabetes they have demonstrated that loss of corneal nerves especially those innervating the cornea epithelium occurs early in disease. They have also shown that in the sub-epithelial layer of the cornea early detection of nerve loss can be achieved by examining the region of the whorl. These results have translational importance for the early detection of obesity- and diabetic-induced peripheral neuropathy that could be used for examining the progression and repair of neuropathy in patients. In this regard they have been conducting studies in the use of menhaden oil (fish oil), a natural source for n-3 fatty acids, for the treatment of obesity- and diabetic-induced peripheral neuropathy. They have demonstrated that treating rodent models of pre-diabetes and types 1 and 2 diabetes with menhaden oil improves insulin resistance and vascular and neural complications. They have also shown that treating type 2 diabetic mice with resolvin D1 can improve diabetic peripheral neuropathy. They believe that the mechanism(s) responsible for the beneficial effects of menhaden oil is the reduction in inflammatory stress and production of resolvins and neuroprotectin, metabolites of n-3 fatty acids that have anti-inflammatory and neuroprotection properties. Studies are ongoing to investigate the mechanism(s) responsible for the beneficial effects of fish oils in obesity and diabetes. In addition clinical studies are being designed to test the benefits of fish oil treatment in subjects with diabetes.
Selected Publications
- Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy. Ebert SM, Rasmussen BB, Judge AR, Judge SM, Larsson L, Wek RC, Anthony TG, Marcotte GR, Miller MJ, Yorek MA, Vella A, Volpi E, Stern JI, Strub MD, Ryan Z, Talley JJ, Adams CM. J Nutr. 2022 Apr 1;152(4):926-938. doi: 10.1093/jn/nxab440. Review. PubMed PMID: 34958390; PubMed Central PMCID: PMC8970988.
- Comparative Effect Of A High Fat With Or Without High Levels Of Sucrose Diets On Peripheral Neuropathy In C57bl/6j Mice. Obrosov A, Coppey LJ, Shevalye H, Yorek MA. Journal of Diabetic Complications & Therapy. 2021 April; 1(1).
- Treatment for Diabetic Peripheral Neuropathy: What have we Learned from Animal Models? Yorek M. Curr Diabetes Rev. 2022;18(5):e040521193121. doi: 10.2174/1573399817666210504101609. Review. PubMed PMID: 33949936; PubMed Central PMCID: PMC8965779.
- Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil. Coppey L, Obrosov A, Shevalye H, Davidson E, Paradee W, Yorek MA. J Diabetes Res. 2021 Mar 15;2021:5564477. doi: 10.1155/2021/5564477. eCollection 2021. PMID: 33816635.
- Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats. Fink BD, Yu L, Coppey L, Obrosov A, Shevalye H, Kerns RJ, Yorek MA, Sivitz WI. Pharmacol Res Perspect. 2021 Feb;9(1):e00701. doi: 10.1002/prp2.701. PMID: 33547885.
- Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models. Strom A, Strassburger K, Schmuck M, Shevalye H, Davidson E, Zivehe F, Bönhof G, Reimer R, Belgardt B-F, Fleming T, Biermann B, Burkart V, Müssig K, Szendroedi J, Yorek MA, Fritsche E, Nawroth PP, Roden M, Ziegler D, GDS Group. Mol Metab. 2021 Jan;43:101114. doi: 10.1016/j.molmet.2020.101114. Epub 2020 Nov 6. PMID: 33166742 PMCID: PMC7704399.
- Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes. Andreasen LJ, Kirk RK, Fledelius C, Yorek MA, Lykkesfeldt J, Akerstrom T. J Diabetes Res. 2020;2020:9626398. doi: 10.1155/2020/9626398. eCollection 2020. PubMed PMID: 32832565; PubMed Central PMCID: PMC7424504.
- Effect of mitoquinone (Mito-Q) on neuropathic endpoints in an obese and type 2 diabetic rat model. Fink B, Coppey L, Davidson E, Shevalye H, Obrosov A, Chheda PR, Kerns R, Sivitz W, Yorek M. Free Radic Res. 2020 May;54(5):311-318. doi: 10.1080/10715762.2020.1754409. Epub 2020 Apr 24. PubMed PMID: 32326763; PubMed Central PMCID: PMC7329571.
- Progressive Loss of Corneal Nerve Fibers and Sensitivity in Rats Modeling Obesity and Type 2 Diabetes is Reversible with Omega-3 Fatty Acid Intervention: Supporting Cornea Analyses as a Marker for Peripheral Neuropathy and Treatment. Lawrence Coppey, Eric Davidson, Hanna Shevalye, Alexander Obrosov, Michael Torres and Mark Yorek. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2020;13:1367-1384. doi: 10.2147/DMSO.S247571. eCollection 2020. PubMed PMID: 32425569; PubMed Central PMCID: PMC7189026
- Diabetic Neuropathy: New Insights to Early Diagnosis and Treatments. Yorek M, Malik RA, Calcutt NA, Vinik A, Yagihashi S. J Diabetes Res. 2018 Dec 10;2018:5378439, 2018.