Raymond J. Hohl, MD, PhD

Portrait
Emeritus Professor of Internal Medicine - Hematology, Oncology and Blood and Marrow Transplantation

Contact Information

Education

BS, Biochemistry, University of Illinois
MD, Rush Medical College, Rush University
PhD, Pharmacology, Graduate College, Rush University

Resident, University of Chicago
Fellow, Hematology/Oncology, University of Chicago

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Molecular and Cellular Biology, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Research Summary

Dr. Hohl's research interests focus on understanding the interactions between mevalonic acid and cholesterol biosynthesis and the proliferation of acute myeloid leukemia cells. These studies investigate the relative affinities of various growth regulating proteins, such as RAS and KREV1, for the isoprene intermediates of the mevalonic acid to cholesterol biosynthetic pathway. His clinical interests involve evaluation of the potential role for pharmacologic inhibitors of this biosynthetic pathway in the treatment of various hematologic malignancies and solid tumors. Additionally, he has continued interest in studying how various erythrocyte enzymothathies predispose the human red blood cell to drug-induced oxidative damage.