Qian Shi, PhD
Research Assistant Professor of Internal Medicine-Endocrinology and Metabolism
Current Positions
- Research Assistant Professor of Internal Medicine-Endocrinology and Metabolism
Education
- PhD, Nankai University, Tianjin, China
- Postdoctoral Fellow, Pharmacology, University of Illinois at Urbana Champaign, Urbana, Illinois
- Postdoctoral Fellow, Pharmacology, University of California, Davis, Davis, California
Selected Publications
- Wang Y, Zhao M, Shi Q, Xu B, Zhu C, Li M, Mir V, Bers DM, Xiang YK. Monoamine Oxidases Desensitize Intracellular β1AR Signaling in Heart Failure. Circulation Research. 2021. Oct 29;129(10):965-967.
- Nelson MM, Efird JT, Kew KA, Katunga LA, Monroe TB, Doorn JA, Beatty CN, Shi Q, Akhter SA, Alwair H, Robidoux J, Anderson EJ. Enhanced Catecholamine Flux and Impaired Carbonyl Metabolism Disrupt Cardiac Mitochondrial Oxidative Phosphorylation in Diabetes Patients. Antioxid Redox Signal. 2021 Aug 1;35(4):235-251.
- Wang Y*, Shi Q*, Li MH, Zhao MM, Gopireddy RR, Teoh JP, Xu B, Zhu CQ, Ireton KE, Srinivasan S, Chen SL, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK. Intracellular β1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate 3 Phospholamban Phosphorylation to Enhance Cardiac Contractility. Circulation Research. 2021 Jan 22;128(2):246-261. (*Co-first author)
- Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Raghavender Reddy G, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintrón M, Xiang YK. GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failure. Circulation Research. 2020 Aug 28;127(6):796-810.
- Riehle C, Weatherford ET, Wende AR, Jaishy BP, Seei AW, McCarty NS, Rech M, Shi Q, Reddy GR, Kutschke WJ, Oliveira K, Pires KM, Anderson JC, Diakos NA, Weiss RM, White MF, Drakos SG, Xiang YK, Abel ED. Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. JCI Insight. 2020 Mar; 26;5(6): e134920.
- Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, Martinez JM, Man KM, Nieves-Cintron M, Hell JW, Navedo MF, Yu XY, Xiang YK. β-blockers Augment L-type Ca 2+ Channel Activity by Targeting Spatially Restricted β2 AR Signaling in Neurons. Elife 2019 Oct 14; 8: e49464.
- Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK. Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. J Gen Physiol. 2018 Nov 5;150(11):1567-1582.
- Shi Q, Li M, Mika D, Fu Q, Kim S, Phan J, Shen A, Vandecasteele G, Xiang YK. Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes. Cardiovascular Research. 2017. Feb 113(6): 656-670.
- Barbagallo F, Xu B, Reddy GR, West T, Wang Q, Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure. Circulation Research. 2016 Sep 30;119(8):931-43.
- Fu Q, Shi Q, West TM, Xiang YK. Crosstalk between insulin signaling and GPCRs. J Cardiovasc Pharmacol. 2017 Aug; 70(2): 74–86.