Nicholas Zavazava, MD, PhD

Portrait
Emeritus Professor of Internal Medicine - Immunology
Emeritus Professor of Biomedical Engineering (BME)

Contact Information

Primary Office
C429-1 GH
Iowa City, IA 52242
319-384-6577

Education

MD, University of Kiel
PhD, University of Kiel
Fellow, Clinical Immunology, University of Kiel
Fellow, Clinical Chemistry, University of Kiel

Licensure and Certifications


Education/Training Program Affiliations

Interdisciplinary Graduate Program in Immunology, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases, Holden Comprehensive Cancer Center, Institute for Clinical and Translational Science

Research Summary

The work pursued in our laboratory primarily focusses on stem cells. We are interested in studying stem cell derived hematopoietic cell and insulin producing cells. Type 1 diabetes is one of the most devastating chronic diseases which costs billions of dollars every year. By establishing a stem cell based source of insulin producing cells, we might be able to treat many patients who would otherwise remain untreatable. Similarly, induced pluripotent stem cells are a novel source of hematopoietic cells for the treatment of leukemia and other hematopoietic malignancies. We have established nopvel approaches for the derivation of mouse and human hematopoietic cells. Our lab has several in vivo models for probing the efficacy of these cells in vivo.

Publications

Kim, E. M., Manzar, G. & Zavazava, N. (2013). Human iPS cell-derived hematopoietic progenitor cells induce T-cell anergy in in vitro-generated alloreactive CD8+ T cells. Blood, 121(26), 5167-75. PMID: 23687092.

Kim, E. M., Stultz, R., Bonde, S. & Zavazava, N. (2012). Embryonic stem cell-derived T cells induce lethal graft-versus-host disease and reject allogenic skin grafts upon thymic selection. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 12(3), 600-9. PMID: 22070732.

Tabayoyong, W. B., Salas, J. G., Bonde, S. & Zavazava, N. (2009). HOXB4-transduced embryonic stem cell-derived Lin-c-kit+ and Lin-Sca-1+ hematopoietic progenitors express H60 and are targeted by NK cells. Journal of immunology (Baltimore, Md. : 1950), 183(9), 5449-57. PMID: 19828634.

Berg, M., Zavazava, N. (2003). Re-direction of Tumor-Relevant Peptides into the Soluble MHC Class I Variants: A New Strategy to Escape Immune-Surveillance. (Vols. 17). (7 (Suppl)), pp. C124-C125. FASEB J.

Freese, A., Zavazava, N. (2002). HLA-B7 beta-pleated sheet-derived synthetic peptides are immunodominant T-cell epitopes regulating alloresponses. Blood, 99(9), 3286-92. PMID: 11964295.

Fändrich, F., Lin, X., Chai, G. X., Schulze, M., Ganten, D., Bader, M., Holle, J., Huang, D. S., Parwaresch, R., Zavazava, N. & Binas, B. (2002). Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning. Nature medicine, 8(2), 171-8. PMID: 11821902.

Zavazava, N., Krönke, M. (1996). Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes. Nature medicine, 2(9), 1005-10. PMID: 8782458.

Manzar, G. S., Kim, E. M. & Zavazava, N. (2017). Demethylation of Induced Pluripotent Stem Cells from Type 1 Diabetic Patients Enhances Differentiation into Functional Pancreatic ß-cells. The Journal of biological chemistry. PMID: 28360105.

Kim, E. M., Manzar, G. & Zavazava, N. (2017). iPS Cell-Derived Gamete-Associated Proteins (GAPs) Incite Rejection of iPSCs in Syngeneic Mice. Immunology. PMID: 28185259.

Zavazava, N. (2015). iPS Cell-Derived Immunosuppressive Myeloid Cells. (Vols. 99). (11), pp. 2245-6. Transplantation. PMID: 26451526.

Raikwar, S. P., Kim, E. M., Sivitz, W. I., Allamargot, C., Thedens, D. R. & Zavazava, N. (2015). Human iPS cell-derived insulin producing cells form vascularized organoids under the kidney capsules of diabetic mice. PloS one, 10(1), e0116582. PMID: 25629318.

Bassi, R., Lancerotto, L., Giatsidis, G., Nasr, M. B., Valderrama-Vasquez, A., Zavazava, N., Orgill, D. P. & Fiorina, P. (2015). Acellular embryonic cell extracts improve wound healing in diabetic mice. Diabetes, 64, A184. DOI: 10.2337/db15386741.

Manzar, G. S., Kim, E. M., Rotti, P. & Zavazava, N. (2015). Generation of glucose-responsive pancreatic ß-cells from type 1 diabetic patient human IPS cells in vitro. Diabetes, 64, A65. DOI: 10.2337/db151385.

Manzar, G., Kim, E. M., Rotti, P. & Zavazava, N. (2015). Human iPS cell-derived pancreatic ß-cells correct hyperglycemia in diabetic mice. American Journal of Transplantation, 15.

Kim, E. M., Manzar, G. & Zavazava, N. (2015). Immune rejection of IPS cells is triggered by gamete-associated proteins (GAPS). American Journal of Transplantation, 15.

Zavazava, N. (2014). Progress toward establishing embryonic stem or induced pluripotent stem cell-based clinical translation. Current opinion in organ transplantation, 19(6), 598-602. PMID: 25333832.

Duong, K. L., Das, S., Yu, S., Barr, J. Y., Jena, S., Kim, E., Zavazava, N., Colgan, J. D., Xue, H. H. & Levasseur, D. N. (2014). Identification of hematopoietic-specific regulatory elements from the CD45 gene and use for lentiviral tracking of transplanted cells. Experimental hematology, 42(9), 761-72.e1-10. PMID: 24852660.

Manzar, G. S., Kim, E. M., Rotti, P. & Zavazava, N. (2014). Skin deep: from dermal fibroblasts to pancreatic beta cells. Immunologic research, 59(1-3), 279-86. PMID: 24838150.

Kim, E. M., Miyake, B., Aggarwal, M., Voetlause, R., Griffith, M. & Zavazava, N. (2014). Embryonic stem cell-derived haematopoietic progenitor cells down-regulate the CD3 ? chain on T cells, abrogating alloreactive T cells. Immunology, 142(3), 421-30. PMID: 24527810.

Manzar, G., Rotti, P., Kim, E., Raikwar, S. & Zavazava, N. (2014). Human ips cell-derived insulin producing cells form organoids in vivo that are glucose responsive in diabetic mice. Transplantation, 98, 48. DOI: 10.1097/01.tp.0000452119.89845.c6.

Kim, E., Manzar, G. & Zavazava, N. (2014). Rejection of iPS cells, but not that of ES cells, in autologous recipients is caused by meiotic antigens. Transplantation, 98, 303. DOI: 10.1097/01.tp.0000452129.50834.32.

Sui, H., Olivier, A. K., Klesney-Tait, J. A., Brooks, L., Tyler, S. R., Sun, X., Skopec, A., Kline, J., Sanchez, P. G., Meyerholz, D. K., Zavazava, N., Iannettoni, M., Engelhardt, J. F. & Parekh, K. R. (2013). Ferret lung transplant: an orthotopic model of obliterative bronchiolitis. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 13(2), 467-73. PMID: 23205765.

Hayes, M., Zavazava, N. (2013). Strategies to generate induced pluripotent stem cells. Methods in molecular biology (Clifton, N.J.), 1029, 77-92. PMID: 23756943.

Miyake, B., Zavazava, N. (2013). The Role of NK Cells and T Cells in the Rejection of Embryonic Stem Cell-Derived Tissues. In The Immunological Barriers to Regenerative Medicine. pp. 69-76. Springer Nature. DOI: 10.1007/978-1-4614-5480-9_4.

Raikwar, S. P., Kim, E., John Ma, M. C., Thedens, D., Allamargot, C., Xie, W., Sivitz, W. I., Engelhardt, J., Kwitek, A. & Zavazava, N. (2013). Human induced pluripotent stem cell-derived insulin producing cells correct hyperglycemia in diabetic mice. Diabetes, 62, A564. DOI: 10.2337/db13-2161-2296.

Kim, E. M., Manzar, G. & Zavazava, N. (2013). Human iPS cell-derived CD34+ hematopoietic progenitor cells induce T cell anergy in alloreactive CD8+ T cells (P2188). Journal of Immunology, 190(1).

Zavazava, N., Kim, E. M. (2013). iPS cells but not their hematopoietic derivatives are immunogenic in the autologous recipient (P2210). Journal of Immunology, 190(1).

Singh, M. V., Cicha, M. Z., Whiteis, C. A., Chapleau, M. W., Zavazava, N. & Abboud, F. M. (2013). Is genetic hypertension immunologically mediated and adoptively transferrable by bone marrow from the spontaneously hypertensive rat?. Circulation, 128(22).

