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Ravinder Reddy Gaddam, PhD

Research Assistant Professor of Internal Medicine-Cardiovascular Medicine

Current Positions

  • Research Assistant Professor of Internal Medicine-Cardiovascular Medicine

Education

  • MS (Pharm), Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, India
  • PhD, Pathology, University of Otago-Christchurch, New Zealand
  • Postdoctoral Research Scholar, Department of Internal Medicine, University of Iowa, Iowa City, Iowa

Center, Program and Institute Affiliations

Selected Publications

  • Li Q, Zhang Q, Kim YR, Gaddam RR, Jacobs JS, Bachschmid MM, Cai A, Younis T, Zingman L, Taylor E, Norris A, Vikram A. Irani K. Endothelial Sirtuin1 Suppresses Whole-body Insulin Sensitivity by Modulating the Secretome. Nature Communications. 2023. 14(1), 5595. doi: 10.1038/s41467-023-41351-1.
  • Yoon JY, Greiner AM, Jacobs JS; Kim YR, Rasmussen TP, Kutschke W; Matasic DS, Vikram A, Gaddam RR, Mehdi H, Irani K, London B. SUMOylation of the Cardiac Sodium Channel NaV1.5 Modifies Inward Current and Cardiac Excitability. Heart Rhythm. 2023. 02549-3 (23), S1547-5271. doi: 10.1016/j.hrthm.2023.07.067.
  • Gaddam RR, Amalkar VS, Sali VK, Nakuluri K, Julie JS, Kim YR, Li Q, Bahal R, Irani K, Vikram A. Role of miR-204 in segmental cardiac effects of phenylephrine and pressure overload. Biochemical and Biophysical Research Communications. 2023, 672, 85-91. doi: 10.1016/j.bbrc.2023.07.011.
  • Martz LM, Geesala R, Gaddam RR, Shi XZ. Understanding the role of gut hormones, microbiota, and miRNAs in metabolic regulation and glucose homeostasis in obesity and type-2-diabetes. Frontiers in Endocrinology. 2023, 14, 1-2. doi: 10.3389/fendo.2023.1255942.
  • Yadav P, Sarode LP, Gaddam RR, Kumar P, Bhatti JS, Khurana A, Navik U. Zebrafish as an emerging tool for drug discovery and development for thyroid diseases. Fish & Shellfish Immunology. 2022, 130, 53-60. doi: 10.1016/j.fsi.2022.09.001.
  • Gundu C, Arruri VK, Yadav P, Navik U, Kumar A, Amalkar VS, Vikram A, Gaddam RR*. Dynamin-independent mechanisms of endocytosis and receptor trafficking. Cells. 2022, 11(6). *Corresponding author. doi: 10.3390/cells11162557.
  • Gaddam RR, Dhuri K, Kim YR, Jacobs JS, Li Q, Irani K, Bahal R, Vikram A. γ peptide nucleic acid-based miR-122 inhibition rescues vascular endothelial dysfunction in mice fed a high-fat diet. Journal of Medicinal Chemistry. 2022, 1c01831. doi: 10.1021/acs.jmedchem.1c01831.
  • Gaddam RR, Kim YR, Jacobs JS, Yoon JY, Li Q, Shankaiahgari H, London B, Irani K, Vikram A. The microRNA-204-5p inhibits APJ signaling and confers resistance to cardiac hypertrophy and dysfunction. Clinical and Translational Medicine. 2022, 12(1), e693. doi: 10.1002/ctm2.693.
  • Momin MY, Gaddam RR, Kravitz M, Gupta A, Vikram A. The challenges and opportunities in the development of microRNA therapeutics: A multidisciplinary viewpoint. Cells. 2021, 10(11), 3097. doi: 10.3390/cells10113097.
  • Navik U, Sheth VG, Khurana A, Jawalekare SS, Allawadhi P, Gaddam RR, Bhatti JS, Tikoo K. Methionine as a double-edged sword in health and disease: Current perspective and future challenges. Ageing Research Reviews. 2021, 17, 1105-1110. doi: 10.1016/j.arr.2021.101500.