Rebecca Dodd, PhD
Associate Professor of Internal Medicine-Hematology, Oncology, and Blood and Marrow Transplantation
Introduction
The Dodd lab studies soft-tissue sarcomas, a type of cancer that develops in connective tissue such as muscle, nerves, fat, or tendons. Our research program designs and utilizes powerful in vivo model systems to directly address critical questions in tumor biology. Specific areas of research include 1) the genetics of sarcoma, 2) the tumor microenvironment, 3) preclinical platform applications, and 4) novel genome editing tools.
Current Positions
- Associate Professor of Internal Medicine-Hematology, Oncology, and Blood and Marrow Transplantation
Education
- PhD, Cell Biology, Duke University, Durham, North Carolina
- Postdoctoral Fellow, Radiation Oncology, Duke University Medical Center, Durham, North Carolina
Graduate Program Affiliations
Center, Program and Institute Affiliations
Selected Publications
- Dodd, R. D., Sachdeva, M., Mito, J. K., Eward, W. C., Brigman, B. E., Ma, Y., Dodd, L., Kim, Y., Lev, D. & Kirsch, D. G. (2016). Myogenic transcription factors regulate pro-metastatic miR-182. Oncogene 35 (14) 1868–1875. PMCID: PMC4523886.
- Dodd, R. D. (2016). Emerging targets in sarcoma: Rising to the challenge of RAS signaling in undifferentiated pleomorphic sarcoma. Cancer 122 (1) 17–19. DOI: 10.1002/cncr.29730.
- Sachdeva, M., Dodd, R. D., Huang, Z., Grenier, C., Ma, Y., Lev, D. C., Cardona, D. M., Murphy, S. K. & Kirsch, D. G. (2015). Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182. Cancer Letters 369 (1) 202–211. DOI: 10.1016/j.canlet.2015.08.016.
- Dodd, R., Añó, L., Blum, J. M., Li, Z., Van Mater, D. & Kirsch, D. G. (2015). Methods to Generate Genetically Engineered Mouse Models of Soft Tissue Sarcoma. In Mouse Models of Cancer. pp. 283–295. Springer New York [Methods in Molecular Biology 1267].
- Sachdeva, M., Mito, J. K., Lee, C., Zhang, M., Li, Z., Dodd, R. D., Cason, D., Luo, L., Ma, Y., Van Mater, D., Gladdy, R., Lev, D. C., Cardona, D. M. & Kirsch, D. G. (2014). MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. Journal of Clinical Investigation 124 (10) 4305–4319. DOI: 10.1172/JCI77116.
- Blum, J. M., Añó, L., Li, Z., Van Mater, D., Bennett, B. D., Sachdeva, M., Lagutina, I., Zhang, M., Mito, J. K., Dodd, L. G., Cardona, D. M., Dodd, R. D., Williams, N., Ma, Y., Lepper, C., Linardic, C. M., Mukherjee, S., Grosveld, G. C., Fan, C. & Kirsch, D. G. (2013). Distinct and Overlapping Sarcoma Subtypes Initiated from Muscle Stem and Progenitor Cells. Cell Reports 5 (4) 933–940. DOI: 10.1016/j.celrep.2013.10.020.
- Dodd, R. D., Mito, J. K., Eward, W. C., Chitalia, R., Sachdeva, M., Ma, Y., Barretina, J., Dodd, L. & Kirsch, D. G. (2013). NF1 Deletion Generates Multiple Subtypes of Soft-Tissue Sarcoma That Respond to MEK Inhibition. Molecular Cancer Therapeutics 12 (9) 1906–1917. PMID: 23858101.
- Epple, L. M., Dodd, R. D., Merz, A. L., Dechkovskaia, A. M., Herring, M., Winston, B. A., Lencioni, A. M., Russell, R. L., Madsen, H., Nega, M., Dusto, N. L., White, J., Bigner, D. D., Nicchitta, C. V., Serkova, N. J. & Graner, M. W. (2013). Induction of the Unfolded Protein Response Drives Enhanced Metabolism and Chemoresistance in Glioma Cells. PLOS ONE 8 (8) e73267. DOI: 10.1371/journal.pone.0073267.
- Dodd, R. D., Barretina, J., Fletcher, J. A. & Kirsch, D. G. (2013). Recent Advances in the Characterization of Mesenchymal Tumors: from Sarcoma Genomics to Targeted Therapies. In Randall, R. L., O'Sullivan, B., Baker, L. H. & Pollock, R. E. (Eds.) Sarcoma Oncology: A Multidisciplinary Approach.
- Mito, J. K., Ferrer, J. M., Brigman, B. E., Lee, C., Dodd, R. D., Eward, W. C., Marshall, L. F., Cuneo, K. C., Carter, J. E., Ramasunder, S., Kim, Y., Lee, W. D., Griffith, L. G., Bawendi, M. G. & Kirsch, D. G. (2012). Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging. Cancer 118 (21) 5320–5330. DOI: 10.1002/cncr.27458.