Kim, E. M., Manzar, G. & Zavazava, N. (2013). Mouse ES cell-derived hematopoietic progenitor cells. Methods in molecular biology (Clifton, N.J.), 1029, 109-17. PMID: 23756945.

Manzar, G., Kim, E. M. & Zavazava, N. (2013). Deficiency in IL-4Ra signaling is associated with impaired tumor immunity (P2057). Journal of Immunology, 190(1).

Raikwar, S. P., Zavazava, N. (2013). Differentiation and lineage commitment of murine embryonic stem cells into insulin producing cells. Methods in molecular biology (Clifton, N.J.), 1029, 93-108. PMID: 23756944.

Zavazava, N. (Eds.) (2013). Embryonic stem cell immunobiology: methods and protocols. New York: Humana Press ; Springer.

Kim, E., Miyake, B., Aggarwal, M. & Zavazava, N. (2013). Es cell-derived hematopoietic progenitor cells downregulate alloreactive t cells using arginase 1. American Journal of Transplantation, 13, 255. DOI: 10.1111/ajt.12266.

Das, S., Jena, S., Kim, E. M., Zavazava, N. & Levasseur, D. N. (2012). Transcriptional Regulation of Human NANOG by Alternate Promoters in Embryonic Stem Cells. Journal of stem cell research & therapy, Suppl 10, 009. PMID: 25077040.

Fan, R., Bonde, S., Gao, P., Sotomayor, B., Chen, C., Mouw, T., Zavazava, N. & Tan, K. (2012). Dynamic HoxB4-regulatory network during embryonic stem cell differentiation to hematopoietic cells. Blood, 119(19), e139-47. PMID: 22438249.

S, D., S, J., Em, K., N, Z. & Dn, L. (2012). Transcriptional Regulation of Human NANOG by Alternate Promoters in Embryonic Stem Cells. Journal of stem cell research & therapy, Suppl 10, 009–009. DOI: 10.4172/2157-7633.S10-009.

Manzar, G., Kim, E. M., Tabayoyong, W. & Zavazava, N. (2012). Ym1 is a stem cell factor that strongly activates NK cells and is secreted by murine embryonic stem cell-derived hematopoietic progenitor cells. American Journal of Transplantation, 12, 149–150. DOI: 10.1111/j.1600-6143.2012.04112.x.

Manzar, G., Kim, E. M., Tabayoyong, W. & Zavazava, N. (2012). Ym1 is a stem cell secreted factor that augments NK cell killing of tumor cells. Journal of Immunology, 188(1).

Sui, H., Brooks, L., Klesney-Tait, J. A., Olivier, A., Meyerholz, D., Zavazava, N., Engelhardt, J. F. & Parekh, K. R. (2012). Ferret lung transplant: An orthotopic model for obliterative bronchiolitis. Journal of Heart and Lung Transplantation, 31(4), S104–S105. DOI: 10.1016/j.healun.2012.01.298.

Kim, E. M., Manzar, G. & Zavazava, N. (2012). Human iPS cell-derived CD34+ hematopoietic progenitor cells induce T cell anergy in alloreactive CD8+ T cells. American Journal of Transplantation, 12, 459. DOI: 10.1111/j.1600-6143.2012.04112.x.

Kim, E. M., Manzar, G. & Zavazava, N. (2012). iPS cells are rejected in syngeneic mice and induce immunological rejection of ES cells. American Journal of Transplantation, 12, 92. DOI: 10.1111/j.1600-6143.2012.04112.x.

Raikwar, S. P., Zavazava, N. (2012). PDX1-engineered embryonic stem cell-derived insulin producing cells regulate hyperglycemia in diabetic mice. Transplantation research, 1(1), 19. PMID: 23369186.

Fiorina, P., Voltarelli, J. & Zavazava, N. (2011). Immunological applications of stem cells in type 1 diabetes. Endocrine reviews, 32(6), 725-54. PMID: 21862682.

Zavazava, N. (2011). Immunity of embryonic stem cell-derived hematopoietic progenitor cells. Seminars in immunopathology, 33(6), 613-7. PMID: 21547436.

Kim, E. M., Zavazava, N. (2011). Reverse chimerism: stem cells going the other way. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 11(10), 2005-6. PMID: 21883904.

Raikwar, S. P., Zavazava, N. (2011). Spontaneous in vivo differentiation of embryonic stem cell-derived pancreatic endoderm-like cells corrects hyperglycemia in diabetic mice. Transplantation, 91(1), 11-20. PMID: 21452407.

Miyake, B. K., Ahmed, A., Tabayoyong, W. & Zavazava, N. (2011). Murine embryonic stem cell-derived hematopoietic progenitor cells fail to elicit allospecific cytotoxic T cell responses in vitro. Journal of Allergy and Clinical Immunology, 127(2), AB166. DOI: 10.1016/j.jaci.2010.12.659.

Kim, E. M., Stultz, R., Bonde, S. & Zavazava, N. (2011). Embryonic stem cell-derived T cells reject allogenic skin grafts. American Journal of Transplantation, 11, 207. DOI: 10.1111/j.1600-6143.2011.03533.x.

Bonde, S., Pedram, M., Stultz, R. & Zavazava, N. (2010). Cell fusion of bone marrow cells and somatic cell reprogramming by embryonic stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(2), 364-73. PMID: 19762558.

Kim, E. M., Zavazava, N. (2010). Differentiation of human embryonic stem cells into hematopoietic cells in vitro. Methods in molecular biology (Clifton, N.J.), 651, 89-101. PMID: 20686962.

Miyake, B. K., Tabayoyong, W. & Zavazava, N. (2010). Hematopoietic progenitor cells derived from murine embryonic stem cells are not susceptible to alloreactive cytotoxic T cells despite surface expression of mhc class I antigens. American Journal of Transplantation, 10, 301–302. DOI: 10.1111/j.1600-6143.2010.03108.x.

Kim, E. M., Zavazava, N. (2010). Low antigenicity of hematopoietic cells derived from human ES cells. Transplantation and Risk Management, 2, 15-22.

Miyake, B. K., Aggarwal, M., Bonde, S. & Zavazava, N. (2010). CD41+ hematopoietic progenitor cells derived from murine embryonic stem cells achieve higher levels of engraftment in immunodeficient mice. American Journal of Transplantation, 10, 233. DOI: 10.1111/j.1600-6143.2010.03108.x.

S, B., M, P., R, S. & N, Z. (2010). Cell fusion of bone marrow cells and somatic cell reprogramming by embryonic stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(2), 364–373. DOI: 10.1096/fj.09-137141.

Bonde, S., Pedram, M., Stultz, R. & Zavazava, N. (2009). Cell fusion of bone marrow cells and somatic cell reprogramming by embryonic stem cells. FASEB J.

Tabayoyong, W. B., Zavazava, N. (2009). Meet the inlaws: embryonic stem cell derivatives meet the immune system. Cell research, 19(4), 397-8. PMID: 19339976.

Raikwar, S. P., Zavazava, N. (2009). Insulin producing cells derived from embryonic stem cells: are we there yet?. Journal of cellular physiology, 218(2), 256-63. PMID: 18932230.

Pollmann, H., Westfeld, M., Eifrig, B., Klamroth, R., Kreuz, W., Lenk, H., Oldenburg, J., Pabinger, I., Schramm, W., Schwarz, T., Zavazava, N. & Zimmermann, R. (2009). A pharmacovigilance evaluation of B-Domain deleted recombinant factor VIII - interim results after 9 years. Journal of Thrombosis and Haemostasis, 7(S2), 827–828. DOI: 10.1111/j.1538-7836.2009.03473-2.x.

Aggarwal, M., Bonde, S. & Zavazava, N. (2009). CD41+ progenitors are critical for the engraftment of hematopoietic cells derived from embryonic stem cells. Blood, 114(22).

Zavazava, N., Tabayoyong, W., Kim, E. M. & Bonde, S. (2009). Embryonic stem cell-derived hematopoietic cells: Are they immunocompetent?. The FASEB Journal, 23(S1).

Tabayoyong, W., Salas, J., Bonde, S. & Zavazava, N. (2009). Embryonic stem cell-derived lin-c-kit+ and lin-sca-1+ hematopoietic progenitor cells highly express H60 which abrogates their engraftment due to NK cell-mediated killing. American Journal of Transplantation, 9, 298.

Zavazava, N. (2009). Immune regulation of embryonic stem cell-derived hematopoietic progenitor cells (HPCs). European Journal of Immunology, 39, S762. DOI: 10.1002/eji.200990288.

Raikwar, S. P., Zavazava, N. (2009). In vivo differentiation of Pdx1+CXCR4+ definitive endodermal cells into insulin producing cells efficiently correct hyperglycemia in diabetic mice. American Journal of Transplantation, 9, 191.

