1. People

Olha Koval, PhD

Research Assistant Professor of Internal Medicine-Cardiovascular Medicine

Current Positions

  • Research Assistant Professor of Internal Medicine-Cardiovascular Medicine

Education

  • PhD, Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
  • Postdoctoral Fellow, Pharmacology, University College London, London, England
  • Postdoctoral Fellow, Physiology, University of Texas Health Science Center, San Antonio, Texas
  • Postdoctoral Fellow, Biophysics, University of Iowa Carver College of Medicine, Iowa City, Iowa

Selected Publications

  • Koval, O. M., Nguyen, E. K., Santhana, V., Fidler, T. P., Sebag, S. C., Rasmussen, T. P., Mittauer, D. J., Strack, S., Goswami, P. C., Abel, E. D. & Grumbach, I. M. (2019). Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation. Science signaling 12 (579). DOI: 10.1126/scisignal.aav1439. PMID: 31040260. PMCID: PMC6768401.
  • Pennington, S. M., Klutho, P. R., Xie, L., Broadhurst, K., Koval, O. M., McCormick, M. L., Spitz, D. R. & Grumbach, I. M. (2018). Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription. Redox biology 16 401-413. DOI: 10.1016/j.redox.2018.04.001. PMID: 29649787. PMCID: PMC5953240.
  • Nguyen, E. K., Koval, O. M., Noble, P., Broadhurst, K., Allamargot, C., Wu, M., Strack, S., Thiel, W. H. & Grumbach, I. M. (2018). CaMKII (Ca2+/Calmodulin-Dependent Kinase II) in Mitochondria of Smooth Muscle Cells Controls Mitochondrial Mobility, Migration, and Neointima Formation. Arteriosclerosis, thrombosis, and vascular biology 38 (6) 1333-1345. DOI: 10.1161/ATVBAHA.118.310951. PMID: 29599132. PMCID: PMC5970052.
  • Sebag, S. C., Koval, O. M., Paschke, J. D., Winters, C. J., Comellas, A. P. & Grumbach, I. M. (2018). Inhibition of the mitochondrial calcium uniporter prevents IL-13 and allergen-mediated airway epithelial apoptosis and loss of barrier function. Experimental cell research 362 (2) 400-411. DOI: 10.1016/j.yexcr.2017.12.003. PMID: 29225050. PMCID: PMC6330015.
  • Murthy, S., Koval, O. M., Ramiro Diaz, J. M., Kumar, S., Nuno, D., Scott, J. A., Allamargot, C., Zhu, L. J., Broadhurst, K., Santhana, V., Kutschke, W. J., Irani, K., Lamping, K. G. & Grumbach, I. M. (2017). Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity. PloS one 12 (10) e0186311. DOI: 10.1371/journal.pone.0186311. PMID: 29059213. PMCID: PMC5653296.
  • Koval, O. M., Paschke, J. D., Winters, C. J., Jaffer, O. A., Dworski, R., Sutterwala, F. S., Anderson, M. E., Grumbach, I. M. & Sebag, S. C. (2017). Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma. JCI insight 2 (3) e88297. PMID: 28194433. DOI: 10.1172/jci.insight.88297.
  • Winters, C. J., Koval, O., Murthy, S., Allamargot, C., Sebag, S. C., Paschke, J. D., Jaffer, O. A., Carter, A. B. & Grumbach, I. M. (2016). CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosis. American journal of physiology. Lung cellular and molecular physiology 310 (1) L86-94. DOI: 10.1152/ajplung.00132.2015. PMID: 26545899. PMCID: PMC4698436.
  • Rasmussen, T. P., Wu, Y., Joiner, M. L., Koval, O. M., Wilson, N. R., Luczak, E. D., Wang, Q., Chen, B., Gao, Z., Zhu, Z., Wagner, B. A., Soto, J., McCormick, M. L., Kutschke, W., Weiss, R. M., Yu, L., Boudreau, R. L., Abel, E. D., Zhan, F., Spitz, D. R., Buettner, G. R., Song, L. S., Zingman, L. V. & Anderson, M. E. (2015). Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proceedings of the National Academy of Sciences of the United States of America 112 (29) 9129-34. DOI: 10.1073/pnas.1504705112. PMID: 26153425. PMCID: PMC4517214.
  • Wu, Y., Rasmussen, T. P., Koval, O. M., Joiner, M. L., Hall, D. D., Chen, B., Luczak, E. D., Wang, Q., Rokita, A. G., Wehrens, X. H., Song, L. S. & Anderson, M. E. (2015). Corrigendum: The mitochondrial uniporter controls fight or flight heart rate increases. (Vols. 6). pp. 7241. Nature communications. DOI: 10.1038/ncomms8241. PMID: 26037243. PMCID: PMC5132347.
  • Joiner, M. L. & Koval, O. M. (2014). CaMKII and stress mix it up in mitochondria. Frontiers in pharmacology 5 67. DOI: 10.3389/fphar.2014.00067. PMID: 24822046. PMCID: PMC4013469.

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