1. Home
  2. Faculty

Rebecca Dodd, PhD

Associate Professor of Internal Medicine-Hematology, Oncology, and Blood and Marrow Transplantation
Photo of Rebecca Dodd, PhD
Rebecca Dodd, PhD - University of Iowa
rebecca-dodd@uiowa.edu
Dr. Dodd's lab
ORCID record

Introduction

The Dodd lab studies soft-tissue sarcomas, a type of cancer that develops in connective tissue such as muscle, nerves, fat, or tendons. Our research program designs and utilizes powerful in vivo model systems to directly address critical questions in tumor biology. Specific areas of research include 1) the genetics of sarcoma, 2) the tumor microenvironment, 3) preclinical platform applications, and 4) novel genome editing tools.

Current Positions

  • Associate Professor of Internal Medicine-Hematology, Oncology, and Blood and Marrow Transplantation

Education

  • Postdoctoral Fellow, Radiation Oncology, Duke University Medical Center, Durham, North Carolina
  • PhD, Cell Biology, Duke University, Durham, North Carolina

Graduate Program Affiliations

Center, Program and Institute Affiliations

Selected Publications

  • Swier VJ, White KA, Negrão de Assis PL, Johnson TB, Leppert HG, Rechtzigel MJ, Meyerholz DK, Dodd RD, Quelle DE, Khanna R, Rogers CS, Weimer JM. NF1+/ex42del miniswine model the cellular disruptions and behavioral presentations of NF1-associated cognitive and motor impairment. Clin Transl Sci. 2024 Jun;17(6):e13858. doi: 10.1111/cts.13858. PMID: 38932491; PMCID: PMC11208292. My independent laboratory assisted with model characterization and data generation
  • Brockman QR, Rytlewski JD, Milhem M, Monga V, Dodd RD. Integrated Epigenetic and Transcriptomic Analysis Identifies Interleukin 17 DNA Methylation Signature of Malignant Peripheral Nerve Sheath Tumor Progression and Metastasis. JCO Precis Oncol. 2024 May;8:e2300325. doi: 10.1200/PO.23.00325. PMID: 38820476; PMCID: PMC11552688. All data generated from my independent laboratory
  • Brockman QR, Scherer A, McGivney GR, Gutierrez WR, Rytlewski J, Sheehan A, Warrier A, Laverty EA, Roughton G, Carnevale NC, Knepper-Adrian V, Dodd RD. Discrepancies in Indel Software Resolution with Somatic CRISPR/Cas9 Tumorigenesis Models. Scientific Reports, Sept 2023 PMID: 37684258 PMCID: PMC10491828 DOI: 10.1038/s41598-023-41109-1 All data generated from my independent laboratory
  • Kohlmeyer JL, Lingo JJ, Kaemmer CA, Scherer A, Warrier A, Voigt E, Garay JA, McGivney GR, Brockman QR , Tang A, Calizo A, Pollard K, Zhang X, Hirbe AC, Pratilas CA, Leidinger M, Breheny P, Chimenti MS, Sieren JC, Monga V, Tanas MR, Meyerholz DK, Darbro BW, Dodd RD, and Quelle DE. CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression. Clin Cancer Res (2023) 29 (17): 3484–3497 PMID: 37410426 PMCID: PMC10528807 DOI: 10.1158/1078-0432.CCR-23-0749 My independent laboratory developed the murine model system analyzed in this paper; assisted with data interpretation
  • Gutierrez W, Rytlewski J, Scherer A, Roughton G, Carnevale N, Vyas K, McGivney G, Brockman Q, Knepper-Adrian V, and Dodd RD. Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma. Current Issues in Molecular Biology, Feb 2023 PMID: 36826025 PMCID: PMC9955904 DOI: 10.3390/cimb45020080 All data generated from my independent laboratory
  • Gutierrez WR, Scherer A, Rytlewski JD, Laverty EA, Sheehan AP, McGivney GR, Brockman QR, Knepper-Adrian V, Roughton G, Quelle DE, Gordon DJ, Monga V, Dodd RD. Augmenting chemotherapy with low-dose decitabine through an immune-independent mechanism. JCI Insight. 2022 Nov 22;7(22):e159419. doi: 10.1172/jci.insight.159419. PMID: 36227698; PMCID: PMC9746804 DOI: 10.1172/jci.insight.159419 All data generated from my independent laboratory
  • Meyerholz DK, Leidinger MR, Goeken JA, Businga TR, Akers A, Vizuett S, Kaemmer CA, Kohlmeyer JL, Dodd RD, Quelle DE. Utility of CD138/syndecan-1 immunohistochemistry for localization of plasmacytes is tissue-dependent in B6 mice. BMC Research Notes 2022 Jun 25;15(1):219. PMID: 35752869 PMCID: PMC9233769 DOI: 10.1186/s13104-022-06100-5 My independent laboratory developed the murine model system analyzed in this paper; assisted with data interpretation
  • Kohlmeyer J, Kaemmer C, Lingo JJ, Voigt, Leidinger MR, McGivney GR, Scherer A, Koppenhafer SL, Gordon DJ, Breheny P, Meyerholz DK, Tanas MR, Dodd RD, Quelle DE. Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo. Neurooncol Adv 2022 Apr 9;4(1): vdac047. PMID: 35571990 PMCID: PMC9092646 DOI: 10.1093/noajnl/vdac047 My independent laboratory developed the murine model system introduced in this paper; assisted with data generation and interpretation
  • Gutierrez WR, Scherer A, McGivney GR, Brockman QR, Knepper-Adrian V, Laverty EA, Roughton GA, Dodd RD. Divergent immune landscapes of primary and syngeneic Kras-driven mouse tumor models. Sci Rep 2021; Jan 13;11(1):1098. PMID: 33441747 PMCID: PMC7806664 DOI: 10.1038/s41598-020-80216-1 All data generated from my independent laboratory