Zavazava, N., Kabelitz, D. (2009). Insulin Producing Cells Derived from Embryonic Stem Cells: Are We There Yet?. J. Cell Physiol, 218(2), 256-263. DOI: 10.1002/jcp.21615.

Raikwar, S. P., Zavazava, N. (2009). Pdx1 promotes ESC differentiation into insulin producing cells. The FASEB Journal, 23(S1).

Raikwar, S., Zavazava, N. (2009). Real-Time Non-invasive Imaging of ES Cell-Derived Insulin Producing Cells. pp. 317-334. Methods in Molecular Biology.

Raikwar, S. P., Zavazava, N. (2009). Real-time non-invasive imaging of ES cell-derived insulin producing cells. In O. K. Park-Sarge , T. E. Curry Jr , O. K. Park-Sarge , T. E. Curry Jr (Eds.) Molecular Endocrinology. pp. 317-34. Methods in molecular biology (Clifton, N.J.). PMID: 19763514.

Bonde, S., Dowden, A. M., Chan, K. M., Tabayoyong, W. B. & Zavazava, N. (2008). HOXB4 but not BMP4 confers self-renewal properties to ES-derived hematopoietic progenitor cells. Transplantation, 86(12), 1803-9. PMID: 19104426.

Berg, M., Zavazava, N. (2008). Regulation of CD28 expression on CD8+ T cells by CTLA-4. Journal of leukocyte biology, 83(4), 853-63. PMID: 18162511.

Chan, K. M., Bonde, S., Klump, H. & Zavazava, N. (2008). Hematopoiesis and immunity of HOXB4-transduced embryonic stem cell-derived hematopoietic progenitor cells. Blood, 111(6), 2953-61. PMID: 18056836.

Zavazava, N., Chan, K. M., Xie, L., Sarvida, M. E., McCray Jr, P. B. & Lee, W. C. (2008). Embryonic Stem Cell-Derived CXCR4+ Definitive Endodermal Progenitor Cells Correct Factor VIII Deficiency in Mice. (Suppl 2S), pp. S107(#301). Transplantation.

Bonde, S., Chan, K. M. & Zavazava, N. (2008). ES-cell derived hematopoietic cells induce transplantation tolerance. PloS one, 3(9), e3212. PMID: 18791641.

Zavazava, N., Bonde, S., Chan, K. M. & Tabayoyong, W. B. (2008). HOXB4 Regulates Differentiation of Hematopoietic Progenitor Cells from Embryonic Stem Cells. (Suppl 2S), pp. S107(#302). Transplantation.

Raikwar, S. P., Zavazava, N. (2008). "Insulin Producing Cells Derived from Embryonic Stem Cells: Are we there yet?". J Cell Physiology.

Raikwar, S. P., Zavazava, N. (2008). "Real-Time Non-Invasive Imaging of ES Cell-Derived Insulin Producing Cells. Molecular Protocols.

Pollmann, H., Externest, D., Ganser, A., Eifrig, B., Kreuz, W., Lenk, H., Pabinger, I., Schramm, W., Schwarz, T. F., Zimmermann, R., Zavazava, N., Oldenburg, J. & Klamroth, R. (2007). Efficacy, safety and tolerability of recombinant factor VIII (REFACTO) in patients with haemophilia A: interim data from a postmarketing surveillance study in Germany and Austria. Haemophilia : the official journal of the World Federation of Hemophilia, 13(2), 131-43. PMID: 17286765.

Tabayoyong, W. B., Zavazava, N. (2007). Soluble HLA revisited. Leukemia research, 31(2), 121-5. PMID: 16860865.

Pollmann, H., Externest, D., Ganser, A., Eifrig, B., Kreuz, W., Lenk, H., Pabinger, I., Schramm, W., Schwarz, T. F., Zimmermann, R., Zavazava, N., Oldenburg, J. & Klamroth, R. (2007). Efficacy, safety and tolerability of recombinant factor VIII (REFACTO®) in patients with haemophilia A: Interim data from a postmarketing surveillance study in Germany and Austria. Haemophilia, 13(2), 131–143. DOI: 10.1111/j.1365-2516.2006.01416.x.

Raikwar, S. P., Zavazava, N. (2007). Maximizing De Novo insulin secretion in Insulin Producing Cells Newly Derived from ES Cells Using TAT-Pdx1 and Pax4 Transcription Factors. Am J Transplant.

Chan, K. M., Raikwar, S. P. & Zavazava, N. (2007). Strategies for differentiating embryonic stem cells (ESC) into insulin-producing cells and development of non-invasive imaging techniques using bioluminescence. Immunologic research, 39(1-3), 261-70. PMID: 17917070.

Bonde, S., Zavazava, N. (2006). Immunogenicity and engraftment of mouse embryonic stem cells in allogeneic recipients. Stem cells (Dayton, Ohio), 24(10), 2192-201. PMID: 16794265.

Lindaman, A., Dowden, A. & Zavazava, N. (2006). Soluble HLA-G molecules induce apoptosis in natural killer cells. American journal of reproductive immunology (New York, N.Y. : 1989), 56(1), 68-76. PMID: 16792533.

Raikwar, S. P., Zavazava, N. (2006). Real-time imaging of insulin producing cells derived from embryonic stem cells. ISSCR.

Dresske, B., Haendschke, F., Lenz, P., Ungefroren, H., Jenisch, S., Exner, B., El Mokhtari, N. E., Lu, T., Zavazava, N. & Faendrich, F. (2006). WOFIE stimulates regulatory T cells: a 2-year follow-up of renal transplant recipients. Transplantation, 81(11), 1549-57. PMID: 16770244.

Rickert, U., Welke, J., Behrens, D. & Zavazava, N. (2006). A divalent human leukocyte antigen-B7 fusion-protein up-regulates CD25 and CD69 in alloreactive CD8+ T cells bypassing CD28 costimulation. Transplantation, 81(9), 1337-44. PMID: 16699464.

Raikwar, S. P., Mueller, T. & Zavazava, N. (2006). Strategies for developing therapeutic application of human embryonic stem cells. Physiology (Bethesda, Md.), 21, 19-28. PMID: 16443819.

Doshi, D. R., Ballas, Z. K., Tabata, Y., Filipovich, L. & Zavazava, N. (2006). A Near Fatal Adenoviral Infection Caused by a Previously Unrecognized SH2D1A Mutation. (Vols. 116). (S), pp. S77(#108). J Allergy Clin. Immunol.

Dowden, A. M., Bonde, S., Hook, J. & Zavazava, N. (2006). Bone Morphogenic Protein-4 (BMP-4) Promotes in vivo Differentiation of Embryonic Stem Cells (ESC) into Lymphoid and Myeloid Hematopoietic Cells. (Suppl 2), pp. 186. Am J Transplant.

Raikwar, S. P., Zavazava, N. (2006). Real-Time in vivo Bioluminescence Imaging for Monitoring Insulin-Producing Cells from Embryonic Stem Cells. (Suppl 2), pp. 128. Am J Transplant.

Bonde, S., Hook, J. & Zavazava, N. (2006). Reprogramming of Adult Hematopoietic Cells by Fusion with Embryonic Stem Cells. (Vols. 6). (Suppl 2), pp. 218. Am J Transplant.

Raikwar, S. p., Mueller, T. (2006). Strategies for Developing Therapeutic Application of Human Embryonic Stem Cells. Physiology, 21, 19-28. DOI: 10.1152/physiol.00034.2005.

Fried, A., Berg, M., Sharma, B., Bonde, S. & Zavazava, N. (2005). Recombinant dimeric MHC antigens protect cardiac allografts from rejection and visualize alloreactive T cells. Journal of leukocyte biology, 78(3), 595-604. PMID: 16000395.

Fabricius, D., Bonde, S. & Zavazava, N. (2005). Induction of stable mixed chimerism by embryonic stem cells requires functional Fas/FasL engagement. Transplantation, 79(9), 1040-4. PMID: 15880040.

Chandraker, A., Huurman, V., Hallett, K., Yuan, X., Tector, A. J., Park, C. H., Lu, E., Zavazava, N. & Oaks, M. (2005). CTLA-4 is important in maintaining long-term survival of cardiac allografts. Transplantation, 79(8), 897-903. PMID: 15849541.

Dowden, A. M., Doshi, D. R. & Zavazava, N. (2005). Cyclosporine Resistant Atopic Dermatitis and Keratoconjuncticitis Treated with Mycophenolate. (Vols. 115). (S), pp. S106(#424). J Allergy Clin Immunol.

Berg, M., Zavazava, N. (2005). Expression of Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) in CD8+ T Cells Promotes the Internationalization and Intracellular Proteolytic Degradation of CD28. (Vols. 11). (5), pp. (#280). Am J Transplant.

Bonde, S. L., Scoville, H. & Zavazava, N. (2005). In vivo Imaging of the Homing and Migration of Embryonic Stem Cells and Allogeneic Lymphoid Tissue. (Vols. 11). (5), pp. (#1441). Allergy Clinic Immunol.

Mueller, T., Scoville, H., Bonde, S. L. & Zavazava, N. (2005). CD117+ cells derived from embryonic stem cells induce stable mixed chimerism in allogeneic recipients. (Vols. 11). (5), pp. (#1441). Am J Transplant.

Berg, M., Barnea, E., Admon, A. & Zavazava, N. (2004). A novel DNA methyltransferase I-derived peptide eluted from soluble HLA-A*0201 induces peptide-specific, tumor-directed cytotoxic T cells. International journal of cancer. Journal international du cancer, 112(3), 426-32. PMID: 15382068.

Fabricius, D., Bonde, S. & Zavazava, N. (2004). CD95/CD95L Engagement is a Requirement for Stable Embryonic Stem Cell Engraftment in Allogeneic Recipients. (Vols. 8). pp. 155. Transplantation.

Berg, M., Zavazava, N. (2004). CTLA-4 Enhances Endocytosis of CD28 and Abrogates Phosphorylation of TCR Proximal Tyrosine Kinase in CD8+ T Cells. (Vols. 8). (4), pp. 79 (#417). Am J Transplant.

Bonde, S., Zavazava, N. (2004). Embryonic Stem Cell Homing and Engraftment in Allogeneic Recipients Requires Functional FAS/FASL Engagement. (Vols. 78). (2), pp. 162. Am J Transplant.

Fabricius, D., Zavazava, N. (2004). Embryonic Stem Cells: Technical Aspects and Hurdles in Organ Transplantation. Curr Opin Organ Transplant, 9, 289-293. DOI: 10.1097/01.mot.0000136852.89056.44.

Zou, G. M., Zavazava, N. (2003). Potential applications of embryonic stem cells in organ transplantation. Transplantation proceedings, 35(7), 2827-9. PMID: 14612131.

Dresske, B., Zavazava, N., Jenisch, S., Exner, B., Lenz, P., El Mokhtari, N. E., Kremer, B. & Faendrich, F. (2003). WOFIE synergizes with calcineurin-inhibitor treatment and early steroid withdrawal in kidney transplantation. Transplantation, 75(8), 1286-91. PMID: 12717217.

Zavazava, N. (2003). Embryonic stem cells and potency to induce transplantation tolerance. Expert opinion on biological therapy, 3(1), 5-13. PMID: 12718727.

Berg, M., Welke, J. & Zavazava, N. (2003). CTLA-4 Antagonizes CD28 Surface Expression in V Cells. (Vols. 3). (Suppl), pp. 273. Am J Transplant.

Berg, M., Zavazava, N. (2003). CTLA-4 Antagonizes CD28 Surface Expression on T Cells. (Vols. 17). (7 (Suppl)), pp. C62-C62. FASEB J.

Fried, A., Zavazava, N. (2003). Dimeric Soluble MHC Class I Antigens Promote Graft Survival by Selectively Down Regulating Direct Recognition of Alloantigen. (Vols. 3). (Suppl), pp. 267. Am J Transplant.

Rickert, U., Welke, J. & Zavazava, N. (2003). Divalent HLA-B7 Up Regulates CD25 and CD69 in Alloreactive CD8- T Cells Bypassing CD28 Co-stimulation. (Vols. 3). (Suppl), pp. 435. Am J Transplant.

Bonde, S., Varzavand, A., Zou, G., Field, E., Walters, E., Wheeler, M. & Zavazava, N. (2003). Porcine-Derived Embryonic Stem Cells are Immune-Privileged and Resistant to Natural Killer Cell Lysis. (Vols. 3). (Suppl), pp. 546. Am J Transplant.

Zou, M., Zavazava, N. (2003). Potential Applications of Embryonic Stem Cells in Organ Transplantation. Transplant Proc, 35, 2827-2829. DOI: 10.1016/j.transproceed.2003.09.044.

Welke, J., Zavazava, N. (2002). P59(fyn) is upregulated in anergic CD8+ T cells. Human immunology, 63(10), 834-43. PMID: 12368035.

Noelle, B., Zavazava, N., Jenisch, S. & Westphal, E. (2002). Augenbanken.

Rickert, U., Zavazava, N. (2002). Dichotomy of Alloreactive CTL Regulation by Chimeric Dimeric HLA-B7 Molecules in vitro. (Vols. 2). (Suppl 3), pp. 1199. Am J Transplant.

Fresse, A., Zavazava, N. (2002). HLA-B7 ß-pleated sheet-derived synthetic peptides are immunodominant T-cell epitopes regulating alloresponses. Blood, 99(9), 3286–3292. DOI: 10.1182/blood.V99.9.3286.

Welke, J., Zavazava, N. (2002). P59fyn is upregulated in anergic CD8+ T cells. Human Immunology, 63(10), 834–843. DOI: 10.1016/S0198-8859(02)00455-X.

Von der Damerau-Dambrowski, V., Brockmeyer, N. H., Ewig, S., Wenisch, H. J., Füsgen, I., Ullmann, A. J., Zavazava, N., Jelinek, T., Shah, P. M., Von Knoblauch, G., Hülße, C. & Reinert, R. R. (2002). Pneumococci immunization. Atemwegs- und Lungenkrankheiten, 28(9), 454–460.

Adler, S. H., Bensinger, S. j. & Turka, L. A. (2002). Stemming the Tide of Rejection. (Vols. 8). pp. 107-108. Nature medicine. DOI: 10.1038/nm0202-107.

Barnea, E., Beer, I., Patoka, R., Ziv, T., Kessler, O., Tzehoval, E., Eisenbach, L., Zavazava, N. & Admon, A. (2002). Analysis of endogenous peptides bound by soluble MHC class I molecules: a novel approach for identifying tumor-specific antigens. European journal of immunology, 32(1), 213-22. PMID: 11782012.

Behrens, D., Lange, K., Fried, A., Yoo-Ott, K. A., Richter, K., Fändrich, F., Krönke, M. & Zavazava, N. (2001). Donor-derived soluble MHC antigens plus low-dose cyclosporine induce transplantation unresponsiveness independent of the thymus by down-regulating T cell-mediated alloresponses in a rat transplantation model. Transplantation, 72(12), 1974-82. PMID: 11773898.

Sharma, B. B., Behrens, D., Kabelitz, D. & Zavazava, N. (2001). Peptide loaded allogeneic divalent MHC class i molecules visualize allo-reactive T-cells and discriminate tolerant from rejecting graft recipients. (Vols. 1). pp. 981. Am J Transplant.

Yoo-Ott, K. A., Fricke, B., Steude, J. & Zavazava, N. (2001). Recombinant dimeric MHC class I molecules stain in vitro generated allo-reactive T cells and show a critical role for CD8. (Vols. 1). pp. 107. Am J Transplant.

Janssen, E., Göhlen, B., Behrens, D., Richter, K. & Zavazava, N. (2001). Allogeneic recombinant soluble MHC class I molecules modify urinary odor cues in rats. Physiology & behavior, 72(1-2), 107-14. PMID: 11239987.

Stegmann, S., Müller, A. & Zavazava, N. (2000). Synthetic HLA-A2 derived peptides are recognized and presented in renal graft recipients. Human immunology, 61(12), 1363-9. PMID: 11163094.

Steude, J., Zavazava, N. (2000). Charakterisierung von alloreaktiven CD8+ T-Zellen durch dimerisiertes HLA-B7. 9. Jahrestagung der deutschen Gesellschaft.

Kapasi, K., Albert, S. E., Yie, S., Zavazava, N. & Librach, C. L. (2000). HLA-G has a concentration-dependent effect on the generation of an allo-CTL response. Immunology, 101(2), 191-200. PMID: 11012772.

Zavazava, N., Kabelitz, D. (2000). Alloreactivity and apoptosis in graft rejection and transplantation tolerance. Journal of leukocyte biology, 68(2), 167-74. PMID: 10947059.

Yoo-Ott, K. A., Schiller, H., Fändrich, F., Oswald, H., Richter, K., Xhu, X. F., Kampen, W. U., Krönke, M. & Zavazava, N. (2000). Co-transplantation of donor-derived hepatocytes induces long-term tolerance to cardiac allografts in a rat model. Transplantation, 69(12), 2538-46. PMID: 10910274.

Kaven, C. W., Spraul, C. W., Zavazava, N. K., Lang, G. K. & Lang, G. E. (2000). Growth factor combinations modulate human retinal pigment epithelial cell proliferation. Current eye research, 20(6), 480-7. PMID: 10980660.

Zavazava, N., Fändrich, F., Zhu, X., Freese, A., Behrens, D. & Yoo-Ott, K. A. (2000). Oral feeding of an immunodominant MHC donor-derived synthetic class I peptide prolongs graft survival of heterotopic cardiac allografts in a high-responder rat strain combination. Journal of leukocyte biology, 67(6), 793-800. PMID: 10857851.

Zavazava, N. (2000). Allo-reactivity and Apoptosis in Graft Rejection and Transplantation Tolerance. J. Leukoc. Biol, 68, 167-174.

Steude, J., Zavazava, N. (2000). Characterisierung von alloreaktinen CD8+ T Zellen durch dimerisiertes HCA-B7. (Suppl), pp. S71. Transplantationsmedizin.

Steude, J., Kabelitz, D. & Zavazava, N. (2000). Chimeric Dimeric HLA-B7 Recombinant Molecules Regulate Alloreactive CD8+ T cells. (Vols. 203). pp. B15. Immunobiology.

Kabelitz, D., Schuetze, S. & Zavazava, N. (2000). Rationaler Einsatz der Zytokin-Diagnostik in der Intensivmedizin. Schleswit-Holsteinisches Aertzeblatt, 5(2), 38-40.

Noelle, B., Zavazava, N., Westphal, E., Jenisch, S. & Duncker, G. (2000). Stellenwert von HLA-Klasse II Antigenen bei Risikokeratoplastiken. (Vols. 41). (4), pp. 472. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde.

Spraul, C. W., Kaven, C., Zavazava, N., Lang, G. K. & Lang, G. E. (2000). Thalidomide and prednisolone inhibit growth factor-induced human RPE cell proliferation. (Vols. 41). (4), pp. 3206B304. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde.

Fändrich, F., Dresske, B., Lin, X., Huang, D. S., Zavazava, N. & Henne-Bruns, D. (1999). Allopeptide-mediated expression of endothelial Fas-ligand (CD95L) in long-term tolerized heterotopic rat heart grafts. Transplantation proceedings, 31(3), 1558-9. PMID: 10330999.

Fändrich, F., Zepernick-Kalinski, C., Gebhardt, H., Henne-Bruns, D., Zavazava, N. & Lin, X. (1999). The role of natural killer cell mediated caspases activation in a graft-versus-host disease model of semiallogeneic small bowel transplantation. Transplant immunology, 7(1), 1-7. PMID: 10375071.

Fändrich, F., Zhu, X., Schröder, J., Dresske, B., Henne-Bruns, D., Oswald, H. & Zavazava, N. (1999). Different in vivo tolerogenicity of MHC class I peptides. Journal of leukocyte biology, 65(1), 16-27. PMID: 9886242.

Janssen, E., Zavazava, N. (1999). How does the major histocompatibility complex influence behavior?. Archivum immunologiae et therapiae experimentalis, 47(3), 139-42. PMID: 10470440.

Dresske, B., Zavazava, N., Kremer, B. & Fandrich, F. (1999). Operational Tolerance ("WOFIE"): Characterization of the Effector Cells in a Rat Heart Transplantation Model. (Vols. 67). pp. S600. Transplantation.

Behrens, D., Lange, K., Kronke, M. & Zavazava, N. (1999). Soluble Recombinant MHC Class I Molecules Induce Indefinite Graft Survival. (Vols. 67). (7), pp. S69. Transplantation. DOI: 10.1097/00007890-199904150-00277.

Kaven, C., Amann, J., Spraul, C. W., Lang, G. K., Zavazava, N. & Lang, G. E. (1999). Synergistic effect of growth factor combinations on the proliferation of human cells in vitro.

Sharma, B. B., Yoo-Ott, K. A., Behrens, D., Kronke, M. & Zavazava, N. (1999). Visualization of Alloreactive T Cells by Rat MHC Class I Molecules. (Vols. 200). (003-005), pp. 335. Immunobiology.

Schiller, H., Yoo-Ott, K. A., Richter, K., Fandrich, F., Kronke, M. & Zavazava, N. (1999). Donor Hepatocytes, but not Intrahepatic Leukocytes Induce Graft-Specific Tolerance. (Vols. 67). (7), pp. S68. Transplantation. DOI: 10.1097/00007890-199904150-00276.

Fried, A., Behrens, D., Lange, K., Yoo-Ott, K. A., Kronke, M. & Zavazava, N. (1999). Donor Monomeric Class I Molecules Down-Regulate Cytolytic Alloresponse of T cells In Vivo. (Vols. 200). (003-005), pp. 483. Immunobiology.

Janssen, E. (1999). How Does the Major Histocompatibility Complex (MHC) Influence Behavior?. Arch. Immunol. Therapiae Exp, 47, 139-142.

Hansen, B., Janssen, E., Machleidt, T., Krönke, M. & Zavazava, N. (1998). Purified truncated recombinant HLA-B7 molecules abrogate cell function in alloreactive cytotoxic T lymphocytes by apoptosis induction. Transplantation, 66(12), 1818-22. PMID: 9884281.

Dresske, B., Zavazava, N., Huang, D. S., Lin, X., Kremer, B. & Fändrich, F. (1998). WOFIE augments the immunosuppressive potency of FK-506. Window of opportunity for immunological engagement. Transplant immunology, 6(4), 243-9. PMID: 10342738.

Dresske, B., Zavazava, N., Brötzmann, K., Kremer, B. & Fändrich, F. (1998). Tissue-specific immune response: the role of innate immunity in small bowel and heart transplantation. Transplantation proceedings, 30(6), 2566-7. PMID: 9745490.

Zavazava, N. (1998). Soluble HLA class I molecules: biological significance and clinical implications. Molecular medicine today, 4(3), 116-21. PMID: 9575494.

Dresske, B., Schröder, J., Zavazava, N., Kremer, B. & Fändrich, F. (1998). [Significance of allopeptide-induced expression of Fas ligand (FasL) in parenchyma of allogenic heart transplants as the cause of donor-specific tolerance induction]. Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress, 115(Suppl I), 83-7. PMID: 14518218.

Dresske, B., Schröder, J., Zavazava, N., Kremer, B. & Fändrich, F. (1998). Die Bedeutung der allopeptid-induzierten expression von Fas-Ligand (Fas-Lig) im paranchym allogener herztransplantate als ursache der spenderspezifischen toleranzinduktion. Langebecks Arc. Chir. Suppl. Kongressbld., 115, 83-87.

Dresske, B., Zavazava, N., Brotzmann, K., Kremer, B. & Fandrich, F. (1998). Innate Immunity in Small Bowel and Heart Transplantation. (Vols. 65). (12), pp. S28. Transplantation.

Drebke, B., Zavazava, N., Brötzmann, K., Kremer, B. & Fandrich, F. (1998). Innate Immunity in Small Bowel and Heart Transplantation. (Vols. 65). (12), pp. 28. Transplantation. DOI: 10.1097/00007890-199806270-00123.

Wobst, B., Zavazava, N., Luszyk, D., Lange, K., Ussat, S., Eggert, F., Ferstl, R. & Müller-Ruchholtz, W. (1998). Molecular forms of soluble HLA in body fluids: Potential determants of body odor cues. Genetica, 104(3), 275–283. DOI: 10.1023/A:1026487421626.

Hansen, B., Janssen, E., Machleidt, T., Kronke, M. & Zavazava, N. (1998). Purified truncated Recombinant HLA-B7 Molecules Abrogate Cell Function in Alloreactive Cytotoxic T Lymphocytes by Apoptosis Induction. (Vols. 66). (12), pp. 1818-1822. Transplantation. DOI: 10.1097/00007890-199812270-00041.

Zavazava, N., Kronke, M. (1998). Soluble MHC Class I Molecules Abrogate T Cell Function. Transplantation. (Vols. 65). (12), pp. 21. Transplantation. DOI: 10.1097/00007890-199805131-00075.

Dresske, B., Zavazava, N., Huang, D. S., Lin, X., Kremer, B. & Fändrich, F. (1998). WOFIE augments the immunosuppressive potency of FK-506. Transplant Immunology, 6(4), 243–249. DOI: 10.1016/S0966-3274(98)80014-2.

Schiller, H., Zhu, X., Yoo-Ott, K. A., Kroker, M. & Zavazava, N. (1997). Donor-derived hepatocytes induce indefinite cardiac allograft survival. Immunobiology, 197(2-4), 269.

Fandrich, F., Zhu, X., Kremer, B. & Zavazava, N. (1997). Donor-specific tolerance induction following allo-peptide immunization: An experimental study using an allogenic model of heart transplantation in the rat. Langenbecks Arch Chir Suppl Kongressbd, 114, 719-24.

Behrens, D., Jenisch, S., Kronke, M. & Zavazava, N. (1997). Enhanced IL-4 Expression after MHC-Peptide Induced Tolerance. (Vols. 196). pp. 249. Immunobiology.

Zavazava, N., Eggert, F. (1997). MHC and Behaviour. Immunol. Today, 18(1), 008-010. DOI: 10.1016/S0167-5699(97)80006-0.

Zavazava, N. (1997). Soluble MHC Class I Molecules: Biological and Clinical Significance. Molecular medicine today, 4(3), 116-121. DOI: 10.1016/S1357-4310(97)01185-4.

Zavazava, N., Eggert, F. (1997). MHC and behavior. Immunology today, 18(1), 8-10. PMID: 9018966.

Fändrich, F., Schröder, J., Jahnke, T., Dresske, B., Chambers, W. H. & Zavazava, N. (1996). Modulation of graft-vs-host-related disease by host-specific natural killer cell activity following semiallogeneic small bowel transplantation in the rat. Transplantation proceedings, 28(6), 3267-8. PMID: 8962268.

Fändrich, F., Schröder, J., Exner, B., Papachrysanthou, A., Peters, J., Chambers, W. & Zavazava, N. (1996). Correlation between graft-versus-host induced immunosuppression and host natural killer cell activity in small bowel transplantation. World journal of surgery, 20(8), 1041-51. PMID: 8798363.

Fändrich, F., Exner, B., Papachrysanthou, A., Jahnke, T., Chambers, W. H. & Zavazava, N. (1996). Impact of natural killer cells in mediating graft-versus-host disease following small bowel transplantation in a rat model. Transplantation proceedings, 28(5), 2465-6. PMID: 8907904.

Zavazava, N., Nölle, B., Duncker, G., Jenisch, S., Westphal, E., Eckstein, V. & Müller-Ruchholtz, W. (1996). Cross-matches on donor cadaver retinal pigment epithelial cells in corneal risk patients. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie, 234(3), 164-70. PMID: 8720715.

Fändrich, F., Jahnke, T., Peters, J., Exner, B., Papachrysanthou, A. & Zavazava, N. (1996). Circumvention of natural killer cell and T-cell mediated allogeneic target killing with tacrolimus (FK506) in small bowel transplantation related graft-vs-host disease. Transplant international : official journal of the European Society for Organ Transplantation, 9 Suppl 1, S263-8. PMID: 8959843.

Freese, A., Zavazava, N. (1996). Determination of HLA-B7 T-cell epitopes. Transplant international : official journal of the European Society for Organ Transplantation, 9 Suppl 1, S352-5. PMID: 8959863.

Zavazava, N., Kronke, M. (1996). Erratum: Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes (Nature Medicine 2, 1005-1010 (1996)). Nature Medicine, 2(11), 1267. DOI: 10.1038/nm1196-1267.

Fändrich, F., Exner, B., Papachrysanthou, A., Zhu, X., Jahnke, T., Chambers, W. H. & Zavazava, N. (1996). In vivo depletion of NKR-P1 positive cells in the recipient prior to small bowel transplantation enhances graft-versus-host disease (GvHD) in the rat. Transplant international : official journal of the European Society for Organ Transplantation, 9 Suppl 1, S275-80. PMID: 8959845.

Zavazava, N., Fandrich, F., Ott, K. A., Freese, A. & Turnewitsch, K. (1996). Rat MHC class I peptides are immunogenic. Transplant international : official journal of the European Society for Organ Transplantation, 9 Suppl 1, S337-9. PMID: 8959859.

Abendroth, D., Storck, M., Techt, B. & Zavazava, N. (1995). Analysis of the rejection markers tumor necrosis factor, ICAM-1, neopterin, interleukin-10, and soluble HLA in simultaneous pancreas and kidney transplantation with bladder drainage. Transplantation proceedings, 27(6), 3114-5. PMID: 8539869.

Jenisch, S., Westphal, E., Zavazava, N., Dürr, C., Duncker, G., Nölle, B. & Müller-Ruchholtz, W. (1995). DNA-based HLA class II postmortem typing: evaluation of different techniques for prospective corneal allografting. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie, 233(10), 635-41. PMID: 8529907.

Zavazava, N., Simon, A. & Müller-Ruchholtz, W. (1995). Evidence that the degeneration of heart valve grafts is immunologic. Transplantation proceedings, 27(3), 2107-8. PMID: 7792900.

Fändrich, F., Exner, B., Papachrysanthou, A., Chambers, W. H. & Zavazava, N. (1995). Paradoxical rejection pattern of donor small bowel in young F1-rats in a graft-versus-host strain combination. Transplantation proceedings, 27(2), 1620-1. PMID: 7725426.

Zavazava, N., Simon, A., Sievers, H. H., Bernhard, A. & Müller-Ruchholtz, W. (1995). Porcine valves are reendothelialized by human recipient endothelium in vivo. The Journal of thoracic and cardiovascular surgery, 109(4), 702-6. PMID: 7715217.

Zavazava, N., Duncker, G., Jenisch, S., Nölle, B., Westphal, E. & Müller-Ruchholtz, W. (1995). Anti-donor antibodies in allogeneic cornea transplantation. Transplantation proceedings, 27(1), 1410-1. PMID: 7878928.

Zavazava, N., Duncker, G., Jenisch, S., Nolle, B., Westphal, E. & Mullerruchholtz, W. (1995). Antidonor Antibodies in Allogeneic Cornea Transplantation. Transplantation Proceedings, 27(1), 1410–1411.

Zavazava, N., Stegmann, S., Freese, A. & Müller-Ruchholtz, W. (1995). Recognition of HLA-derived peptides in transplant patients. Transplantation proceedings, 27(1), 489-90. PMID: 7879072.

Zavazava, N. (1995). "T-cell, Tolerance Transplantation and Tumor,". N. Zavazava , N. Zavazava (Eds.) Pabst Science publishers.

Sommerville, B. A., Wobst, B., McCormick, J. P., Eggert, F., Zavazava, N. & Broom, D. M. (1995). Advances in Biosciences 93. In R. Apfelbach , D. Muller-Schwarze , K. Reutter , E. Weiler , R. Apfelbach & D. Muller-Schwarze , K. Reutter , E. Weiler (Eds.) Advances in Bioscience 94. pp. 535-538. Elsevier Science Ltd.

Luszyk, D., Wobst, B., Eggert, F., Zavazava, N., Müller-Ruchholtz, W. & Ferstl, R. (1995). Advances in Biosciences 93. In R. Apfelbach , D. Muller-Schwarze , K. Reutter , E. Weiler , R. Apfelbach & D. Muller-Schwarze , K. Reutter , E. Weiler (Eds.) Advances in Bioscience 94. pp. 523-528. Elsevier Science Ltd.

Wobst, B., Luszyk, D., Zavazava, N., Eggert, F., Ferstl, F. & Müller-Ruchholtz, W. (1995). Advances in Biosciences 93. In R. Apfelbach , D. Muller-Schwarze , K. Reutter , E. Weiler , R. Apfelbach & D. Muller-Schwarze , K. Reutter , E. Weiler (Eds.) Advances in Bioscience 94. pp. 517-522. Elsevier Science Ltd.

Zavazava, N., Stegmann, S. & Müller-Ruchholtz, W. (1995). HLA-A2 Derived Peptides are Recognized in Both the Direct and Indirect Pathways. (Vols. 9). (4), pp. 4751. FASEB J.

Stegmann, S., Müller-Ruchholtz, W. & Zavazava, N. (1995). Indirekte Erkennung HLA-A2 Abgeleiteter Peptide durch Nierenempfänger T-Lymphozyten. (Vols. 33). pp. 237-238. Z. Gastroenterol..

Wobst, B., Luszyk, D., Zavazava, N., Eggert, F., Ferstl, R. & Müller-Ruchholtz, W. (1995). Influence of the Menstrual Cycle on the Excretion of Soluble MHC Molecules in Humans. In R. Apfelbach , R. Apfelbach (Eds.) Chemical Signals iN Vertebrates VII. pp. 517-522. Springer Verlag.

Duncker, G., Nöelle, B., Zavazava, N., Westphal, E., Jenisch, S. (Eds.) (1995). Kornea transplantation: grundsätzliche betrachtungen zur immunologie. Deutsche Ärzteblatt, 92, A2010.

Luszyk, D., Wobst, B., Eggert, F., Zavazava, N., Müller-Ruchholtz, W. & Ferstl, R. (1995). MHC Molecules and Urine Odor Formation. In R. Apfelbach , R. Apfelbach (Eds.) Chemical Signals iN Vertebrates VII. pp. 523-528. Springer Verlag.

Zavazava, N., Yoo-Ott, K. A. & Fandrich, F. (1995). Organ transplantation in Rats and Mice. In W. Timmermann , H. J. Gassel & R. Ulrichs , A. Zhong , A. Thiede , W. Timmermann , H. J. Gassel , R. Ulrichs , A. Zhong , A. Thiede (Eds.) Organ transplantation in Rats and Mice. pp. 277-284. Springer.

Zavazava, N., Ferstl, R. & Müller-Ruchholtz, W. (1995). Physiological Regulation and Influence of Soluble MHC Class I Molecules in Humans on Body Odor.

Zavazava, N., Ferstl, R. & Müller-Ruchholtz, W. (1995). Regulation of Soluble MHC Class I Molecules. In R. Apfelbach , D. Muller-Schwarze & K. Reutter , E. Weiler , R. Apfelbach , D. Muller-Schwarze , K. Reutter , E. Weiler (Eds.) Advances in Bioscience 93. pp. 507-510. Elsevier Science Ltd.

Somerville, B. A., Wobst, B., McCormick, J. P., Zavazava, N. & Broom, D. M. (1995). Volatile Identity Signals in Human Axillary Sweat: The Possible Influence of Class I HLA Loci. In R. Apfelbach , R. Apfelbach (Eds.) Chemical Signals in Vertebrates VII. pp. 535-538. Springer Verlag.

Duncker, G., Nölle, B., Fricke, I., Robiller, S., Zavazava, N., Westphal, E., Jenisch, S. & Müller-Ruchholz, W. (1995). Zwei jahre hornhautbank Kiel-eine zwischenbilanz. Klinische Monatsblaetter fuer Augenheilkunde, 204(136).

Zavazava, N., Müller-Ruchholtz, W. (1994). Quantitative and biochemical characterization of soluble HLA class I antigens shed by cultured human cells. Human immunology, 40(3), 174-8. PMID: 7960959.

Claus, R., Hausmann, S., Zavazava, N., Walzel, H., Schulze, H. A., Köhler, H., Friemel, H. & Müller-Ruchholtz, W. (1994). In vitro effects of solubilized HLA-DR--role in immunoregulation?. Cellular immunology, 155(2), 476-85. PMID: 8181077.

Eggert, F., Wobst, B., Höller, C., Uharek, L., Luszyk, D., Zavazava, N., Müller-Ruchholtz, W. & Ferstl, R. (1994). Determinanten der Chemosensorischen Identität: Ein Model für die Olfaktorische Expresison von MHC-Genen. TW Neurologie et Psychiatrie, 8, 90-95.

Zavazava, N., Muller-Ruchholtz, W. (1994). Human liver MHC class I molecules and their ability to prolong graft-survival. Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft, 6(1), 60–62.

Stegmann, S., Zavazava, N., Freese, A. & Müller-Ruchholtz, W. (1994). Indirect Recognition of HLA-A2 Derived Peptides. (Vols. 191). pp. 168. Immunobiology.

Zavazava, N., Müller-Ruchholtz, W. (1994). Molekulare Heterogenität Menschlicher Leber MHC-Klasse-I-Antigene und ihr Potential Alloreaktive T-Zellen zu Blockieren. (Vols. 32). pp. 311. Ger. J. Gastroenterol.

Eggert, F., Wobst, B., Höller, C., Luszyk, D., Uharek, L., Zavazava, N., Müller-Ruchholtz, W. & Ferstl, R. (1994). Olfactory expression of the MHC = Olfaktorische expression des MHC. Psychologische Beiträge, 36(1/2), 158-163.

Eggert, F., Wobst, B., Zavazava, N., Müller-Ruchholtz, W. & Ferstl, R. (1994). Psychobiology of the immune system: behavioural factors in the maintenance of immunogenetical variability = Psychobiologie des immunsystems: behaviorale faktoren bei der aufrechterhaltung immungenetischer variabilität. Psychologische Beiträge, 36(1/2), 152-157.

Prinz, S., Zavazava, N., Schroder, O. J. & Müller-Ruchholtz, W. (1994). Soluble HLA-DR in Autoimmune Disease Patients. (Vols. 191). pp. 107. Immunobiology.

Zavazava, N., Wobst, B., Ferstl, R. & Müller-Ruchholtz, W. (1994). Soluble MHC class I molecules in human body fluids. Journal of clinical laboratory analysis, 8(6), 432-6. PMID: 7869184.

Fandrich, F., Exner, B., Papachrysanthou, A., Chambers, W. H. & Zavazava, N. (1994). Verschiebung des Immunologischen Gleichgewichts Zwischen Spender und Empfänger am Beispiel der Heterotopen Dünndarmtransplantation im Graft-versus-Host Modell. (Vols. S14). (Suppl I.) Transplantationsmed.

Simon, A., Zavazava, N., Sievers, H. H. & Müller-Ruchholtz, W. (1993). In vitro cultivation and immunogenicity of human cardiac valve endothelium. Journal of cardiac surgery, 8(6), 656-65. PMID: 8286871.

Zavazava, N., Böttcher, H. & Ruchholtz, W. M. (1993). Soluble MHC class I antigens (sHLA) and anti-HLA antibodies in heart and kidney allograft recipients. Tissue antigens, 42(1), 20-6. PMID: 8248891.

Hirsch, N., Nölle, B., Zavazava, N., Westphal, E., Duncker, G., Rochels, R. & Müller-Ruchholtz, W. (1993). [HLA typing in high risk keratoplasty]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 90(2), 174-7. PMID: 8490302.

N, H., B, N., N, Z., E, W., G, D., R, R. & W, M. (1993). [HLA typing in high risk keratoplasty]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 90(2), 174–177. PMID: 8490302.

Warambwa, C. A., Zavazava, N., Claus, R. & Müller-Ruchholtz, W. (1993). Isolation, Quantification and Biochemical Characterization of Serum and Cell Membrane-Derived MHC Class II Molecules. (Vols. 189). pp. 68. Immunobiology.

Henseler, T., Westphal, E., Jenisch, S., Nair, R. P., Zavazava, N., Elder, J. T., Voorhees, J. J. & Christophers, E. (1993). Mechanism of Linkage Disequilibrium Between CW6 and DR7 in Type I Psoriasis: Examples of Inheritance. (Vols. 100). pp. 320. Trans. J. Invest. Dermatol..

Zavazava, N. (1993). Neue molekulare Konzepte zur Senkung der Transplantatabstossung: Grundlage und klinische Bedeutung löslicher MHC-Klasse-I-Moleküle und postmortale Gewebetypisierung. Lengerich; Berlin; Prag; Riga; Wien; Zagreb: Pabst.

Hausmann, R., Zavazava, N., Steinmann, J. & Müller-Ruchholtz, W. (1993). Interaction of papain-digested HLA class I molecules with human alloreactive cytotoxic T lymphocytes (CTL). Clinical and experimental immunology, 91(1), 183-8. PMID: 8419081.

Freese, A., Zavazava, N. & Müller-Ruchholtz, W. (1993). Synthesis, Purification and In Vitro Biological Studies of MHC Peptides. (Vols. 189). pp. 54. Immunobiology.

Bottcher, H., Zavazava, N., Steinmann, J. & Müller-Ruchholtz, W. (1992). Anti-HLA-Antikörper nach Herztransplantation. (Vols. 26). (Suppl I.) Zschr. Transplantationsmed.

Wobst, B., Zavazava, N. & Müller-Ruchholtz, W. (1992). Biochemische Charakterisierung von Löslichen MHC-Klasse-I-Molekülen in Menschlichen Körperflüssigkeiten. (Vols. 19). pp. 315. Infusionsther. und Transfusionsmed.

Zavazava, N., Hausmann, R., Kraatz, E. & Müller-Ruchholtz, W. (1992). Clinical relevance of soluble HLA and interaction of papain derived class I molecules with alloreactive CTL. Transplant international : official journal of the European Society for Organ Transplantation, 5 Suppl 1, S606-8. PMID: 14621888.

Jenisch, S., Westphal, E., Zavazava, N. & Müller-Ruchholtz, W. (1992). Cornea-Bank Kiel (CBK): Prospektive Spender-Empfänger-Auswahl durch HLA-Klasse-I- und -II-Matching bei Patienten mit Erhöhtem Abstobungsrisiko. (Vols. 19). pp. 307. Infusionsther. und Transfusionsmed.

Jenisch, S., Westphal, E., Marget, M., Zavazava, N. & Müller-Ruchholtz, W. (1992). HLA-DRB1-Typisierung mit Nicht-Radioactiv Markierten Sequenz-Spezifischen Oligonukleotiden (PCR-SSO) bei Hornhauttransplantation. (Vols. 19). pp. 307. Infusionsther. und Transfusionsmed.

Claus, R., Zavazava, N., Hausmann, S., Schulze, H. A., Walzel, H., Kohler, H., Friemel, H. & Müller-Ruchholtz, W. (1992). Immunomodulation In Vitro by Soluble HLA-DR. (Vols. 19). pp. 307. Infusionsther. und Transfusionsmed.

Ferstl, R., Eggert, F., Westphal, E., Zavazava, N. & Müller-Ruchholtz, W. (1992). MHC-Related Odors in Humans. In R. L. Doty , R. L. Doty (Eds.) Chemical Signals in Vertebrates VI. pp. 205-211. Plenum Publishing.

Zavazava, N., Westphal, E., Duncker, G., Nölle, B. & Müller-Ruchholtz, W. (1992). Post-mortem HLA tissue typing of retinal pigment epithelial cells. Scandinavian journal of immunology. Supplement, 11, 192-4. PMID: 1514040.

Schwehn, S., Zavazava, N., Dreger, P., Schmitz, N., Loffler, H. & Müller-Ruchholtz, W. (1992). sHLA Levels after Bone Marrow Transplantation: Influence of G-CSF Administration. (Vols. 186). pp. 13. Immunobiology.

Wobst, B., Zavazava, N. & Müller-Ruchholtz, W. (1992). Soluble MHC Class I Molecules in Human Body Fluids. (Vols. 186). pp. 15. Immunobiology.

Bottcher, H., Zavazava, N., Steinmann, J., Westphal, E. & Müller-Ruchholtz, W. (1992). Verbesserung der Nachweisbarkeit von Anti-HLA-Antikörpern nach Transplantation. (Vols. 19). pp. 305. Infusionsther. und Transfusionsmed.

Hausmann, R., Zavazava, N. & Müller-Ruchholtz, W. (1991). Interaction of purified HLA class I molecules with alloreactive CTL. Transplantation proceedings, 23(4), 2255-7. PMID: 1871864.

Zavazava, N., Kraatz, E., Gassel, A. M. & Müller-Ruchholtz, W. (1991). Plasma MHC class I expression in cardiac graft patients: donor-specific soluble antigen in a presensitised graft patient. Transplantation proceedings, 23(4), 2258-60. PMID: 1871865.

Zavazava, N., Hausmann, R. & Müller-Ruchholtz, W. (1991). Inhibition of anti-HLA-B7 alloreactive CTL by affinity-purified soluble HLA. Transplantation, 51(4), 838-42. PMID: 2014539.

Zavazava, N., Halene, M., Westphal, E., Nölle, B., Duncker, G., Eckstein, E., Harpprecht, J. & Müller-Ruchholtz, W. (1991). Expression of MHC class I and II molecules by cadaver retinal pigment epithelium cells: optimization of post-mortem HLA typing. Clinical and experimental immunology, 84(1), 163-6. PMID: 1901778.

Nölle, B., Halene, M., Zavazava, N., Westphal, E., Duncker, G. & Müller-Ruchholtz, W. (1991). [Postmortem serologic and biochemical HLA typing with cultivated retinal pigment epithelium cells]. Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 88(6), 629-32. PMID: 1794780.

Zavazava, N., Müller-Ruchholtz, W. (1991). Distribution, Heterogeneity and Quantitative Differences of Human Serum Class I Products. (Vols. 4). pp. 63. Chem. Signals Vertebrates.

Hirsch, N., Nölle, B., Zavazava, N., Westphal, E., Duncker, G. & Müller-Ruchholtz, W. (1991). HLA Typisierung bei Risikokeratoplastiken. Fortschr. Ophthmal. (Vols. 88). (Suppl I.), pp. 218. Immunobiology.

Ferstl, R., Eggert, F., Pause, B., Schuler, D., Luszyk, E., Westphal, N., Zavazava, N. & Müller-Ruchholtz, W. (1991). Immune System Signaling to the Others Brain: MHC-Specific Body Scents in Humans. In R. C. Frederickson , J. L. McGaugh , D. L. Felten , R. C. Frederickson , J. L. McGaugh , D. L. Felten (Eds.) Neuronal Control of Bodily Function basic and Clinical Aspects. Peripheral Signaling of the Brain. pp. 497-502. Hogrefe & Huber Publishers.

Claus, R., Schulze, H. A., Schiller, H., Slowik, C., Friemel, H., Walzel, H., Zavazava, N. & Müller-Ruchholtz, W. (1991). Immunosuppressive Effects of Soluble HLA-DR Molecules. (Vols. 183). pp. 268. Immunobiology.

Ferstl, R., Eggert, F., Westphal, E., Zavazava, N. & Müller-Ruchholtz, W. (1991). MHC-Related Odors in Humans. (Vols. 4). pp. 57. Chem. Signals Vertebrates.

Nolle, B., Halene, M., Zavazava, N., Westphal, E., Duncker, G. & Muller-Ruchholtz, W. (1991). Postmortem serological and biochemical HLA typing using cultured human retinal pigment epithelial cells. Fortschritte der Ophthalmologie, 88(6), 629–632.

Simon, A., Zavazava, N., Sievers, H. H., Kraatz, E., Loose, R., Wottge, H. U. & Müller-Ruchholtz, W. (1991). Volatile Identity Signals in Human Axillary Sweat: The Possible Influence of Class I HLA Loci. (Vols. 183). pp. 276. Immunobiology.

Zavazava, N., Westphal, E. & Müller-Ruchholtz, W. (1990). Characterization of soluble HLA molecules in sweat and quantitative HLA differences in serum of healthy individuals. Journal of immunogenetics, 17(6), 387-94. PMID: 2096183.

Hausmann, R., Zavazava, N. & Müller-Ruchholtz, W. (1990). Affinity-purified HLA class I molecules specifically inhibit a human CTL line in vitro. Transplantation proceedings, 22(4), 1874-5. PMID: 2389467.

Zavazava, N., Westphal, E., Olofsson, L., Treumer, J., Eckstein, V. & Müller-Ruchholtz, W. (1990). Expression of soluble class I molecules in healthy persons and renal graft patients. Transplantation proceedings, 22(4), 1876-7. PMID: 2389468.

B, N., M, H., N, Z., E, W., G, D. & W, M. (1990). [Postmortem serologic and biochemical HLA typing with cultivated retinal pigment epithelium cells]. Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 88(6), 629–632. PMID: 1794780.

Zavazava, N., Hausmann, R., Steinmann, J. & Muller Ruchholtz, W. (1990). In vitro inhibition of alloreactive human CTL by soluble HLA class I molecules. EOS Rivista di Immunologia ed Immunofarmacologia, 10(4), 230.

Zavazava, N., Leimenstoll, G. & Müller-Ruchholtz, W. (1990). Measurement of soluble MHC class I molecules in renal graft patients: a noninvasive allograft monitor. Journal of clinical laboratory analysis, 4(6), 426-9. PMID: 2283561.

Halene, M., Zavazava, N., Westphal, E., Nölle, B., Duncker, G. & Müller-Ruchholtz, W. (1990). Post-Mortem MHC Class I and II Typing on Retinal Pigment Epithelial Cells. (Vols. 181). pp. 243. Immunobiology.

Hausmann, N., Zavazava, N. & Müller-Ruchholtz, W. (1990). Soluble Human MHC Class I Molecules Down Regulate Cytotoxicity of Alloreactive CTL. (Vols. 181). pp. 144. Immunobiology.

Zavazava, N., Müller-Ruchholtz, W. (1989). Biochemical Nature of Serum Class I Antigens. (Vols. 3). pp. 1715. FASEB J.

Hausmann, R., Zavazava, N., Steinmann, J. & Müller-Ruchholtz, W. (1989). Specific Inhibition of Alloreactive Human Cytotoxic T Lymphocytes by Souluble HLA Class I Molecultes. (Vols. 9). pp. 119. EOS-J. Immunol. Immunopharmacol..

Zavazava, N. (1988). Lichtmikroskopisches und ultrastrukturelles Reaktionsmuster sowie Molekulargewichtsbestimmung der Antigene der monoklonalen Antikörper Ki-M1 [Ki-M], Ki-M6 [Ki-M] und Ki-M8 [Ki-M]. Kiel: University of Kiel.

Radzun, H. J., Kreipe, H., Zavazava, N., Hansmann, M. L. & Parwaresch, M. R. (1988). Diversity of the human monocyte/macrophage system as detected by monoclonal antibodies. Journal of leukocyte biology, 43(1), 41-50. PMID: 3275733.

Kyba, M. An ES cell-derived immune system. pp. 2948-4949. Blood III.

Wobst, B., Zavazava, N., Luszyk, D., Lange, K., Ussat, S., Eggert, F., Ferstl, R. & Müller-Ruchholtz, W. Molecular forms of soluble HLA in body fluids: potential determinants of body odor cues. Genetica, 104(3), 275-83. PMID: 10386394.

Kaven, C., Spraul, C. W., Zavazava, N., Lang, G. K. & Lang, G. E. Thalidomide and prednisolone inhibit growth factor-induced human retinal pigment epithelium cell proliferation in vitro. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde, 215(4), 284-9. PMID: 11399